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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K4
All Species:
7.88
Human Site:
S435
Identified Species:
21.67
UniProt:
Q9Y6R4
Number Species:
8
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y6R4
NP_005913.2
1607
181552
S435
E
I
P
S
P
R
P
S
K
G
N
E
P
E
Y
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_851019
1604
181061
S436
E
I
P
S
P
R
S
S
K
G
N
E
P
E
D
Cat
Felis silvestris
Mouse
Mus musculus
O08648
1597
179930
S428
E
I
P
S
P
R
P
S
K
G
Y
E
P
E
D
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512333
716
80761
Chicken
Gallus gallus
XP_419617
1576
178289
E414
P
S
K
D
D
D
P
E
D
E
G
V
D
R
E
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_689836
1475
168741
E402
S
E
A
T
S
D
G
E
Q
S
A
C
S
P
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_732373
1571
177332
Q429
C
K
D
C
M
D
H
Q
E
L
A
L
R
E
V
Honey Bee
Apis mellifera
XP_392650
1209
140403
K136
P
I
D
I
E
E
K
K
I
E
I
K
I
N
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_797473
1747
197449
E503
D
L
P
G
Y
C
V
E
N
P
F
Q
S
E
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
93
N.A.
88.3
N.A.
N.A.
38.9
84.5
N.A.
67
N.A.
25.2
29.6
N.A.
36.1
Protein Similarity:
100
N.A.
N.A.
95.5
N.A.
92.4
N.A.
N.A.
41.8
90.6
N.A.
78.2
N.A.
42
47.1
N.A.
53
P-Site Identity:
100
N.A.
N.A.
86.6
N.A.
86.6
N.A.
N.A.
0
6.6
N.A.
0
N.A.
6.6
6.6
N.A.
13.3
P-Site Similarity:
100
N.A.
N.A.
86.6
N.A.
86.6
N.A.
N.A.
0
6.6
N.A.
13.3
N.A.
13.3
13.3
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
12
0
0
0
0
0
0
0
23
0
0
0
0
% A
% Cys:
12
0
0
12
0
12
0
0
0
0
0
12
0
0
0
% C
% Asp:
12
0
23
12
12
34
0
0
12
0
0
0
12
0
23
% D
% Glu:
34
12
0
0
12
12
0
34
12
23
0
34
0
56
23
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
12
0
0
0
0
% F
% Gly:
0
0
0
12
0
0
12
0
0
34
12
0
0
0
0
% G
% His:
0
0
0
0
0
0
12
0
0
0
0
0
0
0
0
% H
% Ile:
0
45
0
12
0
0
0
0
12
0
12
0
12
0
0
% I
% Lys:
0
12
12
0
0
0
12
12
34
0
0
12
0
0
0
% K
% Leu:
0
12
0
0
0
0
0
0
0
12
0
12
0
0
0
% L
% Met:
0
0
0
0
12
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
12
0
23
0
0
12
0
% N
% Pro:
23
0
45
0
34
0
34
0
0
12
0
0
34
12
12
% P
% Gln:
0
0
0
0
0
0
0
12
12
0
0
12
0
0
0
% Q
% Arg:
0
0
0
0
0
34
0
0
0
0
0
0
12
12
0
% R
% Ser:
12
12
0
34
12
0
12
34
0
12
0
0
23
0
12
% S
% Thr:
0
0
0
12
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
12
0
0
0
0
12
0
0
12
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
12
0
0
0
0
0
12
0
0
0
12
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _