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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ARFGEF1 All Species: 18.18
Human Site: S410 Identified Species: 50
UniProt: Q9Y6D6 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y6D6 NP_006412.2 1849 208767 S410 S G N S S G P S P G A K F S H
Chimpanzee Pan troglodytes XP_519797 1849 208795 S410 S G N S S G P S P G A K F S H
Rhesus Macaque Macaca mulatta XP_001096475 1849 208876 S410 S G N S S G P S P G A K F S H
Dog Lupus familis XP_535095 1849 208810 S410 S G N S S G P S P G A K F S H
Cat Felis silvestris
Mouse Mus musculus
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511437 1817 205305 S378 S G N S S G P S P G A K F S H
Chicken Gallus gallus XP_418283 1537 173177 P244 S Q H E P E S P Q L R H I P T
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_002666513 1843 207765 Q417 A E S I H G S Q T A A R F S H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q42510 1451 162600 E158 E V T D P A S E E V V L M K I
Baker's Yeast Sacchar. cerevisiae P11075 2009 226867 D486 L M D A Q Q P D S I A I T N Q
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 99.4 98.7 N.A. N.A. N.A. N.A. 93 79.6 N.A. 73.5 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 100 99.6 99.2 N.A. N.A. N.A. N.A. 95.2 81.5 N.A. 82.8 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 100 100 N.A. N.A. N.A. N.A. 100 6.6 N.A. 33.3 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. N.A. N.A. N.A. 100 13.3 N.A. 53.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 21.1 26 N.A.
Protein Similarity: N.A. N.A. N.A. 38.5 46.7 N.A.
P-Site Identity: N.A. N.A. N.A. 0 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 0 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 12 0 0 12 0 12 0 0 0 12 78 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 12 12 0 0 0 12 0 0 0 0 0 0 0 % D
% Glu: 12 12 0 12 0 12 0 12 12 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 67 0 0 % F
% Gly: 0 56 0 0 0 67 0 0 0 56 0 0 0 0 0 % G
% His: 0 0 12 0 12 0 0 0 0 0 0 12 0 0 67 % H
% Ile: 0 0 0 12 0 0 0 0 0 12 0 12 12 0 12 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 56 0 12 0 % K
% Leu: 12 0 0 0 0 0 0 0 0 12 0 12 0 0 0 % L
% Met: 0 12 0 0 0 0 0 0 0 0 0 0 12 0 0 % M
% Asn: 0 0 56 0 0 0 0 0 0 0 0 0 0 12 0 % N
% Pro: 0 0 0 0 23 0 67 12 56 0 0 0 0 12 0 % P
% Gln: 0 12 0 0 12 12 0 12 12 0 0 0 0 0 12 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 12 12 0 0 0 % R
% Ser: 67 0 12 56 56 0 34 56 12 0 0 0 0 67 0 % S
% Thr: 0 0 12 0 0 0 0 0 12 0 0 0 12 0 12 % T
% Val: 0 12 0 0 0 0 0 0 0 12 12 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _