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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TLL2
All Species:
46.06
Human Site:
S549
Identified Species:
77.95
UniProt:
Q9Y6L7
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y6L7
NP_036597.1
1015
113557
S549
E
K
P
E
D
V
K
S
S
S
N
R
L
W
M
Chimpanzee
Pan troglodytes
XP_507953
1164
129143
S698
E
K
P
E
D
V
K
S
S
S
N
R
L
W
M
Rhesus Macaque
Macaca mulatta
XP_001101883
1013
114718
S547
D
K
P
E
D
I
R
S
T
S
N
T
L
W
M
Dog
Lupus familis
XP_543945
1032
114883
S556
E
K
P
E
D
V
K
S
S
S
N
R
M
W
M
Cat
Felis silvestris
Mouse
Mus musculus
Q9WVM6
1012
113234
S546
E
K
P
E
A
V
K
S
S
A
N
R
L
W
V
Rat
Rattus norvegicus
XP_345032
1014
113481
S548
E
K
P
E
A
V
K
S
S
A
N
R
L
W
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509196
1014
114574
S548
D
K
P
E
D
I
R
S
T
S
N
T
L
W
M
Chicken
Gallus gallus
Q9DER7
1008
114873
S543
D
K
P
E
D
I
R
S
T
S
N
T
L
W
M
Frog
Xenopus laevis
O57382
1019
114873
S552
E
K
P
E
D
I
K
S
T
S
N
K
L
W
I
Zebra Danio
Brachydanio rerio
O57460
1022
115518
S556
D
K
P
E
D
I
R
S
T
S
N
N
L
W
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P25723
1067
121762
T564
K
L
P
P
N
I
K
T
R
S
N
Q
M
Y
I
Honey Bee
Apis mellifera
XP_393866
1225
138704
S743
K
I
P
P
D
I
K
S
T
G
N
K
L
L
V
Nematode Worm
Caenorhab. elegans
Q20176
951
107516
C503
F
T
K
E
L
N
E
C
A
T
D
K
N
I
C
Sea Urchin
Strong. purpuratus
P98069
639
71875
K191
S
V
G
K
N
C
D
K
F
G
V
V
V
H
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
86.5
72.4
89.6
N.A.
90.2
89.6
N.A.
73
72.5
75
73.2
N.A.
41.5
46.2
40.6
37.8
Protein Similarity:
100
86.7
83.3
92.7
N.A.
93.8
93.9
N.A.
83.8
83
86.3
84.4
N.A.
57.4
59.8
57.6
47.9
P-Site Identity:
100
100
66.6
93.3
N.A.
80
80
N.A.
66.6
66.6
73.3
66.6
N.A.
26.6
40
6.6
0
P-Site Similarity:
100
100
93.3
100
N.A.
93.3
93.3
N.A.
93.3
93.3
100
93.3
N.A.
80
73.3
40
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
15
0
0
0
8
15
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
8
0
8
0
0
0
0
0
0
8
% C
% Asp:
29
0
0
0
65
0
8
0
0
0
8
0
0
0
0
% D
% Glu:
43
0
0
79
0
0
8
0
0
0
0
0
0
0
8
% E
% Phe:
8
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% F
% Gly:
0
0
8
0
0
0
0
0
0
15
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
0
8
0
0
0
50
0
0
0
0
0
0
0
8
15
% I
% Lys:
15
72
8
8
0
0
58
8
0
0
0
22
0
0
0
% K
% Leu:
0
8
0
0
8
0
0
0
0
0
0
0
72
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
15
0
50
% M
% Asn:
0
0
0
0
15
8
0
0
0
0
86
8
8
0
0
% N
% Pro:
0
0
86
15
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% Q
% Arg:
0
0
0
0
0
0
29
0
8
0
0
36
0
0
0
% R
% Ser:
8
0
0
0
0
0
0
79
36
65
0
0
0
0
0
% S
% Thr:
0
8
0
0
0
0
0
8
43
8
0
22
0
0
0
% T
% Val:
0
8
0
0
0
36
0
0
0
0
8
8
8
0
22
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
72
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _