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Updated November 2019
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Protein Info
Short Name:
DISP2
Full Name:
Protein dispatched homolog 2
Alias:
dispatched 2; DISPB; HsT16908; KIAA1742
Type:
Membrane protein, integral
Mass (Da):
152000
Number AA:
UniProt ID:
A7MBM2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
D
G
D
S
S
S
S
S
G
G
S
Site 2
S6
_
_
M
D
G
D
S
S
S
S
S
G
G
S
G
Site 3
S7
_
M
D
G
D
S
S
S
S
S
G
G
S
G
P
Site 4
S8
M
D
G
D
S
S
S
S
S
G
G
S
G
P
A
Site 5
S9
D
G
D
S
S
S
S
S
G
G
S
G
P
A
P
Site 6
S12
S
S
S
S
S
G
G
S
G
P
A
P
G
P
G
Site 7
S37
P
L
A
P
D
G
G
S
P
D
S
T
Q
T
K
Site 8
S40
P
D
G
G
S
P
D
S
T
Q
T
K
A
V
P
Site 9
T41
D
G
G
S
P
D
S
T
Q
T
K
A
V
P
P
Site 10
S51
K
A
V
P
P
E
A
S
P
E
R
S
C
S
L
Site 11
S55
P
E
A
S
P
E
R
S
C
S
L
H
S
C
P
Site 12
S57
A
S
P
E
R
S
C
S
L
H
S
C
P
L
E
Site 13
S60
E
R
S
C
S
L
H
S
C
P
L
E
D
P
S
Site 14
S67
S
C
P
L
E
D
P
S
S
S
S
G
P
P
P
Site 15
S68
C
P
L
E
D
P
S
S
S
S
G
P
P
P
T
Site 16
S69
P
L
E
D
P
S
S
S
S
G
P
P
P
T
T
Site 17
S70
L
E
D
P
S
S
S
S
G
P
P
P
T
T
S
Site 18
T75
S
S
S
G
P
P
P
T
T
S
T
L
Q
P
V
Site 19
T76
S
S
G
P
P
P
T
T
S
T
L
Q
P
V
G
Site 20
S77
S
G
P
P
P
T
T
S
T
L
Q
P
V
G
P
Site 21
T78
G
P
P
P
T
T
S
T
L
Q
P
V
G
P
S
Site 22
Y95
L
A
P
A
H
F
T
Y
P
R
A
L
Q
E
Y
Site 23
Y102
Y
P
R
A
L
Q
E
Y
Q
G
G
S
S
L
P
Site 24
S106
L
Q
E
Y
Q
G
G
S
S
L
P
G
L
G
D
Site 25
S107
Q
E
Y
Q
G
G
S
S
L
P
G
L
G
D
R
Site 26
S119
G
D
R
A
A
L
C
S
H
G
S
S
L
S
P
Site 27
S123
A
L
C
S
H
G
S
S
L
S
P
S
P
A
P
Site 28
S125
C
S
H
G
S
S
L
S
P
S
P
A
P
S
Q
Site 29
S127
H
G
S
S
L
S
P
S
P
A
P
S
Q
R
D
Site 30
S131
L
S
P
S
P
A
P
S
Q
R
D
G
T
W
K
Site 31
T136
A
P
S
Q
R
D
G
T
W
K
P
P
A
V
Q
Site 32
S148
A
V
Q
H
H
V
V
S
V
R
Q
E
R
A
F
Site 33
S160
R
A
F
Q
M
P
K
S
Y
S
Q
L
I
A
E
Site 34
S162
F
Q
M
P
K
S
Y
S
Q
L
I
A
E
W
P
Site 35
S197
G
A
R
L
P
D
F
S
K
P
L
L
G
F
E
Site 36
T208
L
G
F
E
P
R
D
T
D
I
G
S
K
L
V
Site 37
S212
P
R
D
T
D
I
G
S
K
L
V
V
W
R
A
Site 38
S233
P
R
K
L
L
F
L
S
P
D
L
E
L
N
S
Site 39
S240
S
P
D
L
E
L
N
S
S
S
S
H
N
T
L
Site 40
S241
P
D
L
E
L
N
S
S
S
S
H
N
T
L
R
Site 41
S242
D
L
E
L
N
S
S
S
S
H
N
T
L
R
P
Site 42
S243
L
E
L
N
S
S
S
S
H
N
T
L
R
P
A
Site 43
T246
N
S
S
S
S
H
N
T
L
R
P
A
P
R
G
Site 44
S254
L
R
P
A
P
R
G
S
A
Q
E
S
A
V
R
Site 45
S258
P
R
G
S
A
Q
E
S
A
V
R
P
R
R
M
Site 46
Y286
C
G
P
P
E
K
S
Y
A
K
L
V
F
M
S
Site 47
S318
M
E
Q
D
Q
I
R
S
H
T
S
F
G
A
L
Site 48
T320
Q
D
Q
I
R
S
H
T
S
F
G
A
L
C
Q
Site 49
S321
D
Q
I
R
S
H
T
S
F
G
A
L
C
Q
R
Site 50
Y343
P
S
W
S
L
G
N
Y
L
A
V
L
S
N
R
Site 51
S348
G
N
Y
L
A
V
L
S
N
R
S
S
C
L
D
Site 52
S352
A
V
L
S
N
R
S
S
C
L
D
T
T
Q
A
Site 53
T356
N
R
S
S
C
L
D
T
T
Q
A
D
A
A
R
Site 54
T357
R
S
S
C
L
D
T
T
Q
A
D
A
A
R
T
Site 55
S383
H
S
G
A
L
V
P
S
C
L
G
P
G
Q
N
Site 56
S392
L
G
P
G
Q
N
K
S
P
R
C
A
Q
V
P
Site 57
T400
P
R
C
A
Q
V
P
T
K
C
S
Q
S
S
A
Site 58
S403
A
Q
V
P
T
K
C
S
Q
S
S
A
I
Y
Q
Site 59
S422
L
L
D
R
D
F
L
S
P
Q
T
T
D
Y
Q
Site 60
T426
D
F
L
S
P
Q
T
T
D
Y
Q
V
P
S
L
Site 61
Y428
L
S
P
Q
T
T
D
Y
Q
V
P
S
L
K
Y
Site 62
S432
T
T
D
Y
Q
V
P
S
L
K
Y
S
L
L
F
Site 63
T458
I
Y
L
D
R
L
A
T
P
W
G
L
A
D
N
Site 64
Y466
P
W
G
L
A
D
N
Y
T
S
V
T
G
M
D
Site 65
T467
W
G
L
A
D
N
Y
T
S
V
T
G
M
D
L
Site 66
S468
G
L
A
D
N
Y
T
S
V
T
G
M
D
L
G
Site 67
S569
F
F
D
L
W
R
L
S
K
S
Q
L
P
S
G
Site 68
S571
D
L
W
R
L
S
K
S
Q
L
P
S
G
G
L
Site 69
S575
L
S
K
S
Q
L
P
S
G
G
L
A
Q
R
V
Site 70
Y647
S
A
V
L
H
E
R
Y
L
A
R
G
C
A
R
Site 71
S663
A
R
G
R
W
E
G
S
A
P
R
R
L
L
L
Site 72
T686
L
R
R
A
A
A
G
T
S
R
L
L
F
Q
R
Site 73
T731
S
P
R
L
R
L
P
T
L
P
P
P
G
G
Q
Site 74
S743
G
G
Q
V
F
R
P
S
H
P
F
E
R
F
D
Site 75
Y753
F
E
R
F
D
A
E
Y
R
Q
L
F
L
F
E
Site 76
T783
W
G
V
L
P
V
D
T
G
D
P
L
D
P
R
Site 77
S791
G
D
P
L
D
P
R
S
N
S
S
L
V
R
D
Site 78
S793
P
L
D
P
R
S
N
S
S
L
V
R
D
P
A
Site 79
S794
L
D
P
R
S
N
S
S
L
V
R
D
P
A
F
Site 80
S802
L
V
R
D
P
A
F
S
A
S
G
P
E
A
Q
Site 81
S804
R
D
P
A
F
S
A
S
G
P
E
A
Q
R
W
Site 82
S823
C
H
R
A
R
N
Q
S
F
F
D
T
L
Q
E
Site 83
T827
R
N
Q
S
F
F
D
T
L
Q
E
G
W
P
T
Site 84
S847
T
L
Q
R
W
M
E
S
P
S
C
A
R
L
G
Site 85
S849
Q
R
W
M
E
S
P
S
C
A
R
L
G
P
D
Site 86
T887
L
E
Q
G
P
D
G
T
Q
D
L
G
L
R
F
Site 87
S914
F
Q
T
N
F
R
N
S
P
D
Y
N
Q
T
Q
Site 88
Y917
N
F
R
N
S
P
D
Y
N
Q
T
Q
L
F
Y
Site 89
Y924
Y
N
Q
T
Q
L
F
Y
N
E
V
S
H
W
L
Site 90
T948
G
L
R
R
G
W
F
T
S
R
L
E
L
Y
S
Site 91
S949
L
R
R
G
W
F
T
S
R
L
E
L
Y
S
L
Site 92
S955
T
S
R
L
E
L
Y
S
L
Q
H
S
L
S
T
Site 93
S959
E
L
Y
S
L
Q
H
S
L
S
T
E
P
A
V
Site 94
S1050
C
P
H
P
D
R
L
S
R
V
A
F
S
L
R
Site 95
S1055
R
L
S
R
V
A
F
S
L
R
Q
T
S
C
A
Site 96
T1136
H
L
P
W
D
A
G
T
G
D
P
G
G
E
K
Site 97
S1151
A
G
R
P
R
P
G
S
V
G
G
M
P
G
S
Site 98
S1158
S
V
G
G
M
P
G
S
C
S
E
Q
Y
E
L
Site 99
S1160
G
G
M
P
G
S
C
S
E
Q
Y
E
L
Q
P
Site 100
Y1163
P
G
S
C
S
E
Q
Y
E
L
Q
P
L
A
R
Site 101
S1173
Q
P
L
A
R
R
R
S
P
S
F
D
T
S
T
Site 102
S1175
L
A
R
R
R
S
P
S
F
D
T
S
T
A
T
Site 103
S1179
R
S
P
S
F
D
T
S
T
A
T
S
K
L
S
Site 104
T1180
S
P
S
F
D
T
S
T
A
T
S
K
L
S
H
Site 105
S1183
F
D
T
S
T
A
T
S
K
L
S
H
R
P
S
Site 106
S1186
S
T
A
T
S
K
L
S
H
R
P
S
V
L
S
Site 107
S1190
S
K
L
S
H
R
P
S
V
L
S
E
D
L
Q
Site 108
S1193
S
H
R
P
S
V
L
S
E
D
L
Q
L
H
D
Site 109
S1205
L
H
D
G
P
C
C
S
R
P
P
P
A
P
A
Site 110
S1213
R
P
P
P
A
P
A
S
P
R
E
L
L
L
D
Site 111
S1226
L
D
H
Q
A
V
F
S
Q
C
P
A
L
Q
T
Site 112
T1233
S
Q
C
P
A
L
Q
T
S
S
P
Y
K
Q
A
Site 113
S1234
Q
C
P
A
L
Q
T
S
S
P
Y
K
Q
A
G
Site 114
S1235
C
P
A
L
Q
T
S
S
P
Y
K
Q
A
G
P
Site 115
S1243
P
Y
K
Q
A
G
P
S
P
K
T
R
A
R
Q
Site 116
T1246
Q
A
G
P
S
P
K
T
R
A
R
Q
D
S
Q
Site 117
S1252
K
T
R
A
R
Q
D
S
Q
G
E
E
A
E
P
Site 118
S1263
E
A
E
P
L
P
A
S
P
E
A
P
A
H
S
Site 119
S1270
S
P
E
A
P
A
H
S
P
K
A
K
A
A
D
Site 120
S1284
D
P
P
D
G
F
C
S
S
A
S
T
L
E
G
Site 121
S1285
P
P
D
G
F
C
S
S
A
S
T
L
E
G
L
Site 122
S1295
T
L
E
G
L
S
V
S
D
E
T
C
L
S
T
Site 123
T1298
G
L
S
V
S
D
E
T
C
L
S
T
S
E
P
Site 124
S1301
V
S
D
E
T
C
L
S
T
S
E
P
S
A
R
Site 125
T1302
S
D
E
T
C
L
S
T
S
E
P
S
A
R
V
Site 126
S1303
D
E
T
C
L
S
T
S
E
P
S
A
R
V
P
Site 127
S1306
C
L
S
T
S
E
P
S
A
R
V
P
D
S
V
Site 128
S1312
P
S
A
R
V
P
D
S
V
G
V
S
P
D
D
Site 129
S1316
V
P
D
S
V
G
V
S
P
D
D
L
D
D
T
Site 130
T1323
S
P
D
D
L
D
D
T
G
Q
P
V
L
E
R
Site 131
T1339
Q
L
N
G
K
R
D
T
L
W
L
A
L
R
E
Site 132
Y1349
L
A
L
R
E
T
V
Y
D
P
S
L
P
A
S
Site 133
S1352
R
E
T
V
Y
D
P
S
L
P
A
S
H
H
S
Site 134
S1356
Y
D
P
S
L
P
A
S
H
H
S
S
L
S
W
Site 135
S1359
S
L
P
A
S
H
H
S
S
L
S
W
K
G
R
Site 136
S1360
L
P
A
S
H
H
S
S
L
S
W
K
G
R
G
Site 137
S1362
A
S
H
H
S
S
L
S
W
K
G
R
G
G
P
Site 138
S1373
R
G
G
P
G
D
G
S
P
V
V
L
P
N
S
Site 139
S1380
S
P
V
V
L
P
N
S
Q
P
D
L
P
D
V
Site 140
S1393
D
V
W
L
R
R
P
S
T
H
T
S
G
Y
S
Site 141
T1394
V
W
L
R
R
P
S
T
H
T
S
G
Y
S
S
Site 142
T1396
L
R
R
P
S
T
H
T
S
G
Y
S
S
_
_
Site 143
S1397
R
R
P
S
T
H
T
S
G
Y
S
S
_
_
_
Site 144
S1401
T
H
T
S
G
Y
S
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation