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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PSD
Full Name:
PH and SEC7 domain-containing protein 1
Alias:
EFA6; EFA6A; KIAA2011; Pleckstrin and Sec7 domain containing; Pleckstrin and Sec7 domain protein; PSD1; TYL
Type:
Guanine nucleotide exchange factor, ARF
Mass (Da):
109543
Number AA:
1024
UniProt ID:
A5PKW4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005086
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0032012
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
Q
G
A
M
R
F
C
S
E
G
D
C
A
I
S
Site 2
S17
S
E
G
D
C
A
I
S
P
P
R
C
P
R
R
Site 3
S34
P
E
G
P
V
P
Q
S
P
P
A
S
M
Y
G
Site 4
S38
V
P
Q
S
P
P
A
S
M
Y
G
S
T
G
S
Site 5
Y40
Q
S
P
P
A
S
M
Y
G
S
T
G
S
L
L
Site 6
S42
P
P
A
S
M
Y
G
S
T
G
S
L
L
R
R
Site 7
S45
S
M
Y
G
S
T
G
S
L
L
R
R
V
A
G
Site 8
T64
G
R
E
L
G
R
V
T
A
P
C
T
P
L
R
Site 9
T68
G
R
V
T
A
P
C
T
P
L
R
G
P
P
S
Site 10
S75
T
P
L
R
G
P
P
S
P
R
V
A
P
S
P
Site 11
S81
P
S
P
R
V
A
P
S
P
W
A
P
S
S
P
Site 12
S87
P
S
P
W
A
P
S
S
P
T
G
Q
P
P
P
Site 13
T89
P
W
A
P
S
S
P
T
G
Q
P
P
P
G
A
Site 14
S110
F
R
F
V
E
K
A
S
V
R
P
L
N
G
L
Site 15
S124
L
P
A
P
G
G
L
S
R
S
W
D
L
G
G
Site 16
S126
A
P
G
G
L
S
R
S
W
D
L
G
G
V
S
Site 17
S133
S
W
D
L
G
G
V
S
P
P
R
P
T
P
A
Site 18
T138
G
V
S
P
P
R
P
T
P
A
L
G
P
G
S
Site 19
S145
T
P
A
L
G
P
G
S
N
R
K
L
R
L
E
Site 20
S154
R
K
L
R
L
E
A
S
T
S
D
P
L
P
A
Site 21
T155
K
L
R
L
E
A
S
T
S
D
P
L
P
A
R
Site 22
S156
L
R
L
E
A
S
T
S
D
P
L
P
A
R
G
Site 23
S165
P
L
P
A
R
G
G
S
A
L
P
G
S
R
N
Site 24
S170
G
G
S
A
L
P
G
S
R
N
L
V
H
G
P
Site 25
Y189
Q
V
G
A
D
G
L
Y
S
S
L
P
N
G
L
Site 26
S190
V
G
A
D
G
L
Y
S
S
L
P
N
G
L
G
Site 27
S191
G
A
D
G
L
Y
S
S
L
P
N
G
L
G
G
Site 28
T205
G
P
P
E
R
L
A
T
L
F
G
G
P
A
D
Site 29
T221
G
F
L
N
Q
G
D
T
W
S
S
P
R
E
V
Site 30
S223
L
N
Q
G
D
T
W
S
S
P
R
E
V
S
S
Site 31
S224
N
Q
G
D
T
W
S
S
P
R
E
V
S
S
H
Site 32
S229
W
S
S
P
R
E
V
S
S
H
A
Q
R
I
A
Site 33
S230
S
S
P
R
E
V
S
S
H
A
Q
R
I
A
R
Site 34
Y244
R
A
K
W
E
F
F
Y
G
S
L
D
P
P
S
Site 35
S246
K
W
E
F
F
Y
G
S
L
D
P
P
S
S
G
Site 36
S251
Y
G
S
L
D
P
P
S
S
G
A
K
P
P
E
Site 37
S252
G
S
L
D
P
P
S
S
G
A
K
P
P
E
Q
Site 38
S263
P
P
E
Q
A
P
P
S
P
P
G
V
G
S
R
Site 39
S269
P
S
P
P
G
V
G
S
R
Q
G
S
G
V
A
Site 40
S273
G
V
G
S
R
Q
G
S
G
V
A
V
G
R
A
Site 41
S284
V
G
R
A
A
K
Y
S
E
T
D
L
D
T
V
Site 42
T290
Y
S
E
T
D
L
D
T
V
P
L
R
C
Y
R
Site 43
Y296
D
T
V
P
L
R
C
Y
R
E
T
D
I
D
E
Site 44
T299
P
L
R
C
Y
R
E
T
D
I
D
E
V
L
A
Site 45
S313
A
E
R
E
E
A
D
S
A
I
E
S
Q
P
S
Site 46
S317
E
A
D
S
A
I
E
S
Q
P
S
S
E
G
P
Site 47
S320
S
A
I
E
S
Q
P
S
S
E
G
P
P
G
T
Site 48
S321
A
I
E
S
Q
P
S
S
E
G
P
P
G
T
A
Site 49
T327
S
S
E
G
P
P
G
T
A
Y
P
P
A
P
R
Site 50
Y329
E
G
P
P
G
T
A
Y
P
P
A
P
R
P
G
Site 51
S344
P
L
P
G
P
H
P
S
L
G
S
G
N
E
D
Site 52
S378
S
E
G
A
R
P
G
S
R
M
P
L
K
S
P
Site 53
S384
G
S
R
M
P
L
K
S
P
V
P
F
L
P
G
Site 54
T392
P
V
P
F
L
P
G
T
S
P
S
A
D
G
P
Site 55
S393
V
P
F
L
P
G
T
S
P
S
A
D
G
P
D
Site 56
S395
F
L
P
G
T
S
P
S
A
D
G
P
D
S
F
Site 57
S401
P
S
A
D
G
P
D
S
F
S
C
V
F
E
A
Site 58
S412
V
F
E
A
I
L
E
S
H
R
A
K
G
T
S
Site 59
T418
E
S
H
R
A
K
G
T
S
Y
T
S
L
A
S
Site 60
S419
S
H
R
A
K
G
T
S
Y
T
S
L
A
S
L
Site 61
S431
A
S
L
E
A
L
A
S
P
G
P
T
Q
S
P
Site 62
S437
A
S
P
G
P
T
Q
S
P
F
F
T
F
E
L
Site 63
T441
P
T
Q
S
P
F
F
T
F
E
L
P
P
Q
P
Site 64
S468
L
A
P
L
E
P
D
S
G
T
S
S
A
A
D
Site 65
S472
E
P
D
S
G
T
S
S
A
A
D
G
P
W
T
Site 66
T479
S
A
A
D
G
P
W
T
Q
R
G
E
E
E
E
Site 67
S501
A
P
G
R
E
P
P
S
P
C
H
S
E
D
S
Site 68
S505
E
P
P
S
P
C
H
S
E
D
S
L
G
L
G
Site 69
S508
S
P
C
H
S
E
D
S
L
G
L
G
A
A
P
Site 70
S523
L
G
S
E
P
P
L
S
Q
L
V
S
D
S
D
Site 71
S527
P
P
L
S
Q
L
V
S
D
S
D
S
E
L
D
Site 72
S529
L
S
Q
L
V
S
D
S
D
S
E
L
D
S
T
Site 73
S531
Q
L
V
S
D
S
D
S
E
L
D
S
T
E
R
Site 74
S535
D
S
D
S
E
L
D
S
T
E
R
L
A
L
G
Site 75
T536
S
D
S
E
L
D
S
T
E
R
L
A
L
G
S
Site 76
S543
T
E
R
L
A
L
G
S
T
D
T
L
S
N
G
Site 77
T544
E
R
L
A
L
G
S
T
D
T
L
S
N
G
Q
Site 78
T546
L
A
L
G
S
T
D
T
L
S
N
G
Q
K
A
Site 79
S548
L
G
S
T
D
T
L
S
N
G
Q
K
A
D
L
Site 80
Y566
Q
R
L
A
K
R
L
Y
R
L
D
G
F
R
K
Site 81
S587
L
G
K
N
N
D
F
S
K
L
V
A
G
E
Y
Site 82
Y636
L
A
H
F
S
Q
R
Y
F
Q
C
N
P
E
A
Site 83
S646
C
N
P
E
A
L
S
S
E
D
G
A
H
T
L
Site 84
Y700
R
E
L
L
K
A
L
Y
S
S
I
K
N
E
K
Site 85
S701
E
L
L
K
A
L
Y
S
S
I
K
N
E
K
L
Site 86
S720
D
E
E
E
L
R
R
S
L
S
E
L
A
D
P
Site 87
S722
E
E
L
R
R
S
L
S
E
L
A
D
P
N
P
Site 88
S736
P
K
V
I
K
R
I
S
G
G
S
G
S
G
S
Site 89
S739
I
K
R
I
S
G
G
S
G
S
G
S
S
P
F
Site 90
S741
R
I
S
G
G
S
G
S
G
S
S
P
F
L
D
Site 91
S743
S
G
G
S
G
S
G
S
S
P
F
L
D
L
T
Site 92
S744
G
G
S
G
S
G
S
S
P
F
L
D
L
T
P
Site 93
T776
A
D
P
D
C
R
K
T
P
R
G
K
R
G
W
Site 94
S785
R
G
K
R
G
W
K
S
F
H
G
I
L
K
G
Site 95
Y796
I
L
K
G
M
I
L
Y
L
Q
K
E
E
Y
K
Site 96
S809
Y
K
P
G
K
A
L
S
E
T
E
L
K
N
A
Site 97
S828
H
A
L
A
T
R
A
S
D
Y
S
K
R
P
H
Site 98
Y830
L
A
T
R
A
S
D
Y
S
K
R
P
H
V
F
Site 99
S831
A
T
R
A
S
D
Y
S
K
R
P
H
V
F
Y
Site 100
Y838
S
K
R
P
H
V
F
Y
L
R
T
A
D
W
R
Site 101
S881
P
P
F
P
A
A
V
S
S
Q
K
K
F
S
R
Site 102
S882
P
F
P
A
A
V
S
S
Q
K
K
F
S
R
P
Site 103
S887
V
S
S
Q
K
K
F
S
R
P
L
L
P
S
A
Site 104
S893
F
S
R
P
L
L
P
S
A
A
T
R
L
S
Q
Site 105
S899
P
S
A
A
T
R
L
S
Q
E
E
Q
V
R
T
Site 106
T906
S
Q
E
E
Q
V
R
T
H
E
A
K
L
K
A
Site 107
S916
A
K
L
K
A
M
A
S
E
L
R
E
H
R
A
Site 108
Y944
E
Q
R
Q
K
E
A
Y
L
E
F
E
K
S
R
Site 109
S950
A
Y
L
E
F
E
K
S
R
Y
S
T
Y
A
A
Site 110
Y952
L
E
F
E
K
S
R
Y
S
T
Y
A
A
L
L
Site 111
S953
E
F
E
K
S
R
Y
S
T
Y
A
A
L
L
R
Site 112
T954
F
E
K
S
R
Y
S
T
Y
A
A
L
L
R
V
Site 113
Y955
E
K
S
R
Y
S
T
Y
A
A
L
L
R
V
K
Site 114
S967
R
V
K
L
K
A
G
S
E
E
L
D
A
V
E
Site 115
S982
A
A
L
A
Q
A
G
S
T
E
D
G
L
P
P
Site 116
S990
T
E
D
G
L
P
P
S
H
S
S
P
S
L
Q
Site 117
S992
D
G
L
P
P
S
H
S
S
P
S
L
Q
P
K
Site 118
S993
G
L
P
P
S
H
S
S
P
S
L
Q
P
K
P
Site 119
S995
P
P
S
H
S
S
P
S
L
Q
P
K
P
S
S
Site 120
S1001
P
S
L
Q
P
K
P
S
S
Q
P
R
A
Q
R
Site 121
S1002
S
L
Q
P
K
P
S
S
Q
P
R
A
Q
R
H
Site 122
S1010
Q
P
R
A
Q
R
H
S
S
E
P
R
P
G
A
Site 123
S1011
P
R
A
Q
R
H
S
S
E
P
R
P
G
A
G
Site 124
S1019
E
P
R
P
G
A
G
S
G
R
R
K
P
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation