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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ARFGEF2
All Species:
29.39
Human Site:
S489
Identified Species:
92.38
UniProt:
Q9Y6D5
Number Species:
7
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y6D5
NP_006411.2
1785
202038
S489
F
L
N
I
L
E
T
S
T
S
S
F
E
H
R
Chimpanzee
Pan troglodytes
XP_001165584
1785
202142
S489
F
L
N
I
L
E
T
S
T
S
S
F
E
H
R
Rhesus Macaque
Macaca mulatta
XP_001096475
1849
208876
S538
F
L
Y
I
L
E
T
S
T
S
S
F
D
H
K
Dog
Lupus familis
XP_534448
1785
201926
S489
F
L
N
I
L
E
T
S
T
S
S
F
E
H
R
Cat
Felis silvestris
Mouse
Mus musculus
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506892
1755
198270
S454
F
L
N
I
L
E
T
S
T
S
S
F
E
H
K
Chicken
Gallus gallus
XP_417388
1798
202562
S496
F
L
N
I
L
E
T
S
S
S
S
F
E
H
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002666513
1843
207765
S545
F
L
T
I
L
E
T
S
S
S
S
F
E
H
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P11075
2009
226867
T623
Y
F
P
I
S
E
L
T
T
S
T
S
Q
Q
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
74.7
97.6
N.A.
N.A.
N.A.
N.A.
90.4
86.9
N.A.
77.3
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.7
83.8
98.4
N.A.
N.A.
N.A.
N.A.
93.4
91.4
N.A.
85
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
80
100
N.A.
N.A.
N.A.
N.A.
93.3
86.6
N.A.
80
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
93.3
100
N.A.
N.A.
N.A.
N.A.
100
100
N.A.
93.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
26.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
47.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
13
0
0
% D
% Glu:
0
0
0
0
0
100
0
0
0
0
0
0
75
0
0
% E
% Phe:
88
13
0
0
0
0
0
0
0
0
0
88
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
88
0
% H
% Ile:
0
0
0
100
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
63
% K
% Leu:
0
88
0
0
88
0
13
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
63
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
13
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
13
13
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
38
% R
% Ser:
0
0
0
0
13
0
0
88
25
100
88
13
0
0
0
% S
% Thr:
0
0
13
0
0
0
88
13
75
0
13
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
13
0
13
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _