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Updated November 2019
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Protein Info
Short Name:
FAM149A
Full Name:
Protein FAM149A
Alias:
Type:
Mass (Da):
82698
Number AA:
773
UniProt ID:
A5PLN7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T20
A
K
L
F
E
T
S
T
A
P
P
A
G
P
S
Site 2
S27
T
A
P
P
A
G
P
S
S
R
P
S
G
G
A
Site 3
S28
A
P
P
A
G
P
S
S
R
P
S
G
G
A
A
Site 4
S31
A
G
P
S
S
R
P
S
G
G
A
A
A
A
G
Site 5
S39
G
G
A
A
A
A
G
S
G
G
S
R
A
G
T
Site 6
T46
S
G
G
S
R
A
G
T
P
L
G
T
A
P
T
Site 7
S62
L
R
A
L
A
P
D
S
P
S
A
S
R
R
S
Site 8
S64
A
L
A
P
D
S
P
S
A
S
R
R
S
P
A
Site 9
S66
A
P
D
S
P
S
A
S
R
R
S
P
A
P
L
Site 10
S69
S
P
S
A
S
R
R
S
P
A
P
L
L
S
S
Site 11
S75
R
S
P
A
P
L
L
S
S
P
Y
S
R
G
S
Site 12
S76
S
P
A
P
L
L
S
S
P
Y
S
R
G
S
A
Site 13
S79
P
L
L
S
S
P
Y
S
R
G
S
A
A
S
R
Site 14
S82
S
S
P
Y
S
R
G
S
A
A
S
R
A
A
G
Site 15
S85
Y
S
R
G
S
A
A
S
R
A
A
G
A
V
G
Site 16
S96
G
A
V
G
T
L
L
S
W
P
S
S
P
R
A
Site 17
S99
G
T
L
L
S
W
P
S
S
P
R
A
G
K
A
Site 18
S100
T
L
L
S
W
P
S
S
P
R
A
G
K
A
P
Site 19
T112
K
A
P
P
Q
P
P
T
P
S
G
G
G
C
S
Site 20
S114
P
P
Q
P
P
T
P
S
G
G
G
C
S
P
A
Site 21
T170
G
P
R
T
L
F
L
T
L
P
D
I
G
E
E
Site 22
S180
D
I
G
E
E
G
A
S
D
G
D
S
G
D
G
Site 23
S184
E
G
A
S
D
G
D
S
G
D
G
E
A
R
G
Site 24
S193
D
G
E
A
R
G
L
S
E
G
R
R
R
H
G
Site 25
T202
G
R
R
R
H
G
F
T
V
R
S
K
D
S
L
Site 26
S205
R
H
G
F
T
V
R
S
K
D
S
L
P
T
H
Site 27
S208
F
T
V
R
S
K
D
S
L
P
T
H
F
T
R
Site 28
T214
D
S
L
P
T
H
F
T
R
N
V
Q
K
A
I
Site 29
Y224
V
Q
K
A
I
D
K
Y
T
C
K
S
L
S
S
Site 30
T225
Q
K
A
I
D
K
Y
T
C
K
S
L
S
S
F
Site 31
S228
I
D
K
Y
T
C
K
S
L
S
S
F
S
S
S
Site 32
S230
K
Y
T
C
K
S
L
S
S
F
S
S
S
G
S
Site 33
S231
Y
T
C
K
S
L
S
S
F
S
S
S
G
S
H
Site 34
S233
C
K
S
L
S
S
F
S
S
S
G
S
H
T
P
Site 35
S234
K
S
L
S
S
F
S
S
S
G
S
H
T
P
T
Site 36
S235
S
L
S
S
F
S
S
S
G
S
H
T
P
T
G
Site 37
S237
S
S
F
S
S
S
G
S
H
T
P
T
G
A
H
Site 38
T239
F
S
S
S
G
S
H
T
P
T
G
A
H
T
S
Site 39
T241
S
S
G
S
H
T
P
T
G
A
H
T
S
W
S
Site 40
S246
T
P
T
G
A
H
T
S
W
S
G
S
A
T
Q
Site 41
S248
T
G
A
H
T
S
W
S
G
S
A
T
Q
S
S
Site 42
S250
A
H
T
S
W
S
G
S
A
T
Q
S
S
T
T
Site 43
T252
T
S
W
S
G
S
A
T
Q
S
S
T
T
G
S
Site 44
S254
W
S
G
S
A
T
Q
S
S
T
T
G
S
S
T
Site 45
S255
S
G
S
A
T
Q
S
S
T
T
G
S
S
T
E
Site 46
T256
G
S
A
T
Q
S
S
T
T
G
S
S
T
E
R
Site 47
S259
T
Q
S
S
T
T
G
S
S
T
E
R
G
S
V
Site 48
S260
Q
S
S
T
T
G
S
S
T
E
R
G
S
V
Y
Site 49
T261
S
S
T
T
G
S
S
T
E
R
G
S
V
Y
S
Site 50
S265
G
S
S
T
E
R
G
S
V
Y
S
W
R
D
D
Site 51
Y267
S
T
E
R
G
S
V
Y
S
W
R
D
D
E
F
Site 52
S268
T
E
R
G
S
V
Y
S
W
R
D
D
E
F
D
Site 53
S279
D
E
F
D
E
A
S
S
Q
S
V
Q
R
L
L
Site 54
S281
F
D
E
A
S
S
Q
S
V
Q
R
L
L
W
E
Site 55
T302
E
G
K
V
N
P
Q
T
Q
S
L
L
A
E
C
Site 56
S316
C
G
E
W
T
R
R
S
L
H
L
R
V
L
G
Site 57
T330
G
R
Q
L
I
L
P
T
D
K
G
V
Q
H
F
Site 58
S340
G
V
Q
H
F
Q
G
S
T
P
A
S
A
V
H
Site 59
T341
V
Q
H
F
Q
G
S
T
P
A
S
A
V
H
R
Site 60
S344
F
Q
G
S
T
P
A
S
A
V
H
R
P
P
L
Site 61
S352
A
V
H
R
P
P
L
S
A
C
G
H
S
S
N
Site 62
T392
D
T
G
V
A
D
L
T
A
R
S
S
L
E
E
Site 63
S396
A
D
L
T
A
R
S
S
L
E
E
E
V
Y
H
Site 64
Y402
S
S
L
E
E
E
V
Y
H
V
D
G
K
I
E
Site 65
Y411
V
D
G
K
I
E
E
Y
F
A
F
D
R
K
E
Site 66
S444
K
L
G
L
P
P
V
S
P
R
D
C
V
K
D
Site 67
T479
L
I
R
K
H
W
E
T
T
L
T
E
G
K
K
Site 68
T482
K
H
W
E
T
T
L
T
E
G
K
K
Q
R
E
Site 69
T490
E
G
K
K
Q
R
E
T
L
K
V
A
G
N
R
Site 70
S512
H
A
H
A
D
G
A
S
G
P
P
S
G
H
A
Site 71
S516
D
G
A
S
G
P
P
S
G
H
A
E
A
H
G
Site 72
S525
H
A
E
A
H
G
I
S
L
A
S
R
L
N
P
Site 73
S539
P
P
Q
I
H
H
F
S
S
S
F
Y
S
D
M
Site 74
Y543
H
H
F
S
S
S
F
Y
S
D
M
N
G
V
M
Site 75
T551
S
D
M
N
G
V
M
T
I
Q
A
K
P
L
Q
Site 76
Y563
P
L
Q
R
R
P
A
Y
F
A
D
R
T
Q
N
Site 77
T568
P
A
Y
F
A
D
R
T
Q
N
E
K
E
D
K
Site 78
S577
N
E
K
E
D
K
A
S
G
G
G
A
G
A
L
Site 79
S585
G
G
G
A
G
A
L
S
S
A
P
H
R
L
G
Site 80
S586
G
G
A
G
A
L
S
S
A
P
H
R
L
G
R
Site 81
S595
P
H
R
L
G
R
A
S
D
T
H
G
L
S
P
Site 82
T597
R
L
G
R
A
S
D
T
H
G
L
S
P
S
A
Site 83
S601
A
S
D
T
H
G
L
S
P
S
A
K
K
T
P
Site 84
S603
D
T
H
G
L
S
P
S
A
K
K
T
P
V
P
Site 85
T607
L
S
P
S
A
K
K
T
P
V
P
W
R
L
P
Site 86
S615
P
V
P
W
R
L
P
S
L
A
S
D
S
Q
R
Site 87
S618
W
R
L
P
S
L
A
S
D
S
Q
R
L
K
T
Site 88
S620
L
P
S
L
A
S
D
S
Q
R
L
K
T
P
N
Site 89
T625
S
D
S
Q
R
L
K
T
P
N
I
Y
S
D
E
Site 90
S630
L
K
T
P
N
I
Y
S
D
E
V
L
R
G
T
Site 91
T637
S
D
E
V
L
R
G
T
K
L
P
T
G
V
D
Site 92
S648
T
G
V
D
H
M
A
S
P
L
V
Q
T
S
R
Site 93
S654
A
S
P
L
V
Q
T
S
R
S
R
F
P
P
L
Site 94
S656
P
L
V
Q
T
S
R
S
R
F
P
P
L
V
T
Site 95
T670
T
E
T
R
G
Q
N
T
A
V
P
G
C
R
L
Site 96
S679
V
P
G
C
R
L
V
S
Y
R
G
R
H
L
Q
Site 97
Y680
P
G
C
R
L
V
S
Y
R
G
R
H
L
Q
N
Site 98
S691
H
L
Q
N
R
V
L
S
A
M
P
D
G
T
E
Site 99
T697
L
S
A
M
P
D
G
T
E
R
S
R
L
R
E
Site 100
T706
R
S
R
L
R
E
R
T
A
T
L
E
R
L
S
Site 101
T708
R
L
R
E
R
T
A
T
L
E
R
L
S
R
P
Site 102
S713
T
A
T
L
E
R
L
S
R
P
S
T
T
H
T
Site 103
S716
L
E
R
L
S
R
P
S
T
T
H
T
F
R
Q
Site 104
T717
E
R
L
S
R
P
S
T
T
H
T
F
R
Q
S
Site 105
T720
S
R
P
S
T
T
H
T
F
R
Q
S
D
T
P
Site 106
S724
T
T
H
T
F
R
Q
S
D
T
P
R
K
S
S
Site 107
T726
H
T
F
R
Q
S
D
T
P
R
K
S
S
L
T
Site 108
S730
Q
S
D
T
P
R
K
S
S
L
T
Q
M
E
F
Site 109
S731
S
D
T
P
R
K
S
S
L
T
Q
M
E
F
A
Site 110
T733
T
P
R
K
S
S
L
T
Q
M
E
F
A
A
H
Site 111
S751
G
Q
S
I
L
T
G
S
Q
Y
V
P
K
S
F
Site 112
Y753
S
I
L
T
G
S
Q
Y
V
P
K
S
F
Q
R
Site 113
S757
G
S
Q
Y
V
P
K
S
F
Q
R
T
T
L
T
Site 114
T761
V
P
K
S
F
Q
R
T
T
L
T
F
K
R
R
Site 115
T762
P
K
S
F
Q
R
T
T
L
T
F
K
R
R
F
Site 116
T764
S
F
Q
R
T
T
L
T
F
K
R
R
F
Q
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation