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Updated November 2019
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Protein Info
Short Name:
KIAA1853
Full Name:
Serine/arginine repetitive matrix protein 4
Alias:
K1853; medulloblastoma antigen MU-MB-2.76; neural-specific SR-related protein of 100 kDa; nSR100; serine/arginine repetitive matrix 4
Type:
Unknown function
Mass (Da):
68559
Number AA:
611
UniProt ID:
A7MD48
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003729
PhosphoSite+
KinaseNET
Biological Process:
GO:0030154
GO:0006397
GO:0007399
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T19
F
E
K
F
W
R
G
T
F
K
A
V
A
T
P
Site 2
T74
L
A
T
E
P
L
G
T
N
S
W
E
R
D
K
Site 3
T82
N
S
W
E
R
D
K
T
C
R
E
L
G
A
T
Site 4
T89
T
C
R
E
L
G
A
T
R
G
H
S
A
S
H
Site 5
S93
L
G
A
T
R
G
H
S
A
S
H
D
K
D
L
Site 6
S95
A
T
R
G
H
S
A
S
H
D
K
D
L
T
P
Site 7
T101
A
S
H
D
K
D
L
T
P
P
P
S
S
R
G
Site 8
S105
K
D
L
T
P
P
P
S
S
R
G
K
K
K
K
Site 9
S106
D
L
T
P
P
P
S
S
R
G
K
K
K
K
K
Site 10
S115
G
K
K
K
K
K
K
S
T
R
K
K
R
R
R
Site 11
S123
T
R
K
K
R
R
R
S
S
S
Y
S
P
S
P
Site 12
S124
R
K
K
R
R
R
S
S
S
Y
S
P
S
P
V
Site 13
S125
K
K
R
R
R
S
S
S
Y
S
P
S
P
V
K
Site 14
S127
R
R
R
S
S
S
Y
S
P
S
P
V
K
K
K
Site 15
S129
R
S
S
S
Y
S
P
S
P
V
K
K
K
K
K
Site 16
S138
V
K
K
K
K
K
K
S
S
K
K
H
K
R
R
Site 17
S139
K
K
K
K
K
K
S
S
K
K
H
K
R
R
R
Site 18
S147
K
K
H
K
R
R
R
S
F
S
K
K
R
R
H
Site 19
S149
H
K
R
R
R
S
F
S
K
K
R
R
H
S
S
Site 20
S155
F
S
K
K
R
R
H
S
S
S
S
P
K
S
K
Site 21
S156
S
K
K
R
R
H
S
S
S
S
P
K
S
K
R
Site 22
S157
K
K
R
R
H
S
S
S
S
P
K
S
K
R
R
Site 23
S158
K
R
R
H
S
S
S
S
P
K
S
K
R
R
D
Site 24
S161
H
S
S
S
S
P
K
S
K
R
R
D
E
K
R
Site 25
S173
E
K
R
H
K
K
Q
S
R
S
R
P
R
K
S
Site 26
S175
R
H
K
K
Q
S
R
S
R
P
R
K
S
H
R
Site 27
S180
S
R
S
R
P
R
K
S
H
R
H
R
H
H
R
Site 28
S190
H
R
H
H
R
C
P
S
R
S
Q
S
S
E
S
Site 29
S192
H
H
R
C
P
S
R
S
Q
S
S
E
S
R
P
Site 30
S194
R
C
P
S
R
S
Q
S
S
E
S
R
P
S
S
Site 31
S195
C
P
S
R
S
Q
S
S
E
S
R
P
S
S
C
Site 32
S197
S
R
S
Q
S
S
E
S
R
P
S
S
C
E
S
Site 33
S200
Q
S
S
E
S
R
P
S
S
C
E
S
R
H
R
Site 34
S201
S
S
E
S
R
P
S
S
C
E
S
R
H
R
G
Site 35
S204
S
R
P
S
S
C
E
S
R
H
R
G
R
S
P
Site 36
S210
E
S
R
H
R
G
R
S
P
E
E
G
Q
K
S
Site 37
S217
S
P
E
E
G
Q
K
S
R
R
R
H
S
R
R
Site 38
S222
Q
K
S
R
R
R
H
S
R
R
C
S
K
T
L
Site 39
S226
R
R
H
S
R
R
C
S
K
T
L
C
K
D
S
Site 40
T228
H
S
R
R
C
S
K
T
L
C
K
D
S
P
E
Site 41
S233
S
K
T
L
C
K
D
S
P
E
A
Q
S
S
R
Site 42
S238
K
D
S
P
E
A
Q
S
S
R
P
P
S
Q
P
Site 43
S239
D
S
P
E
A
Q
S
S
R
P
P
S
Q
P
L
Site 44
S243
A
Q
S
S
R
P
P
S
Q
P
L
Q
M
L
G
Site 45
T259
L
S
A
R
G
V
I
T
G
S
G
S
A
A
D
Site 46
T269
G
S
A
A
D
L
F
T
K
T
A
S
P
L
T
Site 47
S273
D
L
F
T
K
T
A
S
P
L
T
T
S
R
G
Site 48
T276
T
K
T
A
S
P
L
T
T
S
R
G
R
S
Q
Site 49
T277
K
T
A
S
P
L
T
T
S
R
G
R
S
Q
E
Site 50
S278
T
A
S
P
L
T
T
S
R
G
R
S
Q
E
Y
Site 51
S282
L
T
T
S
R
G
R
S
Q
E
Y
D
S
G
N
Site 52
Y285
S
R
G
R
S
Q
E
Y
D
S
G
N
D
T
S
Site 53
S287
G
R
S
Q
E
Y
D
S
G
N
D
T
S
S
P
Site 54
T291
E
Y
D
S
G
N
D
T
S
S
P
P
S
T
Q
Site 55
S292
Y
D
S
G
N
D
T
S
S
P
P
S
T
Q
T
Site 56
S293
D
S
G
N
D
T
S
S
P
P
S
T
Q
T
S
Site 57
S296
N
D
T
S
S
P
P
S
T
Q
T
S
S
A
R
Site 58
T297
D
T
S
S
P
P
S
T
Q
T
S
S
A
R
S
Site 59
T299
S
S
P
P
S
T
Q
T
S
S
A
R
S
R
G
Site 60
S300
S
P
P
S
T
Q
T
S
S
A
R
S
R
G
Q
Site 61
S301
P
P
S
T
Q
T
S
S
A
R
S
R
G
Q
E
Site 62
S304
T
Q
T
S
S
A
R
S
R
G
Q
E
K
G
S
Site 63
S311
S
R
G
Q
E
K
G
S
P
S
G
G
L
S
K
Site 64
S313
G
Q
E
K
G
S
P
S
G
G
L
S
K
S
R
Site 65
S317
G
S
P
S
G
G
L
S
K
S
R
E
L
N
S
Site 66
S319
P
S
G
G
L
S
K
S
R
E
L
N
S
G
N
Site 67
S324
S
K
S
R
E
L
N
S
G
N
T
S
D
S
G
Site 68
S328
E
L
N
S
G
N
T
S
D
S
G
N
S
F
T
Site 69
S330
N
S
G
N
T
S
D
S
G
N
S
F
T
T
S
Site 70
S333
N
T
S
D
S
G
N
S
F
T
T
S
S
P
Q
Site 71
T335
S
D
S
G
N
S
F
T
T
S
S
P
Q
N
K
Site 72
S337
S
G
N
S
F
T
T
S
S
P
Q
N
K
G
A
Site 73
S338
G
N
S
F
T
T
S
S
P
Q
N
K
G
A
M
Site 74
S350
G
A
M
L
E
N
L
S
P
T
S
R
G
R
E
Site 75
S353
L
E
N
L
S
P
T
S
R
G
R
E
S
R
G
Site 76
S358
P
T
S
R
G
R
E
S
R
G
F
Q
S
P
C
Site 77
S363
R
E
S
R
G
F
Q
S
P
C
L
E
C
A
E
Site 78
S374
E
C
A
E
V
K
K
S
S
L
V
P
S
T
A
Site 79
S375
C
A
E
V
K
K
S
S
L
V
P
S
T
A
R
Site 80
S379
K
K
S
S
L
V
P
S
T
A
R
S
S
P
M
Site 81
T380
K
S
S
L
V
P
S
T
A
R
S
S
P
M
K
Site 82
S383
L
V
P
S
T
A
R
S
S
P
M
K
G
C
S
Site 83
S384
V
P
S
T
A
R
S
S
P
M
K
G
C
S
R
Site 84
S390
S
S
P
M
K
G
C
S
R
S
S
S
Y
A
S
Site 85
S392
P
M
K
G
C
S
R
S
S
S
Y
A
S
T
R
Site 86
S393
M
K
G
C
S
R
S
S
S
Y
A
S
T
R
S
Site 87
S394
K
G
C
S
R
S
S
S
Y
A
S
T
R
S
S
Site 88
Y395
G
C
S
R
S
S
S
Y
A
S
T
R
S
S
S
Site 89
S397
S
R
S
S
S
Y
A
S
T
R
S
S
S
H
S
Site 90
T398
R
S
S
S
Y
A
S
T
R
S
S
S
H
S
S
Site 91
S400
S
S
Y
A
S
T
R
S
S
S
H
S
S
R
S
Site 92
S401
S
Y
A
S
T
R
S
S
S
H
S
S
R
S
P
Site 93
S402
Y
A
S
T
R
S
S
S
H
S
S
R
S
P
N
Site 94
S404
S
T
R
S
S
S
H
S
S
R
S
P
N
P
R
Site 95
S405
T
R
S
S
S
H
S
S
R
S
P
N
P
R
A
Site 96
S407
S
S
S
H
S
S
R
S
P
N
P
R
A
S
P
Site 97
S413
R
S
P
N
P
R
A
S
P
R
Y
T
Q
S
R
Site 98
Y416
N
P
R
A
S
P
R
Y
T
Q
S
R
S
T
S
Site 99
T417
P
R
A
S
P
R
Y
T
Q
S
R
S
T
S
S
Site 100
S419
A
S
P
R
Y
T
Q
S
R
S
T
S
S
E
K
Site 101
S421
P
R
Y
T
Q
S
R
S
T
S
S
E
K
R
S
Site 102
T422
R
Y
T
Q
S
R
S
T
S
S
E
K
R
S
Y
Site 103
S423
Y
T
Q
S
R
S
T
S
S
E
K
R
S
Y
S
Site 104
S424
T
Q
S
R
S
T
S
S
E
K
R
S
Y
S
R
Site 105
S428
S
T
S
S
E
K
R
S
Y
S
R
S
P
S
Y
Site 106
Y429
T
S
S
E
K
R
S
Y
S
R
S
P
S
Y
S
Site 107
S430
S
S
E
K
R
S
Y
S
R
S
P
S
Y
S
S
Site 108
S432
E
K
R
S
Y
S
R
S
P
S
Y
S
S
K
S
Site 109
S434
R
S
Y
S
R
S
P
S
Y
S
S
K
S
G
K
Site 110
Y435
S
Y
S
R
S
P
S
Y
S
S
K
S
G
K
R
Site 111
S436
Y
S
R
S
P
S
Y
S
S
K
S
G
K
R
S
Site 112
S437
S
R
S
P
S
Y
S
S
K
S
G
K
R
S
P
Site 113
S439
S
P
S
Y
S
S
K
S
G
K
R
S
P
P
S
Site 114
S443
S
S
K
S
G
K
R
S
P
P
S
R
S
S
R
Site 115
S446
S
G
K
R
S
P
P
S
R
S
S
R
S
R
R
Site 116
S448
K
R
S
P
P
S
R
S
S
R
S
R
R
S
P
Site 117
S449
R
S
P
P
S
R
S
S
R
S
R
R
S
P
S
Site 118
S451
P
P
S
R
S
S
R
S
R
R
S
P
S
Y
S
Site 119
S454
R
S
S
R
S
R
R
S
P
S
Y
S
R
Y
S
Site 120
S456
S
R
S
R
R
S
P
S
Y
S
R
Y
S
P
S
Site 121
Y457
R
S
R
R
S
P
S
Y
S
R
Y
S
P
S
R
Site 122
S458
S
R
R
S
P
S
Y
S
R
Y
S
P
S
R
E
Site 123
Y460
R
S
P
S
Y
S
R
Y
S
P
S
R
E
R
D
Site 124
S461
S
P
S
Y
S
R
Y
S
P
S
R
E
R
D
P
Site 125
S463
S
Y
S
R
Y
S
P
S
R
E
R
D
P
K
Y
Site 126
Y470
S
R
E
R
D
P
K
Y
S
E
K
D
S
Q
Q
Site 127
S471
R
E
R
D
P
K
Y
S
E
K
D
S
Q
Q
R
Site 128
S475
P
K
Y
S
E
K
D
S
Q
Q
R
E
R
E
R
Site 129
S489
R
A
R
R
R
R
R
S
Y
S
P
M
R
K
R
Site 130
Y490
A
R
R
R
R
R
S
Y
S
P
M
R
K
R
R
Site 131
S491
R
R
R
R
R
S
Y
S
P
M
R
K
R
R
R
Site 132
S500
M
R
K
R
R
R
D
S
P
S
H
L
E
A
R
Site 133
S502
K
R
R
R
D
S
P
S
H
L
E
A
R
R
I
Site 134
T510
H
L
E
A
R
R
I
T
S
A
R
K
R
P
I
Site 135
S511
L
E
A
R
R
I
T
S
A
R
K
R
P
I
P
Site 136
Y519
A
R
K
R
P
I
P
Y
Y
R
P
S
P
S
S
Site 137
Y520
R
K
R
P
I
P
Y
Y
R
P
S
P
S
S
S
Site 138
S523
P
I
P
Y
Y
R
P
S
P
S
S
S
G
S
L
Site 139
S525
P
Y
Y
R
P
S
P
S
S
S
G
S
L
S
S
Site 140
S526
Y
Y
R
P
S
P
S
S
S
G
S
L
S
S
T
Site 141
S527
Y
R
P
S
P
S
S
S
G
S
L
S
S
T
S
Site 142
S529
P
S
P
S
S
S
G
S
L
S
S
T
S
S
W
Site 143
S531
P
S
S
S
G
S
L
S
S
T
S
S
W
Y
S
Site 144
S532
S
S
S
G
S
L
S
S
T
S
S
W
Y
S
S
Site 145
T533
S
S
G
S
L
S
S
T
S
S
W
Y
S
S
S
Site 146
S534
S
G
S
L
S
S
T
S
S
W
Y
S
S
S
S
Site 147
S535
G
S
L
S
S
T
S
S
W
Y
S
S
S
S
S
Site 148
Y537
L
S
S
T
S
S
W
Y
S
S
S
S
S
R
S
Site 149
S538
S
S
T
S
S
W
Y
S
S
S
S
S
R
S
A
Site 150
S539
S
T
S
S
W
Y
S
S
S
S
S
R
S
A
S
Site 151
S540
T
S
S
W
Y
S
S
S
S
S
R
S
A
S
R
Site 152
S541
S
S
W
Y
S
S
S
S
S
R
S
A
S
R
S
Site 153
S542
S
W
Y
S
S
S
S
S
R
S
A
S
R
S
Y
Site 154
S544
Y
S
S
S
S
S
R
S
A
S
R
S
Y
S
R
Site 155
S546
S
S
S
S
R
S
A
S
R
S
Y
S
R
S
W
Site 156
S548
S
S
R
S
A
S
R
S
Y
S
R
S
W
S
R
Site 157
Y549
S
R
S
A
S
R
S
Y
S
R
S
W
S
R
S
Site 158
S550
R
S
A
S
R
S
Y
S
R
S
W
S
R
S
R
Site 159
S552
A
S
R
S
Y
S
R
S
W
S
R
S
R
S
R
Site 160
S554
R
S
Y
S
R
S
W
S
R
S
R
S
R
R
R
Site 161
S556
Y
S
R
S
W
S
R
S
R
S
R
R
R
S
R
Site 162
S558
R
S
W
S
R
S
R
S
R
R
R
S
R
T
R
Site 163
S562
R
S
R
S
R
R
R
S
R
T
R
T
S
S
S
Site 164
T564
R
S
R
R
R
S
R
T
R
T
S
S
S
S
S
Site 165
T566
R
R
R
S
R
T
R
T
S
S
S
S
S
S
R
Site 166
S567
R
R
S
R
T
R
T
S
S
S
S
S
S
R
S
Site 167
S568
R
S
R
T
R
T
S
S
S
S
S
S
R
S
P
Site 168
S569
S
R
T
R
T
S
S
S
S
S
S
R
S
P
S
Site 169
S570
R
T
R
T
S
S
S
S
S
S
R
S
P
S
P
Site 170
S571
T
R
T
S
S
S
S
S
S
R
S
P
S
P
G
Site 171
S572
R
T
S
S
S
S
S
S
R
S
P
S
P
G
S
Site 172
S574
S
S
S
S
S
S
R
S
P
S
P
G
S
R
S
Site 173
S576
S
S
S
S
R
S
P
S
P
G
S
R
S
R
S
Site 174
S579
S
R
S
P
S
P
G
S
R
S
R
S
R
S
R
Site 175
S581
S
P
S
P
G
S
R
S
R
S
R
S
R
S
R
Site 176
S583
S
P
G
S
R
S
R
S
R
S
R
S
R
S
R
Site 177
S585
G
S
R
S
R
S
R
S
R
S
R
S
R
S
R
Site 178
S587
R
S
R
S
R
S
R
S
R
S
R
S
R
S
R
Site 179
S589
R
S
R
S
R
S
R
S
R
S
R
S
R
S
Q
Site 180
S591
R
S
R
S
R
S
R
S
R
S
R
S
Q
S
R
Site 181
S593
R
S
R
S
R
S
R
S
R
S
Q
S
R
S
Y
Site 182
S595
R
S
R
S
R
S
R
S
Q
S
R
S
Y
S
S
Site 183
S597
R
S
R
S
R
S
Q
S
R
S
Y
S
S
A
D
Site 184
S599
R
S
R
S
Q
S
R
S
Y
S
S
A
D
S
Y
Site 185
Y600
S
R
S
Q
S
R
S
Y
S
S
A
D
S
Y
S
Site 186
S601
R
S
Q
S
R
S
Y
S
S
A
D
S
Y
S
S
Site 187
S602
S
Q
S
R
S
Y
S
S
A
D
S
Y
S
S
T
Site 188
S605
R
S
Y
S
S
A
D
S
Y
S
S
T
R
R
_
Site 189
Y606
S
Y
S
S
A
D
S
Y
S
S
T
R
R
_
_
Site 190
S607
Y
S
S
A
D
S
Y
S
S
T
R
R
_
_
_
Site 191
S608
S
S
A
D
S
Y
S
S
T
R
R
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation