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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
METT5D1
Full Name:
Probable S-adenosyl-L-methionine-dependent methyltransferase METT5D1
Alias:
Methyltransferase 5 domain-containing protein 1
Type:
Mass (Da):
46121
Number AA:
407
UniProt ID:
A6NJ78
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T35
V
W
P
N
R
I
H
T
T
A
E
K
Y
R
E
Site 2
Y43
T
A
E
K
Y
R
E
Y
E
A
R
E
Q
T
D
Site 3
T49
E
Y
E
A
R
E
Q
T
D
Q
T
Q
A
Q
E
Site 4
T52
A
R
E
Q
T
D
Q
T
Q
A
Q
E
L
H
R
Site 5
S60
Q
A
Q
E
L
H
R
S
Q
D
R
D
F
E
T
Site 6
T67
S
Q
D
R
D
F
E
T
M
A
K
L
H
I
P
Site 7
S85
D
E
V
V
H
C
L
S
P
Q
K
G
Q
I
F
Site 8
T103
T
F
G
S
G
G
H
T
K
A
I
L
Q
K
E
Site 9
T123
Y
A
L
D
R
D
P
T
A
Y
A
L
A
E
H
Site 10
Y125
L
D
R
D
P
T
A
Y
A
L
A
E
H
L
S
Site 11
S132
Y
A
L
A
E
H
L
S
E
L
Y
P
K
Q
I
Site 12
Y135
A
E
H
L
S
E
L
Y
P
K
Q
I
R
A
M
Site 13
S174
L
M
D
L
G
C
S
S
M
Q
L
D
T
P
E
Site 14
T179
C
S
S
M
Q
L
D
T
P
E
R
G
F
S
L
Site 15
S185
D
T
P
E
R
G
F
S
L
R
K
D
G
P
L
Site 16
Y201
M
R
M
D
G
G
R
Y
P
D
M
P
T
A
A
Site 17
T225
A
L
A
S
I
L
R
T
Y
G
E
E
K
H
A
Site 18
Y226
L
A
S
I
L
R
T
Y
G
E
E
K
H
A
K
Site 19
Y246
I
V
Q
A
R
S
I
Y
P
I
T
R
T
Q
Q
Site 20
T249
A
R
S
I
Y
P
I
T
R
T
Q
Q
L
A
S
Site 21
S265
V
A
G
A
F
P
P
S
A
I
Y
T
R
K
D
Site 22
Y268
A
F
P
P
S
A
I
Y
T
R
K
D
L
L
Q
Site 23
T269
F
P
P
S
A
I
Y
T
R
K
D
L
L
Q
R
Site 24
T278
K
D
L
L
Q
R
S
T
H
I
A
T
K
T
F
Site 25
T305
E
L
Y
T
G
L
K
T
A
Q
K
F
L
R
P
Site 26
S320
G
G
R
L
V
A
L
S
F
H
S
L
E
D
R
Site 27
S345
M
T
E
R
F
N
L
S
V
R
Q
Q
V
M
K
Site 28
S354
R
Q
Q
V
M
K
T
S
Q
L
G
S
D
H
E
Site 29
S358
M
K
T
S
Q
L
G
S
D
H
E
N
T
E
E
Site 30
T363
L
G
S
D
H
E
N
T
E
E
V
S
M
R
R
Site 31
S367
H
E
N
T
E
E
V
S
M
R
R
A
P
L
M
Site 32
S384
L
I
H
K
K
V
L
S
P
Q
D
Q
D
V
Q
Site 33
S398
Q
D
N
P
R
G
R
S
A
K
L
R
A
A
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation