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Updated November 2019
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Protein Info
Short Name:
LRRC53
Full Name:
Leucine-rich repeat-containing protein 53
Alias:
Type:
Mass (Da):
140742
Number AA:
1247
UniProt ID:
A6NM62
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S47
I
T
D
G
Y
L
S
S
I
E
S
T
N
L
S
Site 2
T85
H
G
L
T
M
L
R
T
L
L
L
E
H
N
Q
Site 3
S94
L
L
E
H
N
Q
I
S
S
S
S
L
T
D
H
Site 4
S95
L
E
H
N
Q
I
S
S
S
S
L
T
D
H
T
Site 5
S96
E
H
N
Q
I
S
S
S
S
L
T
D
H
T
F
Site 6
S97
H
N
Q
I
S
S
S
S
L
T
D
H
T
F
S
Site 7
T99
Q
I
S
S
S
S
L
T
D
H
T
F
S
K
L
Site 8
T102
S
S
S
L
T
D
H
T
F
S
K
L
H
S
L
Site 9
S104
S
L
T
D
H
T
F
S
K
L
H
S
L
Q
V
Site 10
S108
H
T
F
S
K
L
H
S
L
Q
V
L
V
L
S
Site 11
T121
L
S
N
N
A
L
R
T
L
R
G
S
W
F
R
Site 12
S125
A
L
R
T
L
R
G
S
W
F
R
N
T
S
G
Site 13
T130
R
G
S
W
F
R
N
T
S
G
L
T
R
L
Q
Site 14
S131
G
S
W
F
R
N
T
S
G
L
T
R
L
Q
L
Site 15
T147
G
N
Q
I
T
N
L
T
D
S
S
F
G
G
T
Site 16
S149
Q
I
T
N
L
T
D
S
S
F
G
G
T
N
L
Site 17
S150
I
T
N
L
T
D
S
S
F
G
G
T
N
L
H
Site 18
T154
T
D
S
S
F
G
G
T
N
L
H
S
L
R
Y
Site 19
S158
F
G
G
T
N
L
H
S
L
R
Y
L
D
L
S
Site 20
Y161
T
N
L
H
S
L
R
Y
L
D
L
S
N
N
F
Site 21
S189
Q
L
Q
E
V
D
L
S
R
N
R
L
A
H
M
Site 22
S210
L
K
Q
L
I
L
L
S
L
D
K
N
Q
W
S
Site 23
Y232
L
A
R
F
L
R
N
Y
I
K
S
S
A
H
T
Site 24
S235
F
L
R
N
Y
I
K
S
S
A
H
T
L
R
N
Site 25
T239
Y
I
K
S
S
A
H
T
L
R
N
A
K
D
L
Site 26
S265
A
Q
S
V
L
R
L
S
E
T
N
C
D
S
K
Site 27
T267
S
V
L
R
L
S
E
T
N
C
D
S
K
A
P
Site 28
S271
L
S
E
T
N
C
D
S
K
A
P
N
F
T
L
Site 29
S284
T
L
V
L
K
D
R
S
P
L
L
P
G
P
D
Site 30
T335
S
E
N
L
C
C
R
T
F
D
E
P
L
C
A
Site 31
S368
E
N
E
I
K
V
M
S
T
V
G
S
R
K
E
Site 32
S372
K
V
M
S
T
V
G
S
R
K
E
M
P
L
L
Site 33
S383
M
P
L
L
Q
E
N
S
H
Q
A
T
S
A
S
Site 34
T387
Q
E
N
S
H
Q
A
T
S
A
S
E
S
A
T
Site 35
S388
E
N
S
H
Q
A
T
S
A
S
E
S
A
T
L
Site 36
S390
S
H
Q
A
T
S
A
S
E
S
A
T
L
D
G
Site 37
S392
Q
A
T
S
A
S
E
S
A
T
L
D
G
S
F
Site 38
T394
T
S
A
S
E
S
A
T
L
D
G
S
F
R
N
Site 39
S398
E
S
A
T
L
D
G
S
F
R
N
L
K
K
K
Site 40
T412
K
D
R
G
V
G
S
T
L
F
C
Q
D
G
R
Site 41
S423
Q
D
G
R
L
L
H
S
E
C
S
E
P
P
G
Site 42
S426
R
L
L
H
S
E
C
S
E
P
P
G
N
M
R
Site 43
Y444
E
A
G
L
L
T
T
Y
N
P
R
K
V
Q
K
Site 44
T464
P
G
E
V
Q
P
Q
T
L
Q
H
H
I
I
R
Site 45
T472
L
Q
H
H
I
I
R
T
E
D
I
S
S
D
I
Site 46
S476
I
I
R
T
E
D
I
S
S
D
I
F
R
R
R
Site 47
S477
I
R
T
E
D
I
S
S
D
I
F
R
R
R
Y
Site 48
Y484
S
D
I
F
R
R
R
Y
A
T
P
A
S
A
L
Site 49
T486
I
F
R
R
R
Y
A
T
P
A
S
A
L
A
G
Site 50
S489
R
R
Y
A
T
P
A
S
A
L
A
G
E
S
L
Site 51
S495
A
S
A
L
A
G
E
S
L
E
K
R
L
T
N
Site 52
T501
E
S
L
E
K
R
L
T
N
E
S
W
Q
P
P
Site 53
S504
E
K
R
L
T
N
E
S
W
Q
P
P
I
E
K
Site 54
T526
H
R
Q
R
H
F
I
T
S
S
S
S
K
P
C
Site 55
S527
R
Q
R
H
F
I
T
S
S
S
S
K
P
C
E
Site 56
S528
Q
R
H
F
I
T
S
S
S
S
K
P
C
E
P
Site 57
S529
R
H
F
I
T
S
S
S
S
K
P
C
E
P
E
Site 58
S530
H
F
I
T
S
S
S
S
K
P
C
E
P
E
E
Site 59
Y539
P
C
E
P
E
E
H
Y
V
Q
K
I
V
Q
K
Site 60
Y551
V
Q
K
N
R
S
K
Y
D
D
P
C
G
L
L
Site 61
S561
P
C
G
L
L
K
Q
S
K
P
R
Y
F
Q
P
Site 62
Y565
L
K
Q
S
K
P
R
Y
F
Q
P
N
N
S
L
Site 63
Y576
N
N
S
L
I
C
K
Y
V
P
C
E
Q
F
E
Site 64
Y585
P
C
E
Q
F
E
D
Y
M
K
E
K
K
P
N
Site 65
S597
K
P
N
R
R
Q
H
S
K
P
E
K
E
Q
I
Site 66
S616
A
I
E
K
F
L
M
S
E
D
N
I
D
L
S
Site 67
S623
S
E
D
N
I
D
L
S
G
L
S
T
K
T
K
Site 68
T627
I
D
L
S
G
L
S
T
K
T
K
K
A
Y
S
Site 69
S634
T
K
T
K
K
A
Y
S
P
K
R
V
I
F
H
Site 70
S651
D
L
V
E
I
N
R
S
M
M
S
P
K
I
S
Site 71
S654
E
I
N
R
S
M
M
S
P
K
I
S
T
P
W
Site 72
S658
S
M
M
S
P
K
I
S
T
P
W
K
R
Q
K
Site 73
T659
M
M
S
P
K
I
S
T
P
W
K
R
Q
K
N
Site 74
S668
W
K
R
Q
K
N
Q
S
N
Q
L
T
K
L
D
Site 75
T672
K
N
Q
S
N
Q
L
T
K
L
D
V
K
K
F
Site 76
T703
W
V
L
K
R
K
R
T
P
Q
S
D
L
K
G
Site 77
S706
K
R
K
R
T
P
Q
S
D
L
K
G
K
I
K
Site 78
S734
V
R
V
H
P
E
K
S
L
S
S
L
P
K
Q
Site 79
S736
V
H
P
E
K
S
L
S
S
L
P
K
Q
C
K
Site 80
S753
L
L
P
P
K
K
L
S
K
T
S
E
T
E
A
Site 81
T764
E
T
E
A
K
I
N
T
V
C
S
A
D
F
L
Site 82
S767
A
K
I
N
T
V
C
S
A
D
F
L
Q
Q
S
Site 83
S774
S
A
D
F
L
Q
Q
S
E
S
S
N
Y
V
R
Site 84
S776
D
F
L
Q
Q
S
E
S
S
N
Y
V
R
L
T
Site 85
Y779
Q
Q
S
E
S
S
N
Y
V
R
L
T
S
K
R
Site 86
T783
S
S
N
Y
V
R
L
T
S
K
R
L
P
L
K
Site 87
S784
S
N
Y
V
R
L
T
S
K
R
L
P
L
K
H
Site 88
T796
L
K
H
D
S
K
Q
T
P
Y
Y
Q
R
N
T
Site 89
Y798
H
D
S
K
Q
T
P
Y
Y
Q
R
N
T
K
R
Site 90
Y799
D
S
K
Q
T
P
Y
Y
Q
R
N
T
K
R
A
Site 91
T803
T
P
Y
Y
Q
R
N
T
K
R
A
P
L
L
S
Site 92
S810
T
K
R
A
P
L
L
S
A
N
N
L
R
V
V
Site 93
S820
N
L
R
V
V
N
Q
S
S
I
E
S
S
C
Y
Site 94
S821
L
R
V
V
N
Q
S
S
I
E
S
S
C
Y
S
Site 95
S824
V
N
Q
S
S
I
E
S
S
C
Y
S
A
G
H
Site 96
S825
N
Q
S
S
I
E
S
S
C
Y
S
A
G
H
I
Site 97
Y827
S
S
I
E
S
S
C
Y
S
A
G
H
I
P
D
Site 98
S828
S
I
E
S
S
C
Y
S
A
G
H
I
P
D
G
Site 99
S838
H
I
P
D
G
N
T
S
K
L
P
Q
P
T
P
Site 100
T844
T
S
K
L
P
Q
P
T
P
T
D
A
E
H
R
Site 101
S853
T
D
A
E
H
R
H
S
H
S
Q
F
S
T
E
Site 102
S855
A
E
H
R
H
S
H
S
Q
F
S
T
E
Q
M
Site 103
T859
H
S
H
S
Q
F
S
T
E
Q
M
E
D
A
T
Site 104
T866
T
E
Q
M
E
D
A
T
Q
L
E
S
K
V
L
Site 105
S870
E
D
A
T
Q
L
E
S
K
V
L
S
Y
L
A
Site 106
S874
Q
L
E
S
K
V
L
S
Y
L
A
T
T
W
E
Site 107
T878
K
V
L
S
Y
L
A
T
T
W
E
N
T
G
S
Site 108
S893
D
V
L
P
F
Q
H
S
R
R
A
T
D
Q
G
Site 109
T897
F
Q
H
S
R
R
A
T
D
Q
G
T
T
E
S
Site 110
T901
R
R
A
T
D
Q
G
T
T
E
S
T
E
H
M
Site 111
S904
T
D
Q
G
T
T
E
S
T
E
H
M
G
Q
N
Site 112
S913
E
H
M
G
Q
N
V
S
K
T
S
E
L
N
Q
Site 113
S922
T
S
E
L
N
Q
F
S
L
S
P
R
N
Q
T
Site 114
S924
E
L
N
Q
F
S
L
S
P
R
N
Q
T
Q
L
Site 115
T929
S
L
S
P
R
N
Q
T
Q
L
L
D
A
H
K
Site 116
T937
Q
L
L
D
A
H
K
T
D
S
Y
N
K
E
Y
Site 117
S939
L
D
A
H
K
T
D
S
Y
N
K
E
Y
T
L
Site 118
Y940
D
A
H
K
T
D
S
Y
N
K
E
Y
T
L
D
Site 119
S960
Q
H
R
E
Q
N
S
S
H
A
Q
L
E
N
K
Site 120
T970
Q
L
E
N
K
E
K
T
L
M
T
K
P
Q
I
Site 121
T973
N
K
E
K
T
L
M
T
K
P
Q
I
S
H
Q
Site 122
S999
N
D
V
E
K
K
L
S
K
T
E
T
Y
D
S
Site 123
T1001
V
E
K
K
L
S
K
T
E
T
Y
D
S
S
L
Site 124
T1003
K
K
L
S
K
T
E
T
Y
D
S
S
L
I
P
Site 125
S1006
S
K
T
E
T
Y
D
S
S
L
I
P
Q
T
Q
Site 126
S1007
K
T
E
T
Y
D
S
S
L
I
P
Q
T
Q
S
Site 127
T1012
D
S
S
L
I
P
Q
T
Q
S
K
N
N
L
S
Site 128
S1014
S
L
I
P
Q
T
Q
S
K
N
N
L
S
F
M
Site 129
S1019
T
Q
S
K
N
N
L
S
F
M
K
T
N
S
I
Site 130
T1023
N
N
L
S
F
M
K
T
N
S
I
P
Y
Q
N
Site 131
S1039
I
E
L
P
K
D
I
S
T
S
P
V
S
S
Q
Site 132
T1040
E
L
P
K
D
I
S
T
S
P
V
S
S
Q
A
Site 133
S1041
L
P
K
D
I
S
T
S
P
V
S
S
Q
A
V
Site 134
S1044
D
I
S
T
S
P
V
S
S
Q
A
V
W
H
L
Site 135
T1052
S
Q
A
V
W
H
L
T
N
S
S
E
K
G
I
Site 136
S1061
S
S
E
K
G
I
D
S
T
N
A
L
P
R
N
Site 137
T1062
S
E
K
G
I
D
S
T
N
A
L
P
R
N
D
Site 138
T1071
A
L
P
R
N
D
G
T
E
A
L
E
I
K
I
Site 139
S1090
E
K
N
M
L
D
E
S
K
T
D
S
S
M
L
Site 140
T1092
N
M
L
D
E
S
K
T
D
S
S
M
L
T
Q
Site 141
S1094
L
D
E
S
K
T
D
S
S
M
L
T
Q
I
S
Site 142
S1095
D
E
S
K
T
D
S
S
M
L
T
Q
I
S
Q
Site 143
T1098
K
T
D
S
S
M
L
T
Q
I
S
Q
M
T
L
Site 144
T1115
I
T
K
E
R
Q
Q
T
W
E
N
G
T
S
E
Site 145
S1130
K
Y
I
L
H
D
A
S
S
A
E
E
T
I
T
Site 146
S1131
Y
I
L
H
D
A
S
S
A
E
E
T
I
T
A
Site 147
T1135
D
A
S
S
A
E
E
T
I
T
A
K
D
L
S
Site 148
T1137
S
S
A
E
E
T
I
T
A
K
D
L
S
I
T
Site 149
S1142
T
I
T
A
K
D
L
S
I
T
S
S
H
E
T
Site 150
S1146
K
D
L
S
I
T
S
S
H
E
T
Q
N
R
I
Site 151
T1149
S
I
T
S
S
H
E
T
Q
N
R
I
L
C
S
Site 152
S1181
N
I
Q
P
D
K
D
S
A
H
K
E
G
A
M
Site 153
T1189
A
H
K
E
G
A
M
T
V
E
T
H
E
A
L
Site 154
S1197
V
E
T
H
E
A
L
S
F
L
P
G
L
K
D
Site 155
S1205
F
L
P
G
L
K
D
S
F
E
A
E
N
E
V
Site 156
S1225
R
I
N
E
A
E
N
S
A
P
K
P
V
L
Y
Site 157
Y1232
S
A
P
K
P
V
L
Y
P
P
S
A
E
Y
A
Site 158
S1235
K
P
V
L
Y
P
P
S
A
E
Y
A
T
T
S
Site 159
Y1238
L
Y
P
P
S
A
E
Y
A
T
T
S
P
L
E
Site 160
T1241
P
S
A
E
Y
A
T
T
S
P
L
E
T
E
_
Site 161
S1242
S
A
E
Y
A
T
T
S
P
L
E
T
E
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation