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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
COL6A6
Full Name:
Collagen alpha-6(VI) chain
Alias:
co6a6; collagen alpha-6; collagen type vi alpha 6; collagen, type VI, alpha 6
Type:
Mass (Da):
247170
Number AA:
UniProt ID:
A6NMZ7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005578
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
H
I
S
V
N
Q
D
S
G
P
E
Y
A
D
V
Site 2
Y25
N
Q
D
S
G
P
E
Y
A
D
V
V
F
L
V
Site 3
S34
D
V
V
F
L
V
D
S
S
D
R
L
G
S
K
Site 4
S40
D
S
S
D
R
L
G
S
K
S
F
P
F
V
K
Site 5
S42
S
D
R
L
G
S
K
S
F
P
F
V
K
M
F
Site 6
Y64
L
P
I
E
A
D
K
Y
R
V
A
L
A
Q
Y
Site 7
S72
R
V
A
L
A
Q
Y
S
D
K
L
H
S
E
F
Site 8
S82
L
H
S
E
F
H
L
S
T
F
K
G
R
S
P
Site 9
T83
H
S
E
F
H
L
S
T
F
K
G
R
S
P
M
Site 10
S88
L
S
T
F
K
G
R
S
P
M
L
N
H
L
R
Site 11
T117
A
L
Q
E
A
H
R
T
Y
F
S
A
P
A
N
Site 12
Y118
L
Q
E
A
H
R
T
Y
F
S
A
P
A
N
G
Site 13
T188
Q
F
H
F
N
L
R
T
V
R
D
L
S
M
F
Site 14
S193
L
R
T
V
R
D
L
S
M
F
S
Q
N
M
T
Site 15
S241
L
D
M
S
I
N
G
S
E
E
N
F
D
Y
L
Site 16
Y247
G
S
E
E
N
F
D
Y
L
K
G
F
L
E
E
Site 17
S257
G
F
L
E
E
S
V
S
A
L
D
I
K
E
N
Site 18
S274
R
V
G
L
V
A
Y
S
N
E
T
K
V
I
N
Site 19
S284
T
K
V
I
N
S
L
S
M
G
I
N
K
S
E
Site 20
S290
L
S
M
G
I
N
K
S
E
V
L
Q
H
I
Q
Site 21
S300
L
Q
H
I
Q
N
L
S
P
R
T
G
K
A
Y
Site 22
Y307
S
P
R
T
G
K
A
Y
T
G
A
A
I
K
K
Site 23
S321
K
L
R
K
E
V
F
S
A
R
N
G
S
R
K
Site 24
S326
V
F
S
A
R
N
G
S
R
K
N
Q
G
V
P
Site 25
T340
P
Q
I
A
V
L
V
T
H
R
D
S
E
D
N
Site 26
S344
V
L
V
T
H
R
D
S
E
D
N
V
T
K
A
Site 27
T349
R
D
S
E
D
N
V
T
K
A
A
V
N
L
R
Site 28
S371
T
L
G
I
E
G
A
S
D
T
Q
L
E
K
I
Site 29
T373
G
I
E
G
A
S
D
T
Q
L
E
K
I
A
S
Site 30
S380
T
Q
L
E
K
I
A
S
H
P
A
E
Q
Y
V
Site 31
Y386
A
S
H
P
A
E
Q
Y
V
S
K
L
K
T
F
Site 32
S388
H
P
A
E
Q
Y
V
S
K
L
K
T
F
A
D
Site 33
T392
Q
Y
V
S
K
L
K
T
F
A
D
L
A
A
H
Site 34
T402
D
L
A
A
H
N
Q
T
F
L
K
K
L
R
N
Site 35
T412
K
K
L
R
N
Q
I
T
H
T
V
S
V
F
S
Site 36
T414
L
R
N
Q
I
T
H
T
V
S
V
F
S
E
R
Site 37
S419
T
H
T
V
S
V
F
S
E
R
T
E
T
L
K
Site 38
T424
V
F
S
E
R
T
E
T
L
K
S
G
C
V
D
Site 39
S427
E
R
T
E
T
L
K
S
G
C
V
D
T
E
E
Site 40
Y438
D
T
E
E
A
D
I
Y
L
L
I
D
G
S
G
Site 41
T450
G
S
G
S
T
Q
A
T
D
F
H
E
M
K
T
Site 42
T457
T
D
F
H
E
M
K
T
F
L
S
E
V
V
G
Site 43
S483
G
A
V
Q
Y
A
D
S
W
D
L
E
F
E
I
Site 44
Y493
L
E
F
E
I
N
K
Y
S
N
K
Q
D
L
G
Site 45
T515
Q
M
G
G
N
T
N
T
G
A
A
L
N
F
T
Site 46
T545
P
C
H
L
V
V
L
T
N
G
M
S
K
D
S
Site 47
Y568
R
E
E
H
I
R
V
Y
A
I
G
I
K
E
A
Site 48
T578
G
I
K
E
A
N
Q
T
Q
L
R
E
I
A
G
Site 49
Y591
A
G
E
E
K
R
V
Y
Y
V
H
D
F
D
A
Site 50
Y592
G
E
E
K
R
V
Y
Y
V
H
D
F
D
A
L
Site 51
S639
S
I
G
P
E
N
F
S
K
M
K
T
F
M
K
Site 52
T643
E
N
F
S
K
M
K
T
F
M
K
N
L
V
S
Site 53
S650
T
F
M
K
N
L
V
S
K
S
Q
I
G
P
D
Site 54
S652
M
K
N
L
V
S
K
S
Q
I
G
P
D
R
V
Site 55
S667
Q
I
G
V
V
Q
F
S
D
I
N
K
E
E
F
Site 56
S681
F
Q
L
N
R
F
M
S
Q
S
D
I
S
N
A
Site 57
S683
L
N
R
F
M
S
Q
S
D
I
S
N
A
I
D
Site 58
S709
G
S
A
L
S
F
V
S
Q
Y
F
S
P
T
K
Site 59
S713
S
F
V
S
Q
Y
F
S
P
T
K
G
A
R
P
Site 60
T730
R
K
F
L
I
L
I
T
D
G
E
A
Q
D
I
Site 61
S760
Y
S
V
G
V
F
G
S
N
V
T
Q
L
E
E
Site 62
S769
V
T
Q
L
E
E
I
S
G
R
P
E
M
V
F
Site 63
S797
D
L
V
F
G
I
C
S
P
R
E
E
C
K
R
Site 64
Y822
D
S
S
G
S
I
D
Y
D
E
Y
N
I
M
K
Site 65
Y825
G
S
I
D
Y
D
E
Y
N
I
M
K
D
F
M
Site 66
Y862
D
D
P
E
V
L
F
Y
L
D
D
F
G
T
K
Site 67
S895
T
A
E
A
L
G
F
S
D
H
M
F
T
E
A
Site 68
T900
G
F
S
D
H
M
F
T
E
A
R
G
S
R
L
Site 69
S905
M
F
T
E
A
R
G
S
R
L
N
K
G
V
P
Site 70
Y966
M
A
G
S
S
D
K
Y
F
F
V
E
T
F
G
Site 71
S1010
F
L
M
D
G
S
T
S
I
Q
P
N
D
F
K
Site 72
S1045
R
I
G
A
A
Q
F
S
D
T
Y
H
P
E
F
Site 73
T1047
G
A
A
Q
F
S
D
T
Y
H
P
E
F
P
L
Site 74
Y1048
A
A
Q
F
S
D
T
Y
H
P
E
F
P
L
G
Site 75
T1056
H
P
E
F
P
L
G
T
F
I
G
E
K
E
I
Site 76
S1064
F
I
G
E
K
E
I
S
F
Q
I
E
N
I
K
Site 77
Y1089
A
L
R
E
V
E
H
Y
F
R
P
D
M
G
S
Site 78
S1096
Y
F
R
P
D
M
G
S
R
I
N
T
G
T
P
Site 79
T1100
D
M
G
S
R
I
N
T
G
T
P
Q
V
L
L
Site 80
T1110
P
Q
V
L
L
V
L
T
D
G
Q
S
Q
D
E
Site 81
S1114
L
V
L
T
D
G
Q
S
Q
D
E
V
A
Q
A
Site 82
Y1133
R
H
R
G
I
D
I
Y
S
V
G
I
G
D
V
Site 83
S1134
H
R
G
I
D
I
Y
S
V
G
I
G
D
V
D
Site 84
T1157
G
T
A
E
K
K
L
T
V
H
N
F
D
E
L
Site 85
S1195
V
V
V
G
F
D
V
S
T
Q
E
K
G
Q
T
Site 86
T1196
V
V
G
F
D
V
S
T
Q
E
K
G
Q
T
L
Site 87
T1202
S
T
Q
E
K
G
Q
T
L
L
E
G
Q
P
W
Site 88
Y1213
G
Q
P
W
M
E
T
Y
L
Q
D
I
L
R
A
Site 89
Y1250
V
T
N
A
M
E
K
Y
S
P
K
F
E
I
Y
Site 90
S1251
T
N
A
M
E
K
Y
S
P
K
F
E
I
Y
S
Site 91
S1258
S
P
K
F
E
I
Y
S
E
N
I
L
N
S
L
Site 92
S1264
Y
S
E
N
I
L
N
S
L
K
D
I
T
V
K
Site 93
S1283
L
N
A
N
L
L
D
S
L
W
D
T
F
Q
N
Site 94
T1287
L
L
D
S
L
W
D
T
F
Q
N
K
S
A
A
Site 95
S1292
W
D
T
F
Q
N
K
S
A
A
R
G
K
V
V
Site 96
S1317
V
E
K
L
E
Q
K
S
D
E
L
R
K
E
G
Site 97
S1340
L
D
G
P
A
D
S
S
D
L
A
D
L
P
Y
Site 98
Y1347
S
D
L
A
D
L
P
Y
I
E
F
G
K
G
F
Site 99
Y1356
E
F
G
K
G
F
E
Y
R
T
Q
L
S
I
G
Site 100
T1358
G
K
G
F
E
Y
R
T
Q
L
S
I
G
M
R
Site 101
S1372
R
E
L
G
S
R
L
S
K
Q
L
V
N
V
A
Site 102
T1396
K
C
I
G
G
D
G
T
M
G
D
P
G
P
P
Site 103
S1414
G
P
P
G
F
K
G
S
E
G
Y
L
G
E
E
Site 104
Y1417
G
F
K
G
S
E
G
Y
L
G
E
E
G
I
A
Site 105
Y1442
E
Q
G
T
K
G
C
Y
G
T
K
G
P
K
G
Site 106
T1444
G
T
K
G
C
Y
G
T
K
G
P
K
G
N
R
Site 107
S1489
G
E
K
G
D
E
G
S
Q
G
S
P
G
K
R
Site 108
S1492
G
D
E
G
S
Q
G
S
P
G
K
R
G
T
P
Site 109
T1498
G
S
P
G
K
R
G
T
P
G
D
R
G
A
K
Site 110
S1518
P
G
A
P
G
V
D
S
S
I
E
G
P
T
G
Site 111
S1519
G
A
P
G
V
D
S
S
I
E
G
P
T
G
L
Site 112
T1544
G
W
P
G
P
P
G
T
P
G
S
R
R
K
T
Site 113
S1547
G
P
P
G
T
P
G
S
R
R
K
T
A
A
H
Site 114
T1551
T
P
G
S
R
R
K
T
A
A
H
G
R
R
G
Site 115
T1560
A
H
G
R
R
G
H
T
G
P
Q
G
T
A
G
Site 116
S1577
G
P
D
G
L
E
G
S
L
G
L
K
G
P
Q
Site 117
S1601
G
E
K
G
G
V
G
S
K
G
P
Q
G
P
P
Site 118
S1622
G
N
Q
G
R
L
G
S
Q
G
N
K
G
E
P
Site 119
S1652
G
L
Q
G
N
D
G
S
P
G
Y
G
S
V
G
Site 120
Y1655
G
N
D
G
S
P
G
Y
G
S
V
G
R
K
G
Site 121
S1657
D
G
S
P
G
Y
G
S
V
G
R
K
G
A
K
Site 122
S1699
G
A
R
G
K
M
I
S
A
G
L
P
G
E
M
Site 123
S1708
G
L
P
G
E
M
G
S
P
G
E
P
G
P
P
Site 124
Y1737
S
T
C
E
L
I
Q
Y
V
R
D
R
S
P
G
Site 125
S1742
I
Q
Y
V
R
D
R
S
P
G
R
H
G
K
P
Site 126
S1765
L
V
F
A
L
D
H
S
R
D
V
T
E
Q
E
Site 127
T1769
L
D
H
S
R
D
V
T
E
Q
E
F
E
R
M
Site 128
S1793
D
I
K
V
R
E
N
S
C
P
V
G
A
H
I
Site 129
S1804
G
A
H
I
A
I
L
S
Y
N
S
H
A
R
H
Site 130
Y1805
A
H
I
A
I
L
S
Y
N
S
H
A
R
H
L
Site 131
S1816
A
R
H
L
V
R
F
S
D
A
Y
K
K
S
Q
Site 132
Y1819
L
V
R
F
S
D
A
Y
K
K
S
Q
L
L
R
Site 133
S1822
F
S
D
A
Y
K
K
S
Q
L
L
R
E
I
E
Site 134
Y1833
R
E
I
E
T
I
P
Y
E
R
S
S
A
S
R
Site 135
S1836
E
T
I
P
Y
E
R
S
S
A
S
R
E
I
G
Site 136
S1837
T
I
P
Y
E
R
S
S
A
S
R
E
I
G
R
Site 137
S1850
G
R
A
M
R
F
I
S
R
N
V
F
K
R
T
Site 138
T1868
A
H
T
R
K
I
A
T
F
F
S
S
G
Q
S
Site 139
S1871
R
K
I
A
T
F
F
S
S
G
Q
S
A
D
A
Site 140
S1875
T
F
F
S
S
G
Q
S
A
D
A
H
S
I
T
Site 141
S1880
G
Q
S
A
D
A
H
S
I
T
T
A
A
M
E
Site 142
Y1943
L
Q
R
C
T
F
C
Y
D
V
C
K
P
D
A
Site 143
S1962
A
R
P
P
P
V
Q
S
Y
M
D
A
A
F
L
Site 144
T1998
L
L
D
H
F
E
I
T
P
E
P
E
T
S
V
Site 145
S2004
I
T
P
E
P
E
T
S
V
T
G
D
R
V
A
Site 146
T2006
P
E
P
E
T
S
V
T
G
D
R
V
A
L
L
Site 147
T2024
P
P
D
F
L
P
N
T
Q
K
S
P
V
R
A
Site 148
S2027
F
L
P
N
T
Q
K
S
P
V
R
A
E
F
N
Site 149
T2036
V
R
A
E
F
N
L
T
T
Y
R
S
K
R
L
Site 150
T2037
R
A
E
F
N
L
T
T
Y
R
S
K
R
L
M
Site 151
Y2038
A
E
F
N
L
T
T
Y
R
S
K
R
L
M
K
Site 152
S2040
F
N
L
T
T
Y
R
S
K
R
L
M
K
R
H
Site 153
S2051
M
K
R
H
V
H
E
S
V
K
Q
L
N
G
D
Site 154
S2075
T
L
D
N
V
F
L
S
T
P
N
L
R
R
N
Site 155
T2076
L
D
N
V
F
L
S
T
P
N
L
R
R
N
K
Site 156
S2105
G
E
I
L
K
K
E
S
L
R
A
K
C
Q
G
Site 157
S2134
K
E
L
E
D
L
A
S
H
P
L
D
H
H
L
Site 158
S2153
R
I
H
K
P
D
H
S
Y
G
V
K
F
V
K
Site 159
Y2154
I
H
K
P
D
H
S
Y
G
V
K
F
V
K
S
Site 160
S2161
Y
G
V
K
F
V
K
S
F
I
N
S
I
R
R
Site 161
S2165
F
V
K
S
F
I
N
S
I
R
R
A
I
N
K
Site 162
Y2173
I
R
R
A
I
N
K
Y
P
P
I
N
L
K
I
Site 163
S2187
I
K
C
N
R
L
N
S
I
D
P
K
Q
P
P
Site 164
S2199
Q
P
P
R
P
F
R
S
F
V
P
G
P
L
K
Site 165
Y2225
K
F
F
Q
D
K
K
Y
L
S
R
V
A
R
S
Site 166
S2227
F
Q
D
K
K
Y
L
S
R
V
A
R
S
G
R
Site 167
S2232
Y
L
S
R
V
A
R
S
G
R
D
D
A
I
Q
Site 168
S2246
Q
N
F
M
R
S
T
S
H
T
F
K
N
G
R
Site 169
T2248
F
M
R
S
T
S
H
T
F
K
N
G
R
M
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation