KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PION
Full Name:
Gamma-secretase-activating protein
Alias:
Protein pigeon homolog
Type:
Mass (Da):
97802
Number AA:
854
UniProt ID:
A4D1B5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S26
L
R
A
Q
R
A
V
S
E
A
S
G
A
G
S
Site 2
S29
Q
R
A
V
S
E
A
S
G
A
G
S
G
G
A
Site 3
S33
S
E
A
S
G
A
G
S
G
G
A
D
V
L
E
Site 4
Y43
A
D
V
L
E
N
D
Y
E
S
L
H
V
L
N
Site 5
Y61
N
G
N
I
I
Y
T
Y
K
D
D
K
G
N
V
Site 6
Y73
G
N
V
V
F
G
L
Y
D
C
Q
T
R
Q
N
Site 7
T85
R
Q
N
E
L
L
Y
T
F
E
K
D
L
Q
V
Site 8
S94
E
K
D
L
Q
V
F
S
C
S
V
N
S
E
R
Site 9
S96
D
L
Q
V
F
S
C
S
V
N
S
E
R
T
L
Site 10
S107
E
R
T
L
L
A
A
S
L
V
Q
S
T
K
E
Site 11
S111
L
A
A
S
L
V
Q
S
T
K
E
G
K
R
N
Site 12
T112
A
A
S
L
V
Q
S
T
K
E
G
K
R
N
E
Site 13
S124
R
N
E
L
Q
P
G
S
K
C
L
T
L
L
V
Site 14
Y176
L
L
I
S
E
E
K
Y
I
E
Q
F
R
I
H
Site 15
S197
N
R
V
V
I
K
N
S
G
H
L
P
R
D
R
Site 16
Y222
D
M
S
E
Q
R
L
Y
Y
I
D
L
K
K
S
Site 17
Y223
M
S
E
Q
R
L
Y
Y
I
D
L
K
K
S
R
Site 18
S231
I
D
L
K
K
S
R
S
I
L
K
C
I
Q
F
Site 19
Y244
Q
F
Y
A
D
E
S
Y
N
L
M
F
E
V
P
Site 20
Y270
L
V
N
F
G
C
D
Y
H
Q
Y
R
D
K
F
Site 21
Y273
F
G
C
D
Y
H
Q
Y
R
D
K
F
S
K
H
Site 22
T282
D
K
F
S
K
H
L
T
L
C
V
F
T
N
H
Site 23
Y309
A
S
W
G
Q
I
T
Y
S
V
F
Y
I
H
K
Site 24
Y313
Q
I
T
Y
S
V
F
Y
I
H
K
G
H
S
K
Site 25
S319
F
Y
I
H
K
G
H
S
K
T
F
T
T
S
L
Site 26
T321
I
H
K
G
H
S
K
T
F
T
T
S
L
E
N
Site 27
T323
K
G
H
S
K
T
F
T
T
S
L
E
N
V
G
Site 28
S325
H
S
K
T
F
T
T
S
L
E
N
V
G
S
H
Site 29
S331
T
S
L
E
N
V
G
S
H
M
T
K
G
I
T
Site 30
Y404
D
C
C
S
G
K
L
Y
R
A
L
L
S
Q
S
Site 31
S460
E
N
V
S
A
C
H
S
F
D
L
I
Q
E
F
Site 32
Y473
E
F
I
I
A
S
S
Y
W
S
V
Y
S
E
T
Site 33
S475
I
I
A
S
S
Y
W
S
V
Y
S
E
T
S
N
Site 34
Y477
A
S
S
Y
W
S
V
Y
S
E
T
S
N
M
D
Site 35
S478
S
S
Y
W
S
V
Y
S
E
T
S
N
M
D
K
Site 36
S481
W
S
V
Y
S
E
T
S
N
M
D
K
L
L
P
Site 37
S491
D
K
L
L
P
H
S
S
V
L
T
W
N
T
E
Site 38
T494
L
P
H
S
S
V
L
T
W
N
T
E
I
P
G
Site 39
S518
L
P
L
M
K
V
L
S
F
K
G
Y
W
E
K
Site 40
Y522
K
V
L
S
F
K
G
Y
W
E
K
L
N
S
N
Site 41
Y532
K
L
N
S
N
L
E
Y
V
K
Y
A
K
P
H
Site 42
Y535
S
N
L
E
Y
V
K
Y
A
K
P
H
F
H
Y
Site 43
T560
N
L
I
S
E
E
K
T
G
K
R
R
S
A
A
Site 44
S565
E
K
T
G
K
R
R
S
A
A
Y
V
R
N
I
Site 45
Y568
G
K
R
R
S
A
A
Y
V
R
N
I
L
D
N
Site 46
T593
R
N
L
G
P
R
L
T
P
L
L
Q
E
E
D
Site 47
S601
P
L
L
Q
E
E
D
S
H
Q
R
L
L
M
G
Site 48
T741
L
M
K
D
L
D
N
T
E
K
N
E
K
L
K
Site 49
S750
K
N
E
K
L
K
F
S
I
I
V
R
L
P
P
Site 50
S777
P
M
S
S
N
I
I
S
R
N
H
V
T
R
L
Site 51
Y788
V
T
R
L
L
Q
N
Y
K
K
Q
P
R
N
S
Site 52
S795
Y
K
K
Q
P
R
N
S
M
I
N
K
S
S
F
Site 53
S801
N
S
M
I
N
K
S
S
F
S
V
E
F
L
P
Site 54
T817
N
Y
F
I
E
I
L
T
D
I
E
S
S
N
Q
Site 55
S821
E
I
L
T
D
I
E
S
S
N
Q
A
L
Y
P
Site 56
Y827
E
S
S
N
Q
A
L
Y
P
F
E
G
H
D
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation