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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PXDNL
Full Name:
Peroxidasin-like protein
Alias:
Cardiac peroxidase;Vascular peroxidase 2
Type:
Mass (Da):
163654
Number AA:
1463
UniProt ID:
A1KZ92
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S68
R
I
R
E
I
P
G
S
A
F
K
K
L
K
N
Site 2
T78
K
K
L
K
N
L
N
T
L
L
L
N
N
N
H
Site 3
S90
N
N
H
I
R
K
I
S
R
N
A
F
E
G
L
Site 4
Y102
E
G
L
E
N
L
L
Y
L
Y
L
Y
K
N
E
Site 5
Y104
L
E
N
L
L
Y
L
Y
L
Y
K
N
E
I
H
Site 6
S159
F
L
H
N
N
K
L
S
K
I
P
A
G
S
F
Site 7
S167
K
I
P
A
G
S
F
S
N
L
D
S
L
K
R
Site 8
S171
G
S
F
S
N
L
D
S
L
K
R
L
R
L
D
Site 9
Y212
Q
A
A
A
T
C
E
Y
P
R
R
L
H
G
R
Site 10
T225
G
R
A
V
A
S
V
T
V
E
E
F
N
C
Q
Site 11
S233
V
E
E
F
N
C
Q
S
P
R
I
T
F
E
P
Site 12
T237
N
C
Q
S
P
R
I
T
F
E
P
Q
D
V
E
Site 13
Y252
V
P
S
G
N
T
V
Y
F
T
C
R
A
E
G
Site 14
T254
S
G
N
T
V
Y
F
T
C
R
A
E
G
N
P
Site 15
T280
S
L
D
L
E
D
D
T
R
L
N
V
F
D
D
Site 16
T289
L
N
V
F
D
D
G
T
L
M
I
R
N
T
R
Site 17
T295
G
T
L
M
I
R
N
T
R
E
S
D
Q
G
V
Site 18
Y303
R
E
S
D
Q
G
V
Y
Q
C
M
A
R
N
S
Site 19
S310
Y
Q
C
M
A
R
N
S
A
G
E
A
K
T
Q
Site 20
T316
N
S
A
G
E
A
K
T
Q
S
A
M
L
R
Y
Site 21
S324
Q
S
A
M
L
R
Y
S
S
L
P
A
K
P
S
Site 22
S325
S
A
M
L
R
Y
S
S
L
P
A
K
P
S
F
Site 23
S331
S
S
L
P
A
K
P
S
F
V
I
Q
P
Q
D
Site 24
S374
N
G
L
E
L
D
G
S
R
H
V
A
T
S
S
Site 25
S380
G
S
R
H
V
A
T
S
S
G
L
Y
L
Q
N
Site 26
Y384
V
A
T
S
S
G
L
Y
L
Q
N
I
T
Q
R
Site 27
T389
G
L
Y
L
Q
N
I
T
Q
R
D
H
G
R
F
Site 28
T422
V
Q
A
P
P
Q
F
T
V
T
P
K
D
Q
V
Site 29
T424
A
P
P
Q
F
T
V
T
P
K
D
Q
V
V
L
Site 30
S469
E
G
Q
H
T
V
L
S
S
G
T
L
R
I
D
Site 31
S521
T
Q
L
P
Q
D
T
S
V
E
V
G
K
N
I
Site 32
T552
N
K
E
G
V
Q
I
T
E
S
G
K
F
H
V
Site 33
T566
V
D
D
E
G
T
L
T
I
Y
D
A
G
F
P
Site 34
Y568
D
E
G
T
L
T
I
Y
D
A
G
F
P
D
Q
Site 35
Y578
G
F
P
D
Q
G
R
Y
E
C
V
A
R
N
S
Site 36
S585
Y
E
C
V
A
R
N
S
F
G
L
A
V
T
N
Site 37
S623
D
A
V
Q
R
V
D
S
A
I
N
S
T
R
R
Site 38
S627
R
V
D
S
A
I
N
S
T
R
R
H
L
F
S
Site 39
S634
S
T
R
R
H
L
F
S
Q
K
P
H
T
S
S
Site 40
T639
L
F
S
Q
K
P
H
T
S
S
D
L
L
A
Q
Site 41
T681
E
R
V
K
Q
G
L
T
V
D
L
E
G
K
E
Site 42
Y691
L
E
G
K
E
F
R
Y
N
D
L
V
S
P
R
Site 43
S696
F
R
Y
N
D
L
V
S
P
R
S
L
S
L
I
Site 44
T733
K
Y
R
A
H
D
G
T
C
N
N
L
Q
Q
P
Site 45
S773
G
L
G
L
P
V
G
S
R
Q
P
L
P
P
P
Site 46
T785
P
P
P
R
L
V
A
T
V
W
A
R
A
A
A
Site 47
T794
W
A
R
A
A
A
V
T
P
D
H
S
Y
T
R
Site 48
T817
L
E
H
D
L
D
H
T
V
P
A
L
S
T
A
Site 49
S822
D
H
T
V
P
A
L
S
T
A
R
F
S
D
G
Site 50
T823
H
T
V
P
A
L
S
T
A
R
F
S
D
G
R
Site 51
S827
A
L
S
T
A
R
F
S
D
G
R
P
C
S
S
Site 52
S833
F
S
D
G
R
P
C
S
S
V
C
T
N
D
P
Site 53
S834
S
D
G
R
P
C
S
S
V
C
T
N
D
P
P
Site 54
T837
R
P
C
S
S
V
C
T
N
D
P
P
C
F
P
Site 55
T855
R
H
A
D
P
R
G
T
H
A
P
C
M
L
F
Site 56
S871
R
S
S
P
A
C
A
S
G
R
P
S
A
T
V
Site 57
S875
A
C
A
S
G
R
P
S
A
T
V
D
S
V
Y
Site 58
T877
A
S
G
R
P
S
A
T
V
D
S
V
Y
A
R
Site 59
S880
R
P
S
A
T
V
D
S
V
Y
A
R
E
Q
I
Site 60
Y882
S
A
T
V
D
S
V
Y
A
R
E
Q
I
N
Q
Site 61
Y893
Q
I
N
Q
Q
T
A
Y
I
D
G
S
N
V
Y
Site 62
S897
Q
T
A
Y
I
D
G
S
N
V
Y
G
S
S
E
Site 63
S902
D
G
S
N
V
Y
G
S
S
E
R
E
S
Q
A
Site 64
S903
G
S
N
V
Y
G
S
S
E
R
E
S
Q
A
L
Site 65
S907
Y
G
S
S
E
R
E
S
Q
A
L
R
D
P
S
Site 66
S914
S
Q
A
L
R
D
P
S
V
P
R
G
L
L
K
Site 67
T922
V
P
R
G
L
L
K
T
G
F
P
W
P
P
S
Site 68
S929
T
G
F
P
W
P
P
S
G
K
P
L
L
P
F
Site 69
S937
G
K
P
L
L
P
F
S
T
G
P
P
T
E
C
Site 70
T938
K
P
L
L
P
F
S
T
G
P
P
T
E
C
A
Site 71
T942
P
F
S
T
G
P
P
T
E
C
A
R
Q
E
Q
Site 72
S951
C
A
R
Q
E
Q
E
S
P
C
F
L
A
G
D
Site 73
T983
R
E
H
N
R
V
A
T
E
L
S
A
L
N
P
Site 74
S986
N
R
V
A
T
E
L
S
A
L
N
P
H
W
E
Site 75
Y998
H
W
E
G
N
T
V
Y
Q
E
A
R
K
I
V
Site 76
T1013
G
A
E
L
Q
H
I
T
Y
S
H
W
L
P
K
Site 77
Y1014
A
E
L
Q
H
I
T
Y
S
H
W
L
P
K
V
Site 78
T1027
K
V
L
G
D
P
G
T
R
M
L
R
G
Y
R
Site 79
Y1033
G
T
R
M
L
R
G
Y
R
G
Y
N
P
N
V
Site 80
Y1036
M
L
R
G
Y
R
G
Y
N
P
N
V
N
A
G
Site 81
S1087
P
F
H
K
A
L
F
S
P
S
R
I
I
K
E
Site 82
S1115
A
A
K
W
R
A
P
S
Y
L
L
S
P
E
L
Site 83
Y1116
A
K
W
R
A
P
S
Y
L
L
S
P
E
L
T
Site 84
S1119
R
A
P
S
Y
L
L
S
P
E
L
T
Q
R
L
Site 85
T1140
A
A
V
D
S
A
A
T
I
I
Q
R
G
R
D
Site 86
Y1153
R
D
H
G
I
P
P
Y
V
D
F
R
V
F
C
Site 87
S1164
R
V
F
C
N
L
T
S
V
K
N
F
E
D
L
Site 88
S1178
L
Q
N
E
I
K
D
S
E
I
R
Q
K
L
R
Site 89
Y1188
R
Q
K
L
R
K
L
Y
G
S
P
G
D
I
D
Site 90
S1190
K
L
R
K
L
Y
G
S
P
G
D
I
D
L
W
Site 91
Y1234
R
D
G
D
R
F
W
Y
E
N
P
G
V
F
T
Site 92
T1241
Y
E
N
P
G
V
F
T
P
A
Q
L
T
Q
L
Site 93
Y1277
D
V
F
V
K
A
E
Y
P
Q
D
Y
L
N
C
Site 94
Y1281
K
A
E
Y
P
Q
D
Y
L
N
C
S
E
I
P
Site 95
T1312
R
G
Q
F
R
A
V
T
Q
E
S
Q
K
K
R
Site 96
S1315
F
R
A
V
T
Q
E
S
Q
K
K
R
S
A
Q
Site 97
S1320
Q
E
S
Q
K
K
R
S
A
Q
Y
S
Y
P
V
Site 98
Y1323
Q
K
K
R
S
A
Q
Y
S
Y
P
V
D
K
D
Site 99
S1324
K
K
R
S
A
Q
Y
S
Y
P
V
D
K
D
M
Site 100
Y1325
K
R
S
A
Q
Y
S
Y
P
V
D
K
D
M
E
Site 101
S1334
V
D
K
D
M
E
L
S
H
L
R
S
R
Q
Q
Site 102
S1338
M
E
L
S
H
L
R
S
R
Q
Q
D
K
I
Y
Site 103
Y1345
S
R
Q
Q
D
K
I
Y
V
G
E
D
A
R
N
Site 104
T1354
G
E
D
A
R
N
V
T
V
L
A
K
T
K
F
Site 105
S1366
T
K
F
S
Q
D
F
S
T
F
A
A
E
I
Q
Site 106
T1367
K
F
S
Q
D
F
S
T
F
A
A
E
I
Q
E
Site 107
T1396
R
L
R
Q
A
G
C
T
D
V
R
G
V
P
R
Site 108
S1438
C
P
P
A
P
C
P
S
P
E
L
V
K
G
T
Site 109
T1445
S
P
E
L
V
K
G
T
C
C
P
V
C
R
D
Site 110
S1457
C
R
D
R
G
M
P
S
D
S
P
E
K
R
_
Site 111
S1459
D
R
G
M
P
S
D
S
P
E
K
R
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation