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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
UBA6
Full Name:
Ubiquitin-like modifier-activating enzyme 6
Alias:
Monocyte 4; MOP-4; Ubiquitin-activating enzyme 6; Ubiquitin-activating enzyme E1-like protein 2
Type:
Ubiquitin conjugating system
Mass (Da):
117970
Number AA:
1052
UniProt ID:
A0AVT1
International Prot ID:
IPI00023647
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0044424
GO:0044464
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003824
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006464
GO:0006508
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
A
H
Q
G
E
E
A
S
C
S
S
W
G
T
G
Site 2
S18
Q
G
E
E
A
S
C
S
S
W
G
T
G
S
T
Site 3
S19
G
E
E
A
S
C
S
S
W
G
T
G
S
T
N
Site 4
T22
A
S
C
S
S
W
G
T
G
S
T
N
K
N
L
Site 5
S24
C
S
S
W
G
T
G
S
T
N
K
N
L
P
I
Site 6
Y44
V
E
I
D
D
A
L
Y
S
R
Q
R
Y
V
L
Site 7
S45
E
I
D
D
A
L
Y
S
R
Q
R
Y
V
L
G
Site 8
Y49
A
L
Y
S
R
Q
R
Y
V
L
G
D
T
A
M
Site 9
S108
L
G
T
N
F
F
L
S
E
D
D
V
V
N
K
Site 10
Y132
H
I
A
E
L
N
P
Y
V
H
V
T
S
S
S
Site 11
T136
L
N
P
Y
V
H
V
T
S
S
S
V
P
F
N
Site 12
S138
P
Y
V
H
V
T
S
S
S
V
P
F
N
E
T
Site 13
S139
Y
V
H
V
T
S
S
S
V
P
F
N
E
T
T
Site 14
T145
S
S
V
P
F
N
E
T
T
D
L
S
F
L
D
Site 15
T146
S
V
P
F
N
E
T
T
D
L
S
F
L
D
K
Site 16
T208
D
E
F
E
V
L
D
T
T
G
E
E
P
K
E
Site 17
T246
L
E
T
G
Q
F
L
T
F
R
E
I
N
G
M
Site 18
T254
F
R
E
I
N
G
M
T
G
L
N
G
S
I
Q
Site 19
T276
F
S
F
S
I
G
D
T
T
E
L
E
P
Y
L
Site 20
T277
S
F
S
I
G
D
T
T
E
L
E
P
Y
L
H
Site 21
Y282
D
T
T
E
L
E
P
Y
L
H
G
G
I
A
V
Site 22
T296
V
Q
V
K
T
P
K
T
V
F
F
E
S
L
E
Site 23
S301
P
K
T
V
F
F
E
S
L
E
R
Q
L
K
H
Site 24
Y339
L
D
Q
F
Q
E
K
Y
S
R
K
P
N
V
G
Site 25
S360
E
L
L
K
L
A
T
S
I
S
E
T
L
E
E
Site 26
S362
L
K
L
A
T
S
I
S
E
T
L
E
E
K
P
Site 27
T364
L
A
T
S
I
S
E
T
L
E
E
K
P
D
V
Site 28
S427
E
A
A
D
I
V
E
S
L
G
K
P
E
C
E
Site 29
Y443
F
L
P
R
G
D
R
Y
D
A
L
R
A
C
I
Site 30
T453
L
R
A
C
I
G
D
T
L
C
Q
K
L
Q
N
Site 31
T494
S
K
E
K
G
M
I
T
V
T
D
P
D
L
I
Site 32
S504
D
P
D
L
I
E
K
S
N
L
N
R
Q
F
L
Site 33
S522
H
H
I
Q
K
P
K
S
Y
T
A
A
D
A
T
Site 34
S534
D
A
T
L
K
I
N
S
Q
I
K
I
D
A
H
Site 35
Y553
C
P
T
T
E
T
I
Y
N
D
E
F
Y
T
K
Site 36
Y558
T
I
Y
N
D
E
F
Y
T
K
Q
D
V
I
I
Site 37
Y576
D
N
V
E
A
R
R
Y
V
D
S
R
C
L
A
Site 38
S579
E
A
R
R
Y
V
D
S
R
C
L
A
N
L
R
Site 39
S591
N
L
R
P
L
L
D
S
G
T
M
G
T
K
G
Site 40
T593
R
P
L
L
D
S
G
T
M
G
T
K
G
H
T
Site 41
T600
T
M
G
T
K
G
H
T
E
V
I
V
P
H
L
Site 42
T608
E
V
I
V
P
H
L
T
E
S
Y
N
S
H
R
Site 43
S613
H
L
T
E
S
Y
N
S
H
R
D
P
P
E
E
Site 44
T626
E
E
E
I
P
F
C
T
L
K
S
F
P
A
A
Site 45
T637
F
P
A
A
I
E
H
T
I
Q
W
A
R
D
K
Site 46
S647
W
A
R
D
K
F
E
S
S
F
S
H
K
P
S
Site 47
S648
A
R
D
K
F
E
S
S
F
S
H
K
P
S
L
Site 48
S650
D
K
F
E
S
S
F
S
H
K
P
S
L
F
N
Site 49
S654
S
S
F
S
H
K
P
S
L
F
N
K
F
W
Q
Site 50
S664
N
K
F
W
Q
T
Y
S
S
A
E
E
V
L
Q
Site 51
S665
K
F
W
Q
T
Y
S
S
A
E
E
V
L
Q
K
Site 52
S675
E
V
L
Q
K
I
Q
S
G
H
S
L
E
G
C
Site 53
S690
F
Q
V
I
K
L
L
S
R
R
P
R
N
W
S
Site 54
S697
S
R
R
P
R
N
W
S
Q
C
V
E
L
A
R
Site 55
Y710
A
R
L
K
F
E
K
Y
F
N
H
K
A
L
Q
Site 56
S732
D
I
R
L
K
D
G
S
L
F
W
Q
S
P
K
Site 57
S737
D
G
S
L
F
W
Q
S
P
K
R
P
P
S
P
Site 58
S743
Q
S
P
K
R
P
P
S
P
I
K
F
D
L
N
Site 59
S756
L
N
E
P
L
H
L
S
F
L
Q
N
A
A
K
Site 60
S798
K
I
Q
E
F
K
P
S
N
K
V
V
Q
T
D
Site 61
T807
K
V
V
Q
T
D
E
T
A
R
K
P
D
H
V
Site 62
S817
K
P
D
H
V
P
I
S
S
E
D
E
R
N
A
Site 63
S818
P
D
H
V
P
I
S
S
E
D
E
R
N
A
I
Site 64
S834
Q
L
E
K
A
I
L
S
N
E
A
T
K
S
D
Site 65
T838
A
I
L
S
N
E
A
T
K
S
D
L
Q
M
A
Site 66
S840
L
S
N
E
A
T
K
S
D
L
Q
M
A
V
L
Site 67
S848
D
L
Q
M
A
V
L
S
F
E
K
D
D
D
H
Site 68
T863
N
G
H
I
D
F
I
T
A
A
S
N
L
R
A
Site 69
S874
N
L
R
A
K
M
Y
S
I
E
P
A
D
R
F
Site 70
T883
E
P
A
D
R
F
K
T
K
R
I
A
G
K
I
Site 71
Y916
M
I
K
V
T
G
G
Y
P
F
E
A
Y
K
N
Site 72
Y921
G
G
Y
P
F
E
A
Y
K
N
C
F
L
N
L
Site 73
T936
A
I
P
I
V
V
F
T
E
T
T
E
V
R
K
Site 74
T938
P
I
V
V
F
T
E
T
T
E
V
R
K
T
K
Site 75
T944
E
T
T
E
V
R
K
T
K
I
R
N
G
I
S
Site 76
Y979
I
N
A
V
K
E
K
Y
G
I
E
P
T
M
V
Site 77
Y994
V
Q
G
V
K
M
L
Y
V
P
V
M
P
G
H
Site 78
T1017
H
K
L
V
K
P
T
T
E
K
K
Y
V
D
L
Site 79
Y1021
K
P
T
T
E
K
K
Y
V
D
L
T
V
S
F
Site 80
T1025
E
K
K
Y
V
D
L
T
V
S
F
A
P
D
I
Site 81
Y1046
P
G
P
P
V
R
Y
Y
F
S
H
D
T
D
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation