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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PARP3 All Species: 22.73
Human Site: S405 Identified Species: 50
UniProt: Q9Y6F1 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.4
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y6F1 NP_005476.3 533 60070 S405 G L R I M P H S G G R V G K G
Chimpanzee Pan troglodytes XP_001170254 532 60080 S404 G L R I M P H S G G R V G K G
Rhesus Macaque Macaca mulatta XP_001087761 503 56366 S375 G L R I M P H S G G R V G K G
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus O88554 559 63378 E425 G L R V A P P E A P I T G Y M
Rat Rattus norvegicus NP_001008329 526 58850 S398 G L R I M P H S G G R V G K G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520908 193 21776 G75 S G G R V G R G I Y F A S E N
Chicken Gallus gallus
Frog Xenopus laevis P31669 998 111108 E866 G L R I A P P E A P V T G Y M
Zebra Danio Brachydanio rerio NP_956795 531 59822 S404 G L R I M P H S G G R V G R G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_785135 532 59769 S406 G L R I M P H S G G R V G R G
Poplar Tree Populus trichocarpa
Maize Zea mays O50017 653 72977 E522 G L R I A P P E A P V T G Y M
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q11207 637 72157 E507 G L R I A P P E A P V T G Y M
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97 87.8 N.A. N.A. 34.3 80.6 N.A. 27.9 N.A. 20.8 55.1 N.A. N.A. N.A. N.A. 50.2
Protein Similarity: 100 98.3 89.4 N.A. N.A. 52.4 86.8 N.A. 31.7 N.A. 33.4 72.9 N.A. N.A. N.A. N.A. 65.6
P-Site Identity: 100 100 100 N.A. N.A. 33.3 100 N.A. 0 N.A. 40 93.3 N.A. N.A. N.A. N.A. 93.3
P-Site Similarity: 100 100 100 N.A. N.A. 40 100 N.A. 13.3 N.A. 40 100 N.A. N.A. N.A. N.A. 100
Percent
Protein Identity: N.A. 29.7 N.A. 31.2 N.A. N.A.
Protein Similarity: N.A. 46.5 N.A. 47.5 N.A. N.A.
P-Site Identity: N.A. 40 N.A. 40 N.A. N.A.
P-Site Similarity: N.A. 40 N.A. 40 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 37 0 0 0 37 0 0 10 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 37 0 0 0 0 0 10 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % F
% Gly: 91 10 10 0 0 10 0 10 55 55 0 0 91 0 55 % G
% His: 0 0 0 0 0 0 55 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 82 0 0 0 0 10 0 10 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 37 0 % K
% Leu: 0 91 0 0 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 55 0 0 0 0 0 0 0 0 0 37 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % N
% Pro: 0 0 0 0 0 91 37 0 0 37 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 91 10 0 0 10 0 0 0 55 0 0 19 0 % R
% Ser: 10 0 0 0 0 0 0 55 0 0 0 0 10 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 37 0 0 0 % T
% Val: 0 0 0 10 10 0 0 0 0 0 28 55 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 10 0 0 0 37 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _