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Updated November 2019
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Protein Info
Short Name:
SMCHD1
Full Name:
Structural maintenance of chromosomes flexible hinge domain-containing protein 1
Alias:
Type:
Mass (Da):
226356
Number AA:
2005
UniProt ID:
A6NHR9
International Prot ID:
IPI00890837
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005694
GO:0043226
GO:0043228
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006996
GO:0009987
GO:0016043
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
G
G
G
P
G
G
A
S
V
G
T
E
E
D
G
Site 2
T16
P
G
G
A
S
V
G
T
E
E
D
G
G
G
V
Site 3
T27
G
G
G
V
G
H
R
T
V
Y
L
F
D
R
R
Site 4
Y29
G
V
G
H
R
T
V
Y
L
F
D
R
R
E
K
Site 5
S38
F
D
R
R
E
K
E
S
E
L
G
D
R
P
L
Site 6
Y53
Q
V
G
E
R
S
D
Y
A
G
F
R
A
C
V
Site 7
T77
E
K
F
V
I
T
T
T
S
R
K
E
I
T
C
Site 8
S78
K
F
V
I
T
T
T
S
R
K
E
I
T
C
D
Site 9
T90
T
C
D
N
F
D
E
T
V
K
D
G
V
T
L
Site 10
T109
S
V
N
Q
L
L
L
T
A
T
K
E
R
I
D
Site 11
Y121
R
I
D
F
L
P
H
Y
D
T
L
V
K
S
G
Site 12
T123
D
F
L
P
H
Y
D
T
L
V
K
S
G
M
Y
Site 13
Y132
V
K
S
G
M
Y
E
Y
Y
A
S
E
G
Q
N
Site 14
Y133
K
S
G
M
Y
E
Y
Y
A
S
E
G
Q
N
P
Site 15
S135
G
M
Y
E
Y
Y
A
S
E
G
Q
N
P
L
P
Site 16
S152
L
A
E
L
I
D
N
S
L
S
A
T
S
R
N
Site 17
S154
E
L
I
D
N
S
L
S
A
T
S
R
N
I
G
Site 18
T156
I
D
N
S
L
S
A
T
S
R
N
I
G
V
R
Site 19
T190
I
D
N
G
R
G
M
T
S
K
Q
L
N
N
W
Site 20
S213
T
R
Q
G
D
F
E
S
D
H
S
G
Y
V
R
Site 21
S216
G
D
F
E
S
D
H
S
G
Y
V
R
P
V
P
Site 22
Y218
F
E
S
D
H
S
G
Y
V
R
P
V
P
V
P
Site 23
S227
R
P
V
P
V
P
R
S
L
N
S
D
I
S
Y
Site 24
S230
P
V
P
R
S
L
N
S
D
I
S
Y
F
G
V
Site 25
S233
R
S
L
N
S
D
I
S
Y
F
G
V
G
G
K
Site 26
Y234
S
L
N
S
D
I
S
Y
F
G
V
G
G
K
Q
Site 27
S254
G
Q
S
A
R
M
I
S
K
P
A
D
S
Q
D
Site 28
S259
M
I
S
K
P
A
D
S
Q
D
V
H
E
L
V
Site 29
S268
D
V
H
E
L
V
L
S
K
E
D
F
E
K
K
Site 30
Y283
E
K
N
K
E
A
I
Y
S
G
Y
I
R
N
R
Site 31
S284
K
N
K
E
A
I
Y
S
G
Y
I
R
N
R
K
Site 32
Y286
K
E
A
I
Y
S
G
Y
I
R
N
R
K
P
S
Site 33
S293
Y
I
R
N
R
K
P
S
D
S
V
H
I
T
N
Site 34
S295
R
N
R
K
P
S
D
S
V
H
I
T
N
D
D
Site 35
T299
P
S
D
S
V
H
I
T
N
D
D
E
R
F
L
Site 36
S318
I
E
E
K
E
K
D
S
F
T
A
V
V
I
T
Site 37
T320
E
K
E
K
D
S
F
T
A
V
V
I
T
G
V
Site 38
Y334
V
Q
P
E
H
I
Q
Y
L
K
N
Y
F
H
L
Site 39
Y350
T
R
Q
L
A
H
I
Y
H
Y
Y
I
H
G
P
Site 40
Y352
Q
L
A
H
I
Y
H
Y
Y
I
H
G
P
K
G
Site 41
Y353
L
A
H
I
Y
H
Y
Y
I
H
G
P
K
G
N
Site 42
S365
K
G
N
E
I
R
T
S
K
E
V
E
P
F
N
Site 43
T401
E
I
Q
D
D
M
Q
T
L
Y
V
N
T
A
A
Site 44
Y403
Q
D
D
M
Q
T
L
Y
V
N
T
A
A
D
S
Site 45
S410
Y
V
N
T
A
A
D
S
F
E
F
K
A
H
V
Site 46
Y434
I
R
Y
H
P
F
L
Y
D
R
E
T
Y
P
D
Site 47
Y439
F
L
Y
D
R
E
T
Y
P
D
D
P
C
F
P
Site 48
Y483
W
N
G
R
L
I
P
Y
T
S
V
E
D
F
D
Site 49
T484
N
G
R
L
I
P
Y
T
S
V
E
D
F
D
W
Site 50
T493
V
E
D
F
D
W
C
T
P
P
K
K
R
G
L
Site 51
T527
Q
V
S
T
N
K
L
T
F
M
D
L
E
L
K
Site 52
T540
L
K
L
K
D
K
N
T
L
F
T
R
I
L
N
Site 53
Y570
L
K
D
C
H
E
K
Y
D
K
Q
I
K
F
T
Site 54
S590
I
T
R
P
D
L
P
S
K
K
Q
G
P
W
A
Site 55
Y599
K
Q
G
P
W
A
T
Y
A
A
I
E
W
D
G
Site 56
Y634
S
I
V
R
F
F
L
Y
G
D
H
D
G
E
V
Site 57
Y642
G
D
H
D
G
E
V
Y
A
T
G
G
E
V
Q
Site 58
Y658
A
M
E
P
Q
A
L
Y
D
E
V
R
T
V
P
Site 59
T672
P
I
A
K
L
D
R
T
V
A
E
K
A
V
K
Site 60
Y681
A
E
K
A
V
K
K
Y
V
E
D
E
M
A
R
Site 61
S694
A
R
L
P
D
R
L
S
V
T
W
P
E
G
D
Site 62
T713
N
E
V
R
P
A
G
T
P
I
G
A
L
R
I
Site 63
T736
A
M
Q
K
L
P
G
T
S
H
G
G
S
K
K
Site 64
S741
P
G
T
S
H
G
G
S
K
K
L
L
V
E
L
Site 65
S756
K
V
I
L
H
S
S
S
G
N
K
E
I
I
S
Site 66
S763
S
G
N
K
E
I
I
S
H
I
S
Q
H
G
G
Site 67
S766
K
E
I
I
S
H
I
S
Q
H
G
G
K
W
P
Site 68
T803
L
N
E
S
N
A
D
T
Y
A
G
R
P
L
P
Site 69
Y804
N
E
S
N
A
D
T
Y
A
G
R
P
L
P
S
Site 70
S811
Y
A
G
R
P
L
P
S
K
A
I
K
F
S
V
Site 71
S827
E
G
K
P
E
K
F
S
F
G
L
L
D
L
P
Site 72
S855
Q
D
E
F
G
H
T
S
Q
L
V
T
D
I
Q
Site 73
T859
G
H
T
S
Q
L
V
T
D
I
Q
P
V
L
E
Site 74
S896
T
A
K
G
P
V
N
S
C
Q
G
K
N
Y
N
Site 75
S915
L
P
G
L
K
E
D
S
Q
I
L
K
I
R
L
Site 76
S936
R
L
K
V
K
P
D
S
E
I
L
V
I
E
N
Site 77
S957
Q
V
E
V
L
D
E
S
D
N
I
T
A
Q
P
Site 78
T961
L
D
E
S
D
N
I
T
A
Q
P
K
L
I
V
Site 79
S1017
K
A
R
I
E
I
P
S
C
K
D
V
A
P
V
Site 80
T1027
D
V
A
P
V
E
K
T
I
K
L
L
P
S
S
Site 81
Y1074
H
N
L
I
F
Q
M
Y
D
E
G
E
R
E
I
Site 82
T1084
G
E
R
E
I
N
I
T
S
A
L
A
E
K
I
Site 83
T1096
E
K
I
K
V
N
W
T
P
E
I
N
K
E
H
Site 84
Y1123
T
S
V
K
D
M
R
Y
C
Q
V
S
F
Q
D
Site 85
S1134
S
F
Q
D
D
H
V
S
L
E
S
A
F
T
V
Site 86
T1140
V
S
L
E
S
A
F
T
V
R
P
L
P
D
E
Site 87
T1160
C
E
M
K
G
G
K
T
V
Q
M
G
Q
E
L
Site 88
S1187
G
N
Q
I
Q
A
F
S
P
S
S
L
S
S
L
Site 89
S1204
A
G
V
G
L
D
S
S
N
L
K
T
T
F
Q
Site 90
T1208
L
D
S
S
N
L
K
T
T
F
Q
E
N
T
Q
Site 91
T1209
D
S
S
N
L
K
T
T
F
Q
E
N
T
Q
S
Site 92
T1214
K
T
T
F
Q
E
N
T
Q
S
I
S
V
R
G
Site 93
S1216
T
F
Q
E
N
T
Q
S
I
S
V
R
G
I
K
Site 94
S1218
Q
E
N
T
Q
S
I
S
V
R
G
I
K
F
I
Site 95
S1268
D
W
P
E
L
K
E
S
I
P
V
I
N
G
R
Site 96
S1301
P
V
Q
H
V
K
I
S
L
T
K
A
S
N
L
Site 97
T1303
Q
H
V
K
I
S
L
T
K
A
S
N
L
K
L
Site 98
S1313
S
N
L
K
L
M
P
S
N
Q
Q
H
K
T
D
Site 99
T1319
P
S
N
Q
Q
H
K
T
D
E
K
G
R
A
N
Site 100
Y1375
P
V
R
L
N
V
K
Y
D
K
D
A
S
F
L
Site 101
S1400
S
V
I
S
E
D
D
S
I
I
K
N
I
N
P
Site 102
S1418
S
M
K
M
W
K
L
S
T
S
G
N
R
P
P
Site 103
S1420
K
M
W
K
L
S
T
S
G
N
R
P
P
A
N
Site 104
T1430
R
P
P
A
N
A
E
T
F
S
C
N
K
I
K
Site 105
Y1447
D
K
E
D
G
C
F
Y
F
R
D
K
V
I
P
Site 106
T1499
V
P
K
I
K
P
P
T
P
A
V
S
N
V
R
Site 107
S1503
K
P
P
T
P
A
V
S
N
V
R
S
V
A
S
Site 108
S1520
L
V
R
D
L
H
L
S
I
T
D
D
Y
D
N
Site 109
T1522
R
D
L
H
L
S
I
T
D
D
Y
D
N
H
T
Site 110
Y1525
H
L
S
I
T
D
D
Y
D
N
H
T
G
I
D
Site 111
T1549
K
G
S
N
E
E
D
T
D
T
P
L
F
I
G
Site 112
T1551
S
N
E
E
D
T
D
T
P
L
F
I
G
K
V
Site 113
S1580
M
S
L
V
L
A
E
S
S
P
G
R
D
S
T
Site 114
S1581
S
L
V
L
A
E
S
S
P
G
R
D
S
T
E
Site 115
S1586
E
S
S
P
G
R
D
S
T
E
Y
F
I
V
F
Site 116
T1587
S
S
P
G
R
D
S
T
E
Y
F
I
V
F
E
Site 117
Y1589
P
G
R
D
S
T
E
Y
F
I
V
F
E
P
R
Site 118
S1601
E
P
R
L
P
L
L
S
R
T
L
E
P
Y
I
Site 119
Y1614
Y
I
L
P
F
M
F
Y
N
D
V
K
K
Q
Q
Site 120
S1634
T
K
E
K
D
Q
L
S
Q
S
I
V
M
Y
K
Site 121
S1636
E
K
D
Q
L
S
Q
S
I
V
M
Y
K
S
L
Site 122
S1642
Q
S
I
V
M
Y
K
S
L
F
E
A
S
Q
Q
Site 123
S1697
A
L
L
K
R
K
L
S
E
Q
E
E
L
K
K
Site 124
S1709
L
K
K
K
P
R
R
S
C
T
L
P
N
Y
T
Site 125
T1711
K
K
P
R
R
S
C
T
L
P
N
Y
T
K
G
Site 126
Y1715
R
S
C
T
L
P
N
Y
T
K
G
S
G
D
V
Site 127
S1719
L
P
N
Y
T
K
G
S
G
D
V
L
G
K
I
Site 128
Y1764
T
D
A
A
R
R
I
Y
D
E
T
Q
G
R
Q
Site 129
T1767
A
R
R
I
Y
D
E
T
Q
G
R
Q
Q
V
L
Site 130
S1778
Q
Q
V
L
P
L
D
S
I
Y
K
K
T
L
P
Site 131
Y1780
V
L
P
L
D
S
I
Y
K
K
T
L
P
D
W
Site 132
T1783
L
D
S
I
Y
K
K
T
L
P
D
W
K
R
S
Site 133
S1790
T
L
P
D
W
K
R
S
L
P
H
F
R
N
G
Site 134
Y1800
H
F
R
N
G
K
L
Y
F
K
P
I
G
D
P
Site 135
T1815
V
F
A
R
D
L
L
T
F
P
D
N
V
E
H
Site 136
T1854
R
K
E
V
V
K
I
T
H
C
P
T
L
L
T
Site 137
S1869
R
D
G
D
R
I
R
S
N
G
K
F
G
G
L
Site 138
S1914
D
L
L
Q
Q
Y
R
S
A
V
C
K
L
D
S
Site 139
S1921
S
A
V
C
K
L
D
S
V
N
K
D
L
N
S
Site 140
S1928
S
V
N
K
D
L
N
S
Q
L
E
Y
L
R
T
Site 141
Y1932
D
L
N
S
Q
L
E
Y
L
R
T
P
D
M
R
Site 142
T1935
S
Q
L
E
Y
L
R
T
P
D
M
R
K
K
K
Site 143
T1962
I
E
E
K
L
G
M
T
P
I
R
K
C
N
D
Site 144
S1970
P
I
R
K
C
N
D
S
L
R
H
S
P
K
V
Site 145
S1974
C
N
D
S
L
R
H
S
P
K
V
E
T
T
D
Site 146
T1980
H
S
P
K
V
E
T
T
D
C
P
V
P
P
K
Site 147
T1994
K
R
M
R
R
E
A
T
R
Q
N
R
I
I
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation