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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP27X
Full Name:
Ubiquitin carboxyl-terminal hydrolase 27
Alias:
Deubiquitinating enzyme 27;Ubiquitin carboxyl-terminal hydrolase 22-like;Ubiquitin thiolesterase 27;Ubiquitin-specific-processing protease 27;X-linked ubiquitin carboxyl-terminal hydrolase 27
Type:
Mass (Da):
49630
Number AA:
438
UniProt ID:
A6NNY8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S28
E
A
L
K
L
Q
A
S
T
S
T
E
V
S
H
Site 2
S30
L
K
L
Q
A
S
T
S
T
E
V
S
H
Q
Q
Site 3
S34
A
S
T
S
T
E
V
S
H
Q
Q
C
S
V
P
Site 4
S39
E
V
S
H
Q
Q
C
S
V
P
G
L
G
E
K
Site 5
T49
G
L
G
E
K
F
P
T
W
E
T
T
K
P
E
Site 6
T70
N
P
R
R
R
R
I
T
S
S
F
T
I
G
L
Site 7
S71
P
R
R
R
R
I
T
S
S
F
T
I
G
L
R
Site 8
S72
R
R
R
R
I
T
S
S
F
T
I
G
L
R
G
Site 9
S117
R
H
R
C
E
M
P
S
P
E
L
C
L
V
C
Site 10
Y134
S
S
L
F
R
E
L
Y
S
G
N
P
S
P
H
Site 11
S135
S
L
F
R
E
L
Y
S
G
N
P
S
P
H
V
Site 12
S139
E
L
Y
S
G
N
P
S
P
H
V
P
Y
K
L
Site 13
Y160
H
A
R
H
L
A
G
Y
R
Q
Q
D
A
H
E
Site 14
T238
L
D
L
P
G
S
C
T
S
F
W
P
M
S
P
Site 15
S239
D
L
P
G
S
C
T
S
F
W
P
M
S
P
G
Site 16
S244
C
T
S
F
W
P
M
S
P
G
R
E
S
S
V
Site 17
S249
P
M
S
P
G
R
E
S
S
V
N
G
E
S
H
Site 18
S250
M
S
P
G
R
E
S
S
V
N
G
E
S
H
I
Site 19
S255
E
S
S
V
N
G
E
S
H
I
P
G
I
T
T
Site 20
T262
S
H
I
P
G
I
T
T
L
T
D
C
L
R
R
Site 21
T271
T
D
C
L
R
R
F
T
R
P
E
H
L
G
S
Site 22
S278
T
R
P
E
H
L
G
S
S
A
K
I
K
C
G
Site 23
S286
S
A
K
I
K
C
G
S
C
Q
S
Y
Q
E
S
Site 24
S289
I
K
C
G
S
C
Q
S
Y
Q
E
S
T
K
Q
Site 25
Y290
K
C
G
S
C
Q
S
Y
Q
E
S
T
K
Q
L
Site 26
S293
S
C
Q
S
Y
Q
E
S
T
K
Q
L
T
M
N
Site 27
T324
A
K
Q
R
R
K
I
T
T
Y
I
S
F
P
L
Site 28
T325
K
Q
R
R
K
I
T
T
Y
I
S
F
P
L
E
Site 29
Y326
Q
R
R
K
I
T
T
Y
I
S
F
P
L
E
L
Site 30
S328
R
K
I
T
T
Y
I
S
F
P
L
E
L
D
M
Site 31
S342
M
T
P
F
M
A
S
S
K
E
S
R
M
N
G
Site 32
S345
F
M
A
S
S
K
E
S
R
M
N
G
Q
L
Q
Site 33
S357
Q
L
Q
L
P
T
N
S
G
N
N
E
N
K
Y
Site 34
Y364
S
G
N
N
E
N
K
Y
S
L
F
A
V
V
N
Site 35
Y381
G
T
L
E
S
G
H
Y
T
S
F
I
R
H
H
Site 36
T382
T
L
E
S
G
H
Y
T
S
F
I
R
H
H
K
Site 37
S383
L
E
S
G
H
Y
T
S
F
I
R
H
H
K
D
Site 38
Y418
S
E
G
Y
L
L
F
Y
H
K
Q
V
L
E
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation