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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IRG1
Full Name:
Immune-responsive gene 1 protein homolog
Alias:
Type:
Mass (Da):
52628
Number AA:
481
UniProt ID:
A6NK06
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T23
G
L
K
V
G
H
L
T
D
R
V
I
Q
R
S
Site 2
S30
T
D
R
V
I
Q
R
S
K
R
M
I
L
D
T
Site 3
S54
T
E
V
F
H
I
A
S
Q
Y
S
K
I
Y
S
Site 4
Y56
V
F
H
I
A
S
Q
Y
S
K
I
Y
S
S
N
Site 5
Y60
A
S
Q
Y
S
K
I
Y
S
S
N
I
S
S
T
Site 6
S61
S
Q
Y
S
K
I
Y
S
S
N
I
S
S
T
V
Site 7
S62
Q
Y
S
K
I
Y
S
S
N
I
S
S
T
V
W
Site 8
S65
K
I
Y
S
S
N
I
S
S
T
V
W
G
Q
P
Site 9
S66
I
Y
S
S
N
I
S
S
T
V
W
G
Q
P
D
Site 10
T67
Y
S
S
N
I
S
S
T
V
W
G
Q
P
D
I
Site 11
T79
P
D
I
R
L
P
P
T
Y
A
A
F
V
N
G
Site 12
S122
L
A
E
A
L
P
R
S
P
K
F
S
G
L
D
Site 13
S162
P
K
R
F
H
P
P
S
V
V
G
T
L
G
S
Site 14
S174
L
G
S
A
A
A
A
S
K
F
L
G
L
S
S
Site 15
S180
A
S
K
F
L
G
L
S
S
T
K
C
R
E
A
Site 16
T182
K
F
L
G
L
S
S
T
K
C
R
E
A
L
A
Site 17
Y246
E
A
G
F
G
A
F
Y
A
N
Y
S
P
K
V
Site 18
Y249
F
G
A
F
Y
A
N
Y
S
P
K
V
L
P
S
Site 19
S279
K
R
F
P
A
H
L
S
T
H
W
V
A
D
A
Site 20
Y318
L
R
I
P
N
V
Q
Y
V
N
R
P
F
P
V
Site 21
S326
V
N
R
P
F
P
V
S
E
H
E
A
R
H
S
Site 22
S333
S
E
H
E
A
R
H
S
F
Q
Y
V
A
C
A
Site 23
S367
P
Q
V
R
E
L
L
S
K
V
E
L
E
Y
P
Site 24
Y373
L
S
K
V
E
L
E
Y
P
P
D
N
L
P
S
Site 25
T397
V
T
L
K
D
G
A
T
F
T
D
R
S
D
T
Site 26
T399
L
K
D
G
A
T
F
T
D
R
S
D
T
F
Y
Site 27
Y406
T
D
R
S
D
T
F
Y
G
H
W
R
K
P
L
Site 28
S414
G
H
W
R
K
P
L
S
Q
E
D
L
E
E
K
Site 29
S427
E
K
F
R
A
N
A
S
K
M
L
S
W
D
T
Site 30
S431
A
N
A
S
K
M
L
S
W
D
T
V
E
S
L
Site 31
T456
E
D
C
S
V
L
T
T
L
L
K
G
P
S
P
Site 32
S462
T
T
L
L
K
G
P
S
P
P
E
V
A
S
N
Site 33
S468
P
S
P
P
E
V
A
S
N
S
P
A
C
N
N
Site 34
S470
P
P
E
V
A
S
N
S
P
A
C
N
N
S
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation