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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MYH7B
Full Name:
Myosin-7B
Alias:
Myosin heavy chain 7B, cardiac muscle beta isoform
Type:
Mass (Da):
221371
Number AA:
1941
UniProt ID:
A7E2Y1
International Prot ID:
IPI00642716
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005859
GO:0005863
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003774
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
GO:0003008
GO:0003012
GO:0006936
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
D
V
S
E
L
G
E
S
A
R
Y
L
R
Q
G
Site 2
Y13
E
L
G
E
S
A
R
Y
L
R
Q
G
Y
Q
E
Site 3
Y18
A
R
Y
L
R
Q
G
Y
Q
E
M
T
K
V
H
Site 4
Y44
V
P
D
E
Q
D
A
Y
V
E
A
E
V
K
S
Site 5
T59
E
A
T
G
G
R
V
T
V
E
T
K
D
Q
K
Site 6
T62
G
G
R
V
T
V
E
T
K
D
Q
K
V
L
M
Site 7
Y108
L
H
N
L
R
Q
R
Y
A
R
W
M
I
Y
T
Site 8
S147
A
Y
K
G
K
R
R
S
D
S
P
P
H
I
Y
Site 9
S149
K
G
K
R
R
S
D
S
P
P
H
I
Y
A
V
Site 10
Y154
S
D
S
P
P
H
I
Y
A
V
A
D
N
A
Y
Site 11
Y161
Y
A
V
A
D
N
A
Y
N
D
M
L
R
N
R
Site 12
S172
L
R
N
R
D
N
Q
S
M
L
I
T
G
E
S
Site 13
T176
D
N
Q
S
M
L
I
T
G
E
S
G
A
G
K
Site 14
S179
S
M
L
I
T
G
E
S
G
A
G
K
T
V
N
Site 15
T184
G
E
S
G
A
G
K
T
V
N
T
K
R
V
I
Site 16
T187
G
A
G
K
T
V
N
T
K
R
V
I
Q
Y
F
Site 17
T238
E
A
F
G
N
A
K
T
L
R
N
D
N
S
S
Site 18
S244
K
T
L
R
N
D
N
S
S
R
F
G
K
F
I
Site 19
S245
T
L
R
N
D
N
S
S
R
F
G
K
F
I
R
Site 20
S263
G
P
S
G
K
L
A
S
A
D
I
D
S
Y
L
Site 21
S268
L
A
S
A
D
I
D
S
Y
L
L
E
K
S
R
Site 22
Y269
A
S
A
D
I
D
S
Y
L
L
E
K
S
R
V
Site 23
S274
D
S
Y
L
L
E
K
S
R
V
I
F
Q
L
P
Site 24
Y286
Q
L
P
G
E
R
S
Y
H
V
Y
Y
Q
I
L
Site 25
Y289
G
E
R
S
Y
H
V
Y
Y
Q
I
L
S
G
R
Site 26
Y290
E
R
S
Y
H
V
Y
Y
Q
I
L
S
G
R
K
Site 27
S294
H
V
Y
Y
Q
I
L
S
G
R
K
P
E
L
Q
Site 28
Y311
L
L
L
S
M
N
P
Y
D
Y
H
F
C
S
Q
Site 29
Y313
L
S
M
N
P
Y
D
Y
H
F
C
S
Q
G
V
Site 30
T335
D
G
E
E
L
I
A
T
D
H
A
M
D
I
L
Site 31
T381
E
Q
A
E
A
D
G
T
E
S
A
D
K
A
A
Site 32
Y389
E
S
A
D
K
A
A
Y
L
M
G
V
S
S
G
Site 33
Y413
R
V
R
V
G
N
E
Y
V
T
K
G
Q
S
V
Site 34
T415
R
V
G
N
E
Y
V
T
K
G
Q
S
V
E
Q
Site 35
Y435
G
A
L
A
K
A
T
Y
D
R
L
F
R
W
L
Site 36
T452
R
I
N
Q
T
L
D
T
K
L
P
R
Q
F
F
Site 37
T484
E
Q
L
C
I
N
F
T
N
E
K
L
Q
Q
F
Site 38
Y504
F
V
L
E
Q
E
E
Y
K
R
E
G
I
D
W
Site 39
S547
E
C
M
F
P
K
A
S
D
A
S
F
R
A
K
Site 40
S550
F
P
K
A
S
D
A
S
F
R
A
K
L
Y
D
Site 41
Y556
A
S
F
R
A
K
L
Y
D
N
H
A
G
K
S
Site 42
S563
Y
D
N
H
A
G
K
S
P
N
F
Q
Q
P
R
Site 43
Y577
R
P
D
K
K
R
K
Y
Q
A
H
F
E
V
V
Site 44
T608
N
K
D
P
L
N
E
T
V
V
P
I
F
Q
K
Site 45
Y625
N
R
L
L
A
T
L
Y
E
N
Y
A
G
S
C
Site 46
Y628
L
A
T
L
Y
E
N
Y
A
G
S
C
S
T
E
Site 47
S633
E
N
Y
A
G
S
C
S
T
E
P
P
K
S
G
Site 48
T634
N
Y
A
G
S
C
S
T
E
P
P
K
S
G
V
Site 49
S639
C
S
T
E
P
P
K
S
G
V
K
E
K
R
K
Site 50
S650
E
K
R
K
K
A
A
S
F
Q
T
V
S
Q
L
Site 51
S655
A
A
S
F
Q
T
V
S
Q
L
H
K
E
N
L
Site 52
T667
E
N
L
N
K
L
M
T
N
L
R
A
T
Q
P
Site 53
T672
L
M
T
N
L
R
A
T
Q
P
H
F
V
R
C
Site 54
T687
I
V
P
N
E
N
K
T
P
G
V
M
D
A
F
Site 55
Y722
G
F
P
N
R
L
L
Y
T
D
F
R
Q
R
Y
Site 56
Y729
Y
T
D
F
R
Q
R
Y
R
I
L
N
P
S
A
Site 57
S735
R
Y
R
I
L
N
P
S
A
I
P
D
D
T
F
Site 58
T741
P
S
A
I
P
D
D
T
F
M
D
S
R
K
A
Site 59
S745
P
D
D
T
F
M
D
S
R
K
A
T
E
K
L
Site 60
T749
F
M
D
S
R
K
A
T
E
K
L
L
G
S
L
Site 61
T761
G
S
L
D
L
D
H
T
Q
Y
Q
F
G
H
T
Site 62
Y763
L
D
L
D
H
T
Q
Y
Q
F
G
H
T
K
V
Site 63
T793
Q
R
L
A
K
V
L
T
L
L
Q
A
R
S
R
Site 64
S799
L
T
L
L
Q
A
R
S
R
G
R
L
M
R
L
Site 65
Y808
G
R
L
M
R
L
E
Y
Q
R
L
L
G
G
R
Site 66
T883
K
R
Q
E
L
E
E
T
H
V
S
I
T
Q
E
Site 67
S886
E
L
E
E
T
H
V
S
I
T
Q
E
K
N
D
Site 68
S918
R
C
H
L
L
I
K
S
K
V
Q
L
E
G
K
Site 69
S930
E
G
K
V
K
E
L
S
E
R
L
E
D
E
E
Site 70
T955
R
K
L
E
D
E
C
T
E
L
K
K
D
I
D
Site 71
T978
A
E
K
E
K
Q
A
T
E
N
K
V
K
N
L
Site 72
S995
E
M
A
A
L
D
E
S
V
A
R
L
T
K
E
Site 73
T1000
D
E
S
V
A
R
L
T
K
E
K
K
A
L
Q
Site 74
S1025
Q
A
E
E
D
R
V
S
A
L
T
K
A
K
L
Site 75
T1028
E
D
R
V
S
A
L
T
K
A
K
L
R
L
E
Site 76
T1055
E
K
K
L
R
M
D
T
E
R
A
K
R
K
L
Site 77
S1072
D
L
K
L
T
Q
E
S
V
A
D
A
A
Q
D
Site 78
S1092
E
K
L
K
K
K
D
S
E
L
S
Q
L
S
L
Site 79
S1095
K
K
K
D
S
E
L
S
Q
L
S
L
R
V
E
Site 80
S1098
D
S
E
L
S
Q
L
S
L
R
V
E
D
E
Q
Site 81
S1154
A
R
E
L
E
E
L
S
E
R
L
E
E
A
G
Site 82
T1195
A
A
L
R
H
E
A
T
V
A
A
L
R
R
K
Site 83
S1216
E
L
G
E
Q
V
D
S
L
Q
R
V
R
Q
K
Site 84
S1229
Q
K
L
E
K
E
K
S
E
L
R
M
E
V
D
Site 85
T1258
S
A
E
K
L
C
R
T
Y
E
D
Q
L
S
E
Site 86
Y1259
A
E
K
L
C
R
T
Y
E
D
Q
L
S
E
A
Site 87
S1264
R
T
Y
E
D
Q
L
S
E
A
K
I
K
V
E
Site 88
T1282
R
Q
L
A
D
A
S
T
Q
R
G
R
L
Q
T
Site 89
T1289
T
Q
R
G
R
L
Q
T
E
S
G
E
L
S
R
Site 90
S1291
R
G
R
L
Q
T
E
S
G
E
L
S
R
L
L
Site 91
S1295
Q
T
E
S
G
E
L
S
R
L
L
E
E
K
E
Site 92
S1306
E
E
K
E
C
L
I
S
Q
L
S
R
G
K
A
Site 93
S1330
R
R
Q
L
E
E
E
S
K
A
K
S
A
L
A
Site 94
S1334
E
E
E
S
K
A
K
S
A
L
A
H
A
V
Q
Site 95
S1369
A
E
L
Q
R
L
L
S
K
A
N
A
E
V
A
Site 96
Y1382
V
A
Q
W
R
S
K
Y
E
A
D
A
I
Q
R
Site 97
T1430
K
A
K
L
R
L
Q
T
E
S
E
D
V
T
L
Site 98
S1432
K
L
R
L
Q
T
E
S
E
D
V
T
L
E
L
Site 99
T1436
Q
T
E
S
E
D
V
T
L
E
L
E
R
A
T
Site 100
S1444
L
E
L
E
R
A
T
S
A
A
A
A
L
D
K
Site 101
S1481
L
E
A
A
Q
R
E
S
R
G
L
G
T
E
L
Site 102
T1504
E
A
L
E
A
L
E
T
L
K
R
E
N
K
N
Site 103
S1517
K
N
L
Q
E
E
I
S
D
L
T
D
Q
V
S
Site 104
T1520
Q
E
E
I
S
D
L
T
D
Q
V
S
L
S
G
Site 105
S1524
S
D
L
T
D
Q
V
S
L
S
G
K
S
I
Q
Site 106
S1526
L
T
D
Q
V
S
L
S
G
K
S
I
Q
E
L
Site 107
T1536
S
I
Q
E
L
E
K
T
K
K
A
L
E
G
E
Site 108
S1545
K
A
L
E
G
E
K
S
E
I
Q
A
A
L
E
Site 109
T1563
G
A
L
E
L
E
E
T
K
T
L
R
I
Q
L
Site 110
T1565
L
E
L
E
E
T
K
T
L
R
I
Q
L
E
L
Site 111
S1573
L
R
I
Q
L
E
L
S
Q
V
K
A
E
V
D
Site 112
S1603
N
H
Q
R
A
V
E
S
L
Q
A
S
L
D
A
Site 113
S1607
A
V
E
S
L
Q
A
S
L
D
A
E
T
R
A
Site 114
T1644
G
H
A
T
R
Q
A
T
E
A
Q
A
A
T
R
Site 115
S1686
Q
A
L
E
R
R
A
S
L
L
A
A
E
L
E
Site 116
S1725
E
R
L
N
L
L
H
S
Q
N
T
G
L
L
N
Site 117
S1745
E
A
D
L
A
Q
L
S
G
E
V
E
E
A
A
Site 118
S1783
L
K
K
E
Q
D
T
S
A
H
L
E
R
M
K
Site 119
T1796
M
K
K
T
L
E
Q
T
V
R
E
L
Q
A
R
Site 120
Y1859
R
R
V
K
E
L
A
Y
Q
A
E
E
D
R
K
Site 121
S1880
D
L
V
D
K
L
Q
S
K
V
K
S
Y
K
R
Site 122
S1884
K
L
Q
S
K
V
K
S
Y
K
R
Q
F
E
E
Site 123
Y1885
L
Q
S
K
V
K
S
Y
K
R
Q
F
E
E
A
Site 124
T1931
A
N
K
L
R
A
R
T
R
D
A
L
G
P
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation