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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KIAA0922
Full Name:
Transmembrane protein 131-like
Alias:
DKFZp586H1322; FLJ10592; LOC23240; TMEM131L; transmembrane protein 131-like
Type:
Mass (Da):
179340
Number AA:
1609
UniProt ID:
A2VDJ0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y12
R
R
P
Q
P
G
C
Y
C
R
T
A
A
A
V
Site 2
S122
A
Y
N
P
S
R
D
S
E
V
V
V
N
S
V
Site 3
T368
I
I
E
D
V
K
K
T
T
H
T
P
T
L
K
Site 4
T369
I
E
D
V
K
K
T
T
H
T
P
T
L
K
A
Site 5
T371
D
V
K
K
T
T
H
T
P
T
L
K
A
C
L
Site 6
T373
K
K
T
T
H
T
P
T
L
K
A
C
L
F
S
Site 7
T492
L
Q
I
Y
S
A
P
T
K
E
G
S
L
G
F
Site 8
T563
K
R
N
V
L
G
T
T
R
F
A
H
L
K
K
Site 9
S739
R
L
P
G
A
G
G
S
L
R
F
K
V
P
E
Site 10
T903
I
L
M
E
F
M
K
T
R
Q
R
Q
N
A
S
Site 11
S910
T
R
Q
R
Q
N
A
S
S
S
S
Q
Q
N
N
Site 12
S911
R
Q
R
Q
N
A
S
S
S
S
Q
Q
N
N
G
Site 13
S913
R
Q
N
A
S
S
S
S
Q
Q
N
N
G
P
M
Site 14
S924
N
G
P
M
D
V
I
S
P
H
S
Y
K
S
N
Site 15
Y928
D
V
I
S
P
H
S
Y
K
S
N
C
K
N
F
Site 16
T938
N
C
K
N
F
L
D
T
Y
G
P
S
D
K
G
Site 17
Y939
C
K
N
F
L
D
T
Y
G
P
S
D
K
G
R
Site 18
S942
F
L
D
T
Y
G
P
S
D
K
G
R
G
K
N
Site 19
T955
K
N
C
L
P
V
N
T
P
Q
S
R
I
Q
N
Site 20
S958
L
P
V
N
T
P
Q
S
R
I
Q
N
A
A
K
Site 21
S967
I
Q
N
A
A
K
R
S
P
A
T
Y
G
H
S
Site 22
T970
A
A
K
R
S
P
A
T
Y
G
H
S
Q
K
K
Site 23
Y971
A
K
R
S
P
A
T
Y
G
H
S
Q
K
K
H
Site 24
S974
S
P
A
T
Y
G
H
S
Q
K
K
H
K
C
S
Site 25
Y983
K
K
H
K
C
S
V
Y
Y
S
K
H
K
T
S
Site 26
T989
V
Y
Y
S
K
H
K
T
S
T
A
A
A
S
S
Site 27
S990
Y
Y
S
K
H
K
T
S
T
A
A
A
S
S
T
Site 28
T991
Y
S
K
H
K
T
S
T
A
A
A
S
S
T
S
Site 29
T1000
A
A
S
S
T
S
T
T
T
E
E
K
Q
T
S
Site 30
T1006
T
T
T
E
E
K
Q
T
S
P
L
G
S
S
L
Site 31
S1007
T
T
E
E
K
Q
T
S
P
L
G
S
S
L
P
Site 32
S1011
K
Q
T
S
P
L
G
S
S
L
P
A
A
K
E
Site 33
S1031
A
M
R
E
N
W
I
S
L
R
Y
A
S
G
I
Site 34
T1047
V
N
L
Q
K
N
L
T
L
P
K
N
L
L
N
Site 35
T1063
E
E
N
T
L
K
N
T
I
V
F
S
N
P
S
Site 36
S1067
L
K
N
T
I
V
F
S
N
P
S
S
E
C
S
Site 37
S1071
I
V
F
S
N
P
S
S
E
C
S
M
K
E
G
Site 38
S1074
S
N
P
S
S
E
C
S
M
K
E
G
I
Q
T
Site 39
T1081
S
M
K
E
G
I
Q
T
C
M
F
P
K
E
T
Site 40
T1092
P
K
E
T
D
I
K
T
S
E
N
T
A
E
F
Site 41
T1109
R
E
L
C
P
L
K
T
S
K
K
L
P
E
N
Site 42
S1122
E
N
H
L
P
R
N
S
P
Q
Y
H
Q
P
D
Site 43
Y1125
L
P
R
N
S
P
Q
Y
H
Q
P
D
L
P
E
Site 44
T1161
E
N
L
K
K
V
D
T
K
P
S
S
E
K
K
Site 45
S1164
K
K
V
D
T
K
P
S
S
E
K
K
I
H
K
Site 46
S1165
K
V
D
T
K
P
S
S
E
K
K
I
H
K
T
Site 47
T1172
S
E
K
K
I
H
K
T
S
R
E
D
M
F
S
Site 48
S1179
T
S
R
E
D
M
F
S
E
K
Q
D
I
P
F
Site 49
Y1193
F
V
E
Q
E
D
P
Y
R
K
K
K
L
Q
E
Site 50
T1216
L
N
W
S
K
S
R
T
C
R
K
N
K
K
R
Site 51
S1229
K
R
G
V
A
P
V
S
R
P
P
E
Q
S
D
Site 52
S1235
V
S
R
P
P
E
Q
S
D
L
K
L
V
C
S
Site 53
S1242
S
D
L
K
L
V
C
S
D
F
E
R
S
E
L
Site 54
S1247
V
C
S
D
F
E
R
S
E
L
S
S
D
I
N
Site 55
S1251
F
E
R
S
E
L
S
S
D
I
N
V
R
S
W
Site 56
S1257
S
S
D
I
N
V
R
S
W
C
I
Q
E
S
T
Site 57
S1277
A
D
A
E
I
A
S
S
L
P
A
A
Q
R
E
Site 58
Y1288
A
Q
R
E
A
E
G
Y
Y
Q
K
P
E
K
K
Site 59
Y1289
Q
R
E
A
E
G
Y
Y
Q
K
P
E
K
K
C
Site 60
S1302
K
C
V
D
K
F
C
S
D
S
S
S
D
C
G
Site 61
S1304
V
D
K
F
C
S
D
S
S
S
D
C
G
S
S
Site 62
S1305
D
K
F
C
S
D
S
S
S
D
C
G
S
S
S
Site 63
S1306
K
F
C
S
D
S
S
S
D
C
G
S
S
S
G
Site 64
S1310
D
S
S
S
D
C
G
S
S
S
G
S
V
R
A
Site 65
S1311
S
S
S
D
C
G
S
S
S
G
S
V
R
A
S
Site 66
S1312
S
S
D
C
G
S
S
S
G
S
V
R
A
S
R
Site 67
S1314
D
C
G
S
S
S
G
S
V
R
A
S
R
G
S
Site 68
S1318
S
S
G
S
V
R
A
S
R
G
S
W
G
S
W
Site 69
S1321
S
V
R
A
S
R
G
S
W
G
S
W
S
S
T
Site 70
S1324
A
S
R
G
S
W
G
S
W
S
S
T
S
S
S
Site 71
S1326
R
G
S
W
G
S
W
S
S
T
S
S
S
D
G
Site 72
S1327
G
S
W
G
S
W
S
S
T
S
S
S
D
G
D
Site 73
T1328
S
W
G
S
W
S
S
T
S
S
S
D
G
D
K
Site 74
S1329
W
G
S
W
S
S
T
S
S
S
D
G
D
K
K
Site 75
S1330
G
S
W
S
S
T
S
S
S
D
G
D
K
K
P
Site 76
S1331
S
W
S
S
T
S
S
S
D
G
D
K
K
P
M
Site 77
S1350
H
F
L
P
A
G
D
S
V
S
Q
N
D
F
P
Site 78
S1352
L
P
A
G
D
S
V
S
Q
N
D
F
P
S
E
Site 79
S1358
V
S
Q
N
D
F
P
S
E
A
P
I
S
L
N
Site 80
S1363
F
P
S
E
A
P
I
S
L
N
L
S
H
N
I
Site 81
S1378
C
N
P
M
T
V
N
S
L
P
Q
Y
A
E
P
Site 82
Y1382
T
V
N
S
L
P
Q
Y
A
E
P
S
C
P
S
Site 83
S1386
L
P
Q
Y
A
E
P
S
C
P
S
L
P
A
G
Site 84
S1389
Y
A
E
P
S
C
P
S
L
P
A
G
P
T
G
Site 85
S1405
E
E
D
K
G
L
Y
S
P
G
D
L
W
P
T
Site 86
T1412
S
P
G
D
L
W
P
T
P
P
V
C
V
T
S
Site 87
S1442
E
S
A
P
V
H
N
S
F
I
D
W
S
A
T
Site 88
T1449
S
F
I
D
W
S
A
T
C
E
G
Q
F
S
S
Site 89
S1455
A
T
C
E
G
Q
F
S
S
A
Y
C
P
L
E
Site 90
S1456
T
C
E
G
Q
F
S
S
A
Y
C
P
L
E
L
Site 91
Y1458
E
G
Q
F
S
S
A
Y
C
P
L
E
L
N
D
Site 92
Y1466
C
P
L
E
L
N
D
Y
N
A
F
P
E
E
N
Site 93
Y1476
F
P
E
E
N
M
N
Y
A
N
G
F
P
C
P
Site 94
T1501
N
S
Q
S
T
W
N
T
P
P
N
M
P
A
A
Site 95
S1513
P
A
A
W
G
H
A
S
F
I
S
S
P
P
Y
Site 96
S1517
G
H
A
S
F
I
S
S
P
P
Y
L
T
S
T
Site 97
Y1520
S
F
I
S
S
P
P
Y
L
T
S
T
R
S
L
Site 98
T1522
I
S
S
P
P
Y
L
T
S
T
R
S
L
S
P
Site 99
S1523
S
S
P
P
Y
L
T
S
T
R
S
L
S
P
M
Site 100
T1524
S
P
P
Y
L
T
S
T
R
S
L
S
P
M
S
Site 101
S1526
P
Y
L
T
S
T
R
S
L
S
P
M
S
G
L
Site 102
S1536
P
M
S
G
L
F
G
S
I
W
A
P
Q
S
D
Site 103
Y1545
W
A
P
Q
S
D
V
Y
E
N
C
C
P
I
N
Site 104
Y1571
Q
A
V
V
C
K
E
Y
Y
P
G
F
N
P
F
Site 105
Y1572
A
V
V
C
K
E
Y
Y
P
G
F
N
P
F
R
Site 106
S1600
R
N
A
N
F
P
L
S
R
D
S
S
Y
C
G
Site 107
S1603
N
F
P
L
S
R
D
S
S
Y
C
G
N
V
_
Site 108
S1604
F
P
L
S
R
D
S
S
Y
C
G
N
V
_
_
Site 109
Y1605
P
L
S
R
D
S
S
Y
C
G
N
V
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation