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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MEGF11
Full Name:
Multiple epidermal growth factor-like domains protein 11
Alias:
KIAA1781
Type:
Membrane Protein
Mass (Da):
110844
Number AA:
1044
UniProt ID:
A6BM72
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T37
H
W
E
S
Y
A
V
T
V
Q
E
S
Y
A
H
Site 2
Y42
A
V
T
V
Q
E
S
Y
A
H
P
F
D
Q
I
Site 3
Y50
A
H
P
F
D
Q
I
Y
Y
T
R
C
T
D
I
Site 4
Y51
H
P
F
D
Q
I
Y
Y
T
R
C
T
D
I
L
Site 5
S69
K
C
T
R
H
R
I
S
Y
K
T
A
Y
R
R
Site 6
Y70
C
T
R
H
R
I
S
Y
K
T
A
Y
R
R
G
Site 7
T72
R
H
R
I
S
Y
K
T
A
Y
R
R
G
L
R
Site 8
Y74
R
I
S
Y
K
T
A
Y
R
R
G
L
R
T
M
Site 9
T80
A
Y
R
R
G
L
R
T
M
Y
R
R
R
S
Q
Site 10
Y82
R
R
G
L
R
T
M
Y
R
R
R
S
Q
C
C
Site 11
Y92
R
S
Q
C
C
P
G
Y
Y
E
S
G
D
F
C
Site 12
T180
E
E
L
C
A
P
G
T
H
G
K
G
C
Q
L
Site 13
S223
E
E
L
C
P
P
G
S
H
G
A
H
C
E
L
Site 14
T266
A
Q
P
C
P
P
G
T
F
G
Q
N
C
S
Q
Site 15
T330
G
G
Q
C
S
P
T
T
G
A
C
E
C
E
P
Site 16
Y339
A
C
E
C
E
P
G
Y
K
G
P
R
C
Q
E
Site 17
S459
C
N
N
G
G
T
C
S
P
V
D
G
S
C
T
Site 18
T477
G
W
Q
G
L
D
C
T
L
P
C
P
S
G
T
Site 19
S509
S
P
I
D
G
S
C
S
C
T
P
G
W
L
G
Site 20
T511
I
D
G
S
C
S
C
T
P
G
W
L
G
D
T
Site 21
T518
T
P
G
W
L
G
D
T
C
E
L
P
C
P
D
Site 22
T527
E
L
P
C
P
D
G
T
F
G
L
N
C
S
E
Site 23
S586
C
S
C
E
N
G
G
S
C
S
P
E
D
G
S
Site 24
S588
C
E
N
G
G
S
C
S
P
E
D
G
S
C
E
Site 25
S593
S
C
S
P
E
D
G
S
C
E
C
A
P
G
F
Site 26
Y658
N
Q
V
C
A
G
G
Y
F
G
Q
D
C
A
Q
Site 27
T772
S
G
K
C
T
C
R
T
G
F
T
G
Q
H
C
Site 28
Y812
D
H
V
T
G
T
C
Y
C
S
P
G
F
K
G
Site 29
Y835
M
M
E
E
L
N
P
Y
T
K
I
S
P
A
L
Site 30
S839
L
N
P
Y
T
K
I
S
P
A
L
G
A
E
R
Site 31
S888
R
D
L
A
P
R
V
S
Y
T
P
A
M
R
M
Site 32
Y889
D
L
A
P
R
V
S
Y
T
P
A
M
R
M
T
Site 33
T890
L
A
P
R
V
S
Y
T
P
A
M
R
M
T
S
Site 34
T896
Y
T
P
A
M
R
M
T
S
T
D
Y
S
L
S
Site 35
S897
T
P
A
M
R
M
T
S
T
D
Y
S
L
S
G
Site 36
T898
P
A
M
R
M
T
S
T
D
Y
S
L
S
G
A
Site 37
Y900
M
R
M
T
S
T
D
Y
S
L
S
G
A
C
G
Site 38
S901
R
M
T
S
T
D
Y
S
L
S
G
A
C
G
M
Site 39
S903
T
S
T
D
Y
S
L
S
G
A
C
G
M
D
R
Site 40
T914
G
M
D
R
R
Q
N
T
Y
I
M
D
K
G
F
Site 41
Y915
M
D
R
R
Q
N
T
Y
I
M
D
K
G
F
K
Site 42
Y924
M
D
K
G
F
K
D
Y
M
K
E
S
V
C
S
Site 43
S931
Y
M
K
E
S
V
C
S
S
S
T
C
S
L
N
Site 44
S932
M
K
E
S
V
C
S
S
S
T
C
S
L
N
S
Site 45
S933
K
E
S
V
C
S
S
S
T
C
S
L
N
S
S
Site 46
T934
E
S
V
C
S
S
S
T
C
S
L
N
S
S
E
Site 47
S936
V
C
S
S
S
T
C
S
L
N
S
S
E
N
P
Site 48
S940
S
T
C
S
L
N
S
S
E
N
P
Y
A
T
I
Site 49
Y944
L
N
S
S
E
N
P
Y
A
T
I
K
D
P
P
Site 50
T946
S
S
E
N
P
Y
A
T
I
K
D
P
P
I
L
Site 51
S960
L
T
C
K
L
P
E
S
S
Y
V
E
M
K
S
Site 52
S961
T
C
K
L
P
E
S
S
Y
V
E
M
K
S
P
Site 53
Y962
C
K
L
P
E
S
S
Y
V
E
M
K
S
P
V
Site 54
S967
S
S
Y
V
E
M
K
S
P
V
H
M
G
S
P
Site 55
S973
K
S
P
V
H
M
G
S
P
Y
T
D
V
P
S
Site 56
Y975
P
V
H
M
G
S
P
Y
T
D
V
P
S
L
S
Site 57
T976
V
H
M
G
S
P
Y
T
D
V
P
S
L
S
T
Site 58
S980
S
P
Y
T
D
V
P
S
L
S
T
S
N
K
N
Site 59
S982
Y
T
D
V
P
S
L
S
T
S
N
K
N
I
Y
Site 60
S984
D
V
P
S
L
S
T
S
N
K
N
I
Y
E
V
Site 61
Y989
S
T
S
N
K
N
I
Y
E
V
E
P
T
V
S
Site 62
T994
N
I
Y
E
V
E
P
T
V
S
V
V
Q
E
G
Site 63
S996
Y
E
V
E
P
T
V
S
V
V
Q
E
G
C
G
Site 64
Y1013
S
S
Y
I
Q
N
A
Y
D
L
P
R
N
S
H
Site 65
S1019
A
Y
D
L
P
R
N
S
H
I
P
G
H
Y
D
Site 66
S1033
D
L
L
P
V
R
Q
S
P
A
N
G
P
S
Q
Site 67
S1039
Q
S
P
A
N
G
P
S
Q
D
K
Q
S
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation