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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SHOT1
Full Name:
Shootin-1
Alias:
KIAA1598; Shootin1
Type:
Unknown function
Mass (Da):
71640
Number AA:
631
UniProt ID:
A0MZ66
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030424
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0007275
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
N
S
S
D
E
E
K
Q
L
Site 2
S4
_
_
_
_
M
N
S
S
D
E
E
K
Q
L
Q
Site 3
S15
K
Q
L
Q
L
I
T
S
L
K
E
Q
A
I
G
Site 4
Y24
K
E
Q
A
I
G
E
Y
E
D
L
R
A
E
N
Site 5
T34
L
R
A
E
N
Q
K
T
K
E
K
C
D
K
I
Site 6
T78
N
H
L
E
I
E
K
T
C
R
E
S
A
E
A
Site 7
S82
I
E
K
T
C
R
E
S
A
E
A
L
A
T
K
Site 8
T88
E
S
A
E
A
L
A
T
K
L
N
K
E
N
K
Site 9
T96
K
L
N
K
E
N
K
T
L
K
R
I
S
M
L
Site 10
S101
N
K
T
L
K
R
I
S
M
L
Y
M
A
K
L
Site 11
T114
K
L
G
P
D
V
I
T
E
E
I
N
I
D
D
Site 12
S124
I
N
I
D
D
E
D
S
T
T
D
T
D
G
A
Site 13
T125
N
I
D
D
E
D
S
T
T
D
T
D
G
A
A
Site 14
T126
I
D
D
E
D
S
T
T
D
T
D
G
A
A
E
Site 15
T128
D
E
D
S
T
T
D
T
D
G
A
A
E
T
C
Site 16
S153
E
L
R
D
Q
I
V
S
V
Q
E
E
K
K
I
Site 17
T187
N
K
V
K
Q
E
K
T
V
L
N
S
E
V
L
Site 18
S207
L
E
K
C
N
R
V
S
M
L
A
V
E
E
Y
Site 19
Y214
S
M
L
A
V
E
E
Y
E
E
M
Q
V
N
L
Site 20
S233
D
L
R
K
K
A
E
S
F
A
Q
E
M
F
I
Site 21
S249
Q
N
K
L
K
R
Q
S
H
L
L
L
Q
S
S
Site 22
S256
S
H
L
L
L
Q
S
S
I
P
D
Q
Q
L
L
Site 23
Y324
K
K
E
L
E
L
K
Y
Q
N
S
E
E
K
A
Site 24
S327
L
E
L
K
Y
Q
N
S
E
E
K
A
R
N
L
Site 25
S337
K
A
R
N
L
K
H
S
V
D
E
L
Q
K
R
Site 26
S348
L
Q
K
R
V
N
Q
S
E
N
S
V
P
P
P
Site 27
S351
R
V
N
Q
S
E
N
S
V
P
P
P
P
P
P
Site 28
S372
P
P
P
N
P
I
R
S
L
M
S
M
I
R
K
Site 29
S375
N
P
I
R
S
L
M
S
M
I
R
K
R
S
H
Site 30
S381
M
S
M
I
R
K
R
S
H
P
S
G
S
G
A
Site 31
S386
K
R
S
H
P
S
G
S
G
A
K
K
E
K
A
Site 32
T398
E
K
A
T
Q
P
E
T
T
E
E
V
T
D
L
Site 33
T399
K
A
T
Q
P
E
T
T
E
E
V
T
D
L
K
Site 34
T429
H
L
R
P
V
N
Q
T
A
R
P
K
T
K
P
Site 35
T434
N
Q
T
A
R
P
K
T
K
P
E
S
S
K
G
Site 36
S438
R
P
K
T
K
P
E
S
S
K
G
C
E
S
A
Site 37
S439
P
K
T
K
P
E
S
S
K
G
C
E
S
A
V
Site 38
S444
E
S
S
K
G
C
E
S
A
V
D
E
L
K
G
Site 39
T455
E
L
K
G
I
L
G
T
L
N
K
S
T
S
S
Site 40
S459
I
L
G
T
L
N
K
S
T
S
S
R
S
L
K
Site 41
T460
L
G
T
L
N
K
S
T
S
S
R
S
L
K
S
Site 42
S461
G
T
L
N
K
S
T
S
S
R
S
L
K
S
L
Site 43
S464
N
K
S
T
S
S
R
S
L
K
S
L
D
P
E
Site 44
S467
T
S
S
R
S
L
K
S
L
D
P
E
N
S
E
Site 45
S473
K
S
L
D
P
E
N
S
E
T
E
L
E
R
I
Site 46
T475
L
D
P
E
N
S
E
T
E
L
E
R
I
L
R
Site 47
T487
I
L
R
R
R
K
V
T
A
E
A
D
S
S
S
Site 48
S492
K
V
T
A
E
A
D
S
S
S
P
T
G
I
L
Site 49
S494
T
A
E
A
D
S
S
S
P
T
G
I
L
A
T
Site 50
T496
E
A
D
S
S
S
P
T
G
I
L
A
T
S
E
Site 51
T501
S
P
T
G
I
L
A
T
S
E
S
K
S
M
P
Site 52
S502
P
T
G
I
L
A
T
S
E
S
K
S
M
P
V
Site 53
S506
L
A
T
S
E
S
K
S
M
P
V
L
G
S
V
Site 54
S512
K
S
M
P
V
L
G
S
V
S
S
V
T
K
T
Site 55
S515
P
V
L
G
S
V
S
S
V
T
K
T
A
L
N
Site 56
T519
S
V
S
S
V
T
K
T
A
L
N
K
K
T
L
Site 57
T525
K
T
A
L
N
K
K
T
L
E
A
E
F
N
S
Site 58
S532
T
L
E
A
E
F
N
S
P
S
P
P
T
P
E
Site 59
S534
E
A
E
F
N
S
P
S
P
P
T
P
E
P
G
Site 60
T537
F
N
S
P
S
P
P
T
P
E
P
G
E
G
P
Site 61
S552
R
K
L
E
G
C
T
S
S
K
V
T
F
Q
P
Site 62
S553
K
L
E
G
C
T
S
S
K
V
T
F
Q
P
P
Site 63
T556
G
C
T
S
S
K
V
T
F
Q
P
P
S
S
I
Site 64
S561
K
V
T
F
Q
P
P
S
S
I
G
C
R
K
K
Site 65
S562
V
T
F
Q
P
P
S
S
I
G
C
R
K
K
Y
Site 66
Y569
S
I
G
C
R
K
K
Y
I
D
G
E
K
Q
A
Site 67
S586
V
V
V
L
D
P
V
S
T
H
E
P
Q
T
K
Site 68
T587
V
V
L
D
P
V
S
T
H
E
P
Q
T
K
D
Site 69
T602
Q
V
A
E
K
D
P
T
Q
H
K
E
D
E
G
Site 70
S619
Q
P
E
N
K
E
D
S
I
E
N
V
R
E
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation