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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SH3PXD2B
Full Name:
SH3 and PX domain-containing protein 2B
Alias:
Adapter protein HOFI; Factor for adipocyte differentiation 49; FLJ20831; KIAA1295; SH3 and PX domains 2B; SPD2B
Type:
Unknown function
Mass (Da):
101561
Number AA:
911
UniProt ID:
A1X283
International Prot ID:
IPI00023832
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0044424
GO:0044464
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
GO:0005543
PhosphoSite+
KinaseNET
Biological Process:
GO:0007154
GO:0009987
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y25
R
R
V
P
N
K
H
Y
V
Y
I
I
R
V
T
Site 2
Y27
V
P
N
K
H
Y
V
Y
I
I
R
V
T
W
S
Site 3
T32
Y
V
Y
I
I
R
V
T
W
S
S
G
S
T
E
Site 4
T38
V
T
W
S
S
G
S
T
E
A
I
Y
R
R
Y
Site 5
Y42
S
G
S
T
E
A
I
Y
R
R
Y
S
K
F
F
Site 6
Y45
T
E
A
I
Y
R
R
Y
S
K
F
F
D
L
Q
Site 7
S85
G
K
I
L
F
R
R
S
H
I
R
D
V
A
V
Site 8
S113
I
Q
L
P
P
Y
I
S
Q
C
D
E
V
L
Q
Site 9
S142
E
H
I
G
K
K
K
S
G
G
D
Q
T
S
V
Site 10
T147
K
K
S
G
G
D
Q
T
S
V
D
P
M
V
L
Site 11
S148
K
S
G
G
D
Q
T
S
V
D
P
M
V
L
E
Site 12
Y163
Q
Y
V
V
V
A
N
Y
Q
K
Q
E
S
S
E
Site 13
S168
A
N
Y
Q
K
Q
E
S
S
E
I
S
L
S
V
Site 14
S169
N
Y
Q
K
Q
E
S
S
E
I
S
L
S
V
G
Site 15
S172
K
Q
E
S
S
E
I
S
L
S
V
G
Q
V
V
Site 16
S217
D
G
V
Q
D
E
F
S
L
Q
P
E
E
E
E
Site 17
Y226
Q
P
E
E
E
E
K
Y
T
V
I
Y
P
Y
T
Site 18
T227
P
E
E
E
E
K
Y
T
V
I
Y
P
Y
T
A
Site 19
Y230
E
E
K
Y
T
V
I
Y
P
Y
T
A
R
D
Q
Site 20
Y232
K
Y
T
V
I
Y
P
Y
T
A
R
D
Q
D
E
Site 21
S273
K
E
G
W
A
P
A
S
Y
L
K
K
N
S
G
Site 22
Y274
E
G
W
A
P
A
S
Y
L
K
K
N
S
G
E
Site 23
S279
A
S
Y
L
K
K
N
S
G
E
P
L
P
P
K
Site 24
S291
P
P
K
P
G
P
G
S
P
S
H
P
G
A
L
Site 25
S293
K
P
G
P
G
S
P
S
H
P
G
A
L
D
L
Site 26
S318
G
R
E
K
E
L
L
S
S
Q
R
D
G
R
F
Site 27
S319
R
E
K
E
L
L
S
S
Q
R
D
G
R
F
E
Site 28
S339
D
G
D
A
K
Q
R
S
P
K
M
R
Q
R
P
Site 29
T353
P
P
P
R
R
D
M
T
I
P
R
G
L
N
L
Site 30
Y373
P
P
Q
V
E
E
E
Y
Y
T
I
A
E
F
Q
Site 31
Y374
P
Q
V
E
E
E
Y
Y
T
I
A
E
F
Q
T
Site 32
T375
Q
V
E
E
E
Y
Y
T
I
A
E
F
Q
T
T
Site 33
Y407
K
N
L
S
G
W
W
Y
I
Q
I
E
D
K
E
Site 34
T420
K
E
G
W
A
P
A
T
F
I
D
K
Y
K
K
Site 35
Y425
P
A
T
F
I
D
K
Y
K
K
T
S
N
A
S
Site 36
T428
F
I
D
K
Y
K
K
T
S
N
A
S
R
P
N
Site 37
T445
A
P
L
P
H
E
V
T
Q
L
R
L
G
E
A
Site 38
S461
A
L
E
N
N
T
G
S
E
A
T
G
P
S
R
Site 39
S480
A
P
H
G
V
M
D
S
G
L
P
W
S
K
D
Site 40
S485
M
D
S
G
L
P
W
S
K
D
W
K
G
S
K
Site 41
S499
K
D
V
L
R
K
A
S
S
D
M
S
A
S
A
Site 42
S500
D
V
L
R
K
A
S
S
D
M
S
A
S
A
G
Site 43
S503
R
K
A
S
S
D
M
S
A
S
A
G
Y
E
E
Site 44
Y508
D
M
S
A
S
A
G
Y
E
E
I
S
D
P
D
Site 45
S512
S
A
G
Y
E
E
I
S
D
P
D
M
E
E
K
Site 46
S521
P
D
M
E
E
K
P
S
L
P
P
R
K
E
S
Site 47
S528
S
L
P
P
R
K
E
S
I
I
K
S
E
G
E
Site 48
S532
R
K
E
S
I
I
K
S
E
G
E
L
L
E
R
Site 49
T546
R
E
R
E
R
Q
R
T
E
Q
L
R
G
P
T
Site 50
T553
T
E
Q
L
R
G
P
T
P
K
P
P
G
V
I
Site 51
S575
H
I
P
P
A
R
D
S
R
R
P
E
P
K
P
Site 52
S585
P
E
P
K
P
D
K
S
R
L
F
Q
L
K
N
Site 53
S616
K
P
N
L
R
P
I
S
K
S
K
T
D
L
P
Site 54
S618
N
L
R
P
I
S
K
S
K
T
D
L
P
E
E
Site 55
T620
R
P
I
S
K
S
K
T
D
L
P
E
E
K
P
Site 56
T630
P
E
E
K
P
D
A
T
P
Q
N
P
F
L
K
Site 57
S638
P
Q
N
P
F
L
K
S
R
P
Q
V
R
P
K
Site 58
S649
V
R
P
K
P
A
P
S
P
K
T
E
P
P
Q
Site 59
T652
K
P
A
P
S
P
K
T
E
P
P
Q
G
E
D
Site 60
S675
S
K
L
R
P
A
K
S
Q
D
K
S
L
L
D
Site 61
S679
P
A
K
S
Q
D
K
S
L
L
D
G
E
G
P
Site 62
S697
G
G
Q
D
V
A
F
S
R
S
F
L
P
G
E
Site 63
S699
Q
D
V
A
F
S
R
S
F
L
P
G
E
G
P
Site 64
T713
P
G
R
A
Q
D
R
T
G
K
Q
D
G
L
S
Site 65
S720
T
G
K
Q
D
G
L
S
P
K
E
I
S
C
R
Site 66
S725
G
L
S
P
K
E
I
S
C
R
A
P
P
R
P
Site 67
T735
A
P
P
R
P
A
K
T
T
D
P
V
S
K
S
Site 68
T736
P
P
R
P
A
K
T
T
D
P
V
S
K
S
V
Site 69
S740
A
K
T
T
D
P
V
S
K
S
V
P
V
P
L
Site 70
S742
T
T
D
P
V
S
K
S
V
P
V
P
L
Q
E
Site 71
T768
R
P
P
P
P
K
K
T
S
S
S
S
R
P
L
Site 72
S769
P
P
P
P
K
K
T
S
S
S
S
R
P
L
P
Site 73
S770
P
P
P
K
K
T
S
S
S
S
R
P
L
P
E
Site 74
S771
P
P
K
K
T
S
S
S
S
R
P
L
P
E
V
Site 75
S772
P
K
K
T
S
S
S
S
R
P
L
P
E
V
R
Site 76
S788
P
Q
C
E
G
H
E
S
R
A
A
P
T
P
G
Site 77
T793
H
E
S
R
A
A
P
T
P
G
R
A
L
L
V
Site 78
S809
P
K
A
K
P
F
L
S
N
S
L
G
G
Q
D
Site 79
S811
A
K
P
F
L
S
N
S
L
G
G
Q
D
D
T
Site 80
T818
S
L
G
G
Q
D
D
T
R
G
K
G
S
L
G
Site 81
S823
D
D
T
R
G
K
G
S
L
G
P
W
G
T
G
Site 82
S843
R
E
K
A
A
A
A
S
V
P
N
A
D
G
L
Site 83
S853
N
A
D
G
L
K
D
S
L
Y
V
A
V
A
D
Site 84
Y855
D
G
L
K
D
S
L
Y
V
A
V
A
D
F
E
Site 85
T867
D
F
E
G
D
K
D
T
S
S
F
Q
E
G
T
Site 86
S869
E
G
D
K
D
T
S
S
F
Q
E
G
T
V
F
Site 87
S897
Q
V
L
S
G
A
P
S
W
E
G
W
I
P
S
Site 88
Y906
E
G
W
I
P
S
N
Y
L
R
K
K
P
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation