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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
VWA3A
Full Name:
von Willebrand factor A domain-containing protein 3A
Alias:
FLJ40941; FLJ46765; von Willebrand factor A domain containing 3A
Type:
Unknown function
Mass (Da):
134020
Number AA:
1184
UniProt ID:
A6NCI4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T39
N
H
C
I
R
R
N
T
G
R
D
S
K
K
P
Site 2
S43
R
R
N
T
G
R
D
S
K
K
P
L
K
Q
K
Site 3
S80
D
L
L
R
L
Q
G
S
E
T
Q
S
S
D
W
Site 4
T82
L
R
L
Q
G
S
E
T
Q
S
S
D
W
E
D
Site 5
S84
L
Q
G
S
E
T
Q
S
S
D
W
E
D
S
E
Site 6
S85
Q
G
S
E
T
Q
S
S
D
W
E
D
S
E
D
Site 7
S90
Q
S
S
D
W
E
D
S
E
D
W
L
S
A
H
Site 8
S95
E
D
S
E
D
W
L
S
A
H
S
L
K
C
Q
Site 9
S142
R
H
F
E
S
K
L
S
D
T
I
E
V
Y
Q
Site 10
T144
F
E
S
K
L
S
D
T
I
E
V
Y
Q
E
R
Site 11
Y148
L
S
D
T
I
E
V
Y
Q
E
R
I
Q
W
L
Site 12
T156
Q
E
R
I
Q
W
L
T
E
N
S
K
K
A
F
Site 13
S182
I
D
V
S
A
I
S
S
G
P
Q
K
E
E
F
Site 14
S195
E
F
Q
K
D
L
M
S
L
I
D
E
Q
L
S
Site 15
S202
S
L
I
D
E
Q
L
S
H
K
E
K
L
F
V
Site 16
S211
K
E
K
L
F
V
L
S
F
G
T
N
A
G
S
Site 17
S218
S
F
G
T
N
A
G
S
L
W
P
D
P
M
E
Site 18
S229
D
P
M
E
V
S
A
S
T
L
Q
E
L
K
L
Site 19
T240
E
L
K
L
W
V
K
T
L
Q
P
D
G
G
S
Site 20
S271
S
L
V
A
I
M
R
S
C
P
D
Q
P
S
E
Site 21
S277
R
S
C
P
D
Q
P
S
E
I
L
S
D
Y
I
Site 22
S281
D
Q
P
S
E
I
L
S
D
Y
I
Q
Q
S
T
Site 23
Y283
P
S
E
I
L
S
D
Y
I
Q
Q
S
T
M
G
Site 24
Y321
L
A
E
A
V
R
G
Y
Y
H
C
Y
S
P
K
Site 25
Y322
A
E
A
V
R
G
Y
Y
H
C
Y
S
P
K
M
Site 26
T333
S
P
K
M
E
H
Y
T
S
R
D
M
D
E
L
Site 27
S334
P
K
M
E
H
Y
T
S
R
D
M
D
E
L
L
Site 28
S349
A
E
I
Q
K
A
Q
S
L
L
S
H
V
Q
A
Site 29
T367
S
S
P
C
E
A
L
T
C
T
M
E
E
I
S
Site 30
T375
C
T
M
E
E
I
S
T
E
I
T
N
G
P
L
Site 31
T378
E
E
I
S
T
E
I
T
N
G
P
L
I
S
L
Site 32
S384
I
T
N
G
P
L
I
S
L
L
P
K
P
P
K
Site 33
T397
P
K
H
D
A
P
L
T
I
E
F
P
N
L
D
Site 34
T406
E
F
P
N
L
D
K
T
S
A
E
W
L
K
V
Site 35
Y424
K
A
K
K
L
S
L
Y
Q
V
L
A
P
N
A
Site 36
S447
P
I
L
Q
K
T
V
S
S
T
I
H
E
K
A
Site 37
Y476
H
V
D
P
P
F
L
Y
K
Y
Q
Q
Q
L
S
Site 38
Y478
D
P
P
F
L
Y
K
Y
Q
Q
Q
L
S
R
A
Site 39
Y489
L
S
R
A
M
R
M
Y
E
R
R
I
E
W
L
Site 40
S497
E
R
R
I
E
W
L
S
L
A
S
R
R
I
W
Site 41
T506
A
S
R
R
I
W
G
T
V
C
E
K
R
V
V
Site 42
S542
L
L
L
E
E
Q
L
S
N
K
D
C
F
N
L
Site 43
S558
A
F
G
S
T
I
E
S
W
R
P
E
M
V
P
Site 44
S567
R
P
E
M
V
P
V
S
H
N
N
L
Q
S
A
Site 45
S586
L
N
L
R
C
R
G
S
R
N
V
L
S
A
L
Site 46
S591
R
G
S
R
N
V
L
S
A
L
R
K
A
V
E
Site 47
S609
K
D
K
D
K
H
Q
S
Q
G
I
Y
L
F
T
Site 48
Y613
K
H
Q
S
Q
G
I
Y
L
F
T
G
G
I
P
Site 49
T626
I
P
D
Q
D
M
P
T
L
S
A
Y
M
A
E
Site 50
T656
V
G
E
P
K
M
D
T
T
P
P
A
R
Y
A
Site 51
T657
G
E
P
K
M
D
T
T
P
P
A
R
Y
A
S
Site 52
S664
T
P
P
A
R
Y
A
S
H
T
D
T
A
A
A
Site 53
T666
P
A
R
Y
A
S
H
T
D
T
A
A
A
Y
K
Site 54
T668
R
Y
A
S
H
T
D
T
A
A
A
Y
K
E
V
Site 55
T689
R
F
H
W
F
G
D
T
G
I
Y
E
S
D
D
Site 56
Y692
W
F
G
D
T
G
I
Y
E
S
D
D
I
N
S
Site 57
S694
G
D
T
G
I
Y
E
S
D
D
I
N
S
I
M
Site 58
S720
K
C
A
F
L
M
A
S
L
K
N
H
S
G
K
Site 59
S732
S
G
K
V
L
G
S
S
A
L
P
K
E
K
P
Site 60
T741
L
P
K
E
K
P
K
T
L
Q
L
R
S
Q
P
Site 61
S746
P
K
T
L
Q
L
R
S
Q
P
K
K
L
C
P
Site 62
T757
K
L
C
P
P
R
P
T
V
P
L
G
A
R
M
Site 63
S765
V
P
L
G
A
R
M
S
I
K
D
D
P
D
R
Site 64
S775
D
D
P
D
R
E
K
S
P
P
L
K
S
L
K
Site 65
S780
E
K
S
P
P
L
K
S
L
K
W
R
P
L
S
Site 66
S787
S
L
K
W
R
P
L
S
S
R
V
G
I
S
P
Site 67
S788
L
K
W
R
P
L
S
S
R
V
G
I
S
P
A
Site 68
T811
M
M
E
L
R
R
K
T
K
S
R
E
A
E
T
Site 69
S813
E
L
R
R
K
T
K
S
R
E
A
E
T
S
L
Site 70
S819
K
S
R
E
A
E
T
S
L
L
L
F
Y
T
E
Site 71
Y824
E
T
S
L
L
L
F
Y
T
E
K
G
N
D
V
Site 72
S833
E
K
G
N
D
V
G
S
V
Y
K
K
Y
P
Q
Site 73
Y835
G
N
D
V
G
S
V
Y
K
K
Y
P
Q
G
R
Site 74
Y838
V
G
S
V
Y
K
K
Y
P
Q
G
R
G
L
R
Site 75
T847
Q
G
R
G
L
R
R
T
S
S
S
I
D
L
P
Site 76
S848
G
R
G
L
R
R
T
S
S
S
I
D
L
P
R
Site 77
S849
R
G
L
R
R
T
S
S
S
I
D
L
P
R
K
Site 78
S850
G
L
R
R
T
S
S
S
I
D
L
P
R
K
D
Site 79
T858
I
D
L
P
R
K
D
T
V
C
S
S
Q
E
W
Site 80
S862
R
K
D
T
V
C
S
S
Q
E
W
V
A
K
Y
Site 81
Y869
S
Q
E
W
V
A
K
Y
G
L
K
K
L
K
L
Site 82
S879
K
K
L
K
L
E
I
S
R
C
M
G
P
N
C
Site 83
S891
P
N
C
T
H
Q
K
S
G
Q
R
S
A
S
A
Site 84
S895
H
Q
K
S
G
Q
R
S
A
S
A
K
H
C
S
Site 85
S897
K
S
G
Q
R
S
A
S
A
K
H
C
S
I
F
Site 86
T919
V
V
R
H
I
Q
W
T
P
R
E
M
E
V
Y
Site 87
Y926
T
P
R
E
M
E
V
Y
I
R
H
L
E
K
V
Site 88
Y937
L
E
K
V
L
R
R
Y
V
Q
R
L
Q
W
L
Site 89
S946
Q
R
L
Q
W
L
L
S
G
S
R
R
L
F
G
Site 90
T954
G
S
R
R
L
F
G
T
V
L
E
S
K
V
C
Site 91
S969
I
L
L
D
T
S
G
S
M
G
P
Y
L
Q
Q
Site 92
Y973
T
S
G
S
M
G
P
Y
L
Q
Q
V
K
T
E
Site 93
S1000
C
D
S
F
N
L
L
S
F
A
E
S
F
Q
S
Site 94
S1004
N
L
L
S
F
A
E
S
F
Q
S
W
Q
D
T
Site 95
S1007
S
F
A
E
S
F
Q
S
W
Q
D
T
L
V
E
Site 96
T1011
S
F
Q
S
W
Q
D
T
L
V
E
T
T
D
A
Site 97
Y1055
F
H
D
L
E
G
L
Y
L
L
T
D
G
K
P
Site 98
T1064
L
T
D
G
K
P
D
T
S
C
S
L
V
L
N
Site 99
S1065
T
D
G
K
P
D
T
S
C
S
L
V
L
N
E
Site 100
S1067
G
K
P
D
T
S
C
S
L
V
L
N
E
V
Q
Site 101
S1088
D
V
K
V
H
T
I
S
L
N
C
S
D
R
A
Site 102
S1092
H
T
I
S
L
N
C
S
D
R
A
A
V
E
F
Site 103
S1105
E
F
L
R
K
L
A
S
F
T
G
G
R
Y
H
Site 104
Y1111
A
S
F
T
G
G
R
Y
H
C
P
V
G
E
D
Site 105
T1119
H
C
P
V
G
E
D
T
L
S
K
I
H
S
L
Site 106
S1121
P
V
G
E
D
T
L
S
K
I
H
S
L
L
T
Site 107
T1138
F
I
N
E
K
D
P
T
L
P
P
F
E
G
D
Site 108
T1155
R
I
L
A
Q
E
I
T
K
A
R
S
F
L
W
Site 109
S1159
Q
E
I
T
K
A
R
S
F
L
W
Q
A
Q
S
Site 110
S1166
S
F
L
W
Q
A
Q
S
F
R
S
Q
L
Q
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation