KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K4
All Species:
7.88
Human Site:
S59
Identified Species:
21.67
UniProt:
Q9Y6R4
Number Species:
8
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y6R4
NP_005913.2
1607
181552
S59
Q
E
G
T
L
G
D
S
A
C
K
S
P
E
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_851019
1604
181061
S60
Q
E
C
T
V
G
D
S
A
C
K
N
S
E
S
Cat
Felis silvestris
Mouse
Mus musculus
O08648
1597
179930
S52
Q
E
C
M
L
G
E
S
A
R
K
S
M
E
S
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512333
716
80761
Chicken
Gallus gallus
XP_419617
1576
178289
L44
S
E
S
E
P
E
E
L
S
D
E
A
S
A
D
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_689836
1475
168741
E33
S
W
D
E
P
G
Q
E
E
E
T
L
Y
C
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_732373
1571
177332
T56
V
T
A
E
T
P
P
T
P
P
I
P
P
I
P
Honey Bee
Apis mellifera
XP_392650
1209
140403
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_797473
1747
197449
D47
G
Y
K
K
L
S
Q
D
G
D
G
S
F
D
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
93
N.A.
88.3
N.A.
N.A.
38.9
84.5
N.A.
67
N.A.
25.2
29.6
N.A.
36.1
Protein Similarity:
100
N.A.
N.A.
95.5
N.A.
92.4
N.A.
N.A.
41.8
90.6
N.A.
78.2
N.A.
42
47.1
N.A.
53
P-Site Identity:
100
N.A.
N.A.
73.3
N.A.
66.6
N.A.
N.A.
0
6.6
N.A.
6.6
N.A.
6.6
0
N.A.
13.3
P-Site Similarity:
100
N.A.
N.A.
86.6
N.A.
73.3
N.A.
N.A.
0
33.3
N.A.
13.3
N.A.
13.3
0
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
12
0
0
0
0
0
34
0
0
12
0
12
0
% A
% Cys:
0
0
23
0
0
0
0
0
0
23
0
0
0
12
0
% C
% Asp:
0
0
12
0
0
0
23
12
0
23
0
0
0
12
12
% D
% Glu:
0
45
0
34
0
12
23
12
12
12
12
0
0
34
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
12
0
0
% F
% Gly:
12
0
12
0
0
45
0
0
12
0
12
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
12
0
0
12
0
% I
% Lys:
0
0
12
12
0
0
0
0
0
0
34
0
0
0
0
% K
% Leu:
0
0
0
0
34
0
0
12
0
0
0
12
0
0
0
% L
% Met:
0
0
0
12
0
0
0
0
0
0
0
0
12
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
12
0
0
0
% N
% Pro:
0
0
0
0
23
12
12
0
12
12
0
12
23
0
23
% P
% Gln:
34
0
0
0
0
0
23
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
12
0
0
0
0
0
% R
% Ser:
23
0
12
0
0
12
0
34
12
0
0
34
23
0
34
% S
% Thr:
0
12
0
23
12
0
0
12
0
0
12
0
0
0
12
% T
% Val:
12
0
0
0
12
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
12
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
12
0
0
0
0
0
0
0
0
0
0
12
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _