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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AP4B1
All Species:
32.42
Human Site:
Y455
Identified Species:
59.44
UniProt:
Q9Y6B7
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y6B7
NP_006585.2
739
83260
Y455
E
R
I
P
N
A
P
Y
V
L
E
D
F
V
E
Chimpanzee
Pan troglodytes
XP_001152915
739
83180
Y455
E
R
I
P
N
A
P
Y
V
L
E
D
F
V
E
Rhesus Macaque
Macaca mulatta
XP_001110833
739
83267
Y455
E
R
I
P
N
A
P
Y
V
L
E
D
F
V
E
Dog
Lupus familis
XP_540241
663
74543
V389
L
E
D
F
V
E
N
V
K
S
E
T
F
P
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9WV76
739
82600
Y455
E
K
I
P
N
A
P
Y
V
L
E
D
F
V
Q
Rat
Rattus norvegicus
P62944
937
104534
D463
A
E
R
I
D
N
A
D
E
L
L
E
S
F
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508085
739
82256
Y455
E
K
I
P
N
A
P
Y
V
L
E
D
F
V
E
Chicken
Gallus gallus
NP_001026088
534
59115
E261
F
V
E
N
V
K
T
E
V
F
P
A
V
K
M
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_956632
729
81136
Y455
D
Q
I
S
S
A
P
Y
L
L
E
V
Y
I
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002309568
842
92984
Y484
Q
D
M
S
D
A
P
Y
I
L
E
N
L
T
E
Maize
Zea mays
NP_001151584
841
92750
Y485
Q
D
M
H
D
A
P
Y
I
L
E
S
L
V
E
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_196710
841
93248
Y484
Q
D
M
S
D
A
P
Y
V
L
E
N
L
I
E
Baker's Yeast
Sacchar. cerevisiae
P36000
726
81850
N452
K
Q
V
C
A
V
F
N
T
W
S
N
P
E
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99
84.8
N.A.
90.2
24.8
N.A.
83.3
53.8
N.A.
57.7
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.7
99.3
86.4
N.A.
94.4
45.1
N.A.
90.3
61.9
N.A.
74.2
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
13.3
N.A.
86.6
6.6
N.A.
93.3
6.6
N.A.
40
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
13.3
N.A.
100
20
N.A.
100
6.6
N.A.
86.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
31.7
31.5
N.A.
30.9
25.8
N.A.
Protein Similarity:
49.6
49.5
N.A.
49.5
47.5
N.A.
P-Site Identity:
40
46.6
N.A.
46.6
0
N.A.
P-Site Similarity:
73.3
73.3
N.A.
80
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
8
70
8
0
0
0
0
8
0
0
8
% A
% Cys:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
24
8
0
31
0
0
8
0
0
0
39
0
0
8
% D
% Glu:
39
16
8
0
0
8
0
8
8
0
77
8
0
8
54
% E
% Phe:
8
0
0
8
0
0
8
0
0
8
0
0
47
8
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
47
8
0
0
0
0
16
0
0
0
0
16
0
% I
% Lys:
8
16
0
0
0
8
0
0
8
0
0
0
0
8
0
% K
% Leu:
8
0
0
0
0
0
0
0
8
77
8
0
24
0
8
% L
% Met:
0
0
24
0
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
0
8
39
8
8
8
0
0
0
24
0
0
0
% N
% Pro:
0
0
0
39
0
0
70
0
0
0
8
0
8
8
0
% P
% Gln:
24
16
0
0
0
0
0
0
0
0
0
0
0
0
8
% Q
% Arg:
0
24
8
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
24
8
0
0
0
0
8
8
8
8
0
0
% S
% Thr:
0
0
0
0
0
0
8
0
8
0
0
8
0
8
0
% T
% Val:
0
8
8
0
16
8
0
8
54
0
0
8
8
47
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
70
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _