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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ARFGEF1 All Species: 12.42
Human Site: S1591 Identified Species: 34.17
UniProt: Q9Y6D6 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y6D6 NP_006412.2 1849 208767 S1591 R P Q A P L V S A S A V N E E
Chimpanzee Pan troglodytes XP_519797 1849 208795 S1591 R P Q A P L V S A S A V N E E
Rhesus Macaque Macaca mulatta XP_001096475 1849 208876 S1591 R P Q A P L V S A S A V N E E
Dog Lupus familis XP_535095 1849 208810 S1591 R Q Q A P L A S V S T V N E E
Cat Felis silvestris
Mouse Mus musculus
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511437 1817 205305 I1559 R Q Q M Q S S I V P I M N E E
Chicken Gallus gallus XP_418283 1537 173177 D1321 A T I D S F Q D A V K C L S E
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_002666513 1843 207765 G1594 A S D E T W K G K S H T S H R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q42510 1451 162600 G1235 N M G E E D F G K M S Q D I G
Baker's Yeast Sacchar. cerevisiae P11075 2009 226867 E1751 V E R A H Q E E S S E D V G G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 99.4 98.7 N.A. N.A. N.A. N.A. 93 79.6 N.A. 73.5 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 100 99.6 99.2 N.A. N.A. N.A. N.A. 95.2 81.5 N.A. 82.8 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 100 73.3 N.A. N.A. N.A. N.A. 33.3 13.3 N.A. 6.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 73.3 N.A. N.A. N.A. N.A. 40 13.3 N.A. 13.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 21.1 26 N.A.
Protein Similarity: N.A. N.A. N.A. 38.5 46.7 N.A.
P-Site Identity: N.A. N.A. N.A. 0 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 23 0 0 56 0 0 12 0 45 0 34 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 12 0 0 0 % C
% Asp: 0 0 12 12 0 12 0 12 0 0 0 12 12 0 0 % D
% Glu: 0 12 0 23 12 0 12 12 0 0 12 0 0 56 67 % E
% Phe: 0 0 0 0 0 12 12 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 12 0 0 0 0 23 0 0 0 0 0 12 23 % G
% His: 0 0 0 0 12 0 0 0 0 0 12 0 0 12 0 % H
% Ile: 0 0 12 0 0 0 0 12 0 0 12 0 0 12 0 % I
% Lys: 0 0 0 0 0 0 12 0 23 0 12 0 0 0 0 % K
% Leu: 0 0 0 0 0 45 0 0 0 0 0 0 12 0 0 % L
% Met: 0 12 0 12 0 0 0 0 0 12 0 12 0 0 0 % M
% Asn: 12 0 0 0 0 0 0 0 0 0 0 0 56 0 0 % N
% Pro: 0 34 0 0 45 0 0 0 0 12 0 0 0 0 0 % P
% Gln: 0 23 56 0 12 12 12 0 0 0 0 12 0 0 0 % Q
% Arg: 56 0 12 0 0 0 0 0 0 0 0 0 0 0 12 % R
% Ser: 0 12 0 0 12 12 12 45 12 67 12 0 12 12 0 % S
% Thr: 0 12 0 0 12 0 0 0 0 0 12 12 0 0 0 % T
% Val: 12 0 0 0 0 0 34 0 23 12 0 45 12 0 0 % V
% Trp: 0 0 0 0 0 12 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _