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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RICS
Full Name:
Rho GTPase-activating protein 32
Alias:
Brain-specific Rho GTPase-activating protein; GAB-associated Cdc42/Rac GTPase-activating protein; GC-GAP; GRIT; GTPase regulator interacting with TrkA; KIAA0712; P200RhoGAP; P250GAP; RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling
Type:
GTPase-activating protein for G protein
Mass (Da):
230529
Number AA:
2087
UniProt ID:
A7KAX9
International Prot ID:
IPI00334294
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000139
GO:0005938
GO:0030054
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0035091
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
E
T
E
S
E
S
S
T
L
G
D
Site 2
S8
M
E
T
E
S
E
S
S
T
L
G
D
D
S
V
Site 3
T9
E
T
E
S
E
S
S
T
L
G
D
D
S
V
F
Site 4
S14
S
S
T
L
G
D
D
S
V
F
W
L
E
S
E
Site 5
S43
E
K
F
R
K
M
K
S
S
V
H
S
E
E
D
Site 6
S44
K
F
R
K
M
K
S
S
V
H
S
E
E
D
D
Site 7
S47
K
M
K
S
S
V
H
S
E
E
D
D
F
V
P
Site 8
S73
P
D
W
E
E
T
L
S
A
M
A
R
G
A
D
Site 9
T89
P
E
I
P
G
D
L
T
L
K
T
C
G
S
T
Site 10
T92
P
G
D
L
T
L
K
T
C
G
S
T
A
S
M
Site 11
S98
K
T
C
G
S
T
A
S
M
K
V
K
H
V
K
Site 12
T110
H
V
K
K
L
P
F
T
K
G
H
F
P
K
M
Site 13
Y125
A
E
C
A
H
F
H
Y
E
N
V
E
F
G
S
Site 14
S132
Y
E
N
V
E
F
G
S
I
Q
L
S
L
S
E
Site 15
S136
E
F
G
S
I
Q
L
S
L
S
E
E
Q
N
E
Site 16
S138
G
S
I
Q
L
S
L
S
E
E
Q
N
E
V
M
Site 17
S172
K
S
W
I
V
K
R
S
Y
E
D
F
R
V
L
Site 18
Y173
S
W
I
V
K
R
S
Y
E
D
F
R
V
L
D
Site 19
Y188
K
H
L
H
L
C
I
Y
D
R
R
F
S
Q
L
Site 20
S193
C
I
Y
D
R
R
F
S
Q
L
S
E
L
P
R
Site 21
S196
D
R
R
F
S
Q
L
S
E
L
P
R
S
D
T
Site 22
S201
Q
L
S
E
L
P
R
S
D
T
L
K
D
S
P
Site 23
T203
S
E
L
P
R
S
D
T
L
K
D
S
P
E
S
Site 24
S207
R
S
D
T
L
K
D
S
P
E
S
V
T
Q
M
Site 25
S210
T
L
K
D
S
P
E
S
V
T
Q
M
L
M
A
Site 26
S254
H
L
L
V
H
E
E
S
S
I
N
T
P
A
V
Site 27
T258
H
E
E
S
S
I
N
T
P
A
V
G
A
A
H
Site 28
T271
A
H
V
I
K
R
Y
T
A
R
A
P
D
E
L
Site 29
S326
I
N
Q
K
V
P
Q
S
V
T
N
S
V
P
K
Site 30
S330
V
P
Q
S
V
T
N
S
V
P
K
P
V
S
K
Site 31
S336
N
S
V
P
K
P
V
S
K
K
H
G
K
L
I
Site 32
T344
K
K
H
G
K
L
I
T
F
L
R
T
F
M
K
Site 33
T348
K
L
I
T
F
L
R
T
F
M
K
S
R
P
T
Site 34
S352
F
L
R
T
F
M
K
S
R
P
T
K
Q
K
L
Site 35
T355
T
F
M
K
S
R
P
T
K
Q
K
L
K
Q
R
Site 36
S413
Y
R
L
S
G
V
A
S
N
I
Q
R
L
R
H
Site 37
S424
R
L
R
H
E
F
D
S
E
H
V
P
D
L
T
Site 38
T431
S
E
H
V
P
D
L
T
K
E
P
Y
V
Q
D
Site 39
Y435
P
D
L
T
K
E
P
Y
V
Q
D
I
H
S
V
Site 40
S444
Q
D
I
H
S
V
G
S
L
C
K
L
Y
F
R
Site 41
Y449
V
G
S
L
C
K
L
Y
F
R
E
L
P
N
P
Site 42
Y460
L
P
N
P
L
L
T
Y
Q
L
Y
E
K
F
S
Site 43
Y463
P
L
L
T
Y
Q
L
Y
E
K
F
S
D
A
V
Site 44
S467
Y
Q
L
Y
E
K
F
S
D
A
V
S
A
A
T
Site 45
S471
E
K
F
S
D
A
V
S
A
A
T
D
E
E
R
Site 46
Y494
Q
Q
L
P
P
P
H
Y
R
T
L
E
F
L
M
Site 47
T514
L
A
D
Y
C
S
I
T
N
M
H
A
K
N
L
Site 48
S532
W
A
P
N
L
L
R
S
K
Q
I
E
S
A
C
Site 49
S537
L
R
S
K
Q
I
E
S
A
C
F
S
G
T
A
Site 50
S581
A
M
Q
E
G
A
A
S
L
S
R
P
K
S
L
Site 51
S583
Q
E
G
A
A
S
L
S
R
P
K
S
L
L
V
Site 52
S587
A
S
L
S
R
P
K
S
L
L
V
S
S
P
S
Site 53
S591
R
P
K
S
L
L
V
S
S
P
S
T
K
L
L
Site 54
T595
L
L
V
S
S
P
S
T
K
L
L
T
L
E
E
Site 55
T599
S
P
S
T
K
L
L
T
L
E
E
A
Q
A
R
Site 56
S613
R
T
Q
A
Q
V
N
S
P
I
V
T
E
N
K
Site 57
T617
Q
V
N
S
P
I
V
T
E
N
K
Y
I
E
V
Site 58
Y621
P
I
V
T
E
N
K
Y
I
E
V
G
E
G
P
Site 59
T637
D
A
T
N
R
S
P
T
Q
I
V
K
M
K
T
Site 60
S655
P
Q
N
K
M
K
K
S
P
V
G
S
W
R
S
Site 61
S659
M
K
K
S
P
V
G
S
W
R
S
F
F
N
L
Site 62
S662
S
P
V
G
S
W
R
S
F
F
N
L
G
K
S
Site 63
S669
S
F
F
N
L
G
K
S
S
S
V
S
K
R
K
Site 64
S670
F
F
N
L
G
K
S
S
S
V
S
K
R
K
L
Site 65
S671
F
N
L
G
K
S
S
S
V
S
K
R
K
L
Q
Site 66
S673
L
G
K
S
S
S
V
S
K
R
K
L
Q
R
N
Site 67
S682
R
K
L
Q
R
N
E
S
E
P
S
E
M
K
A
Site 68
S685
Q
R
N
E
S
E
P
S
E
M
K
A
M
A
L
Site 69
T700
K
G
G
R
A
E
G
T
L
R
S
A
K
S
E
Site 70
S703
R
A
E
G
T
L
R
S
A
K
S
E
E
S
L
Site 71
S706
G
T
L
R
S
A
K
S
E
E
S
L
T
S
L
Site 72
S709
R
S
A
K
S
E
E
S
L
T
S
L
H
A
V
Site 73
T711
A
K
S
E
E
S
L
T
S
L
H
A
V
D
G
Site 74
S712
K
S
E
E
S
L
T
S
L
H
A
V
D
G
D
Site 75
S720
L
H
A
V
D
G
D
S
K
L
F
R
P
R
R
Site 76
S730
F
R
P
R
R
P
R
S
S
S
D
A
L
S
A
Site 77
S731
R
P
R
R
P
R
S
S
S
D
A
L
S
A
S
Site 78
S732
P
R
R
P
R
S
S
S
D
A
L
S
A
S
F
Site 79
S736
R
S
S
S
D
A
L
S
A
S
F
N
G
E
M
Site 80
S738
S
S
D
A
L
S
A
S
F
N
G
E
M
L
G
Site 81
S750
M
L
G
N
R
C
N
S
Y
D
N
L
P
H
D
Site 82
Y751
L
G
N
R
C
N
S
Y
D
N
L
P
H
D
N
Site 83
S760
N
L
P
H
D
N
E
S
E
E
E
G
G
L
L
Site 84
S777
P
A
L
M
S
P
H
S
A
E
D
V
D
L
S
Site 85
S784
S
A
E
D
V
D
L
S
P
P
D
I
G
V
A
Site 86
S792
P
P
D
I
G
V
A
S
L
D
F
D
P
M
S
Site 87
S799
S
L
D
F
D
P
M
S
F
Q
C
S
P
P
K
Site 88
S803
D
P
M
S
F
Q
C
S
P
P
K
A
E
S
E
Site 89
S809
C
S
P
P
K
A
E
S
E
C
L
E
S
G
A
Site 90
S814
A
E
S
E
C
L
E
S
G
A
S
F
L
D
S
Site 91
S817
E
C
L
E
S
G
A
S
F
L
D
S
P
G
Y
Site 92
S821
S
G
A
S
F
L
D
S
P
G
Y
S
K
D
K
Site 93
Y824
S
F
L
D
S
P
G
Y
S
K
D
K
P
S
A
Site 94
S825
F
L
D
S
P
G
Y
S
K
D
K
P
S
A
N
Site 95
S830
G
Y
S
K
D
K
P
S
A
N
K
K
D
A
E
Site 96
S841
K
D
A
E
T
G
S
S
Q
C
Q
T
P
G
S
Site 97
T845
T
G
S
S
Q
C
Q
T
P
G
S
T
A
S
S
Site 98
S848
S
Q
C
Q
T
P
G
S
T
A
S
S
E
P
V
Site 99
T849
Q
C
Q
T
P
G
S
T
A
S
S
E
P
V
S
Site 100
S851
Q
T
P
G
S
T
A
S
S
E
P
V
S
P
L
Site 101
S852
T
P
G
S
T
A
S
S
E
P
V
S
P
L
Q
Site 102
S856
T
A
S
S
E
P
V
S
P
L
Q
E
K
L
S
Site 103
S863
S
P
L
Q
E
K
L
S
P
F
F
T
L
D
L
Site 104
T867
E
K
L
S
P
F
F
T
L
D
L
S
P
T
E
Site 105
S871
P
F
F
T
L
D
L
S
P
T
E
D
K
S
S
Site 106
T873
F
T
L
D
L
S
P
T
E
D
K
S
S
K
P
Site 107
S877
L
S
P
T
E
D
K
S
S
K
P
S
S
F
T
Site 108
S878
S
P
T
E
D
K
S
S
K
P
S
S
F
T
E
Site 109
S882
D
K
S
S
K
P
S
S
F
T
E
K
V
V
Y
Site 110
Y889
S
F
T
E
K
V
V
Y
A
F
S
P
K
I
G
Site 111
S892
E
K
V
V
Y
A
F
S
P
K
I
G
R
K
L
Site 112
S900
P
K
I
G
R
K
L
S
K
S
P
S
M
S
I
Site 113
S902
I
G
R
K
L
S
K
S
P
S
M
S
I
S
E
Site 114
S904
R
K
L
S
K
S
P
S
M
S
I
S
E
P
I
Site 115
S906
L
S
K
S
P
S
M
S
I
S
E
P
I
S
V
Site 116
S908
K
S
P
S
M
S
I
S
E
P
I
S
V
T
L
Site 117
T914
I
S
E
P
I
S
V
T
L
P
P
R
V
S
E
Site 118
T925
R
V
S
E
V
I
G
T
V
S
N
T
T
A
Q
Site 119
S927
S
E
V
I
G
T
V
S
N
T
T
A
Q
N
A
Site 120
S937
T
A
Q
N
A
S
S
S
T
W
D
K
C
V
E
Site 121
T949
C
V
E
E
R
D
A
T
N
R
S
P
T
Q
I
Site 122
S952
E
R
D
A
T
N
R
S
P
T
Q
I
V
K
M
Site 123
T954
D
A
T
N
R
S
P
T
Q
I
V
K
M
K
T
Site 124
T964
V
K
M
K
T
N
E
T
V
A
Q
E
A
Y
E
Site 125
S972
V
A
Q
E
A
Y
E
S
E
V
Q
P
L
D
Q
Site 126
S994
L
P
G
K
E
D
Q
S
V
S
S
S
Q
S
K
Site 127
S996
G
K
E
D
Q
S
V
S
S
S
Q
S
K
A
V
Site 128
S998
E
D
Q
S
V
S
S
S
Q
S
K
A
V
A
S
Site 129
S1000
Q
S
V
S
S
S
Q
S
K
A
V
A
S
G
Q
Site 130
S1005
S
Q
S
K
A
V
A
S
G
Q
T
Q
T
G
A
Site 131
S1021
T
H
D
P
P
Q
D
S
V
P
V
S
S
V
S
Site 132
S1058
A
Q
Q
A
S
T
Q
S
L
K
R
P
G
T
S
Site 133
T1064
Q
S
L
K
R
P
G
T
S
Q
A
G
Y
T
N
Site 134
S1065
S
L
K
R
P
G
T
S
Q
A
G
Y
T
N
Y
Site 135
Y1069
P
G
T
S
Q
A
G
Y
T
N
Y
G
D
I
A
Site 136
T1079
Y
G
D
I
A
V
A
T
T
E
D
N
L
S
S
Site 137
S1085
A
T
T
E
D
N
L
S
S
S
Y
S
A
V
A
Site 138
S1087
T
E
D
N
L
S
S
S
Y
S
A
V
A
L
D
Site 139
Y1088
E
D
N
L
S
S
S
Y
S
A
V
A
L
D
K
Site 140
S1089
D
N
L
S
S
S
Y
S
A
V
A
L
D
K
A
Site 141
Y1097
A
V
A
L
D
K
A
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L
K
L
H
H
T
Q
N
V
E
R
D
P
Site 294
S2002
Q
N
V
E
R
D
P
S
V
L
Y
Q
Y
Q
P
Site 295
Y2005
E
R
D
P
S
V
L
Y
Q
Y
Q
P
H
G
K
Site 296
Y2007
D
P
S
V
L
Y
Q
Y
Q
P
H
G
K
R
Q
Site 297
S2015
Q
P
H
G
K
R
Q
S
S
V
T
V
V
S
Q
Site 298
S2016
P
H
G
K
R
Q
S
S
V
T
V
V
S
Q
Y
Site 299
T2018
G
K
R
Q
S
S
V
T
V
V
S
Q
Y
D
N
Site 300
S2021
Q
S
S
V
T
V
V
S
Q
Y
D
N
L
E
D
Site 301
Y2023
S
V
T
V
V
S
Q
Y
D
N
L
E
D
Y
H
Site 302
Y2029
Q
Y
D
N
L
E
D
Y
H
S
L
P
Q
H
Q
Site 303
S2031
D
N
L
E
D
Y
H
S
L
P
Q
H
Q
R
G
Site 304
T2047
F
G
G
G
G
M
G
T
Y
V
P
P
G
F
P
Site 305
Y2048
G
G
G
G
M
G
T
Y
V
P
P
G
F
P
H
Site 306
S2058
P
G
F
P
H
P
Q
S
R
T
Y
A
T
A
L
Site 307
Y2061
P
H
P
Q
S
R
T
Y
A
T
A
L
G
Q
G
Site 308
S2076
A
F
L
P
A
E
L
S
L
Q
H
P
E
T
Q
Site 309
T2082
L
S
L
Q
H
P
E
T
Q
I
H
A
E
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation