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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CCDC88B
Full Name:
Coiled-coil domain-containing protein 88B
Alias:
Brain leucine zipper domain-containing protein;Hook-related protein 3
Type:
Mass (Da):
164809
Number AA:
1476
UniProt ID:
A6NC98
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
P
R
L
R
D
F
L
S
G
S
L
A
T
W
A
Site 2
S34
L
V
G
E
A
E
D
S
E
G
E
E
E
E
E
Site 3
S57
E
K
R
F
L
R
L
S
D
G
A
L
L
L
R
Site 4
Y105
W
G
R
L
R
D
F
Y
Q
E
E
L
Q
L
L
Site 5
T122
S
P
P
P
D
L
Q
T
L
G
F
D
P
L
S
Site 6
S129
T
L
G
F
D
P
L
S
E
E
A
V
E
Q
L
Site 7
S147
L
R
L
L
L
G
A
S
V
Q
C
E
H
R
E
Site 8
S164
I
R
H
I
Q
G
L
S
L
E
V
Q
S
E
L
Site 9
S208
E
L
E
M
L
S
R
S
L
M
G
T
L
S
K
Site 10
T212
L
S
R
S
L
M
G
T
L
S
K
L
A
R
E
Site 11
S214
R
S
L
M
G
T
L
S
K
L
A
R
E
R
D
Site 12
S245
C
L
R
P
E
A
P
S
R
A
P
A
E
G
P
Site 13
S284
K
A
E
L
L
L
D
S
Q
A
E
V
Q
G
L
Site 14
S351
Q
A
A
E
A
Y
K
S
Q
L
E
E
E
R
V
Site 15
S360
L
E
E
E
R
V
L
S
G
V
L
E
A
S
K
Site 16
T387
R
C
A
R
L
H
E
T
Q
R
E
N
L
L
L
Site 17
S407
E
A
H
A
E
L
D
S
L
R
H
Q
V
D
Q
Site 18
S429
L
E
L
E
L
Q
R
S
L
E
P
P
P
G
S
Site 19
S436
S
L
E
P
P
P
G
S
P
G
E
A
P
L
A
Site 20
S448
P
L
A
G
A
A
P
S
L
Q
D
E
V
R
E
Site 21
T463
A
E
A
G
R
L
R
T
L
E
R
E
N
R
E
Site 22
T507
V
L
E
E
A
P
Q
T
P
V
A
F
D
H
S
Site 23
S514
T
P
V
A
F
D
H
S
P
Q
G
L
V
Q
K
Site 24
S553
E
C
P
Q
A
P
D
S
D
P
Q
E
A
E
S
Site 25
S560
S
D
P
Q
E
A
E
S
P
L
Q
A
A
A
M
Site 26
S572
A
A
M
D
P
Q
A
S
D
W
S
P
Q
E
S
Site 27
S575
D
P
Q
A
S
D
W
S
P
Q
E
S
G
S
P
Site 28
S579
S
D
W
S
P
Q
E
S
G
S
P
V
E
T
Q
Site 29
S581
W
S
P
Q
E
S
G
S
P
V
E
T
Q
E
S
Site 30
T585
E
S
G
S
P
V
E
T
Q
E
S
P
E
K
A
Site 31
S588
S
P
V
E
T
Q
E
S
P
E
K
A
G
R
R
Site 32
S596
P
E
K
A
G
R
R
S
S
L
Q
S
P
A
S
Site 33
S597
E
K
A
G
R
R
S
S
L
Q
S
P
A
S
V
Site 34
S600
G
R
R
S
S
L
Q
S
P
A
S
V
A
P
P
Site 35
S603
S
S
L
Q
S
P
A
S
V
A
P
P
Q
G
P
Site 36
T612
A
P
P
Q
G
P
G
T
K
I
Q
A
P
Q
L
Site 37
S653
P
E
H
K
P
G
P
S
E
P
S
S
V
Q
L
Site 38
S657
P
G
P
S
E
P
S
S
V
Q
L
E
E
Q
E
Site 39
T689
H
D
Q
R
L
E
G
T
V
R
D
P
A
W
Q
Site 40
S719
E
G
P
I
P
G
E
S
L
A
S
G
V
A
E
Site 41
T760
R
K
L
E
A
Q
N
T
E
A
A
R
L
S
K
Site 42
S766
N
T
E
A
A
R
L
S
K
E
L
A
Q
A
R
Site 43
S808
G
Q
E
L
E
S
A
S
Q
E
R
E
A
L
V
Site 44
S833
R
Q
W
E
R
E
G
S
R
L
R
A
Q
S
E
Site 45
S839
G
S
R
L
R
A
Q
S
E
A
A
E
E
R
M
Site 46
S911
E
F
L
R
E
K
E
S
Q
H
Q
R
Y
Q
G
Site 47
S1022
A
Q
E
L
L
L
Q
S
Q
R
A
Q
E
H
S
Site 48
S1029
S
Q
R
A
Q
E
H
S
S
R
L
Q
A
E
K
Site 49
S1037
S
R
L
Q
A
E
K
S
V
L
E
I
Q
G
Q
Site 50
S1063
E
V
R
A
A
R
Q
S
Q
E
E
T
R
G
Q
Site 51
S1129
Q
L
Q
A
Q
R
A
S
V
E
A
Q
E
V
A
Site 52
S1163
E
E
L
R
R
L
Q
S
E
H
D
R
A
Q
M
Site 53
S1176
Q
M
L
L
A
E
L
S
R
E
R
G
E
L
Q
Site 54
S1207
R
A
Q
L
E
M
Q
S
Q
Q
L
R
E
S
N
Site 55
S1213
Q
S
Q
Q
L
R
E
S
N
Q
Q
L
D
L
S
Site 56
S1220
S
N
Q
Q
L
D
L
S
A
C
R
L
T
T
Q
Site 57
T1232
T
T
Q
C
E
L
L
T
Q
L
R
S
A
Q
E
Site 58
S1236
E
L
L
T
Q
L
R
S
A
Q
E
E
E
N
R
Site 59
S1263
N
R
E
L
L
E
R
S
L
E
S
R
D
H
L
Site 60
Y1277
L
H
R
E
Q
R
E
Y
L
D
Q
L
N
A
L
Site 61
Y1299
V
E
K
I
M
D
Q
Y
R
V
L
E
P
V
P
Site 62
T1310
E
P
V
P
L
P
R
T
K
K
G
S
W
L
A
Site 63
S1314
L
P
R
T
K
K
G
S
W
L
A
D
K
V
K
Site 64
S1345
L
G
A
D
G
A
G
S
T
E
S
L
G
G
P
Site 65
T1346
G
A
D
G
A
G
S
T
E
S
L
G
G
P
P
Site 66
S1348
D
G
A
G
S
T
E
S
L
G
G
P
P
E
T
Site 67
T1355
S
L
G
G
P
P
E
T
E
L
P
E
G
R
E
Site 68
T1366
E
G
R
E
A
D
G
T
G
S
P
S
P
A
P
Site 69
S1368
R
E
A
D
G
T
G
S
P
S
P
A
P
M
R
Site 70
S1370
A
D
G
T
G
S
P
S
P
A
P
M
R
R
A
Site 71
S1379
A
P
M
R
R
A
Q
S
S
L
C
L
R
D
E
Site 72
S1380
P
M
R
R
A
Q
S
S
L
C
L
R
D
E
T
Site 73
T1387
S
L
C
L
R
D
E
T
L
A
G
G
Q
R
R
Site 74
S1397
G
G
Q
R
R
K
L
S
S
R
F
P
V
G
R
Site 75
S1398
G
Q
R
R
K
L
S
S
R
F
P
V
G
R
S
Site 76
S1405
S
R
F
P
V
G
R
S
S
E
S
F
S
P
G
Site 77
S1406
R
F
P
V
G
R
S
S
E
S
F
S
P
G
D
Site 78
S1408
P
V
G
R
S
S
E
S
F
S
P
G
D
T
P
Site 79
S1410
G
R
S
S
E
S
F
S
P
G
D
T
P
R
Q
Site 80
T1414
E
S
F
S
P
G
D
T
P
R
Q
R
F
R
Q
Site 81
S1432
G
P
L
G
A
P
V
S
H
S
K
G
P
G
V
Site 82
S1434
L
G
A
P
V
S
H
S
K
G
P
G
V
G
W
Site 83
S1444
P
G
V
G
W
E
N
S
A
E
T
L
Q
E
H
Site 84
T1471
E
P
E
K
R
P
L
T
P
S
L
S
Q
_
_
Site 85
S1473
E
K
R
P
L
T
P
S
L
S
Q
_
_
_
_
Site 86
S1475
R
P
L
T
P
S
L
S
Q
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation