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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLEKHG3
Full Name:
Pleckstrin homology domain-containing family G member 3
Alias:
KIAA0599; PKHG3; Pleckstrin homology domain containing, family G (with RhoGef domain) member 3; Pleckstriny domain containing, family G (with RhoGef domain) member 3
Type:
Guanine nucleotide exchange factor, Rac/Rho
Mass (Da):
134412
Number AA:
1219
UniProt ID:
A1L390
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005089
PhosphoSite+
KinaseNET
Biological Process:
GO:0035023
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
P
V
S
T
S
L
H
Q
D
G
S
Q
Site 2
S12
T
S
L
H
Q
D
G
S
Q
E
R
P
V
S
L
Site 3
S18
G
S
Q
E
R
P
V
S
L
T
S
T
T
S
S
Site 4
T20
Q
E
R
P
V
S
L
T
S
T
T
S
S
S
G
Site 5
S21
E
R
P
V
S
L
T
S
T
T
S
S
S
G
S
Site 6
T22
R
P
V
S
L
T
S
T
T
S
S
S
G
S
S
Site 7
T23
P
V
S
L
T
S
T
T
S
S
S
G
S
S
C
Site 8
S24
V
S
L
T
S
T
T
S
S
S
G
S
S
C
D
Site 9
S25
S
L
T
S
T
T
S
S
S
G
S
S
C
D
S
Site 10
S26
L
T
S
T
T
S
S
S
G
S
S
C
D
S
R
Site 11
S28
S
T
T
S
S
S
G
S
S
C
D
S
R
S
A
Site 12
S29
T
T
S
S
S
G
S
S
C
D
S
R
S
A
M
Site 13
S32
S
S
G
S
S
C
D
S
R
S
A
M
E
E
P
Site 14
S34
G
S
S
C
D
S
R
S
A
M
E
E
P
S
S
Site 15
S41
S
A
M
E
E
P
S
S
S
E
A
P
A
K
N
Site 16
S42
A
M
E
E
P
S
S
S
E
A
P
A
K
N
G
Site 17
S52
P
A
K
N
G
A
G
S
L
R
S
R
H
L
P
Site 18
S61
R
S
R
H
L
P
N
S
N
N
N
S
S
S
W
Site 19
S65
L
P
N
S
N
N
N
S
S
S
W
L
N
V
K
Site 20
S67
N
S
N
N
N
S
S
S
W
L
N
V
K
G
P
Site 21
S76
L
N
V
K
G
P
L
S
P
F
N
S
R
A
A
Site 22
S80
G
P
L
S
P
F
N
S
R
A
A
A
G
P
A
Site 23
S92
G
P
A
H
H
K
L
S
Y
L
G
R
V
V
R
Site 24
Y93
P
A
H
H
K
L
S
Y
L
G
R
V
V
R
E
Site 25
T104
V
V
R
E
I
V
E
T
E
R
M
Y
V
Q
D
Site 26
Y108
I
V
E
T
E
R
M
Y
V
Q
D
L
R
S
I
Site 27
S150
E
N
I
Y
A
L
N
S
Q
L
L
R
D
L
D
Site 28
S158
Q
L
L
R
D
L
D
S
C
N
S
D
P
V
A
Site 29
S161
R
D
L
D
S
C
N
S
D
P
V
A
V
A
S
Site 30
S168
S
D
P
V
A
V
A
S
C
F
V
E
R
S
Q
Site 31
S174
A
S
C
F
V
E
R
S
Q
E
F
D
I
Y
T
Site 32
Y180
R
S
Q
E
F
D
I
Y
T
Q
Y
C
N
N
Y
Site 33
Y183
E
F
D
I
Y
T
Q
Y
C
N
N
Y
P
N
S
Site 34
Y187
Y
T
Q
Y
C
N
N
Y
P
N
S
V
A
A
L
Site 35
S217
R
Q
E
L
L
Q
H
S
L
P
L
G
S
Y
L
Site 36
S222
Q
H
S
L
P
L
G
S
Y
L
L
K
P
V
Q
Site 37
Y223
H
S
L
P
L
G
S
Y
L
L
K
P
V
Q
R
Site 38
S287
V
R
L
Q
E
I
Q
S
L
L
I
N
W
K
G
Site 39
T298
N
W
K
G
P
D
L
T
T
Y
G
E
L
V
L
Site 40
Y300
K
G
P
D
L
T
T
Y
G
E
L
V
L
E
G
Site 41
T308
G
E
L
V
L
E
G
T
F
R
V
H
R
V
R
Site 42
T319
H
R
V
R
N
E
R
T
F
F
L
F
D
K
T
Site 43
Y339
K
R
G
D
H
F
V
Y
K
G
N
I
P
C
S
Site 44
T361
T
R
D
S
L
C
F
T
V
T
H
Y
K
H
S
Site 45
T363
D
S
L
C
F
T
V
T
H
Y
K
H
S
K
Q
Site 46
Y365
L
C
F
T
V
T
H
Y
K
H
S
K
Q
Q
Y
Site 47
T378
Q
Y
S
I
Q
A
K
T
V
E
E
K
R
N
W
Site 48
T386
V
E
E
K
R
N
W
T
H
H
I
K
R
L
I
Site 49
S414
E
A
I
L
E
M
D
S
Y
Y
P
N
R
Y
R
Site 50
Y415
A
I
L
E
M
D
S
Y
Y
P
N
R
Y
R
C
Site 51
Y416
I
L
E
M
D
S
Y
Y
P
N
R
Y
R
C
S
Site 52
S423
Y
P
N
R
Y
R
C
S
P
E
R
L
K
K
A
Site 53
S432
E
R
L
K
K
A
W
S
S
Q
D
E
V
S
T
Site 54
S433
R
L
K
K
A
W
S
S
Q
D
E
V
S
T
N
Site 55
S448
V
R
Q
G
R
R
Q
S
E
P
T
K
H
L
L
Site 56
T451
G
R
R
Q
S
E
P
T
K
H
L
L
R
Q
L
Site 57
S475
K
G
K
G
R
R
E
S
E
S
S
R
S
S
R
Site 58
S477
K
G
R
R
E
S
E
S
S
R
S
S
R
R
P
Site 59
S478
G
R
R
E
S
E
S
S
R
S
S
R
R
P
S
Site 60
S480
R
E
S
E
S
S
R
S
S
R
R
P
S
G
R
Site 61
S481
E
S
E
S
S
R
S
S
R
R
P
S
G
R
S
Site 62
S485
S
R
S
S
R
R
P
S
G
R
S
P
T
S
T
Site 63
S488
S
R
R
P
S
G
R
S
P
T
S
T
E
K
R
Site 64
T490
R
P
S
G
R
S
P
T
S
T
E
K
R
M
S
Site 65
S491
P
S
G
R
S
P
T
S
T
E
K
R
M
S
F
Site 66
T492
S
G
R
S
P
T
S
T
E
K
R
M
S
F
E
Site 67
S497
T
S
T
E
K
R
M
S
F
E
S
I
S
S
L
Site 68
S500
E
K
R
M
S
F
E
S
I
S
S
L
P
E
V
Site 69
S503
M
S
F
E
S
I
S
S
L
P
E
V
E
P
D
Site 70
S515
E
P
D
P
E
A
G
S
E
Q
E
V
F
S
A
Site 71
S521
G
S
E
Q
E
V
F
S
A
V
E
G
P
S
A
Site 72
S527
F
S
A
V
E
G
P
S
A
E
E
T
P
S
D
Site 73
T531
E
G
P
S
A
E
E
T
P
S
D
T
E
S
P
Site 74
S533
P
S
A
E
E
T
P
S
D
T
E
S
P
E
V
Site 75
T535
A
E
E
T
P
S
D
T
E
S
P
E
V
L
E
Site 76
S537
E
T
P
S
D
T
E
S
P
E
V
L
E
T
Q
Site 77
T543
E
S
P
E
V
L
E
T
Q
L
D
A
H
Q
G
Site 78
S576
T
E
D
L
K
A
L
S
S
E
E
E
E
E
M
Site 79
S577
E
D
L
K
A
L
S
S
E
E
E
E
E
M
G
Site 80
S592
G
A
A
Q
E
P
E
S
L
L
P
P
S
V
L
Site 81
S611
V
I
A
E
R
F
V
S
S
F
S
R
R
S
S
Site 82
S612
I
A
E
R
F
V
S
S
F
S
R
R
S
S
V
Site 83
S614
E
R
F
V
S
S
F
S
R
R
S
S
V
A
Q
Site 84
S617
V
S
S
F
S
R
R
S
S
V
A
Q
E
D
S
Site 85
S618
S
S
F
S
R
R
S
S
V
A
Q
E
D
S
K
Site 86
S624
S
S
V
A
Q
E
D
S
K
S
S
G
F
G
S
Site 87
S626
V
A
Q
E
D
S
K
S
S
G
F
G
S
P
R
Site 88
S627
A
Q
E
D
S
K
S
S
G
F
G
S
P
R
L
Site 89
S631
S
K
S
S
G
F
G
S
P
R
L
V
S
R
S
Site 90
S636
F
G
S
P
R
L
V
S
R
S
S
S
V
L
S
Site 91
S638
S
P
R
L
V
S
R
S
S
S
V
L
S
L
E
Site 92
S639
P
R
L
V
S
R
S
S
S
V
L
S
L
E
G
Site 93
S640
R
L
V
S
R
S
S
S
V
L
S
L
E
G
S
Site 94
S643
S
R
S
S
S
V
L
S
L
E
G
S
E
K
G
Site 95
S647
S
V
L
S
L
E
G
S
E
K
G
L
A
R
H
Site 96
S656
K
G
L
A
R
H
G
S
A
T
D
S
L
S
C
Site 97
T658
L
A
R
H
G
S
A
T
D
S
L
S
C
Q
L
Site 98
S660
R
H
G
S
A
T
D
S
L
S
C
Q
L
S
P
Site 99
S662
G
S
A
T
D
S
L
S
C
Q
L
S
P
E
V
Site 100
S680
V
G
V
A
T
E
D
S
P
S
V
N
G
M
E
Site 101
S682
V
A
T
E
D
S
P
S
V
N
G
M
E
P
P
Site 102
S690
V
N
G
M
E
P
P
S
P
G
C
P
V
E
P
Site 103
S700
C
P
V
E
P
D
R
S
S
C
K
K
K
E
S
Site 104
S701
P
V
E
P
D
R
S
S
C
K
K
K
E
S
A
Site 105
S707
S
S
C
K
K
K
E
S
A
L
S
T
R
D
R
Site 106
S710
K
K
K
E
S
A
L
S
T
R
D
R
L
L
L
Site 107
T711
K
K
E
S
A
L
S
T
R
D
R
L
L
L
D
Site 108
S722
L
L
L
D
K
I
K
S
Y
Y
E
N
A
E
H
Site 109
Y723
L
L
D
K
I
K
S
Y
Y
E
N
A
E
H
H
Site 110
Y724
L
D
K
I
K
S
Y
Y
E
N
A
E
H
H
D
Site 111
S735
E
H
H
D
A
G
F
S
V
R
R
R
E
S
L
Site 112
S741
F
S
V
R
R
R
E
S
L
S
Y
I
P
K
G
Site 113
S743
V
R
R
R
E
S
L
S
Y
I
P
K
G
L
V
Site 114
Y744
R
R
R
E
S
L
S
Y
I
P
K
G
L
V
R
Site 115
S753
P
K
G
L
V
R
N
S
I
S
R
F
N
S
L
Site 116
S755
G
L
V
R
N
S
I
S
R
F
N
S
L
P
R
Site 117
S759
N
S
I
S
R
F
N
S
L
P
R
P
D
P
E
Site 118
S773
E
P
V
P
P
V
G
S
K
R
Q
V
G
S
R
Site 119
S779
G
S
K
R
Q
V
G
S
R
P
T
S
W
A
L
Site 120
T782
R
Q
V
G
S
R
P
T
S
W
A
L
F
E
L
Site 121
S783
Q
V
G
S
R
P
T
S
W
A
L
F
E
L
P
Site 122
S793
L
F
E
L
P
G
P
S
Q
A
V
K
G
D
P
Site 123
S804
K
G
D
P
P
P
I
S
D
A
E
F
R
P
S
Site 124
S811
S
D
A
E
F
R
P
S
S
E
I
V
K
I
W
Site 125
S812
D
A
E
F
R
P
S
S
E
I
V
K
I
W
E
Site 126
S823
K
I
W
E
G
M
E
S
S
G
G
S
P
G
K
Site 127
S827
G
M
E
S
S
G
G
S
P
G
K
G
P
G
Q
Site 128
S861
L
G
A
I
T
E
E
S
A
T
A
S
P
E
S
Site 129
T863
A
I
T
E
E
S
A
T
A
S
P
E
S
S
S
Site 130
S865
T
E
E
S
A
T
A
S
P
E
S
S
S
P
T
Site 131
S868
S
A
T
A
S
P
E
S
S
S
P
T
E
G
R
Site 132
S869
A
T
A
S
P
E
S
S
S
P
T
E
G
R
S
Site 133
S870
T
A
S
P
E
S
S
S
P
T
E
G
R
S
P
Site 134
T872
S
P
E
S
S
S
P
T
E
G
R
S
P
A
H
Site 135
S876
S
S
P
T
E
G
R
S
P
A
H
L
A
R
E
Site 136
S892
K
E
L
V
K
E
L
S
S
S
T
Q
G
E
L
Site 137
S916
Q
L
S
H
V
M
D
S
H
V
S
E
R
V
K
Site 138
S919
H
V
M
D
S
H
V
S
E
R
V
K
N
K
V
Site 139
Y933
V
Y
Q
L
A
R
Q
Y
S
L
R
I
K
S
N
Site 140
S934
Y
Q
L
A
R
Q
Y
S
L
R
I
K
S
N
K
Site 141
S939
Q
Y
S
L
R
I
K
S
N
K
P
V
M
A
R
Site 142
S962
A
P
E
R
D
G
K
S
P
T
V
P
C
L
Q
Site 143
T964
E
R
D
G
K
S
P
T
V
P
C
L
Q
E
E
Site 144
S987
G
K
R
K
P
V
L
S
L
F
D
Y
E
Q
L
Site 145
Y991
P
V
L
S
L
F
D
Y
E
Q
L
M
A
Q
E
Site 146
S1000
Q
L
M
A
Q
E
H
S
P
P
K
P
S
S
A
Site 147
S1005
E
H
S
P
P
K
P
S
S
A
G
E
M
S
P
Site 148
S1006
H
S
P
P
K
P
S
S
A
G
E
M
S
P
Q
Site 149
S1011
P
S
S
A
G
E
M
S
P
Q
R
F
F
F
N
Site 150
S1020
Q
R
F
F
F
N
P
S
A
V
S
Q
R
T
T
Site 151
S1023
F
F
N
P
S
A
V
S
Q
R
T
T
S
P
G
Site 152
T1026
P
S
A
V
S
Q
R
T
T
S
P
G
G
R
P
Site 153
T1027
S
A
V
S
Q
R
T
T
S
P
G
G
R
P
S
Site 154
S1028
A
V
S
Q
R
T
T
S
P
G
G
R
P
S
A
Site 155
S1034
T
S
P
G
G
R
P
S
A
R
S
P
L
S
P
Site 156
S1037
G
G
R
P
S
A
R
S
P
L
S
P
T
E
T
Site 157
S1040
P
S
A
R
S
P
L
S
P
T
E
T
F
S
W
Site 158
T1042
A
R
S
P
L
S
P
T
E
T
F
S
W
P
D
Site 159
T1044
S
P
L
S
P
T
E
T
F
S
W
P
D
V
R
Site 160
S1046
L
S
P
T
E
T
F
S
W
P
D
V
R
E
L
Site 161
S1055
P
D
V
R
E
L
C
S
K
Y
A
S
R
D
E
Site 162
Y1057
V
R
E
L
C
S
K
Y
A
S
R
D
E
A
R
Site 163
S1059
E
L
C
S
K
Y
A
S
R
D
E
A
R
R
A
Site 164
S1079
R
G
P
P
V
N
R
S
H
S
V
P
E
N
M
Site 165
S1081
P
P
V
N
R
S
H
S
V
P
E
N
M
V
E
Site 166
S1092
N
M
V
E
P
P
L
S
G
R
V
G
R
C
R
Site 167
S1100
G
R
V
G
R
C
R
S
L
S
T
K
R
G
R
Site 168
S1102
V
G
R
C
R
S
L
S
T
K
R
G
R
G
G
Site 169
T1103
G
R
C
R
S
L
S
T
K
R
G
R
G
G
G
Site 170
S1115
G
G
G
E
A
A
Q
S
P
G
P
L
P
Q
S
Site 171
S1122
S
P
G
P
L
P
Q
S
K
P
D
G
G
E
T
Site 172
T1137
L
Y
V
T
A
D
L
T
L
E
D
N
R
R
V
Site 173
S1154
M
E
K
G
P
L
P
S
P
T
A
G
L
E
E
Site 174
T1156
K
G
P
L
P
S
P
T
A
G
L
E
E
S
S
Site 175
S1162
P
T
A
G
L
E
E
S
S
G
Q
G
P
S
S
Site 176
S1168
E
S
S
G
Q
G
P
S
S
P
V
A
L
L
G
Site 177
S1169
S
S
G
Q
G
P
S
S
P
V
A
L
L
G
Q
Site 178
S1183
Q
V
Q
D
F
Q
Q
S
A
E
C
Q
P
K
E
Site 179
S1200
S
R
D
P
A
D
P
S
Q
Q
G
R
V
R
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation