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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TARSL2
Full Name:
Probable threonyl-tRNA synthetase 2, cytoplasmic
Alias:
ThrRS
Type:
Enzyme - Synthetase, class-II aminoacyl-tRNA synthetase family
Mass (Da):
92646
Number AA:
802
UniProt ID:
A2RTX5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004829
PhosphoSite+
KinaseNET
Biological Process:
GO:0006435
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
L
A
A
E
A
V
A
S
R
L
E
R
Q
E
E
Site 2
S42
E
Q
L
N
A
P
Y
S
C
Q
A
E
G
P
C
Site 3
S70
D
L
R
H
R
L
C
S
L
R
L
C
L
A
E
Site 4
S80
L
C
L
A
E
E
R
S
R
Q
A
T
L
E
S
Site 5
T84
E
E
R
S
R
Q
A
T
L
E
S
A
E
L
E
Site 6
S103
A
G
A
Q
P
P
P
S
Q
S
Q
D
K
D
M
Site 7
S105
A
Q
P
P
P
S
Q
S
Q
D
K
D
M
K
K
Site 8
S118
K
K
K
K
M
K
E
S
E
A
D
S
E
V
K
Site 9
S122
M
K
E
S
E
A
D
S
E
V
K
H
Q
P
I
Site 10
Y152
H
Q
L
L
L
A
I
Y
G
K
K
G
D
T
S
Site 11
S159
Y
G
K
K
G
D
T
S
N
I
I
T
V
R
V
Site 12
T163
G
D
T
S
N
I
I
T
V
R
V
A
D
G
Q
Site 13
T171
V
R
V
A
D
G
Q
T
V
Q
G
E
V
W
K
Site 14
T179
V
Q
G
E
V
W
K
T
T
P
Y
Q
V
A
A
Site 15
T180
Q
G
E
V
W
K
T
T
P
Y
Q
V
A
A
E
Site 16
Y182
E
V
W
K
T
T
P
Y
Q
V
A
A
E
I
S
Site 17
S217
R
P
L
E
G
D
S
S
L
E
L
L
T
F
D
Site 18
T222
D
S
S
L
E
L
L
T
F
D
N
E
E
A
Q
Site 19
Y232
N
E
E
A
Q
A
V
Y
W
H
S
S
A
H
I
Site 20
Y248
G
E
A
M
E
L
Y
Y
G
G
H
L
C
Y
G
Site 21
Y254
Y
Y
G
G
H
L
C
Y
G
P
P
I
E
N
G
Site 22
Y263
P
P
I
E
N
G
F
Y
Y
D
M
F
I
E
D
Site 23
Y264
P
I
E
N
G
F
Y
Y
D
M
F
I
E
D
R
Site 24
S275
I
E
D
R
A
V
S
S
T
E
L
S
A
L
E
Site 25
T276
E
D
R
A
V
S
S
T
E
L
S
A
L
E
N
Site 26
S301
P
F
E
R
L
E
V
S
K
E
I
L
L
E
M
Site 27
T325
I
L
N
E
K
V
N
T
A
T
T
T
V
Y
R
Site 28
T329
K
V
N
T
A
T
T
T
V
Y
R
C
G
P
L
Site 29
Y331
N
T
A
T
T
T
V
Y
R
C
G
P
L
I
D
Site 30
T348
K
G
P
H
V
R
H
T
G
K
I
K
T
I
K
Site 31
T353
R
H
T
G
K
I
K
T
I
K
I
F
K
N
S
Site 32
Y363
I
F
K
N
S
S
T
Y
W
E
G
N
P
E
M
Site 33
T372
E
G
N
P
E
M
E
T
L
Q
R
I
Y
G
I
Site 34
Y377
M
E
T
L
Q
R
I
Y
G
I
S
F
P
D
N
Site 35
S421
F
H
D
L
S
P
G
S
C
F
F
L
P
R
G
Site 36
T434
R
G
A
F
I
Y
N
T
L
T
D
F
I
R
E
Site 37
T436
A
F
I
Y
N
T
L
T
D
F
I
R
E
E
Y
Site 38
Y443
T
D
F
I
R
E
E
Y
H
K
R
D
F
T
E
Site 39
T449
E
Y
H
K
R
D
F
T
E
V
L
S
P
N
M
Site 40
S453
R
D
F
T
E
V
L
S
P
N
M
Y
N
S
K
Site 41
Y457
E
V
L
S
P
N
M
Y
N
S
K
L
W
E
A
Site 42
S459
L
S
P
N
M
Y
N
S
K
L
W
E
A
S
G
Site 43
T477
H
Y
S
E
N
M
F
T
F
E
I
E
K
D
T
Site 44
T484
T
F
E
I
E
K
D
T
F
A
L
K
P
M
N
Site 45
S505
M
F
A
H
R
P
R
S
W
R
E
M
P
I
R
Site 46
S525
V
L
H
R
N
E
L
S
G
T
L
S
G
L
T
Site 47
T527
H
R
N
E
L
S
G
T
L
S
G
L
T
R
V
Site 48
S529
N
E
L
S
G
T
L
S
G
L
T
R
V
R
R
Site 49
T532
S
G
T
L
S
G
L
T
R
V
R
R
F
Q
Q
Site 50
T547
D
D
A
H
I
F
C
T
V
E
Q
I
E
E
E
Site 51
S578
F
S
F
Q
L
N
L
S
T
R
P
E
N
F
L
Site 52
S601
A
E
K
Q
L
Q
N
S
L
M
D
F
G
E
P
Site 53
Y619
N
P
G
D
G
A
F
Y
G
P
K
I
D
I
K
Site 54
T653
L
P
I
R
F
N
L
T
Y
V
S
K
D
G
D
Site 55
Y654
P
I
R
F
N
L
T
Y
V
S
K
D
G
D
D
Site 56
S656
R
F
N
L
T
Y
V
S
K
D
G
D
D
K
K
Site 57
Y712
V
G
P
T
C
E
K
Y
A
L
Q
V
S
S
E
Site 58
S717
E
K
Y
A
L
Q
V
S
S
E
F
F
E
E
G
Site 59
S734
A
D
V
D
L
D
H
S
C
T
L
N
K
K
I
Site 60
T736
V
D
L
D
H
S
C
T
L
N
K
K
I
R
N
Site 61
Y749
R
N
A
Q
L
A
Q
Y
N
F
I
L
V
V
G
Site 62
T793
K
L
K
N
L
R
K
T
R
T
L
N
A
E
E
Site 63
T795
K
N
L
R
K
T
R
T
L
N
A
E
E
A
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation