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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CCDC66
Full Name:
Coiled-coil domain-containing protein 66
Alias:
coiled-coil domain containing 66; DKFZp686C0433
Type:
Unknown function
Mass (Da):
109411
Number AA:
948
UniProt ID:
A2RUB6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T18
T
E
L
L
D
G
K
T
K
L
I
L
S
P
Y
Site 2
S23
G
K
T
K
L
I
L
S
P
Y
E
H
K
S
K
Site 3
Y25
T
K
L
I
L
S
P
Y
E
H
K
S
K
I
S
Site 4
S29
L
S
P
Y
E
H
K
S
K
I
S
V
K
M
G
Site 5
T50
K
C
P
L
R
T
K
T
G
H
I
L
K
S
T
Site 6
S56
K
T
G
H
I
L
K
S
T
Q
D
T
C
I
G
Site 7
T57
T
G
H
I
L
K
S
T
Q
D
T
C
I
G
S
Site 8
T60
I
L
K
S
T
Q
D
T
C
I
G
S
E
K
L
Site 9
S64
T
Q
D
T
C
I
G
S
E
K
L
L
Q
K
K
Site 10
T88
K
G
E
K
N
G
M
T
F
S
S
T
K
D
L
Site 11
S90
E
K
N
G
M
T
F
S
S
T
K
D
L
C
K
Site 12
S91
K
N
G
M
T
F
S
S
T
K
D
L
C
K
Q
Site 13
S112
L
H
I
Q
K
E
I
S
P
A
T
P
N
M
Q
Site 14
T115
Q
K
E
I
S
P
A
T
P
N
M
Q
K
T
R
Site 15
T121
A
T
P
N
M
Q
K
T
R
N
T
V
N
T
S
Site 16
T124
N
M
Q
K
T
R
N
T
V
N
T
S
L
V
G
Site 17
T141
K
P
H
K
K
H
I
T
A
E
N
M
K
S
S
Site 18
S170
T
V
N
Q
G
N
R
S
L
S
L
T
E
N
G
Site 19
S172
N
Q
G
N
R
S
L
S
L
T
E
N
G
K
E
Site 20
T174
G
N
R
S
L
S
L
T
E
N
G
K
E
A
K
Site 21
S182
E
N
G
K
E
A
K
S
Q
Y
S
L
Y
L
N
Site 22
S185
K
E
A
K
S
Q
Y
S
L
Y
L
N
S
I
S
Site 23
Y187
A
K
S
Q
Y
S
L
Y
L
N
S
I
S
N
Q
Site 24
S192
S
L
Y
L
N
S
I
S
N
Q
P
K
D
E
N
Site 25
S212
K
K
T
E
M
V
S
S
V
P
A
E
N
K
S
Site 26
S219
S
V
P
A
E
N
K
S
V
L
N
E
H
Q
E
Site 27
S248
W
K
P
A
D
I
F
S
T
L
G
E
R
E
C
Site 28
S258
G
E
R
E
C
D
R
S
S
L
E
A
K
K
A
Site 29
S259
E
R
E
C
D
R
S
S
L
E
A
K
K
A
Q
Site 30
S285
K
K
K
E
K
E
V
S
E
K
W
N
D
P
W
Site 31
S297
D
P
W
K
K
S
E
S
D
K
I
I
W
E
K
Site 32
T314
I
L
D
Q
S
R
E
T
V
L
L
E
H
P
F
Site 33
S322
V
L
L
E
H
P
F
S
A
V
K
Q
E
L
Q
Site 34
Y354
K
I
E
E
K
I
I
Y
S
K
G
E
E
H
D
Site 35
S369
R
W
A
M
H
F
D
S
L
K
S
Y
P
G
S
Site 36
S372
M
H
F
D
S
L
K
S
Y
P
G
S
Q
S
Q
Site 37
Y373
H
F
D
S
L
K
S
Y
P
G
S
Q
S
Q
L
Site 38
S376
S
L
K
S
Y
P
G
S
Q
S
Q
L
F
S
Q
Site 39
S378
K
S
Y
P
G
S
Q
S
Q
L
F
S
Q
S
T
Site 40
S382
G
S
Q
S
Q
L
F
S
Q
S
T
H
K
Q
P
Site 41
S384
Q
S
Q
L
F
S
Q
S
T
H
K
Q
P
E
Y
Site 42
Y391
S
T
H
K
Q
P
E
Y
F
C
V
S
P
D
T
Site 43
S395
Q
P
E
Y
F
C
V
S
P
D
T
Q
E
L
A
Site 44
T398
Y
F
C
V
S
P
D
T
Q
E
L
A
D
V
S
Site 45
S406
Q
E
L
A
D
V
S
S
V
C
T
P
T
T
G
Site 46
T412
S
S
V
C
T
P
T
T
G
S
Q
V
E
P
S
Site 47
S414
V
C
T
P
T
T
G
S
Q
V
E
P
S
E
E
Site 48
S419
T
G
S
Q
V
E
P
S
E
E
E
H
I
A
K
Site 49
S444
K
K
T
N
F
L
R
S
M
T
A
L
L
D
P
Site 50
T446
T
N
F
L
R
S
M
T
A
L
L
D
P
A
Q
Site 51
Y511
R
E
E
M
Q
K
Q
Y
E
E
D
I
L
K
Q
Site 52
T526
K
Q
K
E
E
I
M
T
L
K
T
N
E
L
F
Site 53
T529
E
E
I
M
T
L
K
T
N
E
L
F
Q
T
M
Site 54
T535
K
T
N
E
L
F
Q
T
M
Q
R
A
Q
E
L
Site 55
T562
L
A
Q
K
G
H
D
T
S
R
L
I
K
N
L
Site 56
S563
A
Q
K
G
H
D
T
S
R
L
I
K
N
L
G
Site 57
S584
E
Y
N
A
S
N
I
S
N
S
R
H
D
S
D
Site 58
S586
N
A
S
N
I
S
N
S
R
H
D
S
D
E
I
Site 59
S590
I
S
N
S
R
H
D
S
D
E
I
S
G
K
M
Site 60
T599
E
I
S
G
K
M
N
T
Y
M
N
S
T
T
S
Site 61
Y600
I
S
G
K
M
N
T
Y
M
N
S
T
T
S
K
Site 62
S603
K
M
N
T
Y
M
N
S
T
T
S
K
K
D
T
Site 63
T605
N
T
Y
M
N
S
T
T
S
K
K
D
T
G
V
Site 64
T610
S
T
T
S
K
K
D
T
G
V
Q
T
D
D
L
Site 65
T623
D
L
N
I
G
I
F
T
N
A
E
S
H
C
G
Site 66
S627
G
I
F
T
N
A
E
S
H
C
G
S
L
M
E
Site 67
S631
N
A
E
S
H
C
G
S
L
M
E
R
D
I
T
Site 68
T638
S
L
M
E
R
D
I
T
N
C
S
S
P
E
I
Site 69
S641
E
R
D
I
T
N
C
S
S
P
E
I
S
A
E
Site 70
S642
R
D
I
T
N
C
S
S
P
E
I
S
A
E
L
Site 71
S646
N
C
S
S
P
E
I
S
A
E
L
I
G
Q
F
Site 72
T663
K
K
N
K
Q
E
L
T
Q
D
K
G
A
S
L
Site 73
S669
L
T
Q
D
K
G
A
S
L
E
K
E
N
N
R
Site 74
Y697
Q
T
K
H
M
K
K
Y
P
K
R
P
D
W
N
Site 75
S716
P
K
R
Y
I
P
A
S
E
K
Y
P
K
Q
L
Site 76
Y719
Y
I
P
A
S
E
K
Y
P
K
Q
L
Q
K
Q
Site 77
S751
K
N
N
P
G
H
L
S
Q
N
R
G
I
S
P
Site 78
S757
L
S
Q
N
R
G
I
S
P
E
I
F
H
S
S
Site 79
S763
I
S
P
E
I
F
H
S
S
H
Q
E
T
E
S
Site 80
S764
S
P
E
I
F
H
S
S
H
Q
E
T
E
S
K
Site 81
T768
F
H
S
S
H
Q
E
T
E
S
K
L
R
W
H
Site 82
S788
E
E
P
L
N
I
H
S
F
S
K
E
R
S
P
Site 83
S790
P
L
N
I
H
S
F
S
K
E
R
S
P
S
S
Site 84
S794
H
S
F
S
K
E
R
S
P
S
S
P
V
P
V
Site 85
S796
F
S
K
E
R
S
P
S
S
P
V
P
V
V
K
Site 86
S797
S
K
E
R
S
P
S
S
P
V
P
V
V
K
N
Site 87
S820
L
H
L
P
L
K
N
S
S
Y
E
R
E
N
L
Site 88
S821
H
L
P
L
K
N
S
S
Y
E
R
E
N
L
I
Site 89
Y822
L
P
L
K
N
S
S
Y
E
R
E
N
L
I
S
Site 90
S829
Y
E
R
E
N
L
I
S
G
S
N
Q
T
E
L
Site 91
S831
R
E
N
L
I
S
G
S
N
Q
T
E
L
S
S
Site 92
T834
L
I
S
G
S
N
Q
T
E
L
S
S
G
I
S
Site 93
S837
G
S
N
Q
T
E
L
S
S
G
I
S
E
S
S
Site 94
S838
S
N
Q
T
E
L
S
S
G
I
S
E
S
S
H
Site 95
S841
T
E
L
S
S
G
I
S
E
S
S
H
F
I
P
Site 96
S844
S
S
G
I
S
E
S
S
H
F
I
P
Y
V
R
Site 97
Y849
E
S
S
H
F
I
P
Y
V
R
T
N
E
I
Y
Site 98
Y856
Y
V
R
T
N
E
I
Y
Y
L
D
P
D
A
P
Site 99
Y857
V
R
T
N
E
I
Y
Y
L
D
P
D
A
P
L
Site 100
S865
L
D
P
D
A
P
L
S
G
P
S
T
Q
D
P
Site 101
T869
A
P
L
S
G
P
S
T
Q
D
P
Q
Y
Q
N
Site 102
Y874
P
S
T
Q
D
P
Q
Y
Q
N
S
Q
D
C
G
Site 103
S877
Q
D
P
Q
Y
Q
N
S
Q
D
C
G
Q
K
R
Site 104
S889
Q
K
R
Q
L
F
D
S
D
C
V
R
D
P
L
Site 105
S916
Q
A
I
L
K
G
L
S
E
L
R
Q
G
L
L
Site 106
S932
K
Q
K
E
L
E
S
S
L
L
P
L
A
E
N
Site 107
S943
L
A
E
N
Q
E
E
S
F
G
S
S
F
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation