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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TBKBP1
Full Name:
TANK-binding kinase 1-binding protein 1
Alias:
KIAA0775; ProSAPiP2; TBK1 binding 1; TBK1 binding protein 1; TBK1-binding protein 1
Type:
Mass (Da):
67684
Number AA:
615
UniProt ID:
A7MCY6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0045087
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
S
M
F
E
D
D
I
S
I
L
T
Q
E
A
L
Site 2
T13
E
D
D
I
S
I
L
T
Q
E
A
L
G
P
S
Site 3
S26
P
S
E
V
W
L
D
S
P
G
D
P
S
L
G
Site 4
S31
L
D
S
P
G
D
P
S
L
G
G
D
M
C
S
Site 5
Y48
H
F
A
L
I
T
A
Y
G
D
I
K
E
R
L
Site 6
T64
G
L
E
R
E
N
A
T
L
R
R
R
L
K
V
Site 7
Y72
L
R
R
R
L
K
V
Y
E
I
K
Y
P
L
I
Site 8
S80
E
I
K
Y
P
L
I
S
D
F
G
E
E
H
G
Site 9
S89
F
G
E
E
H
G
F
S
L
Y
E
I
K
D
G
Site 10
Y91
E
E
H
G
F
S
L
Y
E
I
K
D
G
S
L
Site 11
S97
L
Y
E
I
K
D
G
S
L
L
E
V
E
K
V
Site 12
Y134
L
G
E
M
I
Q
A
Y
E
K
L
C
V
E
K
Site 13
S142
E
K
L
C
V
E
K
S
D
L
E
T
E
L
R
Site 14
T146
V
E
K
S
D
L
E
T
E
L
R
E
M
R
A
Site 15
T157
E
M
R
A
L
V
E
T
H
L
R
Q
I
C
G
Site 16
S181
G
L
Q
D
A
A
F
S
N
L
S
P
P
P
A
Site 17
S184
D
A
A
F
S
N
L
S
P
P
P
A
P
A
P
Site 18
T194
P
A
P
A
P
P
C
T
D
L
D
L
H
Y
L
Site 19
Y200
C
T
D
L
D
L
H
Y
L
A
L
R
G
G
S
Site 20
S207
Y
L
A
L
R
G
G
S
G
L
S
H
A
G
W
Site 21
S210
L
R
G
G
S
G
L
S
H
A
G
W
P
G
S
Site 22
S217
S
H
A
G
W
P
G
S
T
P
S
V
S
D
L
Site 23
T218
H
A
G
W
P
G
S
T
P
S
V
S
D
L
E
Site 24
S220
G
W
P
G
S
T
P
S
V
S
D
L
E
R
R
Site 25
S222
P
G
S
T
P
S
V
S
D
L
E
R
R
R
L
Site 26
S277
Q
D
L
A
S
N
Q
S
E
R
D
M
A
W
V
Site 27
S312
L
G
R
L
R
E
L
S
S
L
Q
G
R
I
L
Site 28
S313
G
R
L
R
E
L
S
S
L
Q
G
R
I
L
R
Site 29
S335
R
S
G
G
Q
R
H
S
P
L
S
Q
R
H
S
Site 30
S338
G
Q
R
H
S
P
L
S
Q
R
H
S
P
A
P
Site 31
S342
S
P
L
S
Q
R
H
S
P
A
P
Q
C
P
S
Site 32
S349
S
P
A
P
Q
C
P
S
P
S
P
P
A
R
A
Site 33
S351
A
P
Q
C
P
S
P
S
P
P
A
R
A
A
P
Site 34
S365
P
P
C
P
P
C
Q
S
P
V
P
Q
R
R
S
Site 35
S372
S
P
V
P
Q
R
R
S
P
V
P
P
C
P
S
Site 36
S379
S
P
V
P
P
C
P
S
P
Q
Q
R
R
S
P
Site 37
S385
P
S
P
Q
Q
R
R
S
P
A
S
P
S
C
P
Site 38
S388
Q
Q
R
R
S
P
A
S
P
S
C
P
S
P
V
Site 39
S390
R
R
S
P
A
S
P
S
C
P
S
P
V
P
Q
Site 40
S393
P
A
S
P
S
C
P
S
P
V
P
Q
R
R
S
Site 41
S400
S
P
V
P
Q
R
R
S
P
V
P
P
S
C
Q
Site 42
S405
R
R
S
P
V
P
P
S
C
Q
S
P
S
P
Q
Site 43
S408
P
V
P
P
S
C
Q
S
P
S
P
Q
R
R
S
Site 44
S410
P
P
S
C
Q
S
P
S
P
Q
R
R
S
P
V
Site 45
S415
S
P
S
P
Q
R
R
S
P
V
P
P
S
C
P
Site 46
S420
R
R
S
P
V
P
P
S
C
P
A
P
Q
P
R
Site 47
Y444
R
T
L
A
E
R
A
Y
A
K
P
P
S
H
H
Site 48
S449
R
A
Y
A
K
P
P
S
H
H
V
K
A
G
F
Site 49
S461
A
G
F
Q
G
R
R
S
Y
S
E
L
A
E
G
Site 50
Y462
G
F
Q
G
R
R
S
Y
S
E
L
A
E
G
A
Site 51
S463
F
Q
G
R
R
S
Y
S
E
L
A
E
G
A
A
Site 52
Y471
E
L
A
E
G
A
A
Y
A
G
A
S
P
P
W
Site 53
S475
G
A
A
Y
A
G
A
S
P
P
W
L
Q
A
E
Site 54
Y492
T
L
P
K
P
R
A
Y
G
S
E
L
Y
G
P
Site 55
S494
P
K
P
R
A
Y
G
S
E
L
Y
G
P
G
R
Site 56
Y497
R
A
Y
G
S
E
L
Y
G
P
G
R
P
L
S
Site 57
S504
Y
G
P
G
R
P
L
S
P
R
R
A
F
E
G
Site 58
S521
L
R
F
E
K
Q
P
S
E
E
D
E
W
A
V
Site 59
T530
E
D
E
W
A
V
P
T
S
P
P
S
P
E
V
Site 60
S531
D
E
W
A
V
P
T
S
P
P
S
P
E
V
G
Site 61
S534
A
V
P
T
S
P
P
S
P
E
V
G
T
I
R
Site 62
S568
A
H
A
E
H
A
Q
S
W
P
S
I
N
L
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation