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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FRMD3
Full Name:
FERM domain-containing protein 3
Alias:
Band 4.1-like protein 4; Band 4.1-like protein 4O; EPB41L4O; FERM domain containing 3; MGC20553; Ovary type protein 4.1; P410; Protein 4.1O
Type:
Cytoskeletal protein
Mass (Da):
68753
Number AA:
597
UniProt ID:
A2A2Y4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0008092
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
M
K
M
I
H
F
R
S
S
S
V
K
S
L
S
Site 2
S23
K
M
I
H
F
R
S
S
S
V
K
S
L
S
Q
Site 3
S24
M
I
H
F
R
S
S
S
V
K
S
L
S
Q
E
Site 4
S27
F
R
S
S
S
V
K
S
L
S
Q
E
M
R
C
Site 5
S29
S
S
S
V
K
S
L
S
Q
E
M
R
C
T
I
Site 6
T35
L
S
Q
E
M
R
C
T
I
R
L
L
D
D
S
Site 7
S42
T
I
R
L
L
D
D
S
E
I
S
C
H
I
Q
Site 8
T52
S
C
H
I
Q
R
E
T
K
G
Q
F
L
I
D
Site 9
Y64
L
I
D
H
I
C
N
Y
Y
S
L
L
E
K
D
Site 10
Y72
Y
S
L
L
E
K
D
Y
F
G
I
R
Y
V
D
Site 11
Y77
K
D
Y
F
G
I
R
Y
V
D
P
E
K
Q
R
Site 12
T99
S
I
F
K
Q
M
K
T
H
P
P
Y
T
M
C
Site 13
Y112
M
C
F
R
V
K
F
Y
P
H
E
P
L
K
I
Site 14
Y126
I
K
E
E
L
T
R
Y
L
L
Y
L
Q
I
K
Site 15
Y129
E
L
T
R
Y
L
L
Y
L
Q
I
K
R
D
I
Site 16
Y163
V
Q
A
E
L
G
D
Y
D
P
D
E
H
P
E
Site 17
Y172
P
D
E
H
P
E
N
Y
I
S
E
F
E
I
F
Site 18
S174
E
H
P
E
N
Y
I
S
E
F
E
I
F
P
K
Site 19
S202
K
N
E
L
R
G
Q
S
P
P
V
A
E
F
N
Site 20
T235
K
D
S
T
G
T
T
T
F
L
G
F
T
A
A
Site 21
T270
K
L
K
F
E
G
K
T
F
Y
V
I
G
T
Q
Site 22
Y272
K
F
E
G
K
T
F
Y
V
I
G
T
Q
K
E
Site 23
T276
K
T
F
Y
V
I
G
T
Q
K
E
K
K
A
M
Site 24
Y308
G
V
E
N
Q
A
F
Y
K
Y
A
K
S
S
Q
Site 25
Y310
E
N
Q
A
F
Y
K
Y
A
K
S
S
Q
I
K
Site 26
S313
A
F
Y
K
Y
A
K
S
S
Q
I
K
T
V
S
Site 27
S314
F
Y
K
Y
A
K
S
S
Q
I
K
T
V
S
S
Site 28
T318
A
K
S
S
Q
I
K
T
V
S
S
S
K
I
F
Site 29
S320
S
S
Q
I
K
T
V
S
S
S
K
I
F
F
K
Site 30
S322
Q
I
K
T
V
S
S
S
K
I
F
F
K
G
S
Site 31
S329
S
K
I
F
F
K
G
S
R
F
R
Y
S
G
K
Site 32
Y333
F
K
G
S
R
F
R
Y
S
G
K
V
A
K
E
Site 33
S334
K
G
S
R
F
R
Y
S
G
K
V
A
K
E
V
Site 34
T361
E
V
H
R
A
N
I
T
Q
S
R
S
S
H
S
Site 35
S363
H
R
A
N
I
T
Q
S
R
S
S
H
S
L
N
Site 36
S365
A
N
I
T
Q
S
R
S
S
H
S
L
N
K
Q
Site 37
S366
N
I
T
Q
S
R
S
S
H
S
L
N
K
Q
L
Site 38
S368
T
Q
S
R
S
S
H
S
L
N
K
Q
L
I
I
Site 39
S386
P
L
Q
P
L
L
P
S
P
S
E
Q
E
E
E
Site 40
S388
Q
P
L
L
P
S
P
S
E
Q
E
E
E
L
P
Site 41
S409
L
P
K
E
E
N
I
S
A
P
L
I
S
S
S
Site 42
S415
I
S
A
P
L
I
S
S
S
P
V
K
A
A
R
Site 43
S416
S
A
P
L
I
S
S
S
P
V
K
A
A
R
E
Site 44
Y424
P
V
K
A
A
R
E
Y
E
D
P
P
S
E
E
Site 45
S429
R
E
Y
E
D
P
P
S
E
E
E
D
K
I
K
Site 46
T441
K
I
K
E
E
P
L
T
I
S
E
L
V
Y
N
Site 47
S450
S
E
L
V
Y
N
P
S
A
S
L
L
P
T
P
Site 48
T456
P
S
A
S
L
L
P
T
P
V
D
D
D
E
I
Site 49
S471
D
M
L
F
D
C
P
S
R
L
E
L
E
R
E
Site 50
T480
L
E
L
E
R
E
D
T
D
S
F
E
D
L
E
Site 51
S482
L
E
R
E
D
T
D
S
F
E
D
L
E
A
D
Site 52
S509
K
E
A
R
R
A
L
S
W
S
Y
D
I
L
T
Site 53
S511
A
R
R
A
L
S
W
S
Y
D
I
L
T
G
H
Site 54
Y512
R
R
A
L
S
W
S
Y
D
I
L
T
G
H
I
Site 55
T516
S
W
S
Y
D
I
L
T
G
H
I
R
V
N
P
Site 56
S529
N
P
L
V
K
S
F
S
R
L
L
V
V
G
L
Site 57
T565
F
L
C
E
I
R
Q
T
P
E
F
E
Q
F
H
Site 58
Y573
P
E
F
E
Q
F
H
Y
E
Y
Y
C
P
L
K
Site 59
Y575
F
E
Q
F
H
Y
E
Y
Y
C
P
L
K
E
W
Site 60
Y576
E
Q
F
H
Y
E
Y
Y
C
P
L
K
E
W
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation