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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CAPN8
Full Name:
Calpain-8
Alias:
New calpain 2;Stomach-specific M-type calpain
Type:
Mass (Da):
76665
Number AA:
681
UniProt ID:
A6NHC0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T15
V
S
R
Q
R
A
A
T
Q
G
L
G
S
N
Q
Site 2
Y27
S
N
Q
N
A
L
K
Y
L
G
Q
D
F
K
T
Site 3
T34
Y
L
G
Q
D
F
K
T
L
R
Q
Q
C
L
D
Site 4
S42
L
R
Q
Q
C
L
D
S
G
V
L
F
K
D
P
Site 5
Y60
A
C
P
S
A
L
G
Y
K
D
L
G
P
G
S
Site 6
S67
Y
K
D
L
G
P
G
S
P
Q
T
Q
G
I
I
Site 7
T70
L
G
P
G
S
P
Q
T
Q
G
I
I
W
K
R
Site 8
T79
G
I
I
W
K
R
P
T
E
L
C
P
S
P
Q
Site 9
S84
R
P
T
E
L
C
P
S
P
Q
F
I
V
G
G
Site 10
Y122
T
L
N
E
E
L
L
Y
R
V
V
P
R
D
Q
Site 11
Y135
D
Q
D
F
Q
E
N
Y
A
G
I
F
H
F
Q
Site 12
T160
V
I
D
D
R
L
P
T
K
N
G
Q
L
L
F
Site 13
S170
G
Q
L
L
F
L
H
S
E
Q
G
N
E
F
W
Site 14
Y185
S
A
L
L
E
K
A
Y
A
K
L
N
G
C
Y
Site 15
Y192
Y
A
K
L
N
G
C
Y
E
A
L
A
G
G
S
Site 16
T200
E
A
L
A
G
G
S
T
V
E
G
F
E
D
F
Site 17
T208
V
E
G
F
E
D
F
T
G
G
I
S
E
F
Y
Site 18
Y215
T
G
G
I
S
E
F
Y
D
L
K
K
P
P
A
Site 19
Y225
K
K
P
P
A
N
L
Y
Q
I
I
R
K
A
L
Site 20
S255
A
E
A
E
A
I
T
S
Q
K
L
V
K
S
H
Site 21
S261
T
S
Q
K
L
V
K
S
H
A
Y
S
V
T
G
Site 22
S298
V
E
W
S
G
A
W
S
D
D
A
S
P
V
I
Site 23
S302
G
A
W
S
D
D
A
S
P
V
I
S
P
S
A
Site 24
S306
D
D
A
S
P
V
I
S
P
S
A
E
G
C
R
Site 25
S308
A
S
P
V
I
S
P
S
A
E
G
C
R
V
K
Site 26
T317
E
G
C
R
V
K
H
T
T
M
R
S
M
S
Q
Site 27
S321
V
K
H
T
T
M
R
S
M
S
Q
M
S
L
S
Site 28
S323
H
T
T
M
R
S
M
S
Q
M
S
L
S
D
F
Site 29
S326
M
R
S
M
S
Q
M
S
L
S
D
F
V
R
Q
Site 30
S328
S
M
S
Q
M
S
L
S
D
F
V
R
Q
F
S
Site 31
S335
S
D
F
V
R
Q
F
S
R
L
E
I
C
N
L
Site 32
S343
R
L
E
I
C
N
L
S
P
D
S
L
S
S
E
Site 33
S346
I
C
N
L
S
P
D
S
L
S
S
E
E
V
H
Site 34
S348
N
L
S
P
D
S
L
S
S
E
E
V
H
K
W
Site 35
S484
A
L
L
R
F
R
D
S
F
L
W
L
K
S
R
Site 36
S490
D
S
F
L
W
L
K
S
R
R
L
R
R
I
C
Site 37
S530
E
V
F
Y
R
G
G
S
F
P
H
L
Q
M
I
Site 38
S544
I
R
F
P
L
P
F
S
R
T
D
I
K
F
D
Site 39
T546
F
P
L
P
F
S
R
T
D
I
K
F
D
G
F
Site 40
S563
N
T
C
R
E
M
I
S
L
L
D
S
N
G
T
Site 41
Y588
L
W
L
K
I
Q
K
Y
L
E
I
Y
W
E
T
Site 42
Y592
I
Q
K
Y
L
E
I
Y
W
E
T
D
Y
N
H
Site 43
Y597
E
I
Y
W
E
T
D
Y
N
H
S
G
T
I
D
Site 44
T618
A
L
R
K
A
G
F
T
L
N
S
Q
V
Q
Q
Site 45
S621
K
A
G
F
T
L
N
S
Q
V
Q
Q
T
I
A
Site 46
S658
E
T
L
F
K
L
F
S
L
L
D
E
D
K
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation