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Updated November 2019
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Protein Info
Short Name:
PCNXL2
Full Name:
Pecanex-like protein 2
Alias:
Type:
Mass (Da):
237277
Number AA:
2137
UniProt ID:
A6NKB5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y22
A
A
L
T
G
G
W
Y
H
D
P
E
Q
S
K
Site 2
T114
E
A
K
G
E
H
I
T
N
H
R
N
P
S
N
Site 3
S138
E
E
A
S
R
N
L
S
T
P
P
L
R
C
S
Site 4
T139
E
A
S
R
N
L
S
T
P
P
L
R
C
S
S
Site 5
S145
S
T
P
P
L
R
C
S
S
R
G
Q
S
I
T
Site 6
S146
T
P
P
L
R
C
S
S
R
G
Q
S
I
T
S
Site 7
S150
R
C
S
S
R
G
Q
S
I
T
S
H
H
S
S
Site 8
T152
S
S
R
G
Q
S
I
T
S
H
H
S
S
G
P
Site 9
S153
S
R
G
Q
S
I
T
S
H
H
S
S
G
P
L
Site 10
S157
S
I
T
S
H
H
S
S
G
P
L
E
L
S
A
Site 11
S163
S
S
G
P
L
E
L
S
A
Q
E
T
V
E
D
Site 12
T167
L
E
L
S
A
Q
E
T
V
E
D
L
K
G
V
Site 13
S186
D
H
P
I
A
P
V
S
S
T
S
P
G
I
K
Site 14
S196
S
P
G
I
K
V
E
S
L
P
A
S
Q
A
H
Site 15
S200
K
V
E
S
L
P
A
S
Q
A
H
M
L
E
T
Site 16
T207
S
Q
A
H
M
L
E
T
T
T
K
S
V
I
P
Site 17
S243
Q
P
P
L
R
H
R
S
E
G
G
L
V
D
K
Site 18
S260
L
K
K
L
P
H
L
S
L
S
Q
Y
D
L
L
Site 19
S262
K
L
P
H
L
S
L
S
Q
Y
D
L
L
E
T
Site 20
Y264
P
H
L
S
L
S
Q
Y
D
L
L
E
T
D
V
Site 21
T269
S
Q
Y
D
L
L
E
T
D
V
S
F
Q
P
W
Site 22
S272
D
L
L
E
T
D
V
S
F
Q
P
W
G
S
E
Site 23
S278
V
S
F
Q
P
W
G
S
E
N
S
V
L
I
P
Site 24
S294
P
V
S
C
P
R
G
S
I
R
E
R
V
Q
S
Site 25
S301
S
I
R
E
R
V
Q
S
K
S
P
Q
D
S
L
Site 26
S303
R
E
R
V
Q
S
K
S
P
Q
D
S
L
S
S
Site 27
S307
Q
S
K
S
P
Q
D
S
L
S
S
S
C
P
Q
Site 28
S309
K
S
P
Q
D
S
L
S
S
S
C
P
Q
C
D
Site 29
S311
P
Q
D
S
L
S
S
S
C
P
Q
C
D
T
I
Site 30
T317
S
S
C
P
Q
C
D
T
I
V
A
K
P
V
E
Site 31
T329
P
V
E
E
P
A
D
T
S
C
Q
V
D
T
S
Site 32
S330
V
E
E
P
A
D
T
S
C
Q
V
D
T
S
C
Site 33
T335
D
T
S
C
Q
V
D
T
S
C
Q
G
D
L
P
Site 34
S336
T
S
C
Q
V
D
T
S
C
Q
G
D
L
P
L
Site 35
S350
L
H
Q
E
V
D
S
S
D
S
E
V
A
V
T
Site 36
S352
Q
E
V
D
S
S
D
S
E
V
A
V
T
L
I
Site 37
T357
S
D
S
E
V
A
V
T
L
I
D
T
S
Q
P
Site 38
S362
A
V
T
L
I
D
T
S
Q
P
G
D
P
L
S
Site 39
S369
S
Q
P
G
D
P
L
S
L
H
E
P
I
K
I
Site 40
T379
E
P
I
K
I
V
I
T
M
S
S
T
P
N
S
Site 41
S382
K
I
V
I
T
M
S
S
T
P
N
S
M
T
D
Site 42
S386
T
M
S
S
T
P
N
S
M
T
D
L
E
S
S
Site 43
T388
S
S
T
P
N
S
M
T
D
L
E
S
S
L
H
Site 44
T401
L
H
L
R
V
V
G
T
E
K
T
S
V
K
S
Site 45
T404
R
V
V
G
T
E
K
T
S
V
K
S
D
A
E
Site 46
S408
T
E
K
T
S
V
K
S
D
A
E
P
T
N
P
Site 47
S420
T
N
P
G
A
A
G
S
P
N
A
E
Q
I
S
Site 48
S451
P
C
P
E
G
N
G
S
E
R
T
P
E
R
L
Site 49
T454
E
G
N
G
S
E
R
T
P
E
R
L
K
T
R
Site 50
T460
R
T
P
E
R
L
K
T
R
V
S
T
N
Q
C
Site 51
S463
E
R
L
K
T
R
V
S
T
N
Q
C
S
G
Y
Site 52
T464
R
L
K
T
R
V
S
T
N
Q
C
S
G
Y
G
Site 53
S468
R
V
S
T
N
Q
C
S
G
Y
G
S
G
E
G
Site 54
Y470
S
T
N
Q
C
S
G
Y
G
S
G
E
G
G
N
Site 55
S472
N
Q
C
S
G
Y
G
S
G
E
G
G
N
A
I
Site 56
S483
G
N
A
I
K
D
H
S
S
S
S
R
E
P
W
Site 57
S484
N
A
I
K
D
H
S
S
S
S
R
E
P
W
E
Site 58
S485
A
I
K
D
H
S
S
S
S
R
E
P
W
E
S
Site 59
S486
I
K
D
H
S
S
S
S
R
E
P
W
E
S
V
Site 60
S492
S
S
R
E
P
W
E
S
V
S
R
L
T
P
D
Site 61
T497
W
E
S
V
S
R
L
T
P
D
T
G
S
E
S
Site 62
T500
V
S
R
L
T
P
D
T
G
S
E
S
K
V
G
Site 63
S502
R
L
T
P
D
T
G
S
E
S
K
V
G
K
E
Site 64
S517
G
Q
T
N
L
D
P
S
S
C
K
S
S
H
E
Site 65
S518
Q
T
N
L
D
P
S
S
C
K
S
S
H
E
K
Site 66
S521
L
D
P
S
S
C
K
S
S
H
E
K
R
H
A
Site 67
S522
D
P
S
S
C
K
S
S
H
E
K
R
H
A
R
Site 68
S532
K
R
H
A
R
V
L
S
V
D
S
G
T
D
V
Site 69
S544
T
D
V
F
L
S
K
S
S
A
E
I
V
N
D
Site 70
T552
S
A
E
I
V
N
D
T
E
K
T
M
P
T
S
Site 71
T555
I
V
N
D
T
E
K
T
M
P
T
S
K
S
D
Site 72
S559
T
E
K
T
M
P
T
S
K
S
D
L
E
A
K
Site 73
S561
K
T
M
P
T
S
K
S
D
L
E
A
K
E
G
Site 74
S585
E
F
V
S
L
L
E
S
I
N
T
S
K
M
T
Site 75
T588
S
L
L
E
S
I
N
T
S
K
M
T
A
S
S
Site 76
S589
L
L
E
S
I
N
T
S
K
M
T
A
S
S
Q
Site 77
S595
T
S
K
M
T
A
S
S
Q
L
N
G
S
A
E
Site 78
S600
A
S
S
Q
L
N
G
S
A
E
Q
N
E
E
S
Site 79
S615
G
L
L
R
D
N
C
S
Q
E
K
K
E
E
I
Site 80
S629
I
L
E
N
E
K
P
S
G
H
S
S
K
Q
G
Site 81
S633
E
K
P
S
G
H
S
S
K
Q
G
K
P
D
L
Site 82
S642
Q
G
K
P
D
L
Q
S
Q
D
H
T
S
T
G
Site 83
T646
D
L
Q
S
Q
D
H
T
S
T
G
P
A
C
T
Site 84
S647
L
Q
S
Q
D
H
T
S
T
G
P
A
C
T
Q
Site 85
Y672
N
R
Q
R
Q
I
I
Y
R
V
T
S
Q
Q
D
Site 86
T675
R
Q
I
I
Y
R
V
T
S
Q
Q
D
S
S
V
Site 87
S676
Q
I
I
Y
R
V
T
S
Q
Q
D
S
S
V
L
Site 88
S680
R
V
T
S
Q
Q
D
S
S
V
L
Q
V
I
S
Site 89
S681
V
T
S
Q
Q
D
S
S
V
L
Q
V
I
S
G
Site 90
T691
Q
V
I
S
G
P
E
T
S
V
Q
E
E
I
S
Site 91
S692
V
I
S
G
P
E
T
S
V
Q
E
E
I
S
V
Site 92
S714
D
E
H
G
E
I
R
S
C
Y
L
K
S
G
N
Site 93
Y716
H
G
E
I
R
S
C
Y
L
K
S
G
N
Q
K
Site 94
S719
I
R
S
C
Y
L
K
S
G
N
Q
K
E
G
P
Site 95
S732
G
P
L
Q
P
L
P
S
N
N
D
C
L
S
Q
Site 96
S738
P
S
N
N
D
C
L
S
Q
A
R
E
M
Q
V
Site 97
S746
Q
A
R
E
M
Q
V
S
S
S
S
T
T
T
S
Site 98
S747
A
R
E
M
Q
V
S
S
S
S
T
T
T
S
E
Site 99
S748
R
E
M
Q
V
S
S
S
S
T
T
T
S
E
S
Site 100
S749
E
M
Q
V
S
S
S
S
T
T
T
S
E
S
Q
Site 101
T750
M
Q
V
S
S
S
S
T
T
T
S
E
S
Q
D
Site 102
T751
Q
V
S
S
S
S
T
T
T
S
E
S
Q
D
P
Site 103
T752
V
S
S
S
S
T
T
T
S
E
S
Q
D
P
S
Site 104
S753
S
S
S
S
T
T
T
S
E
S
Q
D
P
S
S
Site 105
S755
S
S
T
T
T
S
E
S
Q
D
P
S
S
G
D
Site 106
S759
T
S
E
S
Q
D
P
S
S
G
D
P
A
V
S
Site 107
S760
S
E
S
Q
D
P
S
S
G
D
P
A
V
S
A
Site 108
T780
L
L
M
V
A
R
R
T
Q
S
E
T
P
R
H
Site 109
S782
M
V
A
R
R
T
Q
S
E
T
P
R
H
V
S
Site 110
T784
A
R
R
T
Q
S
E
T
P
R
H
V
S
Q
D
Site 111
S789
S
E
T
P
R
H
V
S
Q
D
L
E
A
S
S
Site 112
S795
V
S
Q
D
L
E
A
S
S
C
S
S
T
Q
G
Site 113
S796
S
Q
D
L
E
A
S
S
C
S
S
T
Q
G
K
Site 114
S799
L
E
A
S
S
C
S
S
T
Q
G
K
F
N
R
Site 115
T800
E
A
S
S
C
S
S
T
Q
G
K
F
N
R
E
Site 116
T836
L
L
A
L
L
D
R
T
E
D
I
K
E
N
V
Site 117
S887
C
Q
Y
S
L
L
K
S
V
Q
P
D
P
A
S
Site 118
S894
S
V
Q
P
D
P
A
S
P
I
H
G
H
N
Q
Site 119
T904
H
G
H
N
Q
I
I
T
Y
S
R
P
I
Y
F
Site 120
Y905
G
H
N
Q
I
I
T
Y
S
R
P
I
Y
F
C
Site 121
S932
A
K
A
R
H
P
P
S
Y
V
V
Y
G
L
K
Site 122
Y933
K
A
R
H
P
P
S
Y
V
V
Y
G
L
K
L
Site 123
S994
F
F
G
G
S
A
V
S
G
I
T
S
A
V
Y
Site 124
S1026
S
A
V
K
E
P
W
S
M
Q
H
I
P
A
L
Site 125
S1049
V
A
L
S
Y
H
L
S
R
Q
S
S
D
P
S
Site 126
S1052
S
Y
H
L
S
R
Q
S
S
D
P
S
V
L
M
Site 127
S1053
Y
H
L
S
R
Q
S
S
D
P
S
V
L
M
S
Site 128
S1056
S
R
Q
S
S
D
P
S
V
L
M
S
F
I
Q
Site 129
S1078
L
H
Q
N
L
A
E
S
A
A
D
P
L
P
K
Site 130
S1090
L
P
K
K
M
K
D
S
V
T
D
V
L
K
W
Site 131
T1092
K
K
M
K
D
S
V
T
D
V
L
K
W
D
L
Site 132
Y1166
P
I
L
K
N
K
E
Y
H
Q
R
E
V
R
D
Site 133
S1212
T
I
D
A
F
L
I
S
N
H
R
R
L
G
T
Site 134
T1219
S
N
H
R
R
L
G
T
H
W
D
I
F
L
M
Site 135
S1237
G
M
K
L
L
R
T
S
F
C
N
P
V
Y
Q
Site 136
S1263
H
F
D
Y
K
D
I
S
E
S
F
L
L
D
F
Site 137
S1265
D
Y
K
D
I
S
E
S
F
L
L
D
F
F
M
Site 138
S1366
N
T
R
R
V
D
N
S
N
T
R
L
A
V
Q
Site 139
T1396
F
Y
E
H
L
T
R
T
L
Q
E
S
L
C
G
Site 140
T1452
R
G
L
E
F
R
G
T
Y
C
Q
Q
R
E
V
Site 141
Y1453
G
L
E
F
R
G
T
Y
C
Q
Q
R
E
V
E
Site 142
T1496
A
F
H
L
R
W
L
T
W
E
I
T
Q
T
Q
Site 143
S1549
V
T
S
P
K
L
L
S
W
I
K
N
E
S
L
Site 144
S1555
L
S
W
I
K
N
E
S
L
L
K
S
L
Q
P
Site 145
S1559
K
N
E
S
L
L
K
S
L
Q
P
F
A
K
W
Site 146
Y1568
Q
P
F
A
K
W
H
Y
I
E
R
D
L
A
M
Site 147
Y1584
N
I
N
I
D
D
D
Y
V
P
C
L
Q
G
I
Site 148
T1616
R
K
R
Q
E
P
S
T
T
L
D
S
D
E
D
Site 149
T1617
K
R
Q
E
P
S
T
T
L
D
S
D
E
D
S
Site 150
S1620
E
P
S
T
T
L
D
S
D
E
D
S
P
L
V
Site 151
S1624
T
L
D
S
D
E
D
S
P
L
V
T
L
S
F
Site 152
S1694
V
A
P
A
I
R
M
S
L
K
L
H
Q
D
Q
Site 153
T1703
K
L
H
Q
D
Q
F
T
C
P
D
E
Y
E
D
Site 154
Y1708
Q
F
T
C
P
D
E
Y
E
D
P
A
V
L
Y
Site 155
Y1715
Y
E
D
P
A
V
L
Y
E
A
I
Q
S
F
E
Site 156
S1741
A
W
R
G
A
V
L
S
N
K
E
E
L
L
T
Site 157
T1748
S
N
K
E
E
L
L
T
L
R
H
V
V
D
E
Site 158
Y1760
V
D
E
G
A
D
E
Y
K
V
I
M
L
H
R
Site 159
S1805
N
R
N
P
E
R
G
S
I
Q
N
N
K
Q
V
Site 160
S1819
V
L
R
N
L
I
N
S
S
C
D
Q
P
L
G
Site 161
S1820
L
R
N
L
I
N
S
S
C
D
Q
P
L
G
Y
Site 162
Y1827
S
C
D
Q
P
L
G
Y
P
M
Y
V
S
P
L
Site 163
Y1830
Q
P
L
G
Y
P
M
Y
V
S
P
L
T
T
S
Site 164
T1835
P
M
Y
V
S
P
L
T
T
S
Y
L
G
T
H
Site 165
T1836
M
Y
V
S
P
L
T
T
S
Y
L
G
T
H
R
Site 166
S1837
Y
V
S
P
L
T
T
S
Y
L
G
T
H
R
Q
Site 167
T1841
L
T
T
S
Y
L
G
T
H
R
Q
L
K
N
I
Site 168
S1879
D
C
N
A
R
Q
H
S
G
G
N
I
E
D
V
Site 169
S1901
T
G
G
N
N
A
P
S
G
G
S
Q
E
S
S
Site 170
S1904
N
N
A
P
S
G
G
S
Q
E
S
S
A
E
Q
Site 171
S1907
P
S
G
G
S
Q
E
S
S
A
E
Q
P
R
K
Site 172
S1908
S
G
G
S
Q
E
S
S
A
E
Q
P
R
K
G
Site 173
S1922
G
G
A
Q
H
G
V
S
S
C
E
G
T
Q
R
Site 174
S1923
G
A
Q
H
G
V
S
S
C
E
G
T
Q
R
T
Site 175
T1927
G
V
S
S
C
E
G
T
Q
R
T
G
R
R
K
Site 176
T1930
S
C
E
G
T
Q
R
T
G
R
R
K
G
R
S
Site 177
S1937
T
G
R
R
K
G
R
S
Q
S
V
Q
A
H
S
Site 178
S1939
R
R
K
G
R
S
Q
S
V
Q
A
H
S
A
L
Site 179
S1947
V
Q
A
H
S
A
L
S
Q
R
P
P
M
L
S
Site 180
S1954
S
Q
R
P
P
M
L
S
S
S
G
P
I
L
E
Site 181
S1955
Q
R
P
P
M
L
S
S
S
G
P
I
L
E
S
Site 182
S1956
R
P
P
M
L
S
S
S
G
P
I
L
E
S
R
Site 183
S1962
S
S
G
P
I
L
E
S
R
Q
T
F
L
Q
T
Site 184
T1965
P
I
L
E
S
R
Q
T
F
L
Q
T
S
T
S
Site 185
S1972
T
F
L
Q
T
S
T
S
V
H
E
L
A
Q
R
Site 186
S1981
H
E
L
A
Q
R
L
S
G
S
R
L
S
L
H
Site 187
S1983
L
A
Q
R
L
S
G
S
R
L
S
L
H
A
S
Site 188
S1986
R
L
S
G
S
R
L
S
L
H
A
S
A
T
S
Site 189
S1990
S
R
L
S
L
H
A
S
A
T
S
L
H
S
Q
Site 190
T1992
L
S
L
H
A
S
A
T
S
L
H
S
Q
P
P
Site 191
S1993
S
L
H
A
S
A
T
S
L
H
S
Q
P
P
P
Site 192
S1996
A
S
A
T
S
L
H
S
Q
P
P
P
V
T
T
Site 193
T2002
H
S
Q
P
P
P
V
T
T
T
G
H
L
S
V
Site 194
S2008
V
T
T
T
G
H
L
S
V
R
E
R
A
E
A
Site 195
S2019
R
A
E
A
L
I
R
S
S
L
G
S
S
T
S
Site 196
S2020
A
E
A
L
I
R
S
S
L
G
S
S
T
S
S
Site 197
S2023
L
I
R
S
S
L
G
S
S
T
S
S
T
L
S
Site 198
S2024
I
R
S
S
L
G
S
S
T
S
S
T
L
S
F
Site 199
T2025
R
S
S
L
G
S
S
T
S
S
T
L
S
F
L
Site 200
S2030
S
S
T
S
S
T
L
S
F
L
F
G
K
R
S
Site 201
T2055
S
A
A
E
G
G
N
T
S
D
T
Q
S
S
S
Site 202
S2056
A
A
E
G
G
N
T
S
D
T
Q
S
S
S
S
Site 203
T2058
E
G
G
N
T
S
D
T
Q
S
S
S
S
V
N
Site 204
S2060
G
N
T
S
D
T
Q
S
S
S
S
V
N
I
V
Site 205
S2062
T
S
D
T
Q
S
S
S
S
V
N
I
V
M
G
Site 206
S2063
S
D
T
Q
S
S
S
S
V
N
I
V
M
G
P
Site 207
S2076
G
P
S
A
R
A
A
S
Q
A
T
R
H
L
S
Site 208
S2083
S
Q
A
T
R
H
L
S
E
P
C
E
P
P
D
Site 209
T2092
P
C
E
P
P
D
A
T
E
Q
G
Q
L
H
D
Site 210
S2118
G
V
V
C
R
R
A
S
Q
E
D
M
G
L
D
Site 211
T2127
E
D
M
G
L
D
D
T
A
S
Q
Q
S
V
S
Site 212
S2129
M
G
L
D
D
T
A
S
Q
Q
S
V
S
D
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation