KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
TTLL8
Full Name:
Protein monoglycylase TTLL8
Alias:
Ttll8; Tubulin tyrosine ligase-like family, member 8
Type:
Uncharacterized protein
Mass (Da):
90756
Number AA:
814
UniProt ID:
A6PVC2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0035085
GO:0005737
GO:0005874
Uniprot
OncoNet
Molecular Function:
GO:0070736
GO:0004835
PhosphoSite+
KinaseNET
Biological Process:
GO:0018094
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
R
L
L
D
G
K
Q
T
S
R
Y
S
E
N
A
Site 2
S10
L
L
D
G
K
Q
T
S
R
Y
S
E
N
A
C
Site 3
Y12
D
G
K
Q
T
S
R
Y
S
E
N
A
C
E
K
Site 4
S13
G
K
Q
T
S
R
Y
S
E
N
A
C
E
K
K
Site 5
T66
G
A
R
V
N
D
D
T
C
A
K
V
K
E
N
Site 6
Y98
L
V
K
N
E
M
P
Y
L
L
W
T
I
K
R
Site 7
Y110
I
K
R
D
I
I
D
Y
H
S
L
T
Y
D
Q
Site 8
S127
N
H
Y
A
K
T
A
S
F
T
T
K
I
G
L
Site 9
Y144
N
M
R
S
L
P
W
Y
V
P
A
N
P
D
S
Site 10
Y157
D
S
F
F
P
R
C
Y
S
L
C
T
E
S
E
Site 11
S158
S
F
F
P
R
C
Y
S
L
C
T
E
S
E
Q
Site 12
T175
F
L
E
D
F
R
R
T
M
A
S
S
I
L
K
Site 13
S186
S
I
L
K
W
V
V
S
H
Q
S
C
S
R
S
Site 14
S189
K
W
V
V
S
H
Q
S
C
S
R
S
S
R
S
Site 15
S191
V
V
S
H
Q
S
C
S
R
S
S
R
S
K
P
Site 16
S193
S
H
Q
S
C
S
R
S
S
R
S
K
P
R
D
Site 17
S194
H
Q
S
C
S
R
S
S
R
S
K
P
R
D
Q
Site 18
S196
S
C
S
R
S
S
R
S
K
P
R
D
Q
R
E
Site 19
S207
D
Q
R
E
E
A
G
S
S
D
L
S
S
R
Q
Site 20
S208
Q
R
E
E
A
G
S
S
D
L
S
S
R
Q
D
Site 21
S211
E
A
G
S
S
D
L
S
S
R
Q
D
A
E
N
Site 22
S212
A
G
S
S
D
L
S
S
R
Q
D
A
E
N
A
Site 23
Y241
A
C
K
V
C
Q
A
Y
L
G
Q
L
E
H
E
Site 24
T252
L
E
H
E
D
I
D
T
S
A
D
A
V
E
D
Site 25
S253
E
H
E
D
I
D
T
S
A
D
A
V
E
D
L
Site 26
T261
A
D
A
V
E
D
L
T
E
A
E
W
E
D
L
Site 27
T269
E
A
E
W
E
D
L
T
Q
Q
Y
Y
S
L
V
Site 28
Y272
W
E
D
L
T
Q
Q
Y
Y
S
L
V
H
G
D
Site 29
Y273
E
D
L
T
Q
Q
Y
Y
S
L
V
H
G
D
A
Site 30
S283
V
H
G
D
A
F
I
S
N
S
R
N
Y
F
S
Site 31
Y288
F
I
S
N
S
R
N
Y
F
S
Q
C
Q
A
L
Site 32
S290
S
N
S
R
N
Y
F
S
Q
C
Q
A
L
L
N
Site 33
T300
Q
A
L
L
N
R
I
T
S
V
N
P
Q
T
D
Site 34
S301
A
L
L
N
R
I
T
S
V
N
P
Q
T
D
I
Site 35
T306
I
T
S
V
N
P
Q
T
D
I
D
G
L
R
N
Site 36
S323
I
I
K
P
A
A
K
S
R
G
R
D
I
V
C
Site 37
S348
A
A
A
D
H
P
L
S
R
D
N
K
W
V
V
Site 38
Y389
N
P
L
T
I
W
F
Y
K
E
S
Y
L
R
F
Site 39
Y393
I
W
F
Y
K
E
S
Y
L
R
F
S
T
Q
R
Site 40
S397
K
E
S
Y
L
R
F
S
T
Q
R
F
S
L
D
Site 41
T398
E
S
Y
L
R
F
S
T
Q
R
F
S
L
D
K
Site 42
S402
R
F
S
T
Q
R
F
S
L
D
K
L
D
S
A
Site 43
S408
F
S
L
D
K
L
D
S
A
I
H
L
C
N
N
Site 44
Y420
C
N
N
A
V
Q
K
Y
L
K
N
D
V
G
R
Site 45
S428
L
K
N
D
V
G
R
S
P
L
L
P
A
H
N
Site 46
Y445
T
S
T
R
F
Q
E
Y
L
Q
R
Q
G
R
G
Site 47
S457
G
R
G
A
V
W
G
S
V
I
Y
P
S
M
K
Site 48
S484
H
V
E
P
R
K
N
S
F
E
L
Y
G
A
D
Site 49
Y488
R
K
N
S
F
E
L
Y
G
A
D
F
V
L
G
Site 50
S507
P
W
L
I
E
I
N
S
S
P
T
M
H
P
S
Site 51
S508
W
L
I
E
I
N
S
S
P
T
M
H
P
S
T
Site 52
T510
I
E
I
N
S
S
P
T
M
H
P
S
T
P
V
Site 53
S514
S
S
P
T
M
H
P
S
T
P
V
T
A
Q
L
Site 54
T515
S
P
T
M
H
P
S
T
P
V
T
A
Q
L
C
Site 55
S568
D
L
C
V
A
G
V
S
V
R
R
A
R
R
Q
Site 56
S600
P
L
K
A
R
G
P
S
A
M
P
D
P
A
Q
Site 57
S611
D
P
A
Q
G
P
P
S
P
A
L
Q
R
D
L
Site 58
S640
P
L
R
G
A
A
E
S
G
G
A
A
Q
P
T
Site 59
S667
C
P
C
R
H
V
D
S
Q
A
P
N
T
G
V
Site 60
T672
V
D
S
Q
A
P
N
T
G
V
P
V
A
Q
P
Site 61
S682
P
V
A
Q
P
A
K
S
W
D
P
N
Q
L
N
Site 62
T702
P
V
L
R
G
L
K
T
A
E
G
A
L
R
P
Site 63
T718
P
G
G
K
G
E
G
T
V
C
S
R
L
P
H
Site 64
S721
K
G
E
G
T
V
C
S
R
L
P
H
H
G
H
Site 65
S808
F
V
R
L
G
G
R
S
C
S
P
R
T
P
_
Site 66
S810
R
L
G
G
R
S
C
S
P
R
T
P
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation