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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EFCAB5
Full Name:
EF-hand calcium-binding domain-containing protein 5
Alias:
EFCB5; EF-hand calcium binding domain 5; FLJ46247
Type:
Calcium-binding protein
Mass (Da):
173419
Number AA:
1503
UniProt ID:
A4FU69
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005509
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T28
K
E
R
K
W
N
L
T
E
V
K
E
L
H
E
Site 2
T36
E
V
K
E
L
H
E
T
L
Q
S
V
P
D
V
Site 3
S39
E
L
H
E
T
L
Q
S
V
P
D
V
P
V
K
Site 4
T49
D
V
P
V
K
E
D
T
N
S
V
V
E
K
A
Site 5
S51
P
V
K
E
D
T
N
S
V
V
E
K
A
M
D
Site 6
S62
K
A
M
D
E
I
K
S
Q
E
L
N
L
E
G
Site 7
S74
L
E
G
Q
R
K
I
S
P
G
S
I
K
D
S
Site 8
S77
Q
R
K
I
S
P
G
S
I
K
D
S
K
T
E
Site 9
S81
S
P
G
S
I
K
D
S
K
T
E
A
S
G
N
Site 10
T83
G
S
I
K
D
S
K
T
E
A
S
G
N
I
A
Site 11
T104
V
I
F
A
L
D
E
T
E
L
K
S
K
P
E
Site 12
S108
L
D
E
T
E
L
K
S
K
P
E
H
T
W
K
Site 13
T191
P
G
V
E
N
M
L
T
Q
V
E
K
K
K
V
Site 14
T200
V
E
K
K
K
V
L
T
E
A
D
T
P
S
K
Site 15
T204
K
V
L
T
E
A
D
T
P
S
K
F
D
P
I
Site 16
S206
L
T
E
A
D
T
P
S
K
F
D
P
I
N
Y
Site 17
Y213
S
K
F
D
P
I
N
Y
L
G
E
Y
L
I
R
Site 18
Y217
P
I
N
Y
L
G
E
Y
L
I
R
N
N
P
N
Site 19
Y225
L
I
R
N
N
P
N
Y
I
K
D
P
G
M
S
Site 20
Y234
K
D
P
G
M
S
G
Y
Q
R
L
M
K
E
V
Site 21
T252
L
K
I
Y
V
P
D
T
I
C
N
R
V
S
K
Site 22
S273
Q
N
R
K
Q
R
E
S
I
D
K
I
K
V
K
Site 23
S307
P
K
G
M
I
P
K
S
V
I
Q
N
V
L
Q
Site 24
S326
N
P
D
F
K
L
G
S
H
C
K
Q
L
D
I
Site 25
T334
H
C
K
Q
L
D
I
T
D
S
T
E
P
R
L
Site 26
S336
K
Q
L
D
I
T
D
S
T
E
P
R
L
N
K
Site 27
T337
Q
L
D
I
T
D
S
T
E
P
R
L
N
K
M
Site 28
T347
R
L
N
K
M
E
F
T
E
Y
I
S
S
H
I
Site 29
Y349
N
K
M
E
F
T
E
Y
I
S
S
H
I
K
D
Site 30
S352
E
F
T
E
Y
I
S
S
H
I
K
D
L
K
S
Site 31
S359
S
H
I
K
D
L
K
S
E
M
F
E
E
L
L
Site 32
S372
L
L
K
H
L
C
H
S
A
D
E
F
R
E
V
Site 33
S420
L
E
L
F
Y
D
H
S
S
Q
M
L
R
S
L
Site 34
S421
E
L
F
Y
D
H
S
S
Q
M
L
R
S
L
L
Site 35
S426
H
S
S
Q
M
L
R
S
L
L
R
N
P
R
Q
Site 36
S478
L
L
S
A
N
H
A
S
K
T
Q
S
K
L
L
Site 37
T480
S
A
N
H
A
S
K
T
Q
S
K
L
L
E
S
Site 38
S482
N
H
A
S
K
T
Q
S
K
L
L
E
S
P
D
Site 39
S487
T
Q
S
K
L
L
E
S
P
D
Q
P
K
L
N
Site 40
T498
P
K
L
N
E
Q
R
T
S
T
P
S
P
N
P
Site 41
S499
K
L
N
E
Q
R
T
S
T
P
S
P
N
P
P
Site 42
T500
L
N
E
Q
R
T
S
T
P
S
P
N
P
P
E
Site 43
S502
E
Q
R
T
S
T
P
S
P
N
P
P
E
Q
Q
Site 44
T513
P
E
Q
Q
R
G
V
T
A
E
Q
G
P
Q
R
Site 45
S522
E
Q
G
P
Q
R
I
S
I
E
E
Q
Q
Q
G
Site 46
Y539
P
T
A
E
Q
E
L
Y
I
E
S
V
I
E
P
Site 47
S542
E
Q
E
L
Y
I
E
S
V
I
E
P
G
T
H
Site 48
T548
E
S
V
I
E
P
G
T
H
T
E
S
T
L
E
Site 49
T553
P
G
T
H
T
E
S
T
L
E
Q
G
S
S
R
Site 50
S558
E
S
T
L
E
Q
G
S
S
R
R
L
L
T
E
Site 51
S559
S
T
L
E
Q
G
S
S
R
R
L
L
T
E
Q
Site 52
T564
G
S
S
R
R
L
L
T
E
Q
E
T
H
R
E
Site 53
T568
R
L
L
T
E
Q
E
T
H
R
E
S
T
T
E
Site 54
S572
E
Q
E
T
H
R
E
S
T
T
E
Q
G
Q
H
Site 55
T573
Q
E
T
H
R
E
S
T
T
E
Q
G
Q
H
K
Site 56
S582
E
Q
G
Q
H
K
G
S
I
E
G
Q
G
P
R
Site 57
S592
G
Q
G
P
R
R
V
S
V
S
E
Q
G
S
S
Site 58
S594
G
P
R
R
V
S
V
S
E
Q
G
S
S
R
E
Site 59
S598
V
S
V
S
E
Q
G
S
S
R
E
S
V
A
E
Site 60
S599
S
V
S
E
Q
G
S
S
R
E
S
V
A
E
Q
Site 61
S602
E
Q
G
S
S
R
E
S
V
A
E
Q
G
S
R
Site 62
S608
E
S
V
A
E
Q
G
S
R
R
E
S
I
A
E
Site 63
S612
E
Q
G
S
R
R
E
S
I
A
E
Q
D
R
H
Site 64
S622
E
Q
D
R
H
K
G
S
V
A
E
Q
G
S
R
Site 65
S628
G
S
V
A
E
Q
G
S
R
R
M
S
A
A
E
Site 66
S632
E
Q
G
S
R
R
M
S
A
A
E
Q
G
S
L
Site 67
S638
M
S
A
A
E
Q
G
S
L
R
E
S
V
I
E
Site 68
S642
E
Q
G
S
L
R
E
S
V
I
E
E
P
Y
Q
Site 69
Y648
E
S
V
I
E
E
P
Y
Q
K
S
E
Q
G
P
Site 70
Y656
Q
K
S
E
Q
G
P
Y
G
E
I
I
S
E
E
Site 71
S661
G
P
Y
G
E
I
I
S
E
E
Q
E
D
I
G
Site 72
S669
E
E
Q
E
D
I
G
S
T
S
Q
S
R
K
D
Site 73
S671
Q
E
D
I
G
S
T
S
Q
S
R
K
D
S
I
Site 74
S673
D
I
G
S
T
S
Q
S
R
K
D
S
I
L
K
Site 75
S677
T
S
Q
S
R
K
D
S
I
L
K
S
T
K
Y
Site 76
S681
R
K
D
S
I
L
K
S
T
K
Y
G
E
P
I
Site 77
Y684
S
I
L
K
S
T
K
Y
G
E
P
I
T
S
E
Site 78
S690
K
Y
G
E
P
I
T
S
E
Y
I
E
V
P
L
Site 79
Y692
G
E
P
I
T
S
E
Y
I
E
V
P
L
Q
E
Site 80
S702
V
P
L
Q
E
K
R
S
W
E
Q
T
Y
E
E
Site 81
T706
E
K
R
S
W
E
Q
T
Y
E
E
E
I
F
L
Site 82
S714
Y
E
E
E
I
F
L
S
S
E
L
Q
E
E
V
Site 83
T723
E
L
Q
E
E
V
P
T
L
S
R
K
D
H
F
Site 84
T733
R
K
D
H
F
P
E
T
T
K
K
E
V
Q
K
Site 85
S748
D
K
P
C
E
P
K
S
Q
K
I
E
G
K
S
Site 86
S755
S
Q
K
I
E
G
K
S
W
S
G
E
F
F
T
Site 87
T771
N
W
K
M
K
Y
V
T
F
E
D
E
E
Q
A
Site 88
S785
A
N
L
I
Y
G
N
S
R
F
T
D
L
H
S
Site 89
T788
I
Y
G
N
S
R
F
T
D
L
H
S
I
I
R
Site 90
S792
S
R
F
T
D
L
H
S
I
I
R
N
I
Q
S
Site 91
S834
V
G
E
D
A
P
L
S
V
S
E
T
L
T
S
Site 92
T838
A
P
L
S
V
S
E
T
L
T
S
F
F
K
E
Site 93
T840
L
S
V
S
E
T
L
T
S
F
F
K
E
G
Y
Site 94
S841
S
V
S
E
T
L
T
S
F
F
K
E
G
Y
V
Site 95
Y847
T
S
F
F
K
E
G
Y
V
E
T
E
Q
E
K
Site 96
S862
M
N
A
L
E
Q
F
S
Q
N
A
F
Q
V
R
Site 97
S883
A
I
F
Q
K
W
D
S
D
G
S
G
F
L
D
Site 98
Y899
K
E
V
D
E
L
L
Y
T
Y
K
E
G
M
E
Site 99
T900
E
V
D
E
L
L
Y
T
Y
K
E
G
M
E
K
Site 100
S931
P
G
H
E
V
R
L
S
S
K
Q
F
Q
N
Y
Site 101
S932
G
H
E
V
R
L
S
S
K
Q
F
Q
N
Y
I
Site 102
Y938
S
S
K
Q
F
Q
N
Y
I
E
L
V
V
S
E
Site 103
S944
N
Y
I
E
L
V
V
S
E
L
R
G
N
E
D
Site 104
S956
N
E
D
Q
V
L
E
S
V
V
E
F
L
M
N
Site 105
S968
L
M
N
A
L
E
R
S
H
I
E
S
L
R
N
Site 106
S972
L
E
R
S
H
I
E
S
L
R
N
S
A
R
R
Site 107
S976
H
I
E
S
L
R
N
S
A
R
R
K
W
L
H
Site 108
S995
A
A
E
T
S
G
V
S
L
E
P
V
Y
S
E
Site 109
T1003
L
E
P
V
Y
S
E
T
F
K
A
L
M
Q
D
Site 110
S1020
A
H
G
N
K
K
I
S
A
H
I
S
L
L
E
Site 111
S1066
Y
R
D
M
K
G
I
S
F
T
V
V
D
E
G
Site 112
T1068
D
M
K
G
I
S
F
T
V
V
D
E
G
K
P
Site 113
Y1099
Q
S
R
N
K
H
D
Y
N
G
S
F
L
A
L
Site 114
S1102
N
K
H
D
Y
N
G
S
F
L
A
L
P
L
Q
Site 115
Y1152
A
N
V
F
S
T
A
Y
H
Y
V
H
S
R
E
Site 116
Y1154
V
F
S
T
A
Y
H
Y
V
H
S
R
E
H
I
Site 117
T1184
S
S
I
T
S
I
T
T
Y
F
V
E
P
S
P
Site 118
S1190
T
T
Y
F
V
E
P
S
P
A
Q
D
S
D
Y
Site 119
S1195
E
P
S
P
A
Q
D
S
D
Y
V
L
R
N
M
Site 120
Y1197
S
P
A
Q
D
S
D
Y
V
L
R
N
M
M
V
Site 121
T1219
E
I
H
K
N
P
P
T
I
H
R
K
S
C
I
Site 122
Y1281
R
M
L
L
C
Q
E
Y
K
D
L
Q
K
M
M
Site 123
Y1310
S
G
E
I
K
K
K
Y
I
L
E
I
E
N
V
Site 124
T1356
S
L
L
L
Y
D
H
T
L
V
T
E
P
N
S
Site 125
T1359
L
Y
D
H
T
L
V
T
E
P
N
S
P
Q
D
Site 126
S1363
T
L
V
T
E
P
N
S
P
Q
D
S
K
S
M
Site 127
S1367
E
P
N
S
P
Q
D
S
K
S
M
E
L
E
A
Site 128
S1369
N
S
P
Q
D
S
K
S
M
E
L
E
A
N
V
Site 129
S1397
F
H
P
E
L
E
F
S
S
D
F
G
S
W
D
Site 130
S1398
H
P
E
L
E
F
S
S
D
F
G
S
W
D
K
Site 131
Y1409
S
W
D
K
C
K
F
Y
V
N
K
Y
L
V
N
Site 132
Y1438
N
V
Q
L
I
D
E
Y
I
R
D
H
S
R
T
Site 133
T1480
K
Q
L
N
S
G
I
T
P
P
L
P
S
K
T
Site 134
S1485
G
I
T
P
P
L
P
S
K
T
D
N
Y
M
Y
Site 135
T1487
T
P
P
L
P
S
K
T
D
N
Y
M
Y
A
K
Site 136
Y1490
L
P
S
K
T
D
N
Y
M
Y
A
K
M
P
G
Site 137
Y1492
S
K
T
D
N
Y
M
Y
A
K
M
P
G
E
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation