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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FSD2
Full Name:
Fibronectin type III and SPRY domain-containing protein 2
Alias:
SPRY domain-containing protein 1
Type:
Mass (Da):
85385
Number AA:
749
UniProt ID:
A1L4K1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
E
E
L
G
L
D
R
S
T
P
K
D
F
H
F
Site 2
T15
E
L
G
L
D
R
S
T
P
K
D
F
H
F
Y
Site 3
Y27
H
F
Y
H
M
D
L
Y
D
S
E
D
R
L
H
Site 4
Y103
P
R
T
G
V
S
E
Y
P
P
Y
M
M
K
R
Site 5
Y106
G
V
S
E
Y
P
P
Y
M
M
K
R
R
D
P
Site 6
S123
E
Q
R
D
W
R
L
S
G
E
A
A
E
A
E
Site 7
S139
L
G
F
G
G
W
G
S
A
G
Q
C
Q
D
L
Site 8
Y150
C
Q
D
L
R
E
A
Y
R
Y
T
H
G
R
A
Site 9
Y152
D
L
R
E
A
Y
R
Y
T
H
G
R
A
S
E
Site 10
T153
L
R
E
A
Y
R
Y
T
H
G
R
A
S
E
E
Site 11
Y161
H
G
R
A
S
E
E
Y
E
C
Y
V
I
P
E
Site 12
Y164
A
S
E
E
Y
E
C
Y
V
I
P
E
E
E
D
Site 13
S211
P
L
N
E
A
L
E
S
A
K
D
E
I
H
K
Site 14
T243
H
L
E
E
V
F
I
T
V
E
E
N
F
G
K
Site 15
Y259
E
Q
N
F
E
S
H
Y
N
E
I
L
E
T
L
Site 16
T265
H
Y
N
E
I
L
E
T
L
A
Q
K
Y
E
E
Site 17
Y270
L
E
T
L
A
Q
K
Y
E
E
K
I
Q
A
L
Site 18
Y289
K
E
K
L
E
A
L
Y
G
Q
L
V
S
C
G
Site 19
T301
S
C
G
E
N
L
D
T
C
K
E
L
M
E
T
Site 20
T337
R
L
G
K
F
L
K
T
K
T
D
V
E
I
S
Site 21
T339
G
K
F
L
K
T
K
T
D
V
E
I
S
A
Q
Site 22
S344
T
K
T
D
V
E
I
S
A
Q
P
E
F
E
D
Site 23
T353
Q
P
E
F
E
D
Q
T
L
D
F
S
D
V
E
Site 24
S357
E
D
Q
T
L
D
F
S
D
V
E
Q
L
M
G
Site 25
S384
I
N
P
Q
V
P
N
S
A
T
G
S
S
V
R
Site 26
S388
V
P
N
S
A
T
G
S
S
V
R
V
C
W
S
Site 27
S389
P
N
S
A
T
G
S
S
V
R
V
C
W
S
L
Site 28
S395
S
S
V
R
V
C
W
S
L
Y
S
D
D
T
V
Site 29
Y397
V
R
V
C
W
S
L
Y
S
D
D
T
V
E
S
Site 30
S398
R
V
C
W
S
L
Y
S
D
D
T
V
E
S
Y
Site 31
T401
W
S
L
Y
S
D
D
T
V
E
S
Y
Q
L
S
Site 32
S404
Y
S
D
D
T
V
E
S
Y
Q
L
S
Y
R
P
Site 33
S408
T
V
E
S
Y
Q
L
S
Y
R
P
V
Q
D
S
Site 34
S415
S
Y
R
P
V
Q
D
S
S
P
G
T
D
Q
A
Site 35
S416
Y
R
P
V
Q
D
S
S
P
G
T
D
Q
A
E
Site 36
T419
V
Q
D
S
S
P
G
T
D
Q
A
E
F
T
V
Site 37
T425
G
T
D
Q
A
E
F
T
V
T
V
K
E
T
Y
Site 38
T427
D
Q
A
E
F
T
V
T
V
K
E
T
Y
C
S
Site 39
S434
T
V
K
E
T
Y
C
S
V
T
N
L
V
P
N
Site 40
Y444
N
L
V
P
N
T
Q
Y
E
F
W
V
T
A
H
Site 41
S457
A
H
N
R
A
G
P
S
P
S
S
E
R
A
V
Site 42
S459
N
R
A
G
P
S
P
S
S
E
R
A
V
Y
M
Site 43
S460
R
A
G
P
S
P
S
S
E
R
A
V
Y
M
T
Site 44
Y465
P
S
S
E
R
A
V
Y
M
T
A
P
S
P
P
Site 45
T467
S
E
R
A
V
Y
M
T
A
P
S
P
P
I
I
Site 46
T476
P
S
P
P
I
I
K
T
K
E
I
R
S
C
E
Site 47
S500
G
N
L
N
P
V
D
S
Y
T
V
E
L
T
Q
Site 48
Y501
N
L
N
P
V
D
S
Y
T
V
E
L
T
Q
A
Site 49
T502
L
N
P
V
D
S
Y
T
V
E
L
T
Q
A
E
Site 50
T506
D
S
Y
T
V
E
L
T
Q
A
E
S
P
E
A
Site 51
S510
V
E
L
T
Q
A
E
S
P
E
A
S
G
V
T
Site 52
S514
Q
A
E
S
P
E
A
S
G
V
T
E
S
V
V
Site 53
Y538
Q
L
Q
P
G
R
S
Y
I
I
Y
V
R
A
L
Site 54
Y541
P
G
R
S
Y
I
I
Y
V
R
A
L
N
M
G
Site 55
S551
A
L
N
M
G
G
P
S
V
R
S
E
P
A
T
Site 56
S554
M
G
G
P
S
V
R
S
E
P
A
T
V
H
T
Site 57
T558
S
V
R
S
E
P
A
T
V
H
T
I
G
S
Y
Site 58
S564
A
T
V
H
T
I
G
S
Y
F
R
L
N
K
D
Site 59
Y565
T
V
H
T
I
G
S
Y
F
R
L
N
K
D
T
Site 60
T578
D
T
C
H
P
W
L
T
I
S
E
D
G
L
T
Site 61
T585
T
I
S
E
D
G
L
T
A
V
R
S
E
R
R
Site 62
S589
D
G
L
T
A
V
R
S
E
R
R
T
P
A
R
Site 63
T593
A
V
R
S
E
R
R
T
P
A
R
E
L
S
P
Site 64
S599
R
T
P
A
R
E
L
S
P
S
D
T
H
F
T
Site 65
S601
P
A
R
E
L
S
P
S
D
T
H
F
T
R
C
Site 66
T603
R
E
L
S
P
S
D
T
H
F
T
R
C
V
A
Site 67
Y623
I
P
V
R
G
H
H
Y
W
E
V
E
V
D
E
Site 68
Y634
E
V
D
E
H
L
D
Y
R
V
G
V
A
F
A
Site 69
T661
L
S
W
C
M
R
H
T
F
A
S
S
R
H
K
Site 70
Y669
F
A
S
S
R
H
K
Y
E
F
L
H
N
R
T
Site 71
T677
E
F
L
H
N
R
T
T
P
D
I
R
I
T
V
Site 72
T683
T
T
P
D
I
R
I
T
V
P
P
K
K
I
G
Site 73
Y695
K
I
G
I
L
L
D
Y
E
H
S
K
L
S
F
Site 74
S701
D
Y
E
H
S
K
L
S
F
F
N
V
D
L
S
Site 75
S708
S
F
F
N
V
D
L
S
Q
H
L
Y
T
F
S
Site 76
Y712
V
D
L
S
Q
H
L
Y
T
F
S
C
Q
L
H
Site 77
T713
D
L
S
Q
H
L
Y
T
F
S
C
Q
L
H
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation