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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Leucine-rich repeat and death domain-containing protein LOC401387
Full Name:
Leucine-rich repeat and death domain-containing protein LOC401387
Alias:
Type:
Mass (Da):
98035
Number AA:
860
UniProt ID:
A4D1F6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T14
M
S
E
V
L
E
D
T
I
S
Q
F
R
K
E
Site 2
S16
E
V
L
E
D
T
I
S
Q
F
R
K
E
S
R
Site 3
S22
I
S
Q
F
R
K
E
S
R
S
Q
S
M
K
E
Site 4
S24
Q
F
R
K
E
S
R
S
Q
S
M
K
E
P
G
Site 5
S26
R
K
E
S
R
S
Q
S
M
K
E
P
G
F
I
Site 6
S44
S
N
L
I
N
E
A
S
D
Y
L
E
G
K
S
Site 7
Y46
L
I
N
E
A
S
D
Y
L
E
G
K
S
S
N
Site 8
S52
D
Y
L
E
G
K
S
S
N
Q
I
Y
E
T
H
Site 9
Y56
G
K
S
S
N
Q
I
Y
E
T
H
P
R
Q
N
Site 10
T64
E
T
H
P
R
Q
N
T
L
E
S
T
S
S
S
Site 11
S67
P
R
Q
N
T
L
E
S
T
S
S
S
G
R
K
Site 12
S69
Q
N
T
L
E
S
T
S
S
S
G
R
K
S
K
Site 13
S70
N
T
L
E
S
T
S
S
S
G
R
K
S
K
R
Site 14
S71
T
L
E
S
T
S
S
S
G
R
K
S
K
R
N
Site 15
S75
T
S
S
S
G
R
K
S
K
R
N
E
E
Q
K
Site 16
T90
K
N
L
Q
F
S
E
T
S
T
R
T
G
T
S
Site 17
S91
N
L
Q
F
S
E
T
S
T
R
T
G
T
S
Q
Site 18
T92
L
Q
F
S
E
T
S
T
R
T
G
T
S
Q
S
Site 19
T96
E
T
S
T
R
T
G
T
S
Q
S
L
S
S
L
Site 20
S97
T
S
T
R
T
G
T
S
Q
S
L
S
S
L
T
Site 21
S99
T
R
T
G
T
S
Q
S
L
S
S
L
T
G
R
Site 22
S101
T
G
T
S
Q
S
L
S
S
L
T
G
R
T
A
Site 23
S102
G
T
S
Q
S
L
S
S
L
T
G
R
T
A
E
Site 24
T104
S
Q
S
L
S
S
L
T
G
R
T
A
E
Y
Q
Site 25
S126
H
E
T
V
G
E
V
S
P
Q
V
S
E
E
N
Site 26
S130
G
E
V
S
P
Q
V
S
E
E
N
Q
K
Q
L
Site 27
T145
G
L
G
A
D
N
F
T
V
N
L
E
A
K
G
Site 28
Y165
K
D
I
L
K
I
K
Y
V
K
Y
L
Y
L
D
Site 29
Y168
L
K
I
K
Y
V
K
Y
L
Y
L
D
K
N
Q
Site 30
Y170
I
K
Y
V
K
Y
L
Y
L
D
K
N
Q
I
K
Site 31
T178
L
D
K
N
Q
I
K
T
F
Q
G
A
D
S
G
Site 32
S201
S
L
Q
E
N
G
L
S
S
L
P
S
E
I
Q
Site 33
S202
L
Q
E
N
G
L
S
S
L
P
S
E
I
Q
L
Site 34
S205
N
G
L
S
S
L
P
S
E
I
Q
L
L
H
N
Site 35
S231
S
H
I
P
K
E
I
S
Q
L
G
N
I
R
Q
Site 36
Y242
N
I
R
Q
L
F
F
Y
N
N
Y
I
E
N
F
Site 37
Y245
Q
L
F
F
Y
N
N
Y
I
E
N
F
P
S
D
Site 38
S251
N
Y
I
E
N
F
P
S
D
L
E
C
L
G
N
Site 39
S263
L
G
N
L
E
I
L
S
L
G
K
N
K
L
R
Site 40
T275
K
L
R
H
I
P
D
T
L
P
S
L
K
T
L
Site 41
T281
D
T
L
P
S
L
K
T
L
R
V
L
N
L
E
Site 42
S317
L
T
G
N
L
I
S
S
L
P
K
E
I
R
E
Site 43
T408
S
L
S
D
N
K
L
T
E
L
P
K
Y
I
H
Site 44
Y413
K
L
T
E
L
P
K
Y
I
H
K
L
N
N
L
Site 45
S445
S
H
L
N
N
I
C
S
L
E
F
S
G
N
I
Site 46
S493
L
D
S
L
Y
Y
L
S
V
N
G
N
Y
I
S
Site 47
S500
S
V
N
G
N
Y
I
S
E
I
P
V
D
I
S
Site 48
S507
S
E
I
P
V
D
I
S
F
S
K
Q
L
L
H
Site 49
Y537
C
S
L
I
N
L
K
Y
L
D
L
G
K
N
Q
Site 50
S587
N
L
Q
V
L
D
L
S
E
N
Q
L
Q
K
I
Site 51
S596
N
Q
L
Q
K
I
S
S
D
I
C
N
L
K
G
Site 52
S633
S
L
E
Q
L
N
I
S
Q
I
K
G
R
K
L
Site 53
T641
Q
I
K
G
R
K
L
T
R
L
P
G
E
L
S
Site 54
S648
T
R
L
P
G
E
L
S
N
M
T
Q
L
K
E
Site 55
S659
Q
L
K
E
L
D
I
S
N
N
A
I
R
E
I
Site 56
S678
G
E
L
R
N
L
V
S
L
H
A
Y
N
N
Q
Site 57
Y682
N
L
V
S
L
H
A
Y
N
N
Q
I
S
Y
L
Site 58
S687
H
A
Y
N
N
Q
I
S
Y
L
P
P
S
L
L
Site 59
Y688
A
Y
N
N
Q
I
S
Y
L
P
P
S
L
L
S
Site 60
S705
D
L
Q
Q
L
N
L
S
G
N
N
L
T
A
L
Site 61
T747
C
K
G
K
Q
L
Y
T
I
A
R
Y
L
Q
R
Site 62
S791
Q
K
L
N
L
A
N
S
E
T
D
M
P
T
K
Site 63
T793
L
N
L
A
N
S
E
T
D
M
P
T
K
S
T
Site 64
T797
N
S
E
T
D
M
P
T
K
S
T
V
S
L
S
Site 65
S799
E
T
D
M
P
T
K
S
T
V
S
L
S
E
R
Site 66
T800
T
D
M
P
T
K
S
T
V
S
L
S
E
R
A
Site 67
S802
M
P
T
K
S
T
V
S
L
S
E
R
A
H
Q
Site 68
S804
T
K
S
T
V
S
L
S
E
R
A
H
Q
A
L
Site 69
T816
Q
A
L
V
I
W
K
T
Q
S
N
K
L
S
L
Site 70
S822
K
T
Q
S
N
K
L
S
L
T
A
A
A
L
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation