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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HEAT repeat-containing protein 7B1
Full Name:
HEAT repeat-containing protein 7B1
Alias:
Type:
Mass (Da):
193288
Number AA:
1706
UniProt ID:
A6NES4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T22
I
C
L
I
Q
K
K
T
L
R
K
E
L
E
E
Site 2
T32
K
E
L
E
E
E
M
T
E
A
I
T
E
A
A
Site 3
S43
T
E
A
A
V
A
S
S
E
E
V
S
E
E
R
Site 4
S47
V
A
S
S
E
E
V
S
E
E
R
D
D
L
G
Site 5
S61
G
P
L
E
L
H
D
S
G
T
F
Q
Q
V
V
Site 6
T63
L
E
L
H
D
S
G
T
F
Q
Q
V
V
N
L
Site 7
S76
N
L
L
D
I
I
D
S
E
S
A
K
T
D
T
Site 8
S78
L
D
I
I
D
S
E
S
A
K
T
D
T
T
G
Site 9
T81
I
D
S
E
S
A
K
T
D
T
T
G
A
G
L
Site 10
T83
S
E
S
A
K
T
D
T
T
G
A
G
L
D
M
Site 11
T125
L
Q
V
P
E
I
S
T
Q
R
K
V
N
I
Y
Site 12
Y132
T
Q
R
K
V
N
I
Y
N
I
L
Q
D
I
I
Site 13
Y170
E
I
P
E
M
E
G
Y
M
K
A
E
V
A
S
Site 14
T179
K
A
E
V
A
S
D
T
L
V
A
L
S
R
N
Site 15
Y193
N
H
F
S
L
V
M
Y
E
L
Q
H
H
L
K
Site 16
S272
Y
L
K
H
L
E
E
S
V
Y
P
V
M
T
E
Site 17
Y274
K
H
L
E
E
S
V
Y
P
V
M
T
E
E
E
Site 18
Y301
V
T
V
W
L
R
H
Y
N
P
E
V
K
L
G
Site 19
Y331
D
D
L
R
E
Q
V
Y
D
Y
I
P
L
L
L
Site 20
T363
Q
I
L
E
L
S
V
T
T
N
T
P
V
P
Q
Site 21
T366
E
L
S
V
T
T
N
T
P
V
P
Q
M
Q
L
Site 22
S423
E
L
M
K
F
F
F
S
Q
M
E
T
N
K
E
Site 23
S452
S
A
D
E
P
R
M
S
I
R
A
I
Y
L
A
Site 24
T466
A
I
R
V
V
K
N
T
I
S
D
T
R
S
K
Site 25
S468
R
V
V
K
N
T
I
S
D
T
R
S
K
V
R
Site 26
T470
V
K
N
T
I
S
D
T
R
S
K
V
R
M
A
Site 27
S472
N
T
I
S
D
T
R
S
K
V
R
M
A
I
L
Site 28
Y490
G
Q
L
A
L
C
G
Y
Q
E
R
I
K
G
W
Site 29
T507
K
Y
L
S
V
Q
L
T
L
S
T
Y
K
L
T
Site 30
S509
L
S
V
Q
L
T
L
S
T
Y
K
L
T
N
R
Site 31
T514
T
L
S
T
Y
K
L
T
N
R
R
E
K
F
Y
Site 32
Y521
T
N
R
R
E
K
F
Y
Q
R
D
L
E
E
R
Site 33
S544
T
V
K
I
I
T
S
S
V
S
G
M
T
T
E
Site 34
S592
H
G
Q
D
V
D
V
S
V
A
G
K
S
R
Q
Site 35
S617
A
R
L
L
V
L
M
S
S
P
Y
K
G
E
G
Site 36
S618
R
L
L
V
L
M
S
S
P
Y
K
G
E
G
R
Site 37
S683
L
I
Q
F
L
R
N
S
L
K
K
T
R
G
S
Site 38
T687
L
R
N
S
L
K
K
T
R
G
S
S
W
S
L
Site 39
S690
S
L
K
K
T
R
G
S
S
W
S
L
R
L
S
Site 40
S691
L
K
K
T
R
G
S
S
W
S
L
R
L
S
K
Site 41
S693
K
T
R
G
S
S
W
S
L
R
L
S
K
E
L
Site 42
S697
S
S
W
S
L
R
L
S
K
E
L
N
N
Q
I
Site 43
S706
E
L
N
N
Q
I
A
S
F
D
S
P
S
L
E
Site 44
S709
N
Q
I
A
S
F
D
S
P
S
L
E
K
G
F
Site 45
S711
I
A
S
F
D
S
P
S
L
E
K
G
F
L
Y
Site 46
Y743
V
L
L
L
E
L
L
Y
K
T
D
Y
S
N
D
Site 47
Y747
E
L
L
Y
K
T
D
Y
S
N
D
F
D
S
E
Site 48
S748
L
L
Y
K
T
D
Y
S
N
D
F
D
S
E
G
Site 49
S788
R
I
Q
E
S
E
Q
S
W
Q
I
S
A
W
R
Site 50
T804
D
H
P
W
R
R
E
T
V
K
S
A
L
M
V
Site 51
Y841
T
A
K
I
I
H
H
Y
V
S
S
C
Q
D
I
Site 52
S921
S
K
L
K
P
F
Y
S
T
E
E
N
S
E
L
Site 53
S948
L
P
G
E
D
N
E
S
I
K
T
L
Y
A
N
Site 54
T951
E
D
N
E
S
I
K
T
L
Y
A
N
A
L
S
Site 55
Y953
N
E
S
I
K
T
L
Y
A
N
A
L
S
S
L
Site 56
S990
L
L
E
K
W
I
L
S
E
K
E
W
E
R
E
Site 57
S1047
H
Q
R
T
R
M
A
S
M
N
V
L
S
S
L
Site 58
T1062
L
D
L
H
A
S
Q
T
C
S
L
W
G
P
S
Site 59
S1064
L
H
A
S
Q
T
C
S
L
W
G
P
S
K
Q
Site 60
S1083
K
C
K
G
D
L
Q
S
T
D
V
E
K
I
F
Site 61
T1187
L
A
H
H
H
Q
E
T
I
L
T
S
L
L
R
Site 62
T1190
H
H
Q
E
T
I
L
T
S
L
L
R
Q
P
L
Site 63
S1223
F
A
R
T
M
L
H
S
L
M
G
R
L
Q
S
Site 64
S1230
S
L
M
G
R
L
Q
S
R
L
S
P
R
I
S
Site 65
S1233
G
R
L
Q
S
R
L
S
P
R
I
S
A
T
S
Site 66
S1237
S
R
L
S
P
R
I
S
A
T
S
K
A
D
I
Site 67
S1240
S
P
R
I
S
A
T
S
K
A
D
I
W
R
L
Site 68
S1289
T
L
L
L
Q
L
G
S
S
H
R
P
E
A
A
Site 69
S1290
L
L
L
Q
L
G
S
S
H
R
P
E
A
A
P
Site 70
T1309
M
W
K
L
V
H
T
T
P
L
P
E
E
M
N
Site 71
T1321
E
M
N
L
Q
R
V
T
I
K
S
M
Q
L
L
Site 72
S1324
L
Q
R
V
T
I
K
S
M
Q
L
L
F
K
R
Site 73
S1334
L
L
F
K
R
V
K
S
Q
H
L
A
H
T
L
Site 74
S1392
G
M
D
S
E
V
L
S
C
R
I
S
S
T
A
Site 75
Y1411
F
M
S
G
P
V
L
Y
Q
E
K
L
L
K
P
Site 76
S1474
G
P
L
R
E
P
V
S
N
S
V
T
A
E
G
Site 77
S1476
L
R
E
P
V
S
N
S
V
T
A
E
G
M
E
Site 78
T1478
E
P
V
S
N
S
V
T
A
E
G
M
E
A
L
Site 79
S1500
R
E
G
D
V
G
S
S
F
D
A
M
S
E
Q
Site 80
S1516
R
I
F
F
D
N
E
S
E
L
L
R
L
K
A
Site 81
S1537
L
A
R
V
V
G
M
S
K
K
H
F
F
K
G
Site 82
T1595
S
G
P
S
D
T
A
T
D
D
K
M
T
V
F
Site 83
T1600
T
A
T
D
D
K
M
T
V
F
Q
T
T
M
C
Site 84
T1625
L
Y
R
F
L
L
E
T
M
A
Y
V
K
N
N
Site 85
Y1628
F
L
L
E
T
M
A
Y
V
K
N
N
L
S
R
Site 86
S1667
D
F
P
A
L
R
N
S
L
Q
E
L
Q
L
D
Site 87
S1701
S
Q
H
G
F
L
A
S
P
Q
G
M
S
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation