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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGEF5-like
Full Name:
Rho guanine nucleotide exchange factor 35
Alias:
CTAGE4; FLJ43692; Q6ZUI2
Type:
Uncharacterized protein
Mass (Da):
53287
Number AA:
484
UniProt ID:
A5YM69
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
E
E
A
Q
H
G
A
S
P
P
I
S
A
I
E
Site 2
S30
I
P
E
A
P
M
R
S
S
Q
V
S
A
L
G
Site 3
S31
P
E
A
P
M
R
S
S
Q
V
S
A
L
G
L
Site 4
S34
P
M
R
S
S
Q
V
S
A
L
G
L
E
A
Q
Site 5
S47
A
Q
E
D
E
D
P
S
Y
K
W
R
E
E
H
Site 6
Y48
Q
E
D
E
D
P
S
Y
K
W
R
E
E
H
R
Site 7
S57
W
R
E
E
H
R
L
S
A
T
Q
Q
S
E
L
Site 8
Y70
E
L
R
D
V
C
D
Y
A
I
E
T
M
P
S
Site 9
T74
V
C
D
Y
A
I
E
T
M
P
S
F
P
K
E
Site 10
S77
Y
A
I
E
T
M
P
S
F
P
K
E
G
S
A
Site 11
S83
P
S
F
P
K
E
G
S
A
D
V
E
P
N
Q
Site 12
S92
D
V
E
P
N
Q
E
S
L
V
A
E
A
C
D
Site 13
T100
L
V
A
E
A
C
D
T
P
E
H
W
E
A
V
Site 14
S110
H
W
E
A
V
P
Q
S
L
A
G
R
Q
A
R
Site 15
T118
L
A
G
R
Q
A
R
T
L
A
P
P
E
L
W
Site 16
S140
H
L
D
M
A
P
F
S
S
D
L
G
S
E
E
Site 17
S141
L
D
M
A
P
F
S
S
D
L
G
S
E
E
E
Site 18
S145
P
F
S
S
D
L
G
S
E
E
E
E
V
E
F
Site 19
S158
E
F
W
P
G
L
T
S
L
T
L
G
S
G
Q
Site 20
T160
W
P
G
L
T
S
L
T
L
G
S
G
Q
A
E
Site 21
T172
Q
A
E
E
E
E
E
T
S
S
D
N
S
G
Q
Site 22
S173
A
E
E
E
E
E
T
S
S
D
N
S
G
Q
T
Site 23
S174
E
E
E
E
E
T
S
S
D
N
S
G
Q
T
R
Site 24
S177
E
E
T
S
S
D
N
S
G
Q
T
R
Y
Y
S
Site 25
T180
S
S
D
N
S
G
Q
T
R
Y
Y
S
P
C
E
Site 26
Y182
D
N
S
G
Q
T
R
Y
Y
S
P
C
E
E
H
Site 27
Y183
N
S
G
Q
T
R
Y
Y
S
P
C
E
E
H
P
Site 28
S184
S
G
Q
T
R
Y
Y
S
P
C
E
E
H
P
A
Site 29
S212
R
Q
G
E
E
L
P
S
E
E
L
Q
E
S
Q
Site 30
S218
P
S
E
E
L
Q
E
S
Q
G
L
L
H
P
Q
Site 31
T245
A
G
F
R
G
E
G
T
L
R
E
D
V
C
A
Site 32
T294
Q
G
E
R
M
G
L
T
G
E
P
E
G
L
N
Site 33
S340
P
E
E
N
R
A
D
S
Q
D
E
K
S
Q
T
Site 34
S345
A
D
S
Q
D
E
K
S
Q
T
F
L
G
K
S
Site 35
T347
S
Q
D
E
K
S
Q
T
F
L
G
K
S
E
E
Site 36
S352
S
Q
T
F
L
G
K
S
E
E
V
T
G
K
Q
Site 37
T356
L
G
K
S
E
E
V
T
G
K
Q
E
D
H
G
Site 38
S381
Q
E
A
K
E
P
E
S
W
D
G
G
R
L
G
Site 39
S395
G
A
V
G
R
A
R
S
R
E
E
E
N
E
H
Site 40
S406
E
N
E
H
H
G
P
S
M
P
A
L
I
A
P
Site 41
T430
P
G
A
S
Y
L
V
T
Q
I
P
G
T
Q
T
Site 42
T435
L
V
T
Q
I
P
G
T
Q
T
E
S
R
A
E
Site 43
S439
I
P
G
T
Q
T
E
S
R
A
E
E
L
S
P
Site 44
S445
E
S
R
A
E
E
L
S
P
A
A
L
S
P
L
Site 45
S468
Q
P
I
S
L
L
G
S
F
L
T
E
E
S
P
Site 46
T471
S
L
L
G
S
F
L
T
E
E
S
P
D
K
E
Site 47
S474
G
S
F
L
T
E
E
S
P
D
K
E
K
L
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation