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Updated November 2019
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Protein Info
Short Name:
FAM181B
Full Name:
Protein FAM181B
Alias:
Type:
Mass (Da):
42657
Number AA:
426
UniProt ID:
A6NEQ2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T43
C
C
F
E
D
D
E
T
G
A
P
A
G
A
L
Site 2
T63
G
G
D
V
R
E
A
T
R
D
L
L
S
F
I
Site 3
S68
E
A
T
R
D
L
L
S
F
I
D
S
A
S
S
Site 4
S87
A
L
D
K
P
G
K
S
K
R
K
V
N
H
R
Site 5
Y96
R
K
V
N
H
R
K
Y
L
Q
K
Q
I
K
R
Site 6
S105
Q
K
Q
I
K
R
C
S
G
L
M
G
A
A
P
Site 7
S117
A
A
P
P
G
P
P
S
P
S
A
A
D
T
P
Site 8
S119
P
P
G
P
P
S
P
S
A
A
D
T
P
A
K
Site 9
T123
P
S
P
S
A
A
D
T
P
A
K
R
P
L
A
Site 10
S133
K
R
P
L
A
A
P
S
A
P
T
V
A
A
P
Site 11
T136
L
A
A
P
S
A
P
T
V
A
A
P
A
H
G
Site 12
S152
A
A
P
R
R
E
A
S
Q
A
A
A
A
A
S
Site 13
S159
S
Q
A
A
A
A
A
S
L
Q
S
R
S
L
A
Site 14
S162
A
A
A
A
S
L
Q
S
R
S
L
A
A
L
F
Site 15
S164
A
A
S
L
Q
S
R
S
L
A
A
L
F
D
S
Site 16
S171
S
L
A
A
L
F
D
S
L
R
H
V
P
G
G
Site 17
S230
R
A
R
N
L
P
P
S
F
F
T
E
P
S
R
Site 18
S236
P
S
F
F
T
E
P
S
R
A
G
G
G
G
C
Site 19
S246
G
G
G
G
C
G
P
S
G
P
D
V
S
L
G
Site 20
S251
G
P
S
G
P
D
V
S
L
G
D
L
E
K
G
Site 21
Y272
F
E
L
L
G
P
D
Y
G
A
G
T
E
A
A
Site 22
S295
D
V
F
P
A
G
A
S
V
L
R
G
P
P
E
Site 23
S325
L
L
Y
P
E
P
W
S
V
P
G
C
S
P
T
Site 24
S330
P
W
S
V
P
G
C
S
P
T
K
K
S
P
L
Site 25
S335
G
C
S
P
T
K
K
S
P
L
T
A
P
R
G
Site 26
T338
P
T
K
K
S
P
L
T
A
P
R
G
G
L
T
Site 27
T345
T
A
P
R
G
G
L
T
L
N
E
P
L
S
P
Site 28
Y354
N
E
P
L
S
P
L
Y
P
A
A
A
D
S
P
Site 29
S360
L
Y
P
A
A
A
D
S
P
G
G
E
D
G
R
Site 30
S372
D
G
R
G
H
L
A
S
F
A
P
F
F
P
D
Site 31
S392
P
P
P
P
H
Q
V
S
Y
D
Y
S
A
G
Y
Site 32
Y393
P
P
P
H
Q
V
S
Y
D
Y
S
A
G
Y
S
Site 33
Y395
P
H
Q
V
S
Y
D
Y
S
A
G
Y
S
R
T
Site 34
S396
H
Q
V
S
Y
D
Y
S
A
G
Y
S
R
T
A
Site 35
Y399
S
Y
D
Y
S
A
G
Y
S
R
T
A
Y
S
S
Site 36
S400
Y
D
Y
S
A
G
Y
S
R
T
A
Y
S
S
L
Site 37
T402
Y
S
A
G
Y
S
R
T
A
Y
S
S
L
W
R
Site 38
Y404
A
G
Y
S
R
T
A
Y
S
S
L
W
R
S
D
Site 39
S406
Y
S
R
T
A
Y
S
S
L
W
R
S
D
G
V
Site 40
S410
A
Y
S
S
L
W
R
S
D
G
V
W
E
G
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation