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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Rho guanine nucleotide exchange factor 37
Full Name:
Rho guanine nucleotide exchange factor 37
Alias:
Type:
Mass (Da):
76278
Number AA:
675
UniProt ID:
A1IGU5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
K
H
G
A
D
E
P
S
S
R
S
G
S
P
D
Site 2
S11
H
G
A
D
E
P
S
S
R
S
G
S
P
D
R
Site 3
S13
A
D
E
P
S
S
R
S
G
S
P
D
R
E
G
Site 4
S15
E
P
S
S
R
S
G
S
P
D
R
E
G
R
A
Site 5
S23
P
D
R
E
G
R
A
S
E
D
R
S
L
L
H
Site 6
S27
G
R
A
S
E
D
R
S
L
L
H
Q
R
L
A
Site 7
S54
H
M
L
Q
L
C
A
S
D
I
R
S
R
L
Q
Site 8
S58
L
C
A
S
D
I
R
S
R
L
Q
Q
L
P
Q
Site 9
S94
H
D
L
Q
E
T
A
S
K
E
E
E
Q
V
Q
Site 10
T134
Q
A
L
L
L
V
D
T
Y
R
K
E
P
E
L
Site 11
Y135
A
L
L
L
V
D
T
Y
R
K
E
P
E
L
Q
Site 12
Y175
P
L
Q
R
I
T
R
Y
P
L
L
L
Q
K
I
Site 13
T186
L
Q
K
I
L
E
N
T
V
P
D
A
S
A
Y
Site 14
S191
E
N
T
V
P
D
A
S
A
Y
P
V
L
Q
R
Site 15
S201
P
V
L
Q
R
A
V
S
A
L
Q
D
V
N
T
Site 16
T208
S
A
L
Q
D
V
N
T
N
I
N
E
Y
K
M
Site 17
S221
K
M
R
K
E
V
A
S
K
Y
T
K
V
E
Q
Site 18
Y223
R
K
E
V
A
S
K
Y
T
K
V
E
Q
L
T
Site 19
T230
Y
T
K
V
E
Q
L
T
L
R
E
R
L
A
R
Site 20
T240
E
R
L
A
R
I
N
T
H
T
L
S
K
K
T
Site 21
T242
L
A
R
I
N
T
H
T
L
S
K
K
T
T
R
Site 22
S244
R
I
N
T
H
T
L
S
K
K
T
T
R
L
S
Site 23
T247
T
H
T
L
S
K
K
T
T
R
L
S
Q
L
L
Site 24
T248
H
T
L
S
K
K
T
T
R
L
S
Q
L
L
K
Site 25
S251
S
K
K
T
T
R
L
S
Q
L
L
K
Q
E
A
Site 26
T264
E
A
G
L
I
P
R
T
E
D
K
E
F
D
D
Site 27
S280
E
E
R
F
Q
W
V
S
L
C
V
T
E
L
K
Site 28
Y302
D
N
L
Q
A
F
L
Y
F
R
P
H
E
Y
N
Site 29
Y308
L
Y
F
R
P
H
E
Y
N
L
D
I
P
E
G
Site 30
S383
E
K
L
L
E
V
G
S
V
T
Y
Q
E
E
A
Site 31
T394
Q
E
E
A
A
R
H
T
Y
Q
A
L
N
S
L
Site 32
Y395
E
E
A
A
R
H
T
Y
Q
A
L
N
S
L
L
Site 33
S442
V
L
Q
R
A
E
G
S
M
A
Q
L
P
H
H
Site 34
S468
E
D
A
L
G
R
T
S
N
Q
L
R
S
F
Q
Site 35
S473
R
T
S
N
Q
L
R
S
F
Q
E
T
F
E
K
Site 36
T477
Q
L
R
S
F
Q
E
T
F
E
K
V
Q
P
P
Site 37
T486
E
K
V
Q
P
P
P
T
T
Q
P
L
L
P
G
Site 38
T487
K
V
Q
P
P
P
T
T
Q
P
L
L
P
G
S
Site 39
S494
T
Q
P
L
L
P
G
S
E
R
Q
V
Q
A
L
Site 40
S503
R
Q
V
Q
A
L
L
S
R
Y
G
P
G
K
L
Site 41
Y511
R
Y
G
P
G
K
L
Y
Q
V
T
S
N
I
S
Site 42
T514
P
G
K
L
Y
Q
V
T
S
N
I
S
G
T
G
Site 43
S515
G
K
L
Y
Q
V
T
S
N
I
S
G
T
G
T
Site 44
T522
S
N
I
S
G
T
G
T
L
D
L
T
L
P
R
Site 45
T541
A
I
L
Q
N
K
D
T
K
G
N
S
G
R
W
Site 46
S545
N
K
D
T
K
G
N
S
G
R
W
L
V
D
T
Site 47
T552
S
G
R
W
L
V
D
T
G
G
H
R
G
Y
V
Site 48
Y558
D
T
G
G
H
R
G
Y
V
P
A
G
K
L
Q
Site 49
Y567
P
A
G
K
L
Q
L
Y
H
V
V
P
S
A
E
Site 50
T590
N
K
D
P
R
C
L
T
P
E
P
S
P
A
L
Site 51
S618
Y
P
F
V
A
R
S
S
H
E
V
S
L
Q
A
Site 52
S622
A
R
S
S
H
E
V
S
L
Q
A
G
Q
P
V
Site 53
S644
K
K
G
N
P
E
W
S
L
V
E
V
N
G
Q
Site 54
Y654
E
V
N
G
Q
R
G
Y
V
P
S
G
F
L
A
Site 55
S657
G
Q
R
G
Y
V
P
S
G
F
L
A
R
A
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation