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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ENPP4
All Species:
16.97
Human Site:
S433
Identified Species:
37.33
UniProt:
Q9Y6X5
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y6X5
NP_055751.1
453
51641
S433
I
I
M
Q
N
R
L
S
V
P
R
P
F
S
R
Chimpanzee
Pan troglodytes
XP_518515
453
51609
S433
I
I
M
Q
N
R
L
S
V
P
R
P
F
S
R
Rhesus Macaque
Macaca mulatta
XP_001101698
453
51521
S433
I
I
M
Q
N
R
L
S
V
P
R
P
F
S
R
Dog
Lupus familis
XP_538944
452
51469
S432
I
I
M
Q
N
R
L
S
V
P
R
P
F
S
R
Cat
Felis silvestris
Mouse
Mus musculus
Q8BTJ4
456
51593
S436
I
F
M
R
S
R
A
S
T
S
R
P
F
S
R
Rat
Rattus norvegicus
P84039
477
54271
M460
K
H
L
I
R
S
Q
M
H
T
L
Q
Y
M
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511420
462
52134
G442
I
I
M
K
N
K
M
G
S
P
R
P
F
S
R
Chicken
Gallus gallus
NP_001006422
331
38022
D318
Q
P
I
I
L
I
A
D
E
G
W
T
M
Y
R
Frog
Xenopus laevis
Q6AX80
452
51293
P433
I
M
L
K
K
K
M
P
S
A
R
P
F
S
R
Zebra Danio
Brachydanio rerio
Q566N0
459
51584
V437
K
L
M
K
N
R
N
V
S
S
P
R
P
F
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P25353
742
84715
P693
T
L
L
G
E
T
S
P
S
S
R
S
S
S
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
97.5
89.4
N.A.
81.8
44
N.A.
75.5
49.2
61.1
56.2
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
100
98.9
93.5
N.A.
90.7
61.2
N.A.
86.8
56.7
75.5
74.2
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
60
0
N.A.
66.6
6.6
40
20
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
73.3
20
N.A.
86.6
13.3
73.3
33.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
20.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
34.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
19
0
0
10
0
0
0
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
10
0
0
0
10
0
0
0
0
0
0
% E
% Phe:
0
10
0
0
0
0
0
0
0
0
0
0
64
10
0
% F
% Gly:
0
0
0
10
0
0
0
10
0
10
0
0
0
0
0
% G
% His:
0
10
0
0
0
0
0
0
10
0
0
0
0
0
0
% H
% Ile:
64
46
10
19
0
10
0
0
0
0
0
0
0
0
0
% I
% Lys:
19
0
0
28
10
19
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
19
28
0
10
0
37
0
0
0
10
0
0
0
0
% L
% Met:
0
10
64
0
0
0
19
10
0
0
0
0
10
10
0
% M
% Asn:
0
0
0
0
55
0
10
0
0
0
0
0
0
0
0
% N
% Pro:
0
10
0
0
0
0
0
19
0
46
10
64
10
0
0
% P
% Gln:
10
0
0
37
0
0
10
0
0
0
0
10
0
0
10
% Q
% Arg:
0
0
0
10
10
55
0
0
0
0
73
10
0
0
73
% R
% Ser:
0
0
0
0
10
10
10
46
37
28
0
10
10
73
10
% S
% Thr:
10
0
0
0
0
10
0
0
10
10
0
10
0
0
0
% T
% Val:
0
0
0
0
0
0
0
10
37
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
10
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _