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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CDC14C
Full Name:
Dual specificity protein phosphatase CDC14C
Alias:
CDC14 cell division cycle 14 C; CDC14 cell division cycle 14 homolog C; CDC14 cell division cycle 14C; CDC14B2; CDC14Bretro; MGC26484
Type:
Protein phosphatase, dual-specificity; EC 3.1.3.48; EC 3.1.3.16
Mass (Da):
63300
Number AA:
554
UniProt ID:
A4D256
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0004725
GO:0008138
PhosphoSite+
KinaseNET
Biological Process:
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S44
R
M
V
P
R
I
K
S
N
E
G
Y
G
Y
S
Site 2
Y48
R
I
K
S
N
E
G
Y
G
Y
S
N
R
N
W
Site 3
Y50
K
S
N
E
G
Y
G
Y
S
N
R
N
W
R
K
Site 4
S63
R
K
E
N
T
M
H
S
L
D
R
N
I
V
D
Site 5
S82
L
G
Q
W
K
R
K
S
K
G
R
S
S
W
A
Site 6
S86
K
R
K
S
K
G
R
S
S
W
A
A
A
P
L
Site 7
S87
R
K
S
K
G
R
S
S
W
A
A
A
P
L
C
Site 8
S99
P
L
C
S
Q
R
C
S
L
T
L
Q
G
V
K
Site 9
T101
C
S
Q
R
C
S
L
T
L
Q
G
V
K
K
M
Site 10
S110
Q
G
V
K
K
M
R
S
S
T
L
Q
D
P
R
Site 11
S111
G
V
K
K
M
R
S
S
T
L
Q
D
P
R
R
Site 12
T112
V
K
K
M
R
S
S
T
L
Q
D
P
R
R
W
Site 13
Y126
W
D
P
Q
D
D
V
Y
L
D
I
T
D
R
L
Site 14
T130
D
D
V
Y
L
D
I
T
D
R
L
R
F
A
I
Site 15
Y139
R
L
R
F
A
I
L
Y
S
R
P
K
S
A
S
Site 16
S140
L
R
F
A
I
L
Y
S
R
P
K
S
A
S
N
Site 17
S144
I
L
Y
S
R
P
K
S
A
S
N
V
H
Y
F
Site 18
S146
Y
S
R
P
K
S
A
S
N
V
H
Y
F
S
I
Site 19
Y150
K
S
A
S
N
V
H
Y
F
S
I
D
N
E
L
Site 20
S152
A
S
N
V
H
Y
F
S
I
D
N
E
L
E
Y
Site 21
Y159
S
I
D
N
E
L
E
Y
E
N
F
S
E
D
F
Site 22
Y177
N
L
A
M
V
Y
R
Y
C
C
K
I
N
K
K
Site 23
S187
K
I
N
K
K
L
K
S
I
T
M
L
R
K
K
Site 24
S201
K
I
V
H
F
T
G
S
D
Q
R
K
Q
A
N
Site 25
Y239
L
I
F
G
D
T
P
Y
I
P
F
R
D
A
A
Site 26
Y282
N
S
F
N
L
D
E
Y
E
H
Y
E
K
A
E
Site 27
Y285
N
L
D
E
Y
E
H
Y
E
K
A
E
N
G
D
Site 28
S309
I
A
F
C
G
P
H
S
R
A
R
L
E
S
G
Site 29
S315
H
S
R
A
R
L
E
S
G
Y
H
Q
H
S
P
Site 30
Y317
R
A
R
L
E
S
G
Y
H
Q
H
S
P
E
T
Site 31
S321
E
S
G
Y
H
Q
H
S
P
E
T
Y
I
Q
Y
Site 32
Y325
H
Q
H
S
P
E
T
Y
I
Q
Y
F
K
N
H
Site 33
Y328
S
P
E
T
Y
I
Q
Y
F
K
N
H
N
V
T
Site 34
Y345
I
R
L
N
K
R
M
Y
D
A
K
R
F
T
D
Site 35
Y450
S
L
W
L
E
G
D
Y
F
R
Q
K
L
K
G
Site 36
S468
G
Q
H
R
A
A
F
S
K
L
L
S
G
V
D
Site 37
S478
L
S
G
V
D
D
I
S
I
N
G
V
E
N
Q
Site 38
Y493
D
Q
Q
E
P
K
P
Y
G
D
D
D
E
I
N
Site 39
T503
D
D
E
I
N
G
V
T
Q
G
D
R
S
R
A
Site 40
S508
G
V
T
Q
G
D
R
S
R
A
L
K
R
R
R
Site 41
S517
A
L
K
R
R
R
Q
S
K
T
N
D
I
L
L
Site 42
T519
K
R
R
R
Q
S
K
T
N
D
I
L
L
P
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation