PhosphoNET

           
Protein Info 
   
Short Name:  NKX2-6
Full Name:  Homeobox protein Nkx-2.6
Alias:  NKX2F
Type:  Nucleus Protein
Mass (Da):  32121
Number AA:  301
UniProt ID:  A6NCS4
International Prot ID: 
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005634     Uniprot OncoNet
Molecular Function:  GO:0043565  GO:0003700   PhosphoSite+ KinaseNET
Biological Process:  GO:0055014  GO:0035050  GO:0048565 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S24LRLERERSCPAASPH
Site 2S29ERSCPAASPHPRVRK
Site 3S37PHPRVRKSPENFQYL
Site 4Y43KSPENFQYLRMDAEP
Site 5S53MDAEPRGSEVHNAGG
Site 6S70GDRKLDGSEPPGGPC
Site 7S99QPGLNAASPLGGGTR
Site 8S115PERGVGNSGDSVRGG
Site 9S118GVGNSGDSVRGGRSE
Site 10Y156RRFKQQRYLSAPERE
Site 11S158FKQQRYLSAPEREHL
Site 12S167PEREHLASALQLTST
Site 13S195KRQRQDKSLELAGHP
Site 14T204ELAGHPLTPRRVAVP
Site 15S235PAFPSPYSAAVSPYS
Site 16S239SPYSAAVSPYSCYGG
Site 17Y241YSAAVSPYSCYGGYS
Site 18S242SAAVSPYSCYGGYSG
Site 19Y244AVSPYSCYGGYSGAP
Site 20S248YSCYGGYSGAPYGAG
Site 21Y252GGYSGAPYGAGYGTC
Site 22Y260GAGYGTCYAGAPSGP
Site 23T271PSGPAPHTPLASAGF
Site 24S275APHTPLASAGFGHGG
Site 25T286GHGGQNATPQGHLAA
Site 26T294PQGHLAATLQGVRAW
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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