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Updated November 2019
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Protein Info
Short Name:
NOT1
Full Name:
CCR4-NOT transcription complex subunit 1
Alias:
AD-005; Adrenal gland protein AD-005; CCR4-NOT transcription complex, subunit 1; CDC39; CNOT1; KIAA1007; NOT1 (negative regulator of transcription 1, yeast) homolog; NOT1H
Type:
Transcription, coactivator/corepressor
Mass (Da):
241013
Number AA:
2150
UniProt ID:
A5YKK6
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
N
L
D
S
L
S
L
A
L
S
Q
I
S
Site 2
T21
S
Y
L
V
D
N
L
T
K
K
N
Y
R
A
S
Site 3
S28
T
K
K
N
Y
R
A
S
Q
Q
E
I
Q
H
I
Site 4
S58
L
F
S
H
V
D
F
S
G
D
G
K
S
S
G
Site 5
S63
D
F
S
G
D
G
K
S
S
G
K
D
F
H
Q
Site 6
T71
S
G
K
D
F
H
Q
T
Q
F
L
I
Q
E
C
Site 7
S104
N
P
L
H
Y
Q
K
S
L
K
P
A
P
H
L
Site 8
S159
K
L
P
D
L
L
R
S
Y
I
D
A
D
V
S
Site 9
Y160
L
P
D
L
L
R
S
Y
I
D
A
D
V
S
G
Site 10
S166
S
Y
I
D
A
D
V
S
G
N
Q
E
G
G
F
Site 11
T209
Q
I
D
A
F
L
K
T
L
R
R
D
F
P
Q
Site 12
S243
M
D
R
I
L
P
D
S
G
G
V
A
K
T
M
Site 13
T249
D
S
G
G
V
A
K
T
M
M
E
S
S
L
A
Site 14
S254
A
K
T
M
M
E
S
S
L
A
D
F
M
Q
E
Site 15
S302
G
M
M
A
R
T
H
S
G
L
T
D
G
I
P
Site 16
S312
T
D
G
I
P
L
Q
S
I
S
A
P
G
S
G
Site 17
S318
Q
S
I
S
A
P
G
S
G
I
W
S
D
G
K
Site 18
S322
A
P
G
S
G
I
W
S
D
G
K
D
K
S
D
Site 19
S328
W
S
D
G
K
D
K
S
D
G
A
Q
A
H
T
Site 20
S351
V
L
K
E
L
N
P
S
L
N
F
K
E
V
T
Site 21
Y359
L
N
F
K
E
V
T
Y
E
L
D
H
P
G
F
Site 22
S371
P
G
F
Q
I
R
D
S
K
G
L
H
N
V
V
Site 23
Y379
K
G
L
H
N
V
V
Y
G
I
Q
R
G
L
G
Site 24
Y396
V
F
P
V
D
L
I
Y
R
P
W
K
H
A
E
Site 25
S407
K
H
A
E
G
Q
L
S
F
I
Q
H
S
L
I
Site 26
S450
R
E
I
A
T
W
K
S
L
D
L
I
E
S
L
Site 27
Y466
R
L
A
E
V
G
Q
Y
E
Q
V
K
Q
L
F
Site 28
S474
E
Q
V
K
Q
L
F
S
F
P
I
K
H
C
P
Site 29
S494
A
L
L
Q
I
N
T
S
W
H
T
L
R
H
E
Site 30
T497
Q
I
N
T
S
W
H
T
L
R
H
E
L
I
S
Site 31
Y523
N
S
A
I
I
L
H
Y
A
W
H
G
Q
G
Q
Site 32
S531
A
W
H
G
Q
G
Q
S
P
S
I
R
Q
L
I
Site 33
S533
H
G
Q
G
Q
S
P
S
I
R
Q
L
I
M
H
Site 34
Y552
W
Y
M
R
G
E
Q
Y
D
Q
A
K
L
S
R
Site 35
Y594
A
L
A
S
R
R
E
Y
L
K
L
D
K
W
L
Site 36
T602
L
K
L
D
K
W
L
T
D
K
I
R
E
H
G
Site 37
S640
P
E
K
D
Q
P
K
S
A
Q
L
P
P
E
T
Site 38
S663
Q
A
C
A
G
S
V
S
Q
E
L
S
E
T
I
Site 39
S699
M
P
K
G
R
P
P
S
A
S
S
L
D
A
I
Site 40
S701
K
G
R
P
P
S
A
S
S
L
D
A
I
S
P
Site 41
S702
G
R
P
P
S
A
S
S
L
D
A
I
S
P
V
Site 42
S725
T
S
L
S
I
G
G
S
A
A
P
H
T
Q
S
Site 43
T730
G
G
S
A
A
P
H
T
Q
S
M
Q
G
F
P
Site 44
S732
S
A
A
P
H
T
Q
S
M
Q
G
F
P
P
N
Site 45
S742
G
F
P
P
N
L
G
S
A
F
S
T
P
Q
S
Site 46
S745
P
N
L
G
S
A
F
S
T
P
Q
S
P
A
K
Site 47
T746
N
L
G
S
A
F
S
T
P
Q
S
P
A
K
A
Site 48
S749
S
A
F
S
T
P
Q
S
P
A
K
A
F
P
P
Site 49
S758
A
K
A
F
P
P
L
S
T
P
N
Q
T
T
A
Site 50
T759
K
A
F
P
P
L
S
T
P
N
Q
T
T
A
F
Site 51
T763
P
L
S
T
P
N
Q
T
T
A
F
S
G
I
G
Site 52
S767
P
N
Q
T
T
A
F
S
G
I
G
G
L
S
S
Site 53
S812
V
Q
R
K
L
G
T
S
G
L
N
Q
P
T
F
Site 54
T818
T
S
G
L
N
Q
P
T
F
Q
Q
S
K
M
K
Site 55
S830
K
M
K
P
S
D
L
S
Q
V
W
P
E
A
N
Site 56
Y851
I
D
D
E
A
N
S
Y
F
Q
R
I
Y
N
H
Site 57
Y856
N
S
Y
F
Q
R
I
Y
N
H
P
P
H
P
T
Site 58
S865
H
P
P
H
P
T
M
S
V
D
E
V
L
E
M
Site 59
T880
L
Q
R
F
K
D
S
T
I
K
R
E
R
E
V
Site 60
Y905
E
Y
R
F
F
P
Q
Y
P
D
K
E
L
H
I
Site 61
T927
I
I
E
K
G
L
V
T
Y
M
A
L
G
L
A
Site 62
Y928
I
E
K
G
L
V
T
Y
M
A
L
G
L
A
L
Site 63
Y937
A
L
G
L
A
L
R
Y
V
L
E
A
L
R
K
Site 64
S948
A
L
R
K
P
F
G
S
K
M
Y
Y
F
G
I
Site 65
Y952
P
F
G
S
K
M
Y
Y
F
G
I
A
A
L
D
Site 66
Y968
F
K
N
R
L
K
D
Y
P
Q
Y
C
Q
H
L
Site 67
Y971
R
L
K
D
Y
P
Q
Y
C
Q
H
L
A
S
I
Site 68
Y991
F
P
H
H
L
Q
E
Y
I
E
Y
G
Q
Q
S
Site 69
Y994
H
L
Q
E
Y
I
E
Y
G
Q
Q
S
R
D
P
Site 70
S1008
P
P
V
K
M
Q
G
S
I
T
T
P
G
S
I
Site 71
T1051
T
T
T
T
V
A
K
T
V
T
V
T
R
P
T
Site 72
T1053
T
T
V
A
K
T
V
T
V
T
R
P
T
G
V
Site 73
T1058
T
V
T
V
T
R
P
T
G
V
S
F
K
K
D
Site 74
S1061
V
T
R
P
T
G
V
S
F
K
K
D
V
P
P
Site 75
S1069
F
K
K
D
V
P
P
S
I
N
T
T
N
I
D
Site 76
T1085
L
L
V
A
T
D
Q
T
E
R
I
V
E
P
P
Site 77
S1107
A
F
I
F
N
N
L
S
Q
S
N
M
T
Q
K
Site 78
T1121
K
V
E
E
L
K
E
T
V
K
E
E
F
M
P
Site 79
S1140
Y
L
V
M
K
R
V
S
I
E
P
N
F
H
S
Site 80
S1147
S
I
E
P
N
F
H
S
L
Y
S
N
F
L
D
Site 81
Y1149
E
P
N
F
H
S
L
Y
S
N
F
L
D
T
L
Site 82
T1155
L
Y
S
N
F
L
D
T
L
K
N
P
E
F
N
Site 83
S1187
D
K
A
A
A
N
F
S
D
R
S
L
L
K
N
Site 84
S1190
A
A
N
F
S
D
R
S
L
L
K
N
L
G
H
Site 85
Y1225
K
S
L
L
L
E
A
Y
V
K
G
Q
Q
E
L
Site 86
S1249
V
L
E
S
S
I
R
S
V
V
F
R
P
P
N
Site 87
S1317
K
N
L
D
E
Q
L
S
A
P
K
K
D
V
K
Site 88
T1334
E
E
L
P
P
I
T
T
T
T
T
S
T
T
P
Site 89
S1338
P
I
T
T
T
T
T
S
T
T
P
A
T
N
T
Site 90
T1340
T
T
T
T
T
S
T
T
P
A
T
N
T
T
C
Site 91
T1350
T
N
T
T
C
T
A
T
V
P
P
Q
P
Q
Y
Site 92
Y1357
T
V
P
P
Q
P
Q
Y
S
Y
H
D
I
N
V
Site 93
S1366
Y
H
D
I
N
V
Y
S
L
A
G
L
A
P
H
Site 94
S1432
R
K
D
F
A
L
D
S
E
E
S
R
M
R
I
Site 95
S1435
F
A
L
D
S
E
E
S
R
M
R
I
A
A
H
Site 96
S1464
C
R
E
P
L
L
M
S
I
S
T
N
L
K
N
Site 97
S1466
E
P
L
L
M
S
I
S
T
N
L
K
N
S
F
Site 98
S1472
I
S
T
N
L
K
N
S
F
A
S
A
L
R
T
Site 99
T1479
S
F
A
S
A
L
R
T
A
S
P
Q
Q
R
E
Site 100
S1481
A
S
A
L
R
T
A
S
P
Q
Q
R
E
M
M
Site 101
T1525
E
M
D
K
R
L
A
T
E
F
E
L
R
K
H
Site 102
Y1540
A
R
Q
E
G
R
R
Y
C
D
P
V
V
L
T
Site 103
T1547
Y
C
D
P
V
V
L
T
Y
Q
A
E
R
M
P
Site 104
Y1572
D
P
K
Q
L
A
V
Y
E
E
F
A
R
N
V
Site 105
Y1612
T
D
D
V
A
Q
I
Y
D
K
C
I
T
E
L
Site 106
T1629
H
L
H
A
I
P
P
T
L
A
M
N
P
Q
A
Site 107
S1649
L
L
E
V
V
V
L
S
R
N
S
R
D
A
I
Site 108
Y1701
A
L
Q
D
G
R
A
Y
G
S
P
W
C
N
K
Site 109
T1711
P
W
C
N
K
Q
I
T
R
C
L
I
E
C
R
Site 110
Y1721
L
I
E
C
R
D
E
Y
K
Y
N
V
E
A
V
Site 111
Y1723
E
C
R
D
E
Y
K
Y
N
V
E
A
V
E
L
Site 112
S1798
L
M
R
I
N
A
H
S
R
G
N
A
P
E
G
Site 113
Y1817
M
E
V
V
R
S
N
Y
E
A
M
I
D
R
A
Site 114
S1834
G
P
N
F
M
M
H
S
G
I
S
Q
A
S
E
Site 115
S1840
H
S
G
I
S
Q
A
S
E
Y
D
D
P
P
G
Site 116
Y1842
G
I
S
Q
A
S
E
Y
D
D
P
P
G
L
R
Site 117
Y1854
G
L
R
E
K
A
E
Y
L
L
R
E
W
V
N
Site 118
Y1863
L
R
E
W
V
N
L
Y
H
S
A
A
A
G
R
Site 119
S1872
S
A
A
A
G
R
D
S
T
K
A
F
S
A
F
Site 120
T1954
V
K
H
S
G
E
A
T
N
T
V
T
K
I
N
Site 121
T1956
H
S
G
E
A
T
N
T
V
T
K
I
N
L
L
Site 122
S1983
Q
D
H
D
V
R
Q
S
E
F
Q
Q
L
P
Y
Site 123
T2055
I
A
R
M
L
A
H
T
P
Q
Q
K
G
W
P
Site 124
Y2064
Q
Q
K
G
W
P
M
Y
A
Q
L
L
I
D
L
Site 125
Y2074
L
L
I
D
L
F
K
Y
L
A
P
F
L
R
N
Site 126
S2134
Q
L
R
N
L
I
L
S
A
F
P
R
N
M
R
Site 127
T2147
M
R
L
P
D
P
F
T
P
N
L
K
V
D
M
Site 128
S2156
N
L
K
V
D
M
L
S
E
I
N
I
A
P
R
Site 129
T2166
N
I
A
P
R
I
L
T
N
F
T
G
V
M
P
Site 130
S2182
Q
F
K
K
D
L
D
S
Y
L
K
T
R
S
P
Site 131
Y2183
F
K
K
D
L
D
S
Y
L
K
T
R
S
P
V
Site 132
T2186
D
L
D
S
Y
L
K
T
R
S
P
V
T
F
L
Site 133
S2188
D
S
Y
L
K
T
R
S
P
V
T
F
L
S
D
Site 134
T2191
L
K
T
R
S
P
V
T
F
L
S
D
L
R
S
Site 135
S2194
R
S
P
V
T
F
L
S
D
L
R
S
N
L
Q
Site 136
S2198
T
F
L
S
D
L
R
S
N
L
Q
V
S
N
E
Site 137
S2203
L
R
S
N
L
Q
V
S
N
E
P
G
N
R
Y
Site 138
T2236
H
I
H
N
K
G
S
T
P
S
M
S
T
I
T
Site 139
S2238
H
N
K
G
S
T
P
S
M
S
T
I
T
H
S
Site 140
S2240
K
G
S
T
P
S
M
S
T
I
T
H
S
A
H
Site 141
T2241
G
S
T
P
S
M
S
T
I
T
H
S
A
H
M
Site 142
Y2276
A
I
A
N
Q
L
R
Y
P
N
S
H
T
H
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation