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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SIRT4 All Species: 22.12
Human Site: S292 Identified Species: 40.56
UniProt: Q9Y6E7 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y6E7 NP_036372.1 314 35188 S292 L N I G P T R S D D L A C L K
Chimpanzee Pan troglodytes XP_001160214 314 35188 S292 L N I G P T R S D D L A C L K
Rhesus Macaque Macaca mulatta XP_001115744 165 18788 L148 V T Q N V D A L H T K A G S R
Dog Lupus familis XP_863164 312 34885 S290 L N I G P T R S D D L A C L K
Cat Felis silvestris
Mouse Mus musculus Q8R216 333 37536 S289 L N I G P T R S D D L A C L K
Rat Rattus norvegicus NP_001100617 311 35126 S289 L N I G P T R S D D L A C L K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517990 321 35140 S282 L N I G P T R S D K L A T L K
Chicken Gallus gallus XP_415273 512 56313 L490 L N I G P T R L D H F A S L K
Frog Xenopus laevis NP_001084634 322 36258 A291 L N I G P T R A D H L A T V K
Zebra Danio Brachydanio rerio NP_001005988 310 34078 A288 V N I G A T R A D H L T D I R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_572241 312 34972 A283 V N I G E T R A D H L A D I K
Honey Bee Apis mellifera XP_623654 302 34567 K285 V D N L A K I K V E G R C S N
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_793816 295 33325 P278 T R A D K L G P L K I E G R L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 51.2 84 N.A. 80.7 84.3 N.A. 71 45.7 61.1 59.8 N.A. 47.7 45.5 N.A. 56.3
Protein Similarity: 100 99.6 51.5 91.4 N.A. 86.1 90.4 N.A. 80.3 51.9 76 73.8 N.A. 67.1 63 N.A. 71
P-Site Identity: 100 100 6.6 100 N.A. 100 100 N.A. 86.6 73.3 73.3 46.6 N.A. 60 6.6 N.A. 0
P-Site Similarity: 100 100 20 100 N.A. 100 100 N.A. 86.6 73.3 86.6 73.3 N.A. 80 26.6 N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 0 16 0 8 24 0 0 0 77 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 47 0 0 % C
% Asp: 0 8 0 8 0 8 0 0 77 39 0 0 16 0 0 % D
% Glu: 0 0 0 0 8 0 0 0 0 8 0 8 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % F
% Gly: 0 0 0 77 0 0 8 0 0 0 8 0 16 0 0 % G
% His: 0 0 0 0 0 0 0 0 8 31 0 0 0 0 0 % H
% Ile: 0 0 77 0 0 0 8 0 0 0 8 0 0 16 0 % I
% Lys: 0 0 0 0 8 8 0 8 0 16 8 0 0 0 70 % K
% Leu: 62 0 0 8 0 8 0 16 8 0 70 0 0 54 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 77 8 8 0 0 0 0 0 0 0 0 0 0 8 % N
% Pro: 0 0 0 0 62 0 0 8 0 0 0 0 0 0 0 % P
% Gln: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 8 0 0 0 0 77 0 0 0 0 8 0 8 16 % R
% Ser: 0 0 0 0 0 0 0 47 0 0 0 0 8 16 0 % S
% Thr: 8 8 0 0 0 77 0 0 0 8 0 8 16 0 0 % T
% Val: 31 0 0 0 8 0 0 0 8 0 0 0 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _