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Updated November 2019
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Protein Info
Short Name:
C2orf78
Full Name:
Uncharacterized protein C2orf78
Alias:
Type:
Mass (Da):
97000
Number AA:
892
UniProt ID:
A6NCI8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T30
V
D
V
S
S
S
L
T
M
S
E
Y
F
Q
N
Site 2
S32
V
S
S
S
L
T
M
S
E
Y
F
Q
N
T
S
Site 3
Y34
S
S
L
T
M
S
E
Y
F
Q
N
T
S
L
P
Site 4
S39
S
E
Y
F
Q
N
T
S
L
P
G
T
A
N
S
Site 5
T43
Q
N
T
S
L
P
G
T
A
N
S
R
Q
F
S
Site 6
S46
S
L
P
G
T
A
N
S
R
Q
F
S
L
P
V
Site 7
S50
T
A
N
S
R
Q
F
S
L
P
V
V
S
N
A
Site 8
S68
T
G
S
I
S
N
F
S
R
A
S
A
P
A
I
Site 9
S83
S
S
A
W
L
Q
P
S
A
S
G
T
S
F
Q
Site 10
S85
A
W
L
Q
P
S
A
S
G
T
S
F
Q
P
L
Site 11
T87
L
Q
P
S
A
S
G
T
S
F
Q
P
L
M
G
Site 12
S88
Q
P
S
A
S
G
T
S
F
Q
P
L
M
G
S
Site 13
S95
S
F
Q
P
L
M
G
S
A
Y
L
Y
Q
H
S
Site 14
Y97
Q
P
L
M
G
S
A
Y
L
Y
Q
H
S
S
T
Site 15
Y99
L
M
G
S
A
Y
L
Y
Q
H
S
S
T
T
M
Site 16
S102
S
A
Y
L
Y
Q
H
S
S
T
T
M
L
S
G
Site 17
S103
A
Y
L
Y
Q
H
S
S
T
T
M
L
S
G
V
Site 18
S108
H
S
S
T
T
M
L
S
G
V
T
G
Q
S
H
Site 19
T118
T
G
Q
S
H
I
C
T
S
A
A
S
Y
P
G
Site 20
S119
G
Q
S
H
I
C
T
S
A
A
S
Y
P
G
V
Site 21
S131
P
G
V
F
E
W
D
S
T
A
S
T
V
K
K
Site 22
T132
G
V
F
E
W
D
S
T
A
S
T
V
K
K
S
Site 23
S134
F
E
W
D
S
T
A
S
T
V
K
K
S
S
S
Site 24
T135
E
W
D
S
T
A
S
T
V
K
K
S
S
S
L
Site 25
S141
S
T
V
K
K
S
S
S
L
R
D
F
T
V
T
Site 26
T146
S
S
S
L
R
D
F
T
V
T
V
I
D
Q
N
Site 27
T148
S
L
R
D
F
T
V
T
V
I
D
Q
N
T
A
Site 28
S158
D
Q
N
T
A
V
S
S
M
S
M
T
A
Q
Y
Site 29
S160
N
T
A
V
S
S
M
S
M
T
A
Q
Y
Y
K
Site 30
T162
A
V
S
S
M
S
M
T
A
Q
Y
Y
K
T
S
Site 31
Y165
S
M
S
M
T
A
Q
Y
Y
K
T
S
D
T
N
Site 32
T171
Q
Y
Y
K
T
S
D
T
N
T
M
V
P
L
Y
Site 33
T173
Y
K
T
S
D
T
N
T
M
V
P
L
Y
P
S
Site 34
T191
S
L
V
Q
G
T
L
T
Q
I
P
N
Q
Q
G
Site 35
S202
N
Q
Q
G
H
N
L
S
L
P
C
Q
I
G
S
Site 36
Y212
C
Q
I
G
S
Q
V
Y
Y
Y
N
Q
G
T
L
Site 37
Y213
Q
I
G
S
Q
V
Y
Y
Y
N
Q
G
T
L
G
Site 38
Y214
I
G
S
Q
V
Y
Y
Y
N
Q
G
T
L
G
P
Site 39
T218
V
Y
Y
Y
N
Q
G
T
L
G
P
Q
L
S
C
Site 40
S224
G
T
L
G
P
Q
L
S
C
L
Q
S
Y
G
S
Site 41
S228
P
Q
L
S
C
L
Q
S
Y
G
S
V
S
Y
T
Site 42
Y229
Q
L
S
C
L
Q
S
Y
G
S
V
S
Y
T
G
Site 43
S231
S
C
L
Q
S
Y
G
S
V
S
Y
T
G
Y
R
Site 44
S233
L
Q
S
Y
G
S
V
S
Y
T
G
Y
R
A
S
Site 45
T235
S
Y
G
S
V
S
Y
T
G
Y
R
A
S
A
H
Site 46
Y237
G
S
V
S
Y
T
G
Y
R
A
S
A
H
Q
P
Site 47
S240
S
Y
T
G
Y
R
A
S
A
H
Q
P
E
M
V
Site 48
S263
T
N
V
L
P
P
V
S
T
S
G
M
Y
Y
S
Site 49
Y268
P
V
S
T
S
G
M
Y
Y
S
V
S
S
Q
P
Site 50
Y269
V
S
T
S
G
M
Y
Y
S
V
S
S
Q
P
I
Site 51
S270
S
T
S
G
M
Y
Y
S
V
S
S
Q
P
I
T
Site 52
S272
S
G
M
Y
Y
S
V
S
S
Q
P
I
T
E
T
Site 53
S273
G
M
Y
Y
S
V
S
S
Q
P
I
T
E
T
S
Site 54
T277
S
V
S
S
Q
P
I
T
E
T
S
V
Q
V
M
Site 55
S293
T
S
L
G
M
D
T
S
L
G
L
Q
S
P
S
Site 56
S298
D
T
S
L
G
L
Q
S
P
S
Q
T
F
C
L
Site 57
S300
S
L
G
L
Q
S
P
S
Q
T
F
C
L
P
Q
Site 58
T302
G
L
Q
S
P
S
Q
T
F
C
L
P
Q
T
P
Site 59
T308
Q
T
F
C
L
P
Q
T
P
E
F
S
K
S
F
Site 60
S312
L
P
Q
T
P
E
F
S
K
S
F
S
S
R
N
Site 61
S314
Q
T
P
E
F
S
K
S
F
S
S
R
N
T
Q
Site 62
S316
P
E
F
S
K
S
F
S
S
R
N
T
Q
T
L
Site 63
T320
K
S
F
S
S
R
N
T
Q
T
L
E
S
N
P
Site 64
T322
F
S
S
R
N
T
Q
T
L
E
S
N
P
S
P
Site 65
S325
R
N
T
Q
T
L
E
S
N
P
S
P
E
L
G
Site 66
S328
Q
T
L
E
S
N
P
S
P
E
L
G
D
I
S
Site 67
S335
S
P
E
L
G
D
I
S
I
T
P
V
Q
S
P
Site 68
T337
E
L
G
D
I
S
I
T
P
V
Q
S
P
T
N
Site 69
T347
Q
S
P
T
N
L
L
T
L
S
P
A
P
S
Q
Site 70
S349
P
T
N
L
L
T
L
S
P
A
P
S
Q
E
K
Site 71
S353
L
T
L
S
P
A
P
S
Q
E
K
N
E
N
E
Site 72
S370
D
E
I
K
T
N
L
S
R
N
Q
D
P
P
L
Site 73
S403
G
Q
E
E
Q
P
G
S
E
N
A
N
L
R
N
Site 74
S412
N
A
N
L
R
N
K
S
L
S
L
E
D
Q
G
Site 75
S414
N
L
R
N
K
S
L
S
L
E
D
Q
G
I
F
Site 76
T435
S
S
D
L
A
D
I
T
T
W
V
E
D
T
Y
Site 77
T436
S
D
L
A
D
I
T
T
W
V
E
D
T
Y
L
Site 78
Y442
T
T
W
V
E
D
T
Y
L
P
P
I
F
S
S
Site 79
S448
T
Y
L
P
P
I
F
S
S
L
Q
D
L
D
Q
Site 80
S449
Y
L
P
P
I
F
S
S
L
Q
D
L
D
Q
P
Site 81
S459
D
L
D
Q
P
E
K
S
C
V
I
K
G
H
S
Site 82
S477
R
K
N
K
H
K
A
S
E
P
I
Q
G
A
P
Site 83
S505
E
R
E
V
V
V
G
S
A
T
V
S
N
S
A
Site 84
S513
A
T
V
S
N
S
A
S
V
N
K
A
K
H
S
Site 85
S529
N
K
P
H
K
A
A
S
S
R
I
S
K
T
K
Site 86
S530
K
P
H
K
A
A
S
S
R
I
S
K
T
K
S
Site 87
S533
K
A
A
S
S
R
I
S
K
T
K
S
H
G
Q
Site 88
T535
A
S
S
R
I
S
K
T
K
S
H
G
Q
E
K
Site 89
S537
S
R
I
S
K
T
K
S
H
G
Q
E
K
T
K
Site 90
S550
T
K
G
N
R
K
N
S
S
K
K
S
E
E
S
Site 91
S551
K
G
N
R
K
N
S
S
K
K
S
E
E
S
K
Site 92
S554
R
K
N
S
S
K
K
S
E
E
S
K
Q
S
G
Site 93
T571
V
K
V
E
E
K
Q
T
I
P
N
M
K
R
K
Site 94
S585
K
K
N
Q
P
E
L
S
Q
K
T
L
K
K
P
Site 95
S594
K
T
L
K
K
P
R
S
S
L
G
M
H
M
L
Site 96
S595
T
L
K
K
P
R
S
S
L
G
M
H
M
L
E
Site 97
T618
G
K
K
I
D
M
K
T
G
F
S
S
S
R
T
Site 98
S621
I
D
M
K
T
G
F
S
S
S
R
T
L
G
S
Site 99
S622
D
M
K
T
G
F
S
S
S
R
T
L
G
S
S
Site 100
S623
M
K
T
G
F
S
S
S
R
T
L
G
S
S
S
Site 101
T625
T
G
F
S
S
S
R
T
L
G
S
S
S
N
T
Site 102
S628
S
S
S
R
T
L
G
S
S
S
N
T
Q
N
R
Site 103
S629
S
S
R
T
L
G
S
S
S
N
T
Q
N
R
Q
Site 104
S630
S
R
T
L
G
S
S
S
N
T
Q
N
R
Q
P
Site 105
T632
T
L
G
S
S
S
N
T
Q
N
R
Q
P
F
P
Site 106
S667
K
A
Q
K
L
D
G
S
A
E
K
E
C
T
S
Site 107
T673
G
S
A
E
K
E
C
T
S
P
S
H
S
E
L
Site 108
S674
S
A
E
K
E
C
T
S
P
S
H
S
E
L
P
Site 109
S676
E
K
E
C
T
S
P
S
H
S
E
L
P
P
P
Site 110
S678
E
C
T
S
P
S
H
S
E
L
P
P
P
G
K
Site 111
S705
Q
P
Q
A
R
H
V
S
R
R
P
N
P
L
A
Site 112
S713
R
R
P
N
P
L
A
S
R
R
P
A
V
A
Y
Site 113
Y720
S
R
R
P
A
V
A
Y
P
A
R
P
D
S
T
Site 114
S726
A
Y
P
A
R
P
D
S
T
N
S
A
Q
S
N
Site 115
T727
Y
P
A
R
P
D
S
T
N
S
A
Q
S
N
A
Site 116
S732
D
S
T
N
S
A
Q
S
N
A
V
N
P
S
R
Site 117
S746
R
P
A
P
T
N
T
S
L
T
G
P
A
T
P
Site 118
T748
A
P
T
N
T
S
L
T
G
P
A
T
P
A
Q
Site 119
T752
T
S
L
T
G
P
A
T
P
A
Q
P
I
S
A
Site 120
S758
A
T
P
A
Q
P
I
S
A
K
A
T
Q
P
S
Site 121
T762
Q
P
I
S
A
K
A
T
Q
P
S
S
A
N
P
Site 122
S766
A
K
A
T
Q
P
S
S
A
N
P
T
Q
P
T
Site 123
T770
Q
P
S
S
A
N
P
T
Q
P
T
V
P
Q
S
Site 124
T773
S
A
N
P
T
Q
P
T
V
P
Q
S
A
A
S
Site 125
S777
T
Q
P
T
V
P
Q
S
A
A
S
R
P
S
A
Site 126
S783
Q
S
A
A
S
R
P
S
A
Y
K
T
S
S
C
Site 127
Y785
A
A
S
R
P
S
A
Y
K
T
S
S
C
S
S
Site 128
T787
S
R
P
S
A
Y
K
T
S
S
C
S
S
L
Q
Site 129
S788
R
P
S
A
Y
K
T
S
S
C
S
S
L
Q
R
Site 130
S789
P
S
A
Y
K
T
S
S
C
S
S
L
Q
R
E
Site 131
S792
Y
K
T
S
S
C
S
S
L
Q
R
E
P
V
S
Site 132
S799
S
L
Q
R
E
P
V
S
T
A
V
T
S
L
R
Site 133
T800
L
Q
R
E
P
V
S
T
A
V
T
S
L
R
S
Site 134
T803
E
P
V
S
T
A
V
T
S
L
R
S
L
P
K
Site 135
S804
P
V
S
T
A
V
T
S
L
R
S
L
P
K
P
Site 136
S821
Q
F
L
I
Q
D
F
S
L
Q
P
R
P
W
R
Site 137
T831
P
R
P
W
R
K
P
T
V
P
E
P
V
M
S
Site 138
S838
T
V
P
E
P
V
M
S
T
P
I
T
E
E
Q
Site 139
T839
V
P
E
P
V
M
S
T
P
I
T
E
E
Q
R
Site 140
T842
P
V
M
S
T
P
I
T
E
E
Q
R
P
E
R
Site 141
Y866
E
R
E
N
A
A
K
Y
T
S
L
G
K
V
Q
Site 142
Y887
R
D
M
E
I
A
E
Y
Y
G
Y
T
I
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation